Oxurion NV — Major Shareholding Notification 2025

Aug 7, 2025

Oxurion Receives Transparency Notifications from UBS Group AG

Leuven, BELGIUM – August 7, 2025 – 06:00 PM CET - Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company headquartered in Leuven, today announced that, pursuant to Belgian Transparency legislation¹ it has received transparency notifications as follows:

Oxurion received a transparency notification on August 1, 2025, from UBS Group AG indicating that as of July 24, 2025, it held 803,499 shares of the then outstanding 25,821,963 shares, and therefore crossed above the threshold (3%) by virtue of the purchase of voting securities.

Oxurion received a transparency notification on August 1, 2025, from UBS Group AG indicating that as of July 25, 2025, it held 0,00 shares of the then outstanding 36,983,581 shares, and therefore crossed below the threshold (3%) by virtue of the selling of voting securities.

About Oxurion

Oxurion NV (Euronext Brussels: OXUR) is a biopharmaceutical group in transition, combining therapeutic innovation with technologies applied to clinical research. Through its rapidly expanding technology division, Oxurion is building integrated expertise around clinical data, with the ambition to accelerate, secure, and transform the processes involved in developing new treatments. The Group's headquarters are based in Leuven, Belgium. More information is available at www.oxurion.com.

Important information about forward-looking statements

Certain statements in this press release may be considered "forward-looking". Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forwardlooking statement is contained in the Company's Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

Additional Disclaimer

________

The planned investment in digital assets (such as Bitcoin and Ethereum) exposes the company to specific risks related to volatility, regulatory uncertainty, and cybersecurity. These factors may significantly affect the expected performance of the investments.

For further information please contact:

Oxurion NV Pascal Ghoson Chief Executive Officer Pascal.ghoson@oxurion.com

^1. Article 14, first paragraph, of the Law of 2 May 2007 on disclosure of major holdings.

ANNEX 1

FSMA	FINANCIAL SERVICES AND MARKETS AUTHORITY	Form TR-1 BE PART I	Transparency notification
1) Status of the notification
	Final
2) Issuer
ldentification number 0881-620-924	Name Oxurion NV
3) Reason for the notification
	Acquisition or disposal of financial instruments that are treated as voting securities
4) Notification by
	A parent undertaking or a controlling person
5) Persons subject to the notification requirement
	Name		Address (for legal entities)
	UBS Group AG	Bahnhofstrasse 45, 8001 Zürich
	6) Persons that dispose of votinq rights (only to be filled in if art. 7 of the Law applies)
	Name		Address (for legal entities)
C	Please continue entering the information in part II concerning the persons referred to in Sections 5 and 6		Part II
7) Date on which the threshold is crossed
		24.07.2025 (DD/MM/YYYY)
8) Threshold that is crossed (in %)
		3
	If the holding has fallen below the lowest threshold, you have the option of not entering any numbers in Section 10
9) Denominator
	25.821.963
	Please enter the denominator before filling in the data
10) Notified details
A) Voting rights Previous notification After the transaction
	# of voting rights		# of voting rights		% of voting rights
Holders of voting rights		Linked to securities	Not linked to the secunties	inked to securities	Not linked to the securities

B) Equivalent financial instruments	After the transaction
Holders of equivalent financial instruments	Type of financial instrument	Expiration date	Exercise period or date	# of voting rights that may be acquired if the instrument is exercised	% of voting rights	Settlement
UBS AG	Right Of use over shares		At any time	803,499	3,11%	physical	+
	TOTAL			803 499	3,11%
1	The totals will be updated once you have clicked on

TOTAL (A & B)			# of voting rights % of voting rights
	CALCULATE	803,499	3,11%

11) Full chain of controlled undertakings through which the holding is effectively held, if applicable

12) In case of proxy voting for only one GM

			DUMMAN
Holder	will cease to hold / will hold again	voting rights as of

13) Additional information

The disclosure obligation arse due to the total in voting rights of Oxunon NV, held directly by controlled undertakings, going above 3% on 24th July 2025

	Done at Zurich, Switzerland
On		31.07.2025 (DD/MM/YYYY)
Name & capacity Authorized Officer	Sjoerd Sluimer	Signature
	Ewa Zajac Associate Director	Signature	Eira Toppe

ANNEX 2

FSMA FINANCIAL SERVICES AND MARKETS AUTHORITY	Transparency notification Form TR-1 BE PART I
1) Status of the notification
Final
2) Issuer
Name Oxurion NV
ldentification number 0881-620-924
3) Reason for the notification
	Acquisition or disposal of financial instruments that are treated as voting securities
Downward crossing of the lowest threshold
4) Notification by
A parent undertaking or a controlling person
5) Persons subject to the notification requirement
Name	Address (for legal entities)
UBS Group AG	Bahnhofstrasse 45, 8001 Zürich
6) Persons that dispose of votinq rights (only to be filled in if art. 7 of the Law applies)
Name	Address (for legal entities)
ar persons referred to in Sections 5 and 6	Please continue entering the information in part II concerning the Part II
7) Date on which the threshold is crossed
	25.07.2025 (DD/MM/YYYY)
8) Threshold that is crossed (in %)
	3
	If the holding has fallen below the lowest threshold, you have the option of not entering any numbers in Section 10
9) Denominator
	36.983.581
Please enter the denominator before filling in the data
10) Notified details

A) Voting rights	Previous notification	After the transaction
	# of voting rights	# of voting rights		% of voting rights
Holders of voting rights		Linked to securities	Not linked to the securities	Linked to securities	Not linked to the secunties
UBS Group AG	0	0	0
UBS AG	0	0	0
Subtotal		0	0
	TOTAL	0	0	0,00%	0.00%

-
-
+

B) Equivalent financial instruments	After the transaction
Holders of equivalent financial instruments	Type of financial instrument	Expiration date	Exercise period or date	# of voting rights that may be acquired if the instrument is exercised	% of voting rights	Settlement
							+
	TOTAL			0	0.00%

The totals will be updated once you have clicked on

TOTAL (A & B)			# of voting rights % of voting rights
	CALCULATE	0	0,00%

11) Full chain of controlled undertakings through which the holdinq is effectively held, if applicable

12) In case of proxy voting for only one GM

will cease to hold / Holder voting rights as of will hold again

13) Additional information

The disobsure obligation arse due to the tal indings of US Group AG in voting rights of Durion NV, held directly by controlled undertakings, going below 3% on 25th July 2025

Done at Zurich, Switzerland 31.07.2025 (DD/MM/YYYYY) On Name & capacity Authorized Officer
Officer
Ewa Zajar Ewa Zajal

Signature
Signature EWQ		2996