BRIM Biotechnology, Inc. — Proxy Solicitation & Information Statement 2026

May 12, 2026

Notice of 2026 Annual General Shareholders' Meeting

To: The Shareholders

Dear Sir/Madam,

I. The 2026 annual shareholders' meeting will be held on June 12, 2026 (Friday) at 10:00 a.m. in the 102 Conference Room (t.Hub Startup Incubation Center), No. 335 Ruiguang Road, Neihu District, Taipei City. Registration began at 9:30 a.m. on the day of the meeting, and the registration location was the same as the meeting location. Summary of the Meeting:

1. Reported Matters: (1) 2025 Annual Business Report. (2) Audit Committee's Review Report for 2025. (3) Report on the Implementation of the Sound Business Operation Plan. (4) Report on Accumulated Losses Reaching Half of Paid-in Capital in 2025.
2. Ratification Matters: (1) 2025 Annual Business Report and Individual and Consolidated Financial Statements. (2) 2025 Deficit Compensation Proposal.
3. Matters for Discussion: (1) Amendments to the "Articles of Incorporation". (2) Amendments to the "Regulations Governing the Acquisition and Disposal of Assets". (3) Amendment to the "Rules of Procedure for Shareholders' Meetings". (4) Proposed Issuance of Common Shares for Global Depositary Receipt.
4. Election Matters: (1) Full re-election of the Company's 9 directors (including 3 independent directors).
5. Other Matters: (1) The proposal to release the non-compete restrictions for newly appointed directors (including independent directors) and the entities they represent.
6. Extempore Motions

II. If any proposals require detailed description under Article 172 of the Company Act, please visit the MOPS website (https://mops.twse.com.tw) and navigate to Single Company/Download of Electronic Files/Annual Report and Shareholders' Meeting Related Information/Annual Report and Shareholders' Meeting Related Information (including depository receipt information). Enter the company code

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(or abbreviated name) and the relevant year, then check the “Reference Materials for Shareholders’ Meeting Proposals” or the “Meeting Handbook and Supplementary Materials.”

III. Pursuant to Article 165 of the Company Act, share transfers were suspended from April 14, 2026 to June 12, 2026.

IV. Please find enclosed an attendance card and a proxy form. If you plan to attend the meeting in person, please sign or stamp the “attendance card” (no need to return it) and bring it with you to the meeting for registration. If you are appointing an agent to attend on your behalf, please sign or stamp the “proxy form”, complete the agent’s name and relevant details, and have the agent sign or stamp the “proxy form” in the designated area. Please deliver the completed form to the Company’s stock agent, Yong Feng Jin Securities Agent Department, five days before the meeting so that an attendance card can be issued to the agent.

V. Shareholders, soliciting parties, and proxy agents must present identification for verification upon attending a shareholders’ meeting.

VI. If any shareholder solicits a proxy, the Company prepared a summary of the solicitor’s information and disclosed it on the website of the Securities and Futures Institute before May 12, 2026. Shareholders may visit the website directly (https://free.sfi.org.tw) at “Free Search of Proxy Information” and enter the securities code to inquire.

VII. For this annual general meeting, shareholders may exercise their voting rights electronically. The voting period was from May 13, 2026 to June 9, 2026. Please log in to the “Shareholder e-Service” electronic voting platform webpage of the Taiwan Depository & Clearing Corporation and vote according to the relevant instructions. [Website: https://stockservices.tdcc.com.tw]

VIII. Nine directors (including three independent directors) are to be elected this time. The candidate roster under the nomination system is as follows: [Directors: Lin, Chyun、Shyu, Wen-Chyi、Kuo, Mei-Hui、Chang, Chen-Wu、Edward Yung Do Way、Affinity Health Fund One, L.P]; [Independent Directors: Lee, John-See、Kuo, Chung-Ming、Cheng, Shou-Chen]. The URL for inquiring about the educational background and other relevant information for each candidate is https://mops.twse.com.tw.

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IX. The statistical verification agency of this company is the Stock Affairs Department of SinoPac Securities Corporation..

X. Please proceed as referenced above.

Sincerely Yours,

Board of Directors,

BRIM BIOTECHNOLOGY, INC.