BIOTRON LIMITED — Director's Dealing 2022

Nov 28, 2022

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Level 2, 66 Hunter Street Sydney NSW 2000 Tel: (61-2) 9300 3344 Fax: (61-2) 9221 6333 E-mail: pnightingale@biotron.com.au Website: www.biotron.com.au

29 November 2022

The Manager Companies ASX Limited 20 Bridge Street SYDNEY NSW 2000

(9 pages by email)

Dear Madam,

DIRECTORS’ INTERESTS

In accordance with Listing Rule 3.19A, I attach Appendix 3Y, Change of Director's Interest Notice, for Michael J. Hoy, Michelle Miller, Susan Pond and Robert Thomas.

This announcement has been approved by the Managing Director, Michelle Miller.

Yours sincerely

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Peter J. Nightingale Company Secretary

pjn11482

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	BIOTRON LIMITED
ABN	60 086 399 144

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Michael J. HOY
Date of last notice	7 November 2019.

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect.
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevantinterest.	Umbiram Pty Limited A/C> in which Michael Hoy has a beneficial interest.
Date of change	25 November 2022.
No. of securities held prior to change	9,347,793 fully paid ordinary shares held by Umbiram Pty Limited A/C>.
Class	Fully paid ordinary shares. 25 November 2024, 6 cent listed options.
Number acquired	1,869,559 fully paid ordinary shares acquired on 25 November 2022 under a rights issue and 934,780 attached listed options.
Number disposed	Nil
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation.	Shares at $0.03 each and Listed Options at $0.
No. of securities held after change	11,217,352 fully paid ordinary and 934,780 listed options held by Umbiram Pty Limited Superfund A/C>.
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back.	Acquisition under a rights issue.

• See chapter 19 for defined terms.

Appendix 3Y Page 1

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil.
Nature of interest	N/A.
Name of registered holder (if issued securities)	N/A.
Date of change	N/A.
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed.	N/A.
Interest acquired	N/A.
Interest disposed	N/A.
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation.	N/A.
Interest after change	N/A.

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed above traded during a+closed period where prior written clearance was required?	No.
If so, was prior written clearance provided to allow the trade to proceed during this period?	N/A.
If prior written clearance was provided, on what date was thisprovided?	N/A.

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	BIOTRON LIMITED
ABN	60 086 399 144

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Susan Pond
Date of last notice	10 December 2019.

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect.
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest.	BT Portfolio Services Limited A/C> in which Susan Pond has a beneficial interest.
Date of change	25 November 2022.
No. of securities held prior to change	654,295 fully paid ordinary shares held BT Portfolio Services Limited
Class	Fully paid ordinary shares. 25 November 2024, 6 cent listed options.
Number acquired	130,859 fully paid ordinary shares acquired on 25 November 2022 under a rights issue and 65,430 attached listed options.
Number disposed	Nil
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation.	Shares at $0.03 each and Listed Options at $0.
No. of securities held after change	785,154 fully paid ordinary and 65,430 listed options held by BT Portfolio Services Limited Effeney S/F A/C>
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back.	Acquisition under a rights issue.

• See chapter 19 for defined terms.

Appendix 3Y Page 1

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil.
Nature of interest	N/A.
Name of registered holder (if issued securities)	N/A.
Date of change	N/A.
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed.	N/A.
Interest acquired	N/A.
Interest disposed	N/A.
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation.	N/A.
Interest after change	N/A.

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	No.
If so, was prior written clearance provided to allow the trade to proceed during this period?	N/A.
If prior written clearance was provided, on what date was thisprovided?	N/A.

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	BIOTRON LIMITED
ABN	60 086 399 144

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Michelle Miller
Date of last notice	23 December 2019.

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct and Indirect.
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest.	Michelle Miller + Peter Clarke A/C> in which Michelle Miller has a beneficial interest.
Date of change	25 November 2022 and 26 November 2022
No. of securities held prior to change	1,656,250 fully paid ordinary shares held by Michelle Miller; 1,500,000 Michelle Miller + Peter Clarke Super Fund A/C>; 1,000,000 26 November 2022 20 cent options; 1,000,000 26 November 2023 20 cent options.
Class	Fully paid ordinary shares. 25 November 2024, 6 cent listed options.
Number acquired	631,250 fully paid ordinary shares acquired on 25 November 2022 under a rights issue and 315,625 attached listed options.
Number disposed	1,000,000 26 November 2022 20 cent options (expired);
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation.	Shares acquired under the rights issue at $0.03 each and listed Options at $0. 1,000,000 options expired unexercised $Nil

• See chapter 19 for defined terms.

Appendix 3Y Page 1

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	1,987,500 fully paid ordinary shares and 165,625 listed options held by Michelle Miller; 1,800,000 fully paid ordinary shares and 150,000 listed options held by Michelle Miller + Peter Clarke Super Fund A/C>; 1,000,000 26 November 2023, 20 cents options
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back.	Acquisition under a rights issue.

\Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil.
Nature of interest	N/A.
Name of registered holder (if issued securities)	N/A.
Date of change	N/A.
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed.	N/A.
Interest acquired	N/A.
Interest disposed	N/A.
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation.	N/A.
Interest after change	N/A.

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed above traded during a+closed period where prior written clearance was required?	No.
If so, was prior written clearance provided to allow the trade to proceed during this period?	N/A.
If prior written clearance was provided, on what date was this provided?	N/A.

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	BIOTRON LIMITED
ABN	60 086 399 144

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Robert B. Thomas
Date of last notice	22 January 2020.

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect.
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to therelevantinterest.	Murtoa Flour Mills Pty Ltd in which Robert Thomas has a benefial interest.
Date of change	25 November 2022.
No. of securities held prior to change	2,663,195 fully paid ordinary shares held by Murtoa Flour Mills Pty Ltd
Class	Fully paid ordinary shares. 25 November 2024, 6 cent listed options.
Number acquired	536,805 fully paid ordinary shares acquired on 25 November 2022 under a rights issue and 268,403 attached listed options.
Number disposed	Nil
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation.	Shares at $0.03 each and Options at $0.
No. of securities held after change	4,200,000 fully paid ordinary and 268,403 listed options held by Murtoa Flour Mills Pty Ltd A/C>
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back.	Acquisition under a rights issue.

• See chapter 19 for defined terms.

Appendix 3Y Page 1

01/01/2011

Appendix 3Y Change of Director’s Interest Notice

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Nil.
Nature of interest	N/A.
Name of registered holder (if issued securities)	N/A.
Date of change	N/A.
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed.	N/A.
Interest acquired	N/A.
Interest disposed	N/A.
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation.	N/A.
Interest after change	N/A.

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed above traded during a+closed period where prior written clearance was required?	No.
If so, was prior written clearance provided to allow the trade to proceed during this period?	N/A.
If prior written clearance was provided, on what date was this provided?	N/A.

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011