BIOTRON LIMITED - Annual Report 2018

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Level 2, 66 Hunter Street Sydney NSW 2000 Tel: (61-2) 9300 3344 Fax: (61-2) 9221 6333 E-mail: [email protected] Website: www.biotron.com.au

18 October 2018

The Manager Companies ASX Limited 20 Bridge Street SYDNEY NSW 2000

(60 pages by email)

Dear Madam

ANNUAL REPORT AND NOTICE OF AGM

I attach the Company's Annual Report for the year ended 30 June 2018 and a copy of the Company's Notice of Annual General Meeting to be held on 20 November 2018.

Yours sincerely

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Peter J. Nightingale Company Secretary

pjn9610

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Annual Report 2018

BIOTRON LIMITED ABN 60 086 399 144

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Operating and Financial Review ......................................................................................................... 1 Corporate Governance Statement ....................................................................................................5 Directors’ Report ..........................................................................................................................................6 Lead Auditor’s Independence Declaration ................................................................................16 Statement of Profit or Loss and Other Comprehensive Income ...............................17 Statement of Financial Position ......................................................................................................18 Statement of Changes in Equity ......................................................................................................19 Statement of Cash Flows .................................................................................................................... 20 Notes to the Financial Statements ................................................................................................21 Directors’ Declaration ............................................................................................................................ 38 Independent Auditor’s Report .......................................................................................................... 39 Additional Stock Exchange Information ....................................................................................44 Corporate Directory .................................................................................................................................48

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Operating and Financial Review

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REVIEW OF OPERATIONS

Executive Summary

Biotron’s strategy is to systematically grow the value of the Company and work towards a commercial outcome for shareholders. This is best achieved by the demonstration of positive data from clinical trials and other supporting studies. Focus has been on the planned, step-wise clinical development of the Company’s lead antiviral drug, BIT225.

Data from completed studies have demonstrated that BIT225 has activity (the antiviral effectiveness) against both HIV-1 and Hepatitis C virus (HCV).

During the financial year under review, primary focus has been on the HIV-1 clinical program. A key Phase 2 clinical trial of BIT225 for HIV-1, designed to demonstrate a clear clinical benefit for BIT225 over and above that provided by current anti-HIV drugs, continued throughout the second half of 2017. Since the completion of the clinical phase of the trial in late 2017, focus has been on implementing and completing detailed post-trial analyses, which are currently in progress.

In addition, there has been progression of the Company’s early stage programs with additional screening of the Company’s proprietary compound library against additional viral targets

The Company is now fully focused on achieving commercial transaction(s) for the Company’s portfolio of antiviral programs.

A summary of significant events achieved in the financial year includes:

Completion of enrolment of subjects into the Phase 2 human clinical trial (BIT225-009) of BIT225 in HIV-1 infected individuals.
Several Biotron compounds showed significant antiviral activity against Hepatitis B virus (HBV) in cell culture assays.
The Company received an R&D Tax Incentive refund of $1.6 million for the 2016/17 financial year.
Successful completion of an underwritten renounceable rights issue, raising $1.4 million after costs.
Showcasing the Company to the international investment community at various events in the USA, China and Australia.

Biotron Ltd Annual Report 2018

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Operating and Financial Review

Clinical Programs

Biotron is focused on development of new drugs for serious viral diseases with unmet medical need and large, worldwide markets. The Company specialises in the design and development of a first-in-class portfolio of drugs that have the potential to treat a broad range of diseases.

The clinical programs, which include studies in HIV-1, HCV and HIV-1/HCV co-infected populations, have shown encouraging efficacy and safety results in clinical studies completed to date.

BIT225 is in mid-stage clinical development. Compared to other anti-HIV-1 drugs, BIT225 has a different mechanism of action and targets reservoirs of the virus. These long-lived pools of virus persist despite conventional drug treatment and are never completely eliminated. The reservoirs act as ‘burning embers’, producing low levels of virus that cause chronic disease in people infected with HIV-1 through constant activation of the body’s immune system. These factors mandate life-long treatment using currently available drugs.

Eradication of HIV-1 is a current focus of scientists, clinicians and the pharmaceutical industry and is an area where BIT225 has potential. For patients to be cured of their infection, all HIV-infected cells need to be eliminated. The cells that Biotron’s approach target make up one of several key reservoirs, and it is anticipated that a combination approach with current and other new HIV drugs that target different reservoirs would be required to eradicate HIV from patients.

Despite advances in HIV-1 treatments, the virus continues to be a major global health issue. An estimated 36.7 million people are living with HIV-1; less than one third are receiving antiretroviral treatment (ART). In the USA, approximately 1.1 million people are infected, with 1 in 7 unaware of their infection status. Sales of drugs to treat HIV-1 in major markets (USA and Europe) are US$12 billion per annum. To date, eradication, or cure, of HIV-1 infections remains elusive, with only one person worldwide ever documented to have been cured of their infection.

Biotron has built a detailed data package on its HIV-1 program, including results from a clinical trial (BIT225-004) in patients which showed that BIT225 targets and reduces levels of HIV-1 residing in long-lived monocyte/macrophage reservoirs. These reservoirs exist even in patients undergoing treatment with current antiretroviral drugs and are responsible for ongoing cycles of reseeding HIV-1 infection.

The BIT225-004 study also indicated that BIT225 may reduce immune activation. Immune activation is responsible for a number of ongoing health issues in these patients. New treatment strategies are needed to prevent development of associated disorders that include accelerated aging and neurological dysfunction.

During this current financial year, the Company has continued with its key Phase 2 trial (BIT225-009) of BIT225 for HIV-1 infection. The trial is a

Phase 2, multi-centre, randomised, placebocontrolled, double-blind study of Biotron’s lead molecule, BIT225, and Combination Antiretroviral Therapy (cART): Atripla® in patients with Human Immunodeficiency Virus (HIV-1) infection. HIV-1infected patients had not previously been on antiHIV-1 treatment (i.e. treatment naïve) and were commencing a cART regimen (approved anti- HIV-1 drugs). Patients received cART in addition to 12 weeks with BIT225 or placebo.

Biotron Ltd Annual Report 2018

The objectives of the trial are to assess:

Impact of BIT225 in combination with cART on plasma and intracellular HIV-1 virus levels, and
Impact of BIT225 on HIV-1-induced immune activation.

In July 2017, the Company announced that the BIT225-009 clinical trial was fully recruited, with all 36 subjects successfully enrolled into the study. The subjects completed treatment with BIT225 or placebo in November 2017, and then continued to receive standard anti-HIV-1 drugs. Samples continued to be collected from subjects for three months posttreatment, as per the trial protocol, until early 2018.

Post-trial analyses of samples taken throughout the trial and follow-up period are in progress. This work is being done by a third party that has developed the assay and is completely independent from Biotron. The group has indicated that there have been some delays due to other commitments and that the Biotron results are now expected by the end of September 2018. The samples and the results of the analyses remain blinded until this work is complete.

In parallel, analyses have been continuing to assess the impact of BIT225 on HIV-1-induced immune activation. Data from this key component of the trial have been compiled, and are being reviewed by an independent, internationally renowned HIV immunologist based in Europe. It is expected that this review will be available at the same time as the results from the virology assay.

The purpose of this clinical trial is to demonstrate that the addition of BIT225 to current anti-HIV-1 drug treatments results in an additional, measurable benefit to patients. This is the key outcome that needs to be demonstrated to potential commercial partners.

While the Company’s key focus and major business development activities are on achieving a commercial outcome for its HIV-1 program in worldwide markets, including the USA and Europe, it continues to seek suitable partners for other programs including HCV. The outlook for treatment of HCV is particularly strong in emerging markets such as China, where an estimated 30 million people or more are infected with the virus. The Company remains committed to identifying suitable partners and executing a China commercialisation strategy.

Operating and Financial Review

Non-Clinical Programs

In addition to its potential as a new class of antiHIV-1 and anti-HCV drug, BIT225 is an important asset as it demonstrates the robustness of Biotron’s approach to antiviral drug development and that the Company can generate good drugs with activity against a new class of viral protein targets.

BIT225 is only one of the Company’s compounds. Biotron’s proprietary compound library is a rich source of potential hits against other viruses. Screening against other viruses continues with hits from this screening acting as starting points for further chemistry to generate compounds with increased potency against specific viruses.

Positive data from on-going antiviral screening are important as they demonstrate the additional depth beyond BIT225 of Biotron’s library of compounds and approach to developing drugs that target serious viral diseases. This demonstration of Biotron’s core expertise and validation of its assets is key to attracting a commercial partner for Biotron’s entire platform.

During the current financial year, several of the Company’s compounds demonstrated significant anti-viral activity against Hepatitis B virus (HBV). The studies were completed in the USA in cell culture models that are considered ‘industry standard’ and are well recognised by potential pharma and biotech partners. The World Health Organisation estimates that 257 million people are infected with HBV and that up to 900,000 die every year from the disease for which there is no cure. Estimates by GBI Research indicate that the market for HBV drugs is expected to reach US$3.5 billion by 2021.

The HBV therapeutic space is currently very active within the pharmaceutical and biotech industry, with significant investor interest in the search for and development of effective HBV treatments. While Biotron’s work on its HBV compounds is preclinical, the data from these recent studies further validate Biotron’s approach to antiviral drug development and may provide the Company with an early stage development opportunity with an appropriate partner.

The Company remains focused on achieving a commercial outcome for its antiviral programs in worldwide markets, including the USA, Europe and China. The major focus is on partnering the HIV-1 program. Meetings have been held with potential partners throughout the period under review, and further meetings are anticipated once the Company has data from the current HIV-1 clinical trial in hand.

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Biotron Ltd Annual Report 2018

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Operating and Financial Review

Patents

Biotron continues to progress patents related to its antiviral programs through the international patenting process. The Company recognises that the key to establishment of partnerships is the expansion and continued strengthening of Biotron’s intellectual

property portfolio. Strong, defensible, international patents are essential to attract partners and to ensure a competitive advantage for the Company’s products in the marketplace.

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----- Start of picture text -----

TITLE STATUS
WO0021538 Granted in Australia
Method of modulating ion
channel functional activity
Priority – 12 October 1998
WO04112687 Granted in Australia, Canada, China, India, Japan, Korea, New Zealand,
Singapore and South Africa
Antiviral compounds and
methods Under examination elsewhere (Brazil, Europe, Hong Kong, and USA)
Priority – 26 June 2003
WO06135978 Granted in Austria, Australia, Belgium, Canada, Switzerland,
China, Germany, Denmark, Spain, Finland, France, United Kingdom,
Antiviral compounds and
Hong Kong, Ireland, Italy, Japan, Korea, Luxembourg, Monaco, The
methods
Netherlands, New Zealand, Poland, Portugal, Sweden, Singapore,
Priority – 24 June 2005 Turkey, South Africa and USA
Under examination elsewhere (Brazil, India)
WO2009/018609 Granted in Austria, Australia, Belgium, Switzerland, Canada, China,
Germany, Denmark, Spain, Finland, France, United Kingdom,
Hepatitis C antiviral compounds
Hong Kong, Ireland, Italy, Japan, Korea, Luxembourg, Monaco, The
and methods
Netherlands, New Zealand, Poland, Portugal, Sweden, Singapore,
Priority – 3 August 2007 Turkey and South Africa
Under examination in elsewhere (Brazil, India, and USA)
----- End of picture text -----

Biotron Ltd Annual Report 2018

Operating and Financial Review

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Corporate

In November 2017, the Company received an R&D Tax Incentive rebate of $1.6 million for the 2016/17 financial year. The R&D Tax Incentive is an Australian Government program under which companies receive cash refunds for 43.5% of eligible expenditure on research and development.

The cash refund results from expenditure on Biotron’s antiviral drug development programs. It is an important source of funds for the Company’s ongoing research and development activities.

In the second half of the financial year in review, the Company completed a capital raising by way of an underwritten renounceable rights issue, raising $1.4 million after costs. The funds will be used to support the Company’s ongoing activities described above, including expansion of testing of Biotron compounds against specific viral diseases of interest to potential partners, and importantly, ongoing commercial activities. Thank you to everyone who participated; your ongoing support is appreciated.

On behalf of the Board we would like to thank the Biotron staff for their commitment and dedication during the year. Biotron is poised to achieve the outcome that we have all been working towards – demonstration that its systematic approach to antiviral drug development can result in significant clinical benefit to patients and generate value for our shareholders.

We look forward to the next year with confidence.

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Michael J. Hoy Chairman

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Michelle Miller Managing Director

CORPORATE GOVERNANCE STATEMENT

The Board is committed to maintaining the highest standards of Corporate Governance. Corporate Governance is about having a set of core values and behaviours that underpin the Company’s activities and ensure transparency, fair dealing and protection of the interests of stakeholders. The Company has reviewed its corporate governance practices against the Corporate Governance Principles and Recommendations (3rd edition) published by the ASX Corporate Governance Council.

The 2018 Corporate Governance Statement, dated as at and approved by the Board on 3 August 2018, reflects the corporate governance practices throughout the 2018 financial year. A description of the Company’s current corporate governance practices is set out in the Company’s corporate governance statement which can be viewed at http://www.biotron.com.au/corporate-governance.

Biotron Ltd Annual Report 2018

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Directors’ Report

DIRECTORS

The names and particulars of the directors of the Company at any time during or since the end of the financial year are:

Mr Michael J. Hoy

Independent and Non-Executive Chairman

Mr Hoy has more than 30 years’ corporate experience in Australia, the United Kingdom, USA and Asia. He is Chairman of Lipotek Pty Limited and a former director of John Fairfax Holdings Limited, FXF Trust Limited and Telesso Technologies Limited.

Mr Hoy has been a director since 7 February 2000 and Chairman since 16 March 2000.

Dr Michelle Miller, BSc, MSc, PhD, GCertAppFin (Finsia)

Managing Director

Dr Miller has worked for over 20 years in the bioscience industry, with extensive experience in commercial development of early to mid-stage technologies. She completed her PhD in the Faculty of Medicine at Sydney University investigating molecular models of cancer development. Her experience includes several years at Johnson & Johnson developing anti-HIV gene therapeutics through preclinical research to clinical trials. She has finance industry experience from time spent as an Investment Manager with a specialist bioscience venture capital fund.

Dr Miller was appointed as Managing Director on 21 June 2002.

Dr Susan M. Pond AM, MD DSc, FTSE FAHMS

Independent and Non-Executive Director

Dr Pond has a strong scientific and commercial background having held executive positions in the biotechnology and pharmaceutical industry for 12 years, most recently as chairman and managing director of Johnson & Johnson Research Pty Limited (2003 - 2009). Most recently, she was Director of the University of Sydney Nano Institute from February 2017 - April 2018. She has held many previous board positions including as executive director of Johnson & Johnson Pty Limited, non-executive director and chairman of AusBiotech Limited, director of the Australian Nuclear Science and Technology Organisation and Australian Academy of Technological Sciences and Engineering (ATSE) and board member of Commercialisation Australia and Innovation Australia.

Dr Pond is currently on the boards of the Wound Management Innovation Cooperative Research Centre and Vectus Biosystems Ltd. She is a Fellow of the Australian Institute of Company Directors, the Academy of Technological Sciences & Engineering & the Academy of Health and Medical Sciences.

Dr Pond holds a first class honours degree in Bachelor of Medicine and Surgery from the University of Sydney and a Doctor of Medicine degree from the University of New South Wales. She obtained specialist clinical credentials in internal medicine, clinical pharmacology and clinical toxicology and held academic appointments at the University of California, San Francisco and the University of Queensland before joining the industry.

Dr Pond was appointed as a director on 7 March 2012.

Biotron Ltd Annual Report 2018

Directors’ Report

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Dr Denis N. Wade

Independent and Non-Executive Director

Dr Wade has been involved for over 40 years with the development of research based pharmaceuticals and medical devices in both industry and academia. He has been a director of several private and public companies in the healthcare sector, including Heartware Limited and subsequently Heartware International Inc., since December 2004. He was a director and chairman of Gene Shears Pty Limited and, from 1987 until his retirement in 2002, was managing director and chairman of Johnson & Johnson Research Pty Ltd, a research and development company of Johnson & Johnson Inc. He was also a member of the J&J Corporate Office of Science and Technology. Prior to that, Dr Wade was the Foundation Professor of Clinical Pharmacology at the University of New South Wales and served as a member of a number of state and federal bodies related to the drug industry, including the P3 Committee.

He is a former chairman of the Australian Academy National Committee for Pharmacology, the Australasian Society for Clinical and Experimental Pharmacology and Toxicology and a former chairman of the Clinical Pharmacology Section of the International Union of Pharmacology.

Dr Wade holds a first class honours degree in Medicine and Science from the University of Sydney and a Doctorate of Philosophy from the University of Oxford. He was awarded an Honorary Doctorate of Science by the University of New South Wales and is a Fellow of the Royal Australasian College of Physicians and of the Australian Academy of Technological Sciences and Engineering. In 1999 he was made a Member of the Order of Australia.

Dr Wade was appointed as a director on 30 April 2010 and ceased to be a director on 20 November 2017.

Mr Robert B. Thomas BEc, MSDIA, SF Fin, FICD

Independent and Non-Executive Director

Mr Thomas has over 35 years’ experience in the securities industry, with Potter Partners (now UBS), County NatWest and Citigroup.

He is the chairman of Starpharma Holdings Limited. He is a director of Aus Bio Limited and REVA Medical Limited and a former director of Virgin Australia Limited. He chairs Grahger Retail Securities Pty Ltd and is a director of O’Connell Street Associates Pty Limited.

Mr Thomas has a Bachelor of Economics degree from Monash University (1963 - 1966). He has been a member of the Securities Institute of Australia since 1976 and was appointed as a Fellow to the Institute in 1997. He is a Master Stockbroker and is a Fellow of he Institute of Company Directors.

Mr Thomas was appointed as a director on 7 March 2012.

Mr Peter J. Nightingale

Company Secretary

Mr Nightingale graduated with a Bachelor of Economics degree from the University of Sydney and is a member of the Institute of Chartered Accountants in Australia. He has worked as a chartered accountant in both Australia and the USA.

As a director or company secretary Mr Nightingale has, for more than 25 years, been responsible for the financial control, administration, secretarial and in-house legal functions of a number of private and public listed companies in Australia, the USA and Europe including Bolnisi Gold N.L., Callabonna Uranium Limited, Cockatoo Coal Limited, Mogul Mining N.L., Pangea Resources Limited, Perseverance Corporation Limited, Sumatra Copper & Gold plc, Timberline Minerals, Inc. and Valdora Minerals N.L. Mr Nightingale is currently a director of ASX listed Collerina Cobalt Limited, Planet Gas Limited, Nickel Mines Limited and unlisted public company Prospech Limited.

Mr Nightingale has been Company Secretary since 23 February 1999.

Biotron Ltd Annual Report 2018

Directors’ Report

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DIRECTORS’ MEETINGS

The number of directors’ meetings held and number of meetings attended by each of the directors of the Company, while they were a director, during the year are:

	Directors’	Meetings
Director	No. of Eligible Meetings to Attend	No. of Meetings Attended
Michael J. Hoy	6	6
Michelle Miller	6	6
Susan M. Pond	6	6
Robert B. Thomas	6	5
Denis N. Wade	3	3

DIRECTORS’ INTERESTS

At the date of this report, the beneficial interests of each director of the Company in the issued share capital of the Company and options, each exercisable to acquire one fully paid ordinary share of the Company are:

	Fully Paid		Option Terms
Directors	Ordinary Shares	Options	(Exercise Price and Term)
Michael J. Hoy	7,789,828	1,557,965	$0.05 at any time up to 12 December 2019
	-	1,246,372	$0.06 at any time up to 30 November 2018
Michelle Miller	953,125	190,625	$0.05 at any time up to 12 December 2019
	-	512,500	$0.06 at any time up to 30 November 2018
	-	2,000,000	$0.15 at any time up to 30 November 2018
	-	3,000,000	$0.18 at any time up to 30 November 2018
Susan M. Pond	545,246	109,049	$0.05 at any time up to 12 December 2019
	-	87,239	$0.06 at any time up to 30 November 2018
Robert B. Thomas	8,000,000	1,100,000	$0.05 at any time up to 12 December 2019
	-	1,004,793	$0.06 at any time up to 30 November 2018

There were no options over unissued ordinary shares granted as compensation to directors or executives of the Company during 2018 and 2017 financial years.

UNISSUED SHARES UNDER OPTION

At the date of this report, unissued ordinary shares of the Company under option are:

Number of Shares	Exercise Price Expiry Date
2,000,0001	$0.15 30 November 2018
3,000,0001	$0.18 30 November 2018
78,429,130	$0.06 30 November 2018
116,082,801	$0.05 12 December 2019

1 All options expire on the earlier of their expiry date or termination of the employee’s employment provided the exercise period has been reached. In the event that the employment of the option holder is terminated, any options which have not reached their exercise period will lapse and any options which have reached their exercise period may

Biotron Ltd Annual Report 2018

Directors’ Report

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be exercised within three months of the date of termination of employment. Any options not exercised within this three month period will lapse. The persons entitled to exercise the options do not have, by virtue of the options, the right to participate in a share issue of the Company or any other body corporate.

SHARES ISSUED ON EXERCISE OF OPTIONS

During or since the end of the financial year, the Company issued ordinary shares as a result of the exercise of options as follows (there are no amounts unpaid on the shares issued):

of options as follows (there are no amounts unpaid	on the shares issued):
Number of Shares	Amount paid on each share
30,833	$0.06

PRINCIPAL ACTIVITIES

The principal activities of the Company during the financial year were the funding and management of intermediate and applied biotechnology research and development projects.

FINANCIAL RESULT AND REVIEW OF OPERATIONS

The operating loss of the Company for the financial year after income tax was $1,593,645 (2017 - $3,093,405 loss).

A review of the Company’s operations for the year is set out in the Operating and Financial Review.

IMPACT OF LEGISLATION AND OTHER EXTERNAL REQUIREMENTS

There were no changes in environmental or other legislative requirements during the year that have significantly impacted the results or operations of the Company.

DIVIDENDS

The directors recommend that no dividend be paid by the Company. No dividend has been paid or declared since the end of the previous financial year.

STATE OF AFFAIRS

In the opinion of the directors, there were no significant changes in the state of affairs of the Company that occurred during the year ended 30 June 2018.

ENVIRONMENTAL REGULATIONS

The Company’s operations are not subject to significant environmental regulations under Commonwealth or State legislation in relation to its research projects.

EVENTS SUBSEQUENT TO BALANCE DATE

There has not arisen in the interval between the end of the financial year and the date of this report any item, transaction or event of a material and unusual nature likely, in the opinion of the directors of the Company, to affect significantly the operations of the Company, the results of those operations, or the state of affairs of the Company in future financial years.

LIKELY DEVELOPMENTS

During the year ended 30 June 2018, the Company continued to fund and manage its research and development projects. The success of these research projects, which cannot be assessed on the same fundamentals as trading and manufacturing enterprises, will determine future likely developments.

INDEMNIFICATION OF OFFICERS AND AUDITORS

During or since the end of the financial year, the Company has not indemnified or made a relevant agreement to indemnify an officer or auditor of the Company against a liability incurred by such an officer or auditor. In addition, the Company has not paid or agreed to pay, a premium in respect of a contract insuring against a liability incurred by an officer or auditor.

Biotron Ltd Annual Report 2018

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Directors’ Report

REMUNERATION REPORT - AUDITED

Principles of compensation - Audited

Key management personnel have authority and responsibility for planning, directing and controlling the activities of the Company. Key management personnel comprise the directors of the Company and the Company Secretary. No other employees have been deemed to be key management personnel.

The policy of remuneration of directors and senior executives is to ensure the remuneration package properly reflects the person’s duties and responsibilities, and that remuneration is competitive in attracting, retaining and motivating people of the highest quality. The Board is responsible for reviewing its own performance. The non-executive directors are responsible for evaluating the performance of the executive directors who, in turn, evaluate the performance of all other senior executives. The evaluation process is intended to assess the Company’s business performance, whether long term strategic objectives are being achieved and the achievement of individual performance objectives.

Remuneration generally comprises salary and superannuation. Longer term incentives are able to be provided through the Company’s Incentive Option Plan which acts to align the directors and senior executives’ actions with the interests of the shareholders. The vesting conditions of options issued under the plan are based on a minimum service periods being achieved.

In the event that the employment or office of the option holder is terminated, any options which have not reached their exercise period will lapse and any options which have reached their exercise period may be exercised within three months of the date of termination of employment. Any options not exercised within this three month period will lapse. The remuneration disclosed below represents the cost to the Company for the services provided under these arrangements.

No directors or senior executives receive performance related remuneration.

The number of options that had vested as at 30 June 2018 is 5,000,000. No options were granted as remuneration during the year.

There were no remuneration consultants used by the Company during the year ended 30 June 2018 or in the prior year.

Consequences of performance on shareholder wealth - Audited

In considering the Company’s performance and benefits for shareholders wealth, the Board have regard to the following indices in respect of the current financial year and the previous four financial years.

	2018	2017	2016	2015	2014
Net loss attributable to equity
holders of the Company	$1,593,645	$3,093,405	$3,004,303	$2,723,221	$3,085,814
Dividends paid	-	-	-	-	-
Change in share price	(0.1) cents	(4.0) cents	(7.0) cents	3.0 cents	2.0 cents

The overall level of key management personnel’s compensation is assessed on the basis of market conditions, status of the Company’s projects, and financial performance of the Company.

Biotron Ltd Annual Report 2018

Directors’ Report

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Details of remuneration for the year ended 30 June 2018 - Audited

Details of director and senior executive remuneration and the nature and amount of each major element of the remuneration of each director of the Company, and other key management personnel of the Company are set out below:

				Share Based			Value of
		Primary		Payments	Other		Options
	Year	Fees	Superannuation	- Options	Long Term	Total	as a % of
		$	$	$	$	$	Remuneration
Directors
Non-executive
Michael J. Hoy	2018	68,807	6,537	-	-	75,344	-
(Chairman)	2017	68,807	6,537	-	-	75,344	-
Susan M. Pond	2018	36,697	3,486	-	-	40,183	-
	2017	36,697	3,486	-	-	40,183	-
Robert B. Thomas	2018	36,697	3,486	-	-	40,183	-
	2017	36,697	3,486	-	-	40,183	-
Denis N. Wade*	2018	15,290	1,453	-	-	16,743	-
	2017	36,697	3,486	-	-	40,183	-
Executive
Michelle Miller	2018	300,000	28,500	10,134	5,525	344,159	3%
(Managing Director)	2017	302,548	28,500	31,521	5,525	368,094	9%
Executives
Peter J. Nightingale	2018	75,000	-	-	-	75,000	-
(Company Secretary)	2017	75,000	-	-	-	75,000	-

*resigned as a director on 20 November 2017.

No bonuses were paid during the financial year and no performance based components of remuneration exist. The Company employed no other key management personnel.

Biotron Ltd Annual Report 2018

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Directors’ Report

Options granted as compensation - Audited

Details of options granted as compensation to each key management person:

			Number of	Fair Value	Option Terms
Director		Grant Date	Options Granted	at Grant Date	(Exercise Price and Term)
Michelle Miller	25	November 2015	1,000,000	$17,900	$0.15 at any time to
					30 November 2018
Michelle Miller	25	November 2015	1,000,000	$17,900	$0.15 at any time from
					30 November 2016 up to
					30 November 2018
Michelle Miller	25	November 2015	3,000,000	$48,900	$0.18 at any time from
					30 November 2017 up to
					30 November 2018

The fair value of the options at grant date was determined based on Black- Scholes formula. The model inputs of the options issued, were the Company’s share price of $0.046 at the grant date, a volatility factor of 100% based on historic share price performance, a risk free rate of 2.11% based on the 10 year government bond rate and no dividends paid.

No options were granted during the 2018 and 2017 financial years. The number of options that vested as at 30 June 2018 is 5,000,000 (2017 - 2,000,000). No options lapsed during 2018 and 2017 financial years.

Modification of terms of equity-settled share-based payment transactions - Audited

No terms of equity-settled share-based payment transactions (including options granted as compensation to a key management person) have been altered or modified by the Company during the 2018 financial year.

Exercise of options granted as compensation - Audited

There were no shares issued on the exercise of options previously granted as compensation during the 2018 and 2017 financial years.

Analysis of options and rights over equity instruments granted as compensation - Audited

All options refer to options over ordinary shares of Biotron Limited, which are exercisable on a one-for-one basis.

	Options granted	Options granted
Director	Number		Date	% vested at year end % forfeited at year end Financial year in which grant vests
Michelle Miller	1,000,000	25 November	2015	100% - 1 July 2015
	1,000,000	25 November	2015	100% - 1 July 2016
	3,000,000	25 November	2015	100% - 1 July 2017

The number of options that had vested as at 30 June 2018 is 5,000,000 (2017 - 2,000,000). No options were granted subsequent to year end.

Biotron Ltd Annual Report 2018

Directors’ Report

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Analysis of movements in options - Audited

		Valuation of options
Director	Granted in theyear	exercised in theyear	Lapsed in theyear
Michelle Miller	-	-	-

Options and rights over equity instruments - Audited

The movement during the reporting period in the number of options over ordinary shares in the Company held directly, indirectly or beneficially, by each key management person, including their personally related entities, is as follows:

Option holdings 2018 - Audited

					Held at	Vested and
	Held at	Granted/			30 June	exercisable
	1 July 2017	Purchasedi	Exercised	Expired	2018	at 30 June 2018
Directors
Michael J. Hoy	1,246,372	1,557,965	-	-	2,804,337	2,804,337
Michelle Miller	5,512,500	190,625	-	-	5,703,125	5,703,125
Susan M. Pond	87,239	109,049	-	-	196,288	196,288
Robert B. Thomas	1,004,793	1,100,000	-	-	2,104,793	2,104,793
Denis N. Wade*	409,269	-	-	-	409,269	409,269
Executives
Peter J. Nightingale	-	-	-	-	-	-

[i] Purchased as part of the pro-rata renounceable rights issue to shareholders.

at the date of resignation.

Loans to key management personal and their related parties - Audited

There were no loans made to key management personnel or their related parties during the 2018 and 2017 financial years and no amounts were outstanding at 30 June 2018 (2017 - $nil).

Other transactions with key management personnel - Audited

The following key management person holds a position in another entity that results in them having control or joint control over the financial or operating policies of that entity, and this entity transacted with the Company during the year as follows:

∫ During the year ended 30 June 2018, Peter J. Nightingale had a controlling interest in an entity, MIS Corporate Pty Limited, which provided full administrative services, including rental accommodation, administrative staff, services and supplies, to the Company. Fees paid to MIS Corporate Pty Limited during the year amounted to $144,000 (2017 - $144,000). There were no outstanding amounts at 30 June 2018 (2017 - $nil).

Biotron Ltd Annual Report 2018

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Directors’ Report

Movements in shares - Audited

The movement during the reporting period in the number of ordinary shares in the Company held directly, indirectly or beneficially, by each key management person, including their personally-related entities, is as follows:

Fully paid ordinary shareholdings and transactions 2018 - Audited

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----- Start of picture text -----

|||||||
|---|---|---|---|---|---|
|Received on|
|Held at|exercise of|Held at|
|1 July 2017|Purchased|options|Sold|30 June 2018|
|Directors|
|-|-|
|Michael J. Hoy|6,231,863|1,557,965|7,789,828|
|Michelle Miller|762,500|190,625|-|-|953,125|
|Susan M. Pond|436,197|109,049|-|-|545,246|
|Robert B. Thomas|6,755,929|1,244,071|-|-|8,000,000|
|Denis N. Wade*|2,046,348|-|-|-|2,046,348|
|Executives|
|-|-|-|
|Peter J. Nightingale|5,760,416|5,760,416|

----- End of picture text -----

at the date of resignation.

Service contracts - Audited

In accordance with best practice corporate governance, the Company provided each key management personnel with a letter detailing the terms of appointment, including their remuneration.

Non-executive directors - Audited

Total compensation for all non-executive directors is determined by the Board based on market conditions.

Non-audit Services

During the year KPMG, the Company’s auditor, performed no other services in addition to their statutory duties.

A copy of the auditors’ independence declaration as required under Section 307C of the Corporations Act 2001 is included in the Directors’ Report.

Details of the amounts paid and accrued to the auditor of the Company, KPMG, and its related practices for audit and non-audit services provided during the year are set out below.

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||||
|---|---|---|
|2018|2017|
|$|$|
|Statutory audit|
|Audit and review of financial reports - KPMG|49,950|46,850|

----- End of picture text -----

Biotron Ltd Annual Report 2018

Directors’ Report

LEAD AUDITOR’S INDEPENDENCE DECLARATION

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The Lead Auditor’s Independence Declaration is set out on page 16 and forms part of the Directors’ Report for the year ended 30 June 2018.

This report has been signed in accordance with a resolution of the directors and is dated 29 August 2018:

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Michael J. Hoy Chairman

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Michelle Miller Managing Director

Biotron Ltd Annual Report 2018

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Lead Auditor’s Independence Declaration

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KPMG, an Australian partnership and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative (“KPMG International”) a Swiss entity

Liability limited by a scheme approved under Professional Standards Legislation.

Biotron Ltd Annual Report 2018

Statement of Profit or Loss and Other Comprehensive Income

For The Year Ended 30 June 2018

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Notes	2018 $ 2017 $
Continuing operations Other income 5 Administration and consultants’ expenses Depreciation 11 Employee and director expenses Direct research and development expenses 6 Rent and outgoings expenses Travel expenses Other expenses from ordinary activities Operating loss before fnancing income Interest income Net fnancing income Loss before tax Income tax expense 9 Loss for the year Other comprehensive income Total comprehensive loss for the year Basic and diluted loss per share (cents) 7	1,622,584 1,659,479 (275,674) (241,960) (11,642) (13,074) (817,458) (826,501) (1,692,656) (3,155,423) (77,604) (76,849) (106,549) (82,507) (251,230) (386,216)
	(1,610,229) (3,123,051)
	16,584 29,646
	16,584 29,646
	(1,593,645) (3,093,405) - -
	(1,593,645) (3,093,405) - -
	(1,593,645) (3,093,405)

	(0.40) cents (0.93)cents

The above Statement of Profit or Loss and Other Comprehensive Income should be read in conjunction with the accompanying notes.

Biotron Ltd Annual Report 2018

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Statement of Financial Position As At 30 June 2018

Notes	2018 $ 2017 $
Current assets Cash and cash equivalents 8 Other assets 10 Total current assets Non-current assets Plant and equipment 11 Total non-current assets Total assets Current liabilities Trade and other payables 12 Employee entitlements 13 Total current liabilities Total liabilities Net assets Equity Issued capital 14 Reserves 14 Accumulated losses Total equity	1,543,002 1,987,384 58,354 42,730
	1,601,356 2,030,114
	17,854 29,496
	17,854 29,496
	1,619,210 2,059,610
	160,778 367,671 176,924 251,839
	337,702 619,510
	337,702 619,510
	1,281,508 1,440,100
	41,439,162 40,325,345 599,655 278,419 (40,757,309) (39,163,664)
	1,281,508 1,440,100

The above Statement of Financial Position should be read in conjunction with the accompanying notes.

Biotron Ltd Annual Report 2018

Statement of Changes in Equity For The Year Ended 30 June 2018

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Attributable to equity holders of the Company Notes	Issued Capital $ Option Reserves $ Accumulated Losses $ Total $
Balance at 1 July 2016 Total comprehensive income for the year Loss for the year Other comprehensive income Total comprehensive loss for the year Transactions with owners, recorded directly in equity Contribution by and distribution to owners Ordinary shares/options issued Cost of shares issued Share based payment Transfer of expired options Exercise of options Balance at 30 June 2017 14 Balance at 1 July 2017 Total comprehensive income for the year Loss for the year Other comprehensive income Total comprehensive loss for the year Transactions with owners, recorded directly in equity Contribution by and distribution to owners Ordinary shares/options issued Cost of shares issued Share based payment Transfer of expired options Exercise of options Balance at 30 June 2018 14	39,163,122 860,729 (36,886,884) 3,136,967 - - (3,093,405) (3,093,405) - - - -
	- - (3,093,405) (3,093,405)
	1,374,145 203,996 - 1,578,141 (213,124) - - (213,124) - 31,521 - 31,521 - (816,625) 816,625 - 1,202 (1,202) - -
	40,325,345 278,419 (39,163,664) 1,440,100
	40,325,345 278,419 (39,163,664) 1,440,100 - - (1,593,645) (1,593,645) - - - -
	- - (1,593,645) (1,593,645)
	1,365,967 311,182 - 1,677,149 (252,230) - - (252,230) - 10,134 - 10,134 - - - - 80 (80) - -
	41,439,162 599,655 (40,757,309) 1,281,508

The above Statement of Changes in Equity should be read in conjunction with the accompanying notes.

Biotron Ltd Annual Report 2018

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Statement of Cash Flows For The Year Ended 30 June 2018

Notes	2018 $ 2017 $
Cash fows from operating activities Cash receipts in the course of operations Payments for research and development Cash payments in the course of operations Interest received Net cash used in operating activities 15 Cash fows from investing activities Rental bond Payments for plant and equipment Net cash used in investing activities Cash fows from fnancing activities Proceeds from issue of shares and options Cost of issue of shares and options Net cash from fnancing activities Net increase/(decrease) in cash held Cash and cash equivalents at 1 July Efect of exchange rate adjustments on cash held Cash and cash equivalents at 30 June 8	1,622,584 1,659,479 (1,863,780) (2,977,402) (1,617,399) (1,545,220) 16,584 29,646
	(1,842,011) (2,833,497)
	- (6,412) - (5,495)
	- (11,907)
	1,653,149 1,578,141 (255,528) (163,615)
	1,397,621 1,414,526
	(444,389) (1,430,878) 1,987,384 3,418,453 7 (191)
	1,543,002 1,987,384

The above Statement of Cash Flows should be read in conjunction with the accompanying notes.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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1. REPORTING ENTITY

Biotron Limited (the ‘Company’) is a company domiciled in Australia. The address of the Company’s registered office is at Level 2, 66 Hunter Street, Sydney, NSW 2000. The Company is a for-profit entity and is primarily engaged in the funding and management of intermediate and applied biotechnology research and development projects.

2. BASIS OF PREPARATION

a. Statement of compliance

These financial statements are general purpose financial statements which have been prepared in accordance with Australian Accounting Standards (‘AASBs’) adopted by the Australian Accounting Standards Board (‘AASB’) and the Corporations Act 2001. The financial statements of the Company also comply with International Financial Reporting Standards (‘IFRSs’) adopted by the International Accounting Standards Board (‘IASB’).

The financial report was authorised for issue by the directors on 29 August 2018.

b. Basis of measurement

The financial statements have been prepared on the historical cost basis, unless otherwise stated.

c. Functional and presentation currency

These financial statements are presented in Australian dollars, which is the Company’s functional currency.

d. Use of estimates and judgements

The preparation of financial statements requires management to make judgements, estimates and assumptions that affect the application of accounting policies and the reported amounts of assets, liabilities, income and expenses. Actual results may differ from these estimates.

Estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognised in the period in which the estimate is revised and in any future periods affected.

In particular, information about significant areas of estimation uncertainty and critical judgements in applying accounting policies that have the most significant effect on the amounts recognised in the financial statements are described in the following notes:

∫ Note 9 – Unrecognised deferred tax asset
∫ Note 2(e) – Going concern

e. Going concern

The financial statements have been prepared on a going concern basis which contemplates the realisation of assets and settlement of liabilities in the ordinary course of business.

The Company has incurred a trading loss of $1,593,645 for the year ended 30 June 2018 and has accumulated losses of $40,757,309 at 30 June 2018. The Company has cash on hand of $1,543,002 at 30 June 2018 and used $1,842,011 of cash in operations for the year ended 30 June 2018. These conditions give rise to a material uncertainty that may cast significant doubt upon the Company’s ability to continue as a going concern. The ongoing operation of the Company is dependent on:

∫ the Company raising additional funding from shareholders or other parties; and/or
∫ the Company reducing expenditure in line with available funding.

The directors have prepared cash flow projections that support the ability of the Company to continue as a going concern. These cash flow projections assume the Company obtains sufficient additional funding from shareholders or other parties. If such funding is not achieved, the Company plans to reduce expenditures significantly.

In the event that the Company does not obtain additional funding and/or reduce expenditure in line with available funding, it may not be able to continue its operations as a going concern and therefore may not be able to realise its assets and extinguish its liabilities in the ordinary course of operations and at the amounts stated in the financial statements.

Biotron Ltd Annual Report 2018

For the Year Ended 30 June 2018

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Notes to the Financial Statements

3. SIGNIFICANT ACCOUNTING POLICIES

The accounting policies set out below have been applied consistently to all periods presented in these financial statements, and have been applied consistently by the Company.

a. Cash and cash equivalents

Cash and cash equivalents comprise cash balances and call deposits with an original maturity of three months or less.

b. Trade and other receivables

Trade and other receivables are stated at their amortised cost less impairment losses.

c. Property, plant and equipment

Property plant and equipment are stated at their historical cost less accumulated depreciation and accumulated impairment losses. Depreciation is recognised in profit or loss using the reducing balance method from the date of acquisition at rates between 13% and 40% per annum.

d. Government Grants

Where a grant is received relating to research and development costs that have been expensed, the grant is recognised as other income when the grant becomes receivable and the Company complies with all attached conditions.

Costs

Expenditure on research activities, undertaken with the prospect of gaining new scientific or technical knowledge and understanding, is recognised in profit and loss when incurred.

Development activities involve a plan or design for the production of new or substantially improved products and processes. Development expenditure is capitalised only if development costs can be measured reliably, the product or process is technically and commercially feasible, future economic benefits are probable, and the Company intends to and has sufficient resources to complete development and to use or sell the asset. The expenditure capitalised includes the cost of materials, direct labour and overhead costs that are directly attributable to preparing the asset for its intended use. Other development expenditure is recognised in profit or loss when incurred.

Capitalised development expenditure is measured at cost less accumulated amortisation and accumulated impairment losses.

e. Trade and other payables

Trade and other payables are stated at their amortised cost, are non-interest bearing and are normally settled within 60 days.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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f. Employee entitlements

Short-term employee benefits

Short-term employee benefits are expensed as the related service is provided. A liability is recognised for the amount expected to be paid under short term cash bonus or profit sharing plans if the Company has a present legal or constructive obligation to pay this amount as a result of past service provided by the employee, and the obligation can be estimated reliably.

Long term employee benefits

The Company’s net obligation in respect of long term employee benefits is the amount of future benefit that employees have earned in return for their service in the current and prior periods. That benefit is discounted to determine its present value. Re-measurements are recognised in profit or loss in the period in which they arise.

Share-based payment transactions

The grant-date fair value of share-based payment awards granted to employees is recognised as an employee expense, with a corresponding increase in equity, over the period that the employees become unconditionally entitled to the awards. The amount recognised as an expense is adjusted to reflect the number of awards for which the related service and non-market vesting conditions are expected to be met, such that the amount ultimately recognised as an expense is based on the number of awards that meet the related service and non-market performance conditions at the vesting date. For share-based payment awards with non-vesting conditions, the grant date fair value of the sharebased payment is measured to reflect such conditions and there is no true-up for differences between expected and actual outcomes.

g. Financial Instruments

Non-derivative financial assets

The Company holds loans and receivables. Loans and receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market. Such assets are recognised at fair value plus any directly attributable transaction costs. Subsequent to initial recognition, loans and receivables are measured at amortised cost using the effective interest method, less any impairment losses. They are included in current assets, except for those with maturities greater than 12 months after the reporting period, which are classified as non-current assets. Loans and receivables comprise cash and cash equivalents and trade and other receivables.

The Company initially recognises loans and receivables on the date that they are originated.

The Company derecognises a financial asset when the contractual rights to the cash flows from the asset expire, or it transfers the rights to receive the contractual cash flows on the financial asset in a transaction in which substantially all the risks and rewards of ownership of the financial asset are transferred. Any interest in such transferred financial assets that is created or retained by the Company is recognised as a separate asset or liability.

Financial assets and liabilities are offset and the net amount presented in the Statement of Financial Position when, and only when, the Company has a legal right to offset the amounts and intends either to settle them on a net basis or to realise the asset and settle the liability simultaneously.

Non-derivative financial liabilities

The Company initially recognises debt securities issued and subordinated liabilities on the date that they are originated. All other financial liabilities are recognised initially on the trade date, which is the date that the Company becomes a party to the contractual provisions of the instrument.

The Company derecognises a financial liability when its contractual obligations are discharged, cancelled or expire.

Other financial liabilities comprise trade and other payables.

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

h. Share Capital

Ordinary Shares

Ordinary shares are classified as equity. Incremental costs directly attributable to the issue of ordinary shares are recognised as a deduction from equity, net of any tax effects.

i. Tax

Income tax comprises of current tax and deferred tax and is recognised in profit or loss except to the extent that it relates to a business combination, or items recognised directly in equity or in other comprehensive income.

Current tax

Current tax is the expected tax payable or receivable on the taxable income or loss for the year, using tax rates enacted or substantially enacted at the reporting date, and any adjustment to tax payable in respect of previous years.

Current tax assets and liabilities are offset only if certain criteria are met.

Deferred tax

Deferred tax is recognised in respect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. Deferred tax is not recognised for temporary differences on the initial recognition of assets or liabilities in a transaction that is not a business combination and that affects neither accounting nor taxable profit or loss.

The measurement of deferred tax reflects the tax consequences that would follow the manner in which the Company expects, at the end of the reporting period, to recover or settle the carrying amount of its assets and liabilities.

Deferred tax is measured at the tax rates that are expected to be applied to temporary differences when they reverse, using tax rates enacted or substantively enacted at the reporting date. Deferred tax assets and liabilities are offset if there is a legally enforceable right to offset current tax liabilities and assets, and they relate to taxes levied by the same tax authority on the same taxable entity, or on different tax entities, but they intend to settle current tax liabilities and assets on a net basis or their tax assets and liabilities will be realised simultaneously.

A deferred tax asset is recognised for unused tax losses, tax credits and deductible temporary differences, to the extent that it is probable that future taxable profits will be available against which they can be utilised. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realised.

Goods and services tax

Revenue, expenses and assets are recognised net of the amount of goods and services tax (‘GST’), except where the amount of GST incurred is not recoverable from the taxation authority. In these circumstances, the GST is recognised as part of the cost of acquisition of the asset or as part of the expense.

Receivables and payables are stated with the amount of GST included. The net amount of GST recoverable from, or payable to, the ATO is included as a current asset or liability in the balance sheet.

Cash flows are included in the statement of cash flows on a gross basis. The GST components of cash flows arising from investing and financing activities which are recoverable from, or payable to, the ATO are classified as operating cash flows.

j. Finance income

Finance income comprises interest income on funds invested. Interest income is recognised as it accrues in profit or loss, using the effective interest method.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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k. Earnings per share

The Company presents basic and diluted earnings per share (‘EPS’) data for its ordinary shares. Basic EPS is calculated by dividing the profit or loss attributable to ordinary shareholders of the Company by the weighted average number of ordinary shares outstanding during the period. Diluted EPS is determined by adjusting the profit or loss attributable to ordinary shareholders and the weighted average number of ordinary shares outstanding for the effects of all dilutive potential ordinary shares, which comprise share options.

l. Impairment

Non-derivative financial assets

A financial asset not classified as at fair value through profit or loss is assessed at each reporting date to determine whether there is any objective evidence that it is impaired. A financial asset is considered to be impaired if objective evidence indicates that one or more events have had a negative effect on the estimated future cash flows of that asset.

Financial assets measured at amortised cost

Individually significant financial assets are tested for impairment on an individual basis. The remaining financial assets are assessed collectively in groups that share similar credit risk characteristics.

An impairment loss in respect of a financial asset measured at amortised cost is calculated as the difference between its carrying amount, and the present value of the estimated future cash flows discounted at the original effective interest rate. Losses are recognised within profit or loss. When an event occurring after the impairment was recognised causes the amount of impairment loss to decrease, the decrease in impairment loss is reversed through profit or loss.

Non-financial assets

The carrying amounts of the Company’s non-financial assets are reviewed at each reporting date to determine whether there is any indication of impairment. If any such indication exists then the asset’s recoverable amount is estimated.

An impairment loss is recognised whenever the carrying amount of an asset or its cash-generating unit (‘CGU’) exceeds its recoverable amount. The recoverable amount of an asset or CGU is the greater of their fair value less costs of disposal and value in use. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset or CGU. For impairment testing, assets are grouped together into the smallest group of assets that generates cash inflows from continuing use that are largely independent of the cash inflows of other assets or CGUs. Impairment losses are recognised in profit or loss.

An impairment loss is reversed only to the extent that the asset’s carrying amount does not exceed the carrying amount that would have been determined, net of depreciation or amortisation, if no impairment loss had been recognised.

m. Provisions

A provision is recognised if, as a result of a past event, the Company has a present legal or constructive obligation that can be estimated reliably, and it is probable that an outflow of economic benefits will be required to settle the obligation. Provisions are determined by discounting the expected future cash flows at a pre-tax rate that reflects the current market assessments of the time value of money and the risks specific to the liability. The unwinding of the discount is recognised as a finance cost.

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

n. Segment reporting

Determination and presentation of operating segments

The Company determines and presents operating segments based on the information that is provided internally to the Managing Director, who is the Company’s chief operating decision maker.

An operating segment is a component of the Company that engages in business activities from which it may earn revenues and incur expenses, including revenues and expenses that relate to transactions with any of the Company’s other components. All operating segments’ operating results are regularly reviewed by the Company’s Managing Director to make decisions about resources to be allocated to the segment and assess its performance.

Segment results that are reported to the Managing Director include items directly attributable to a segment as well as those that can be allocated on a reasonable basis. Unallocated items comprise mainly corporate assets (primarily the Company’s headquarters), head office expenses, and income tax assets and liabilities.

o. New standards and interpretations not yet adopted

A number of new standards, amendments to standards and interpretations are effective for annual periods beginning after 1 July 2017, and have not been applied in preparing these financial statements. The Company is in the process of assessing the impact of new standards. Those which may be relevant to the Company are set out below. The Company does not plan to adopt these standards early and is assuming the impact.

AASB 9 Financial Instruments

AASB 9 replaces the existing guidance in AASB 139 Financial Instruments: Recognition and Measurement. AASB 9 includes revised guidance on the classification and measurement of financial instruments, including a new expected credit loss model for calculating impairment on financial assets and the new general hedge accounting requirements. It also carries forward the guidance on recognition and derecognition of financials instruments from AASB 139.

AASB 9 is effective for the Company’s annual reporting period beginning 1 July 2018 and can be early adopted.

4. DETERMINATION OF FAIR VALUES

A number of the Company’s accounting policies and disclosures require the determination of fair value, for both financial and non-financial assets and liabilities. Fair values have been determined for measurement and/ or disclosure purposes based on the following methods. Where applicable, further information about the assumptions made in determining fair values is disclosed in the notes specific to that asset or liability.

Trade and other receivables

The fair value of trade and other receivables is estimated as the present value of future cash flows, discounted at the market rate of interest at the measurement date. Fair value is determined at initial recognition and, for disclosure purposes, at each annual reporting date.

Share-based payment transactions

The fair value of employee share options is measured using the Black-Scholes formula. Measurement inputs include share price on measurement date, exercise price of the instrument, expected volatility (based on weighted average historic volatility adjusted for changes expected due to publicly available information), weighted average expected life of the instruments (based on historical experience and general option holder behaviour), expected dividends, and the risk-free interest rate (based on government bonds). Service and non-market performance conditions attached to the transactions are not taken into account in determining fair value. Share-based payment arrangements in which the Company receives goods or services as consideration for its own equity instruments are accounted for as equity-settled share-based payment transactions.

Non-derivative financial liabilities

Non-derivative financial liabilities are measured at fair value, at initial recognition, and for disclosure purposes, at each annual reporting date. Fair value is calculated based on the present value of future principal and interest cash flows, discounted at the market rate of interest at the measurement date.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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Note 5. OTHER INCOME Research and development rebate Other 6. LOSS FROM OPERATING ACTIVITIES Loss from ordinary activities has been arrived at after charging the following items: Auditors’ remuneration paid to KPMG – Auditor’s and review of fnancial reports Depreciation – Ofce equipment 11 – Plant and equipment 11 Direct research and development expenditure expensed as incurred Provision for employee entitlements Superannuation expense	2018 $ 2017 $ 1,621,653 1,613,724 931 45,755
	1,622,584 1,659,479
	49,950 46,850 10,453 12,311 1,189 763 (1,692,656) 3,155,423 (74,915) 21,482 62,837 65,630

Note
5. OTHER INCOME
Research and development rebate
Other
6. LOSS FROM OPERATING ACTIVITIES
Loss from ordinary activities has been arrived at after
charging the following items:
Auditors’ remuneration paid to KPMG
– Auditor’s and review of fnancial reports
Depreciation
– Ofce equipment
11
– Plant and equipment
11
Direct research and development expenditure
expensed as incurred
Provision for employee entitlements
Superannuation expense

2018
$
2017
$
1,621,653
1,613,724
931
45,755

1,622,584
1,659,479

49,950
46,850
10,453
12,311
1,189
763
(1,692,656)
3,155,423
(74,915)
21,482
62,837
65,630

7. LOSS PER SHARE

The calculation of basic and diluted loss per share at 30 June 2018 was based on the loss attributable to ordinary shareholders of $1,593,645 (2017 - $3,093,405 loss) and a weighted average number of ordinary shares outstanding during the financial year ended 30 June 2018 of 397,150,054 (2017 – 331,742,012), calculated as follows:

Net loss for the year Weighted average number of ordinary shares (basic and diluted) Issued ordinary shares at 1 July Weighted average number of ordinary shares at 30 June	1,593,645 3,093,405
	2018 Number 2017 Number 392,299,816 313,765,334
	397,150,054 331,742,012

As the Company is loss making, none of the potentially dilutive securities are currently dilutive.

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

8. CASH AND CASH EQUIVALENTS Cash at bank Cash and cash equivalents in the statement of cash fows 9. INCOME TAX EXPENSE Current tax expense Current year Tax losses not recognised Deferred tax expense Current year De-recognition of temporary diferences Numerical reconciliation between tax expense and pre-tax net proft Loss before tax - continuing operations Prima facie income tax beneft at the Australian tax rate of 27.5% Increase in income tax expense due to: - Adjustments not resulting in temporary diferences - Efect of tax losses not recognised - Unrecognised temporary diferences Income tax expense current and deferred Deferred tax assets have not been recognised in respect of the following items Deductible temporary diferences (net) Tax losses Net	2018 $ 2017 $ 1,543,002 1,987,384
	1,543,002 1,987,384
	(970,021) (1,341,634) 970,021 1,341,634
	- -
	89,176 44,003 (89,176) (44,003)
	- -
	(1,593,645) (3,093,405)
	(438,252) (850,686) 595,928 621,849 (68,500) 272,840 (89,176) (44,003)
	- -
	204,140 223,323 9,346,799 9,415,299
	9,550,939 9,638,622

The deductible temporary differences and tax losses do not expire under the current tax legislation. Deferred tax assets have not been recognised in respect of these items because it is not probable that future taxable profit will be available against which the Company can utilise the benefits of the deferred tax asset.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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10. OTHER ASSETS Current prepayments Security deposits 11. PLANT AND EQUIPMENT Ofce equipment - at cost Accumulated depreciation Plant and equipment - at cost Accumulated depreciation Total plant and equipment - net book value	2018 $ 2017 $ 36,448 21,319 21,906 21,411
	58,354 42,730
	205,851 205,851 (196,398) (185,945)
	9,453 19,906
	511,958 511,958 (503,557) (502,368)
	8,401 9,590
	17,854 29,496

Reconciliations

Reconciliations of the carrying amounts for each class of plant and equipment are set out below:

Ofce equipment Balance at 1 July Depreciation Carrying amount at the end of the fnancial year Plant and equipment Balance at 1 July Additions Depreciation Carrying amount at the end of the fnancial year Total carrying amount at the end of the fnancial year 12. TRADE AND OTHER PAYABLES Current Creditors Accruals	19,906 32,217 (10,453) (12,311)
	9,453 19,906
	9,590 4,858 - 5,495 (1,189) (763)
	8,401 9,590
	17,854 29,496
	135,778 344,171 25,000 23,500
	160,778 367,671

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

13. EMPLOYEE ENTITLEMENTS Current Employee annual leave provision Long service leave provision Number of employees at the end of the fnancial year	2018 $ 2017 $ 50,282 117,537 126,642 134,302
	176,924 251,839
	3 5

14. CAPITAL AND RESERVES

Issued and paid up capital

502,417,116 (2017 – 392,299,816) fully paid ordinary shares Fully paid ordinary shares Balance at the beginning of the fnancial year Issue of shares Exercise of options Costs of issue Balance at the end of fnancial year	41,439,162 40,325,345
	40,325,345 39,163,122 1,365,967 1,374,145 80 1,202 (252,230) (213,124)
	41,439,162 40,325,345

The Company does not have authorised capital or par value in respect of its issued shares. All issued shares are fully paid.

∫ In June 2018, the Company offered eligible shareholders to purchase one new share and one new listed option under a pro- rata renounceable rights issue. Under this offer, the Company issued 98,078,690 ordinary shares and 98,078,690 listed options for cash totalling $1,471,180. The listed options are each exercisable at 5 cents to acquire one fully paid ordinary share exercisable at any time up to 12 December 2019. Total issue cost of $244,929 was recognised as a reduction in proceeds of issue of these shares. At 30 June 2018, $22,211 was outstanding for payment.
∫ In June 2018, the Company issued 6,000,000 options as part consideration to the lead manager and underwriter under the same terms as offered under the Renounceable Rights Issue. The options were valued at $24,000.
∫ In June 2018, the Company issued 12,007,777 ordinary shares and 12,007,777 listed options for cash totalling $180,119 under a Share Placement Offer. Total issue cost of $7,301 was recognised as a reduction in proceeds of issue of these shares. The listed options are each exercisable at 5 cents to acquire one fully paid ordinary share exercisable at any time up to 12 December 2019.
∫ During the year ended 30 June 2018, 30,833 ordinary shares (2017 – 74,519) were issued through the exercise of the listed options for cash totalling $1,850 (2017 - $8,942). The fair value of the options when granted was $80 (2017 - $1,202).
∫ In June 2017, the Company offered eligible shareholders to purchase one new share and one new listed option under a pro- rata renounceable rights issue. Under this offer, the Company issued 78,459,963 ordinary shares and 78,459,963 listed options for cash totalling $1,569,199. The listed options are each exercisable at 6 cents to acquire one fully paid ordinary share exercisable at any time up to 30 November 2018. Total issue cost of $213,124 was recognised as a reduction in proceeds of issue of these shares. At 30 June 2017, $49,509 was outstanding for payment.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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The following unlisted options were on issue at 30 June 2018:

∫ 1,000,000 options with a fair value at grant date of 1.8 cents, each exercisable at 15 cents to acquire one fully paid ordinary share at any time up to 30 November 2018.
∫ 1,000,000 options with a fair value at grant date of 1.8 cents, each exercisable at 15 cents to acquire one fully paid ordinary share at any time after 30 November 2016 up to 30 November 2018.
∫ 3,000,000 options with a fair value at grant date of 1.6 cents, each exercisable at 18 cents to acquire one fully paid ordinary share at any time after 30 November 2017 up to 30 November 2018.

The fair value of the options at each grant date was determined based on the Black-Scholes formula. The model inputs for those options issued during the year ended 30 June 2016 were the Company’s share price of $.046 at the grant date, a volatility factor of 100% based on historic share price performance, risk free interest rate of 2.11% based on the 10 year government bond rate and no dividends paid.

The following listed options were on issue at 30 June 2018:

Opening Balance	Exercise	Granted	Exercised/Expired	Closing Balance
1 July 2017	Price	during the year	during the year	30 June 2018
Number	$	Number	Number	Number
78,459,963	0.06	-	30,833	78,429,130
-	0.05	116,086,467	-	116,086,467

Terms and conditions - Shares

Holders of ordinary shares are entitled to receive dividends as declared and, are entitled to one vote per share at shareholders’ meetings. In the event of winding up of the Company, ordinary shareholders rank after creditors and are fully entitled to any proceeds of liquidation.

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2018 2017
$ $
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Option Reserves Equity based compensation reserve Option premium reserve Movements during the period Equity based compensation reserve Balance at the beginning of period Share based payment expense Balance at end of period Option premium reserve Balance at the beginning of period Issue of options Exercise of options Expiry of options Balance at end of period	84,557 74,423 515,098 203,996
	599,655 278,419
	74,423 42,902 10,134 31,521
	84,557 74,423
	203,996 817,827 311,182 203,996 (80) (1,202) - (816,625)
	515,098 203,996

Nature and purpose of reserves

Equity based compensation reserve:

The equity based compensation reserve is used to recognise the grant date fair value of options issued but not exercised.

Option premium reserve:

The option premium reserve is used to accumulate proceeds received from the issuing of options.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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2018 2017
$ $
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	2018 $ 2017 $
15. STATEMENT OF CASH FLOWS Reconciliation of cash fows from operating activities Loss for the period Adjustments for: Depreciation of plant and equipment Provisions for employee entitlements Share based payments Interest Efect of exchange rate adjustments Changes in assets and liabilities Decrease/(Increase) in prepayments (Decrease)/Increase in payables Net cash used in operating activities	(1,593,645) (3,093,405)
	11,642 13,073 (74,915) 21,482 10,134 31,521 (495) - (7) 191 (15,129) (8,564) (179,596) 202,205
	(1,842,011) (2,833,497)

16. RELATED PARTIES

Key management personnel and director transactions

∫ During the year ended 30 June 2018, Peter J. Nightingale had a controlling interest in an entity, MIS Corporate Pty Limited, which provided full administrative services, including rental accommodation, administrative staff, services and supplies, to the entity. Fees paid to MIS Corporate Pty Limited during the year, amounted to $144,000 (2017 - $144,000). There were no outstanding amounts at 30 June 2018 (2017 - $nil).

Key management personnel compensation

During the year ended 30 June 2018, compensation of key management personnel totalled $591,612 (2017 - $638,987), which comprised primary salary and fees of $532,491 (2017 - $556,446), superannuation of $43,462 (2017 - $45,495), share based payments of $10,134 (2017 - $31,521) and long service leave of $5,525 (2017 - $5,525). During the 2018 and 2017 financial years, no long term benefits or termination payments were paid.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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17. SHARE BASED PAYMENTS

The Company has an Incentive Option Plan to provide eligible persons, being employees or directors, or individuals whom the Plan Committee determine to be employees for the purposes of the Plan, with the opportunity to acquire options over unissued ordinary shares in the Company. The number of options granted or offered under the Plan will not exceed 10% of the Company’s issued share capital and the exercise price of options will be the greater of the market value of the Company’s shares as at the date of grant of the option or such amount as the Plan Committee determines. Options have no voting or dividend rights. The vesting conditions of options issued under the plan are based on a minimum service periods being achieved. There are no other vesting conditions attached to options issued under the plan.

No options were issued during the year ended 30 June 2018 and 30 June 2017. During the year ended 30 June 2018, 5,000,000 options were on issue to the Managing Director as detailed in note 14.

Options outstanding at 30 June 2018

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|||||||
|---|---|---|---|---|---|
|Number|Exercise|Fair value at|
|Grant date|of options|price|grant date|Vesting date*|Expiry date|
|25 November 2015|1,000,000|$0.15|$0.018|25 November 2015|30 November 2018|
|25 November 2015|1,000,000|$0.15|$0.018|30 November 2016|30 November 2018|
|25 November 2015|3,000,000|$0.18|$0.016|30 November 2017|30 November 2018|

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Vesting conditions are based on minimum service periods being achieved.

Options outstanding at 30 June 2017

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Vesting conditions are based on minimum service periods being achieved.

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

Movement of options in the equity based compensation reserve during the year

			Number of	Weighted average	Number of	Weighted average
			options	exercise price	options	exercise price
			2018	2018	2017	2017
Outstanding at	1	July	5,000,000	$0.17	5,000,000	$0.17

The equity based compensation reserve is used to record the options issued to directors and executives of the Company as compensation. Options are valued using the Black-Scholes option pricing model.

The weighted average remaining contractual life of share options outstanding at the end of the year in the equity based compensation reserve was 0.42 years (2017 – 1.42 years).

No ordinary shares have been issued as a result of the exercise of any option granted pursuant to the Incentive Option Plan during the current and prior financial year.

Fair value of options

The fair value of options granted is measured at grant date and recognised as an expense over the period during which the employee becomes unconditionally entitled to the options. The fair value of the options granted is measured using an option valuation methodology, taking into account the terms and conditions upon which the options were granted. The amount recognised as an expense is adjusted to reflect the actual number of options that vest.

When options on issue are modified and the modification is beneficial to the other party the incremental fair value at the date of the modification is recognised over the remaining modified vesting period and the original grant-date fair value is recognised over the remaining original vesting period. When the modification is to options on issue that have fully vested the incremental fair value is recognised as an expense in the period the modification occurs. The incremental fair value is the difference between the fair value of the share based payment at the date of modification between the old and new terms.

Expenses arising from share-based payment transactions

Total expenses arising from share based payment transactions recognised during the year ended 30 June 2018 was $10,134 (2017 - $31,521).

18. FINANCIAL INSTRUMENTS

Financial risk management objectives and policies

The Company’s financial instruments comprise deposits with banks, receivables, trade and other payables and from time to time short term loans from related parties. The Company does not trade in derivatives or in foreign currency.

The Company manages its risk exposure of its financial instruments in accordance with the guidance of the Board of Directors. The main risks arising from the Company’s financial instruments are market risk, credit risk and liquidity risks. This note presents information about the Company’s exposure to each of these risks, its objectives, policies and processes for measuring and managing risk, and the Company’s management of capital.

Risk management framework

The Board has overall responsibility for the establishment and oversight of the risk management framework. Informal risk management policies are established to identify and analyse the risks faced by the Company.

The primary responsibility to monitor the financial risks lies with the Managing Director and the Company Secretary under the authority of the Board.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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Credit risk

Credit risk arises mainly from the risk of counterparties defaulting on the terms of their agreements.

The carrying amounts of the following assets represent the Company’s maximum exposure to credit risk in relation to financial assets:

elation to fnancial assets:
Note Cash and cash equivalents 8 Security deposits 10	Carrying amount 2018 $ 2017 $ 1,543,002 1,987,384 21,906 21,411
	1,564,908 2,008,795

Cash and cash equivalents

The Company mitigates credit risk on cash and cash equivalents by dealing with regulated banks in Australia.

Trade and other receivables

Credit risk of trade and other receivables is very low as it usually consists predominantly of amounts recoverable from a regulated bank in Australia.

All financial assets are current and are not past due or impaired and the Company does not have any material credit risk exposure to any single debtor or group of debtors under financial instruments entered into by the Company.

Liquidity risk

Liquidity risk is the risk that the Company will not be able to meet its financial obligations as they fall due. The Company’s approach to managing liquidity is to ensure, as far as possible, that it will always have sufficient liquidity to meet its liabilities when due, under both normal and stressed conditions, without incurring unacceptable losses or risking damage to the Company’s reputation.

Ultimate responsibility for liquidity management rests with the Board. The Company monitors rolling forecasts of liquidity on the basis of expected fund raisings, trade payables and other obligations for the ongoing operation of the Company. At balance date, the Company has available funds of $1,543,002 for its immediate use.

The following are the contractual maturities of financial liabilities, including estimated interest payments:

30 June 2018 Trade and other payables 30 June 2017 Trade and other payables	Carrying amount $ Contractual cash fows $ Less than one year $ Between one and fve years $ Interest $ 160,778 (160,778) (160,778) - -
	367,671 (367,671) (367,671) - -

It is not expected that the cash flows included in the maturity analysis could occur significantly earlier, or at significantly different amounts.

Biotron Ltd Annual Report 2018

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Notes to the Financial Statements For the Year Ended 30 June 2018

Market risk

Market risk is the risk that changes in market prices, such as foreign exchange rates, interest rates and equity prices will affect the Company’s income or the value of its holdings of financial instruments. The objective of market risk management is to manage and control market risk exposures within acceptable parameters, while optimising the return.

Interest rate risk

The Company’s income statement is affected by changes in interest rates due to the impact of such changes on interest income from cash and cash equivalents and interest bearing security deposits. The average interest rate on funds held during the year was 0.98% (2017 - 1.30%).

At balance date, the Company had the following mix of financial assets exposed to variable interest rate risk that are not designated as cash flow hedges:

Note Financial assets Cash and cash equivalents 8 Security deposits 10 Net exposure	2018 $ 2017 $ 1,543,002 1,987,384 21,906 21,411
	1,564,908 2,008,795

The Company did not have any interest bearing financial liabilities in the current or prior year.

The Company does not have interest rate swap contracts. The Company always analyses its interest rate exposure when considering renewals of existing positions including alternative financing.

Sensitivity analysis

The following sensitivity analysis is based on the interest rate risk exposures at balance date.

An increase of 100 basis points in interest rates throughout the reporting period would have decreased the loss for the period by the amounts shown below, whilst a decrease would have increased the loss by the same amount. The Company’s equity consists of fully paid ordinary shares. There is no effect on fully paid ordinary shares by an increase or decrease in interest rates during the period.

2018	2017
$	$
11,819	22,773

Currency risk

The Company is exposed to currency risk on cash and cash equivalents that are denominated in United States currency. The company’s gross financial exposure to foreign currency risk at balance date was US$150 (2017 - US$600).

The Company is not exposed to price risks.

Biotron Ltd Annual Report 2018

Notes to the Financial Statements For the Year Ended 30 June 2018

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Capital management

The Board’s policy is to maintain a strong capital base so as to maintain investor, creditor and market confidence and to sustain future development of the business.

The Board ensures costs are not incurred in excess of available funds and will seek to raise additional funding through issues of shares for the continuation of the Company’s operations. There were no changes in the Company’s approach to capital management during the year.

The Company is not subject to externally imposed capital requirements.

Estimation of fair values

The carrying amounts of financial assets and liabilities approximate their net fair values, given the short time frames to maturity and or variable interest rates.

19. FINANCIAL REPORTING BY SEGMENTS

The Company operates in one reportable operating and geographical segment, being the biotechnology industry in Australia.

20. OPERATING LEASES

The Company leases an office in North Ryde, Sydney. The lease is for a period of 3 years starting from November 2013 with monthly renewal after the 3 years.

During the year ended 30 June 2018, $77,604 was recognised as an expense in profit or loss in respect of the operating lease (2017 - $76,849).

The future minimum leases payments under non-cancellable operating leases are payable as follows:

	2018	2017
	$	$
Less than oneyear	6,539	6,488
Between one and fveyears	-	-

21. COMMITMENTS AND CONTINGENCIES

The Company may be party to commercial disputes and litigation in the normal course of business. No material liabilities are expected to arise in respect of the commercial disputes and litigation existing at balance date.

There are no capital commitments at the date of these financial statements.

22. SUBSEQUENT EVENTS

There have been no matters arise in the interval between the end of the financial year and the date of this report any item, transaction or event of a material and unusual nature likely, in the opinion of the directors of the Company, to affect significantly the operations of the Company, the results of those operations, or the state of affairs of the Company in future financial years.

Biotron Ltd Annual Report 2018

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Directors’ Declaration

In the opinion of the directors of Biotron Limited:
a) the financial statements and notes set out on pages 17 to 37, and the Remuneration Report in the Directors’ Report, set out on pages 10 to 14, are in accordance with the Corporations Act 2001 , including:
- (i) giving a true and fair view of the Company’s financial position as at 30 June 2018 and of its performance for the financial year ended on that date; and
- (ii) complying with Australian Accounting Standards (including Australian Accounting Interpretations) and the Corporations Regulations 2001 ;
b) there are reasonable grounds to believe that the Company will be able to pay its debts as and when they become due and payable.
The directors have been given the declarations required by Section 295A of the Corporations Act 2001 from the chief executive officer and chief financial officer for the financial year ended 30 June 2018.
The directors draw attention to note 2(a) of the financial statements, which includes a statement of compliance with International Financial Reporting Standards.

This report has been signed in accordance with a resolution of the directors and is dated 29 August 2018:

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Michael J. Hoy Chairman

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Michelle Miller Managing Director

Biotron Ltd Annual Report 2018

Independent Auditor’s Report

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KPMG, an Australian partnership and a member firm of the KPMG network of independent member firms affiliated with KPMG International Cooperative (“KPMG International”) a Swiss entity

Liability limited by a scheme approved under Professional Standards Legislation.

Biotron Ltd Annual Report 2018

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Independent Auditor’s Report

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Biotron Ltd Annual Report 2018

Independent Auditor’s Report

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1,692,656 • • • •

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Biotron Ltd Annual Report 2018

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Independent Auditor’s Report

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Biotron Ltd Annual Report 2018

Independent Auditor’s Report

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Biotron Ltd Annual Report 2018

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Additional Stock Exchange Information

Home Exchange

The Company is listed on the ASX Limited. The home exchange is Sydney.

Use of Cash and Assets

Since the Company’s listing on the ASX, the Company has used its cash and assets in a way consistent with its stated business objectives.

Class of Shares and Voting Rights

There is only one class of shares in the Company, fully paid ordinary shares.

The rights attaching to shares in the Company are set out in the Company’s Constitution. The following is a summary of the principal rights of the holders of shares in the Company.

Every holder of shares present in person or by proxy, attorney or representative at a meeting of shareholders has one vote on a vote taken by a show of hands, and, on a poll every holder of shares who is present in person or by proxy, attorney or representative has one vote for every fully paid share registered in the shareholder’s name on the Company’s share register.

A poll may be demanded by the chairperson of the meeting, by at least 5 shareholders entitled to vote on the resolution or shareholders with at least 5% of the votes that may be cast on the resolution on a poll.

Distribution of Equity Securityholders

As at 31 July 2018, the distribution of each class of quoted equity securityholders was as follows:

Range 1 - 1,000 1,001 - 5,000 5,001 - 10,000 10,001 - 100,000 100,001 and over	Fully Paid Ordinary Share Holders Total Number of Shares 30 November 2018 $0.06 Listed Option Holders Total Number of Listed Options 12 December 2019 $0.05 Listed Option Holders Total Number of Listed Options 116 30,055 32 14,377 23 13,282 344 1,236,292 137 390,627 90 280,731 339 2,732,982 65 508,853 72 532,222 1,377 55,613,134 178 7,091,019 310 11,941,422 734 442,808,319 102 70,424,254 159 103,315,144
	2,910 502,420,782 514 78,429,130 654 116,082,801

Range
1 - 1,000
1,001 - 5,000
5,001 - 10,000
10,001 - 100,000
100,001 and over

Fully Paid
Ordinary
Share Holders
Total
Number
of Shares
30 November
2018 $0.06
Listed Option
Holders
Total Number
of Listed
Options
12 December
2019 $0.05
Listed Option
Holders
Total Number
of Listed
Options
116
30,055
32
14,377
23
13,282
344
1,236,292
137
390,627
90
280,731
339
2,732,982
65
508,853
72
532,222
1,377
55,613,134
178
7,091,019
310
11,941,422
734
442,808,319
102
70,424,254
159
103,315,144

2,910
502,420,782
514
78,429,130
654
116,082,801

At 31 July 2018, 1,347 shareholders held less than a marketable parcel of shares. At 31 July 2018, 446 30 November 2018 6 cent listed option holders and nil 12 December 2019 5 cent listed option holders held less than a marketable parcel of options.

Biotron Ltd Annual Report 2018

Additional Stock Exchange Information

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TWENTY LARGEST QUOTED SHAREHOLDERS

At 31 July 2018 the twenty largest fully paid ordinary shareholders held 24.13% of fully paid ordinary as follows:

		Fully Paid
	Name	Ordinary Shares	%
1	Armco Barriers Pty Ltd	14,000,000	2.79
2	Dr Angela Fay Dulhunty	10,000,000	1.99
3	HSBC Custody Nominees (Australia) Limited	9,458,524	1.88
4	Scott’s A V Pty Ltd	8,829,000	1.76
5	Umbiram Pty Ltd	7,789,828	1.55
6	Mrs Narelle Fay	7,500,050	1.49
7	Pathold No 222 Pty Ltd	7,500,000	1.49
8	Mr Robert Thomas +Mrs Kyrenia Thomas	7,500,000	1.49
9	Warman Investments Pty Ltd	6,600,695	1.31
10	Rookharp Investments Pty Limited	5,968,718	1.19
11	Fordholm Investments Pty Ltd	5,000,000	1.00
12	Mr Andrew John Meek + Ms Saskia Elle Meek	4,125,749	0.82
13	Jey Investment Pty Ltd	4,000,695	0.80
14	Road & Construction Supplies of Australia Pty Ltd	3,600,000	0.72
15	Mr. Peter James Nightingale	3,594,903	0.72
16	DNS Accounting and Law Consultancy Pty Ltd	3,461,100	0.69
17	Mahe Investments Pty Ltd	3,209,533	0.64
18	Mr Ian Gavin Platt-Hepworth + Mrs S Marion Platt – Hepworth	3,129,182	0.62
19	Mr Russel Wayne Halder	3,000,000	0.60
20	Mr Andrew Fay	2,946,513	0.59

There are no current on-market buy-backs.

Biotron Ltd Annual Report 2018

Additional Stock Exchange Information

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TWENTY LARGEST 30 NOVEMBER 2018 6 CENT QUOTED OPTION HOLDERS

At 31 July 2018 the twenty largest 30 November 2018 6 cent option holders held 56.87% of listed options as follows:

	Name	Quoted Options	%
1	Jey Investment Pty Ltd	6,640,111	8.47
2	Mr Kevin Rowan Edwards + Miss Tehaniana Lilian Newton	3,500,000	4.46
3	Mr Changrok OH	3,165,000	4.04
4	BMMDH Pty Ltd	3,000,000	3.83
5	IQ Global Asset Partners Pty Ltd	2,974,286	3.79
6	DNS Accounting and Law Consultancy Pty Ltd	2,353,888	3.00
7	Mr Mathew Thomas Ryan	2,283,333	2.91
8	Mr Russell Dean Thomson	2,072,516	2.64
9	HSBC Custody Nominees (Australia) Limited	1,980,187	2.52
10	Armco Barriers Pty Ltd	1,901,107	2.42
11	Mrs Amanda Mignot	1,834,305	2.34
12	Lamdian Pty Ltd	1,700,000	2.17
13	Mr Russell Dean Thomson	1,700,000	2.17
14	Mrs Narelle Fay	1,614,475	2.06
15	Mr Peter William Goodall	1,500,000	1.91
16	Mr Edward Patrick O’Brien	1,500,000	1.91
17	Pathold No 222 Pty Ltd	1,350,000	1.72
18	Esdoro Pty Ltd	1,284,955	1.64
19	Umbiram Pty Ltd	1,246,372	1.59
20	Mr Cameron Geofrey Walters	1,000,000	1.28

Biotron Ltd Annual Report 2018

Additional Stock Exchange Information

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TWENTY LARGEST 12 DECEMBER 2019 5 CENT QUOTED OPTION HOLDERS

At 31 July 2018 the twenty largest 12 December 2019 5 cent option holders held 46.66% of listed options as follows:

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|||||
|---|---|---|---|
|Name|Quoted Options|%|
|1|Mr Edward O’Brien & Mrs Naomi O’Brien <OB-Plan SF A/C|9,150,000|7.88|
|2|Mr Michael Soucik & Mrs Heather Soucik |6,200,000|5.34|
|3|Rookharp Investments Pty Limited|4,666,667|4.02|
|4|Ms Nicole Gallin & Mr Kyle Haynes |3,959,533|3.41|
|5|Road & Construction Supplies of Australia Pty Ltd |3,700,000|3.19|
|6|Mrs Narelle Fay|2,500,050|2.15|
|7|Mr Andrew Fay |2,500,000|2.15|
|8|HSBC Custody Nominees (Australia) Limited|2,422,896|2.09|
|9|Goffacan Pty Ltd|2,000,000|1.72|
|10|Sugarloaf Ventures Pty Ltd |2,000,000|1.72|
|11|IQ Global Asset Partners Pty Ltd |1,911,544|1.65|
|12|Pershing Australia Nominees Pty Ltd |1,800,000|1.55|
|13|Mr Bret Joseph Evitt |1,666,667|1.44|
|14|Mr Dale Maurice Raynes|1,666,667|1.44|
|15|Umbiram Pty Ltd |1,557,965|1.34|
|16|Mrs Zi Juan QI |1,333,333|1.15|
|17|Mr Robert Murray Raynes|1,333,333|1.15|
|18|Mr Ryan James Rowe|1,333,333|1.15|
|19|Warman Investments Pty Ltd|1,320,139|1.14|
|20|Mr Peter John Leigh|1,147,828|0.99|

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UNQUOTED OPTIONS

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|||||||
|---|---|---|---|---|---|
|Number of|Number of|Exercise|
|Holders|Options|Grant Date|Vesting Date|Price|Expiry Date|
|1|1,000,000|25/11/2015|25/11/2015|$0.15|30 November 2018|
|1|1,000,000|25/11/2015|30/11/2016|$0.15|30 November 2018|
|1|3,000,000|25/11/2015|30/11/2017|$0.18|30 November 2018|

----- End of picture text -----

Biotron Ltd Annual Report 2018

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Corporate Directory

DIRECTORS:

Mr Michael J. Hoy (Chairman) Dr Michelle Miller (Managing Director) Dr Susan M. Pond Mr Robert B. Thomas

COMPANY SECRETARY:

Mr Peter J. Nightingale

REGISTERED OFFICE:

Level 2, 66 Hunter Street SYDNEY NSW 2000 Phone: 61-2 9300 3344 Fax: 61-2 9221 6333 E-mail: [email protected] Homepage: www.biotron.com.au

PRINCIPAL ADMINISTRATION OFFICE:

Suite 19, 56 Delhi Road NORTH RYDE NSW 2113 Phone: 61-2 9805 0488 Fax: 61-2 9805 0688

SHARE REGISTRAR:

Computershare Investor Services Pty Limited Level 4, 60 Carrington Street SYDNEY NSW 2000 Phone: 1300 787 272 Fax: 61-3 9473 2500

AUDITORS:

KPMG Level 16, Riparian Plaza 71 Eagle Street BRISBANE QLD 4000

HOME EXCHANGE:

ASX Limited 20 Bridge Street SYDNEY NSW 2000

SOLICITORS:

Minter Ellison 88 Phillip Street SYDNEY NSW 2000

Biotron Limited, incorporated and domiciled in Australia, is a publicly listed company limited by shares.

Biotron Ltd Annual Report 2018

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www.biotron.com.au

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Level 2, 66 Hunter Street Sydney NSW 2000 Tel: (61-2) 9300 3344 Fax: (61-2) 9221 6333 E-mail: [email protected] Website: www.biotron.com.au

NOTICE OF ANNUAL GENERAL MEETING

Notice is hereby given that the Annual General Meeting of members is to be convened at the Frazer Room, Level 1, 33 Erskine Street, Sydney, NSW, 2000 on 20 November 2018 at 11.30 am.

AGENDA

BUSINESS

To receive and consider the Company's annual financial report, the directors' report and the auditors' report for the year ended 30 June 2018.

To consider and, if thought fit, pass the following resolutions, with or without amendment:

Ordinary Resolutions

Resolution 1. 'That the Remuneration Report for the year ended 30 June 2018 be and is hereby adopted.'

Resolution 2. Ratification of 12,007,777 Shares – Listing Rule 7.4

“That pursuant to and in accordance with Listing Rule 7.4 and for all other purposes, Shareholders ratify the issue of 12,007,777 Shares on 14 June 2018, on the terms and conditions in the Explanatory Memorandum.”

Resolution 3. Ratification of 12,007,777 Options – Listing Rule 7.4

“That pursuant to and in accordance with Listing Rule 7.4 and for all other purposes, Shareholders ratify the issue of 12,007,111 Listed Options on 14 June 2018, on the terms and conditions in the Explanatory Memorandum.”

Resolution 4. Ratification of 6,000,000 Options – Listing Rule 7.4

“That pursuant to and in accordance with Listing Rule 7.4 and for all other purposes, Shareholders ratify the issue of 6,000,000 Listed Options on 14 June 2018, on the terms and conditions in the Explanatory Memorandum.”

Resolution 5. 'That Dr Susan M. Pond be and is hereby re-elected as a Director.'

Resolution 6. 'That Mr Michael J. Hoy be and is hereby re-elected as a Director.'

To transact any other business that may be brought forward in accordance with the Company's Constitution.

By order of the Board

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Peter J. Nightingale Company Secretary

18 October 2018

Notes:

The Company has determined, in accordance with regulation 7.11.37 of the Corporations Regulations 2001 (Cth) , that the Company's shares quoted on the Australian Stock Exchange Limited at 7.00 pm Sydney time on 18 November 2018 are taken, for the purposes of the Annual General Meeting to be held by the persons who held them at that time. Accordingly, those persons are entitled to attend and vote (if not excluded) at the meeting.

Voting Exclusion Statements

A. The Company will disregard any votes cast on Resolution 1 by or on behalf of a member of the key management personnel of the Company (at the date of the meeting or whose remuneration is disclosed in the remuneration report) ('KMP') and their closely related parties (such as close family members and controlled companies), unless the vote is cast:
as a proxy for a person entitled to vote in accordance with a direction on the proxy appointment; or
by the Chairman of the Meeting as a proxy for a person entitled to vote and the proxy appointment expressly authorises the Chairman of the Meeting to exercise the proxy even if the resolution is connected directly or indirectly with the remuneration of a member of KMP.
B. The Company will disregard any votes cast in favour of Resolutions 2 to 3 by or on behalf of:
any professional and sophisticated investors who participated in the issue; or
an associate of any professional and sophisticated investors person who participated in the issue.
The Company will not disregard a vote if:
it is cast by a person as a proxy for a person who is entitled to vote, in accordance with the directions on the Proxy Form; or
it is cast by the person Chairing the meeting as a proxy for a person who is entitled to vote, in accordance with a direction on the Proxy Form to vote as the proxy decides.
C. The Company will disregard any votes cast in favour of Resolutions 4 by or on behalf of:
CPS Capital Group Pty Ltd or its Nominees; or
an associate of CPS Capital Group Pty Ltd.

The Company will not disregard a vote if:

it is cast by a person as a proxy for a person who is entitled to vote, in accordance with the directions on the Proxy Form; or
it is cast by the person Chairing the meeting as a proxy for a person who is entitled to vote, in accordance with a direction on the Proxy Form to vote as the proxy decides.

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Level 2, 66 Hunter Street Sydney NSW 2000 Tel: (61-2) 9300 3344 Fax: (61-2) 9221 6333 E-mail: [email protected] Website: www.biotron.com.au

EXPLANATORY MEMORANDUM

This is an Explanatory Memorandum to in the Notice of Annual General Meeting of Biotron Limited to be convened at the Frazer Room, Level 1, 33 Erskine Street, Sydney, NSW, 2000 on 20 November 2018 at 11.30 am.

Resolution 1 Adoption of the Remuneration Report

The Remuneration Report, which can be found as part of the Directors’ Report in the Company's 2018 Annual Report, contains certain prescribed details, sets out the policy adopted by the Board of Directors and discloses the payments to key management personnel, Directors and senior executives.

In accordance with section 250R of the Corporations Act, a resolution that the Remuneration Report be adopted must be put to the vote. This resolution is advisory only and does not bind Directors.

The Chairman will allow a reasonable opportunity for shareholders as a whole to ask about, or make comments on the Remuneration Report.

The Chairman intends to exercise all undirected proxies in favour of Resolution 1. If the Chairman of the Meeting is appointed as your proxy and you have not specified the way the Chairman is to vote on Resolution 1, by signing and returning the Proxy Form, you are considered to have provided the Chairman with an express authorisation for the Chairman to vote the proxy in accordance with the Chairman's intention.

The Directors recommend that you vote IN FAVOUR of advisory Resolution 1.

The Chairman of the Meeting intends to vote undirected proxies IN FAVOUR of Resolution 1.

Resolutions 2 to 4 Ratification of Prior Issue of Securities – Listing Rule 7.4

Resolutions 2 to 4 seeks the ratification by Shareholders of the prior issues of securities that have occurred in the 12 months prior to the date of this Notice that have not already been approved by Shareholders for the purposes of Listing Rule 7.4. This ratification will provide the Company with the ability to raise further funds, if required, will maximise the flexibility of the Company’s funds management and will facilitate planning for the Company’s ongoing activities.

Technical information required by Listing Rule 7.5

By way of background, the Company has issued the following securities under the Company’s 15% placement capacity. All shares issued rank equally with all other existing Shares.

(a) As announced on 14 June 2018, pursuant to its then available listing rule 7.1 capacity, the Company issued 12,007,777 fully paid ordinary shares ranking pari passu with existing fully paid ordinary shares at $0.015 per share to professional and sophisticated investors (none of whom were related parties of the Company) under a Share Placement Offer, the proceeds of which were used for the expansion of HBV preclinical program, screening against additional antiviral targets, commercialisation activities and for working capital purposes.
(b) As announced on 14 June 2018, pursuant to its then available listing rule 7.1 capacity, the Company issued 12,007,777 options at nil issue price to professional and sophisticated investors (none of whom were related parties of the Company), who participated in the Share Placement Offer mentioned in (a) above.

The terms of the options are as follows:

Listed options
Each Option entitles the holder to subscribe for and be allotted one ordinary share in Biotron Limited at an exercise price of $0.05 per Option on or before 5.00pm (AEST) on 12 December 2019.
The rights of the option holder can be changed to comply with the listing rules when the company undertakes a reorganisation of capital.
The options do not entitle the holder to participate in new issues without exercising the options.
The Company may change the exercise price of the Listed Options or the number of shares over which the Listed Options are exercisable in the event of the Company making a prorata issue of Shares or other securities to the holders of Shares in the Company (other than bonus issue) in accordance with Listing Rule 6.22.2A.
The options are transferable.
Upon exercise of the options, the options will convert into fully paid ordinary shares which will rank equally in all respect with existing fully paid ordinary shares.
(c) As announced on 14 June 2018, pursuant to its then available listing rule 7.1 capacity, the Company issued 6,000,000 options at nil issue price to CPS Capital Group Pty Ltd or its Nominees in accordance with the mandate to act as the Lead manager and Underwriter for the Renounceable Rights issue as announced on 10 May 2018.

The terms of the options are as follows:

Listed options
Each Option entitles the holder to subscribe for and be allotted one ordinary share in Biotron Limited at an exercise price of $0.05 per Option on or before 5.00pm (AEST) on 12 December 2019.
The rights of the option holder can be changed to comply with the listing rules when the company undertakes a reorganisation of capital.
The options do not entitle the holder to participate in new issues without exercising the options.
The Company may change the exercise price of the Listed Options or the number of shares over which the Listed Options are exercisable in the event of the Company making a prorata issue of Shares or other securities to the holders of Shares in the Company (other than bonus issue) in accordance with Listing Rule 6.22.2A.
The options are transferable.
Upon exercise of the options, the options will convert into fully paid ordinary shares which will rank equally in all respect with existing fully paid ordinary shares.

A voting exclusion statement is included in the Notice.

The Directors recommend that you vote IN FAVOUR of Resolutions 2, 3 and 4.

Resolutions 2, 3 and 4 are ordinary Resolutions.

The Chairman of the Meeting intends to vote undirected proxies IN FAVOUR of Resolutions 2, 3 and 4.

Resolution 5 Re-election of Dr Susan M. Pond as a Director

In accordance with Article 58 of the Company's Constitution and the Corporations Law, Susan Pond retires as a Director by rotation and, being eligible, offers herself for re-election.

Dr Pond has a strong scientific and commercial background having held executive positions in the biotechnology and pharmaceutical industry for 12 years, most recently as chairman and managing director of Johnson & Johnson Research Pt y Limited (2003 - 2009). Most recently, she was Director of the University of Sydney Nano Institute from February 2017 - April 2018. She has held many previous board positions including as executive director of Johnson & Johnson Pty Limited, non-executive director and chairman of AusBiotech Limited, director of the Australian Nuclear Science and Technology Organisation and Australian Academy of Technological Sciences and Engineering (ATSE) and board member of Commercialisation Australia and Innovation Australia.

The Directors recommend that you vote IN FAVOUR of Resolution 5.

Resolution 5 is an ordinary Resolution.

The Chairman of the Meeting intends to vote undirected proxies IN FAVOUR of Resolution 5.

Resolution 6 Re-election of Mr Michael J. Hoy as a Director

In accordance with Article 58 of the Company's Constitution and the Corporations Law, Michael Hoy retires as a Director by rotation and, being eligible, offers himself for re-election.

Mr Hoy has more than 30 years' corporate experience in Australia, the United Kingdom, USA and Asia. He is Chairman of Lipotek Pty Limited and a former director of John Fairfax Holdings Limited, FXF Trust Limited and Telesso Technologies Limited .

The Directors recommend that you vote IN FAVOUR of Resolution 6.

Resolution 6 is an ordinary Resolution.

The Chairman of the Meeting intends to vote undirected proxies IN FAVOUR of Resolution 6.

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Lodge your vote:

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
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Online:

www.investorvote.com.au



By Mail:

Computershare Investor Services Pty Limited GPO Box 242 Melbourne Victoria 3001 Australia

BIT

MR SAM SAMPLE FLAT 123 123 SAMPLE STREET THE SAMPLE HILL SAMPLE ESTATE SAMPLEVILLE VIC 3030

Alternatively you can fax your form to (within Australia) 1800 783 447 (outside Australia) +61 3 9473 2555

For Intermediary Online subscribers only (custodians) www.intermediaryonline.com

For all enquiries call:

(within Australia) 1300 850 505 (outside Australia) +61 3 9415 4000

Proxy Form

XX

Vote and view the annual report online



Go to www.investorvote.com.au or scan the QR Code with your mobile device.
• Follow the instructions on the secure website to vote.

Your access information that you will need to vote:

Control Number: 999999 SRN/HIN: I9999999999 PIN: 99999 PLEASE NOTE: For security reasons it is important that you keep your SRN/HIN confidential.

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 For your vote to be effective it must be received by 11:30am Sunday 18 November 2018

How to Vote on Items of Business

All your securities will be voted in accordance with your directions.

Appointment of Proxy

Voting 100% of your holding: Direct your proxy how to vote by marking one of the boxes opposite each item of business. If you do not mark a box your proxy may vote or abstain as they choose (to the extent permitted by law). If you mark more than one box on an item your vote will be invalid on that item.

Voting a portion of your holding: Indicate a portion of your voting rights by inserting the percentage or number of securities you wish to vote in the For, Against or Abstain box or boxes. The sum of the votes cast must not exceed your voting entitlement or 100%.

Appointing a second proxy: You are entitled to appoint up to two proxies to attend the meeting and vote on a poll. If you appoint two proxies you must specify the percentage of votes or number of securities for each proxy, otherwise each proxy may exercise half of the votes. When appointing a second proxy write both names and the percentage of votes or number of securities for each in Step 1 overleaf.

A proxy need not be a securityholder of the Company.

Signing Instructions for Postal Forms

Individual: Where the holding is in one name, the securityholder must sign.

Joint Holding: Where the holding is in more than one name, all of the securityholders should sign.

Power of Attorney: If you have not already lodged the Power of Attorney with the registry, please attach a certified photocopy of the Power of Attorney to this form when you return it.

Companies: Where the company has a Sole Director who is also the Sole Company Secretary, this form must be signed by that person. If the company (pursuant to section 204A of the Corporations Act 2001) does not have a Company Secretary, a Sole Director can also sign alone. Otherwise this form must be signed by a Director jointly with either another Director or a Company Secretary. Please sign in the appropriate place to indicate the office held. Delete titles as applicable.

Attending the Meeting

Bring this form to assist registration. If a representative of a corporate securityholder or proxy is to attend the meeting you will need to provide the appropriate “Certificate of Appointment of Corporate Representative” prior to admission. A form of the certificate may be obtained from Computershare or online at www.investorcentre.com under the help tab, "Printable Forms".

Comments & Questions: If you have any comments or questions for the company, please write them on a separate sheet of paper and return with this form.

GO ONLINE TO VOTE,  or turn over to complete the form

Samples/000001/000001/i12

MR SAM SAMPLE FLAT 123 123 SAMPLE STREET THE SAMPLE HILL SAMPLE ESTATE SAMPLEVILLE VIC 3030

I ND

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

Change of address. If incorrect, mark this box and make the correction in the space to the left. Securityholders sponsored by a broker (reference number commences with ‘ X ’) should advise your broker of any changes. I 9999999999

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Proxy Form

Please mark

to indicate your directions

Appoint a Proxy to Vote on Your Behalf

XX

I/We being a member/s of Biotron Limited hereby appoint

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the Chairman of the Meeting

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OR
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 PLEASE NOTE: Leave this box blank if you have selected the Chairman of the Meeting. Do not insert your own name(s).

or failing the individual or body corporate named, or if no individual or body corporate is named, the Chairman of the Meeting, as my/our proxy to act generally at the Meeting on my/our behalf and to vote in accordance with the following directions (or if no directions have been given, and to the extent permitted by law, as the proxy sees fit) at the Annual General Meeting of Biotron Limited to be held at the Frazer Room, Level 1, 33 Erskine Street, Sydney, NSW, 2000 on Tuesday, 20 November 2018 at 11:30am and at any adjournment or postponement of that Meeting.

Chairman authorised to exercise undirected proxies on remuneration related resolutions : Where I/we have appointed the Chairman of the Meeting as my/our proxy (or the Chairman becomes my/our proxy by default), I/we expressly authorise the Chairman to exercise my/our proxy on Item 1 (except where I/we have indicated a different voting intention below) even though Item 1 is connected directly or indirectly with the remuneration of a member of key management personnel, which includes the Chairman.

Important Note: If the Chairman of the Meeting is (or becomes) your proxy you can direct the Chairman to vote for or against or abstain from voting on Item 1 by marking the appropriate box in step 2 below.

Items of Business 

1 Adoption of the Remuneration Report
2 Ratification of 12,007,777 Shares
3 Ratification of 12,007,777 Options
4 Ratification of 6,000,000 Options
5 Re-elect Dr Susan M Pond as a director
6 Re-elect Mr Michael J Hoy as a director

PLEASE NOTE: If you mark the Abstain box for an item, you are directing your proxy not to vote on your behalf on a show of hands or a poll and your votes will not be counted in computing the required majority.

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The Chairman of the Meeting intends to vote undirected proxies in favour of each item of business. In exceptional circumstances, the Chairman of the Meeting may change his/her voting intention on any resolution, in which case an ASX announcement will be made.

SIGN

Signature of Securityholder(s) This section must be completed.

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Individual or Securityholder 1 Securityholder 2 Securityholder 3
Sole Director and Sole Company Secretary Director Director/Company Secretary
Contact
Contact Daytime / /
Name Telephone Date
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9 9 9 9 9 9 A

B I T

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All general correspondence to: Computershare Investor Services Pty Limited GPO Box 2975 Melbourne Victoria 3001 Australia Enquiries (within Australia) 1300 855 080 (outside Australia) 61 3 9415 4000 Facsimile 61 3 9473 2500 www.investorcentre.com/contact www.computershare.com

BITRM

MR RETURN SAMPLE 123 SAMPLE STREET SAMPLE SURBURB SAMPLETOWN VIC 3030

Dear Securityholder,

We have been trying to contact you in connection with your securityholding in Biotron Limited. Unfortunately, our correspondence has been returned to us marked “Unknown at the current address”. For security reasons we have flagged this against your securityholding which will exclude you from future mailings, other than notices of meeting.

Please note if you have previously elected to receive a hard copy Annual Report (including the financial report, directors’ report and auditor’s report) the dispatch of that report to you has been suspended but will be resumed on receipt of instructions from you to do so.

We value you as a securityholder and request that you supply your current address so that we can keep you informed about our Company. Where the correspondence has been returned to us in error we request that you advise us of this so that we may correct our records.

You are requested to include the following;

Securityholder Reference Number (SRN);

ASX trading code;

Name of company in which security is held;

Old address; and

New address.

Please ensure that the notification is signed by all holders and forwarded to our Share Registry at:

Computershare Investor Services Pty Limited GPO Box 2975 Melbourne Victoria 3001 Australia

Note: If your holding is sponsored within the CHESS environment you need to advise your sponsoring participant (in most cases this would be your broker) of your change of address so that your records with CHESS are also updated.

Yours sincerely

Biotron Limited

Samples/000002/000003/i12

AI assistant

BIOTRON LIMITED — Annual Report 2018

64528_rns_2018-10-17_eb08f00f-671f-4395-bc2c-1662a5126588.pdf

ANNUAL REPORT AND NOTICE OF AGM

Contents

REVIEW OF OPERATIONS

Executive Summary

Operating and Financial Review

Clinical Programs

Operating and Financial Review

Non-Clinical Programs

Operating and Financial Review

Patents

Operating and Financial Review

Corporate

CORPORATE GOVERNANCE STATEMENT

Directors’ Report

DIRECTORS

Mr Michael J. Hoy

Independent and Non-Executive Chairman

Dr Michelle Miller, BSc, MSc, PhD, GCertAppFin (Finsia)

Managing Director

Dr Susan M. Pond AM, MD DSc, FTSE FAHMS

Independent and Non-Executive Director

Dr Denis N. Wade

Independent and Non-Executive Director

Mr Robert B. Thomas BEc, MSDIA, SF Fin, FICD

Independent and Non-Executive Director

Mr Peter J. Nightingale

Company Secretary

DIRECTORS’ MEETINGS

DIRECTORS’ INTERESTS

UNISSUED SHARES UNDER OPTION

SHARES ISSUED ON EXERCISE OF OPTIONS

PRINCIPAL ACTIVITIES

FINANCIAL RESULT AND REVIEW OF OPERATIONS

IMPACT OF LEGISLATION AND OTHER EXTERNAL REQUIREMENTS

DIVIDENDS

STATE OF AFFAIRS

ENVIRONMENTAL REGULATIONS

EVENTS SUBSEQUENT TO BALANCE DATE

LIKELY DEVELOPMENTS

INDEMNIFICATION OF OFFICERS AND AUDITORS

Directors’ Report

REMUNERATION REPORT - AUDITED

Principles of compensation - Audited

Consequences of performance on shareholder wealth - Audited

Details of remuneration for the year ended 30 June 2018 - Audited

Directors’ Report

Options granted as compensation - Audited

Modification of terms of equity-settled share-based payment transactions - Audited

Exercise of options granted as compensation - Audited

Analysis of options and rights over equity instruments granted as compensation - Audited

Analysis of movements in options - Audited

Options and rights over equity instruments - Audited

Option holdings 2018 - Audited

Loans to key management personal and their related parties - Audited

Other transactions with key management personnel - Audited

Directors’ Report

Movements in shares - Audited

Fully paid ordinary shareholdings and transactions 2018 - Audited

Service contracts - Audited

Non-executive directors - Audited

Non-audit Services

LEAD AUDITOR’S INDEPENDENCE DECLARATION

Lead Auditor’s Independence Declaration

Statement of Profit or Loss and Other Comprehensive Income

Statement of Financial Position As At 30 June 2018

Statement of Changes in Equity For The Year Ended 30 June 2018

Statement of Cash Flows For The Year Ended 30 June 2018

1. REPORTING ENTITY

2. BASIS OF PREPARATION

a. Statement of compliance

b. Basis of measurement

c. Functional and presentation currency

d. Use of estimates and judgements

e. Going concern

Notes to the Financial Statements

3. SIGNIFICANT ACCOUNTING POLICIES

a. Cash and cash equivalents

BIOTRON LIMITED Annual Report 2018