Septerna, Inc. — Director's Dealing 2026

Feb 20, 2026

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Septerna, Inc. (SEPN)
CIK: 0001984086
Period of Report: 2026-02-18

Reporting Person: Bhatt Elizabeth (N/A)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2026-02-18	Common Stock	M	4000	$6.81	Acquired	178209	Direct
2026-02-18	Common Stock	S	2200	$28.4594	Disposed	176009	Direct
2026-02-18	Common Stock	S	1800	$29.5831	Disposed	174209	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2026-02-18	Stock Option (Right to Buy)	$6.81	M	4000	Disposed	2034-09-22	Common Stock (92911)	Direct

Footnotes

F1: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F2: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.09 to $29.07. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.12 to $29.98. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F4: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.