Septerna, Inc. — Director's Dealing 2026

Feb 10, 2026

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Septerna, Inc. (SEPN)
CIK: 0001984086
Period of Report: 2026-02-06

Reporting Person: Labrucherie Gil M (N/A)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2026-02-06	Stock Option (Right to Buy)	$25.41	A	125000	Acquired	2036-02-05	Common Stock (125000)	Direct

Footnotes

F1: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.