Philogen — Capital/Financing Update 2021

Apr 1, 2021

NOT FOR PUBLICATION, DISTRIBUTION OR RELEASE, DIRECTLY OR INDIRECTLY, IN OR INTO THE UNITED STATES, CANADA, JAPAN, AUSTRALIA OR ANY COUNTRY WHERE IT IS UNLAWFUL TO DO SO.

This announcement is an advertisement and not a prospectus and not an offer of securities for sale in or into the United States, Canada, Japan or Australia, or any other jurisdiction where it is unlawful to do so.

COMUNICATO STAMPA

MANCATO ESERCIZIO DELL'OPZIONE GREENSHOE E TERMINE DEL PERIODO DI STABILIZZAZIONE

COMUNICAZIONE FINALE RELATIVA ALL'ATTIVITÀ DI STABILIZZAZIONE

Siena, 1 aprile 2021 - Philogen S.p.A. ("Philogen" o la "Società") comunica il mancato esercizio dell'opzione greenshoe per n. 406.111 azioni ordinarie concessa dagli azionisti Nerbio S.r.l. e Dompè Holdings S.r.l.. In data odierna è, altresì, terminato il periodo di stabilizzazione.

Philogen rende altresì noto, sulla base di quanto comunicato da Mediobanca – Banca di Credito Finanziario S.p.A. ("Mediobanca") in qualità di soggetto incaricato dell'attività di stabilizzazione nell'ambito della quotazione delle azioni ordinarie di Philogen, che Mediobanca ha effettuato operazioni di stabilizzazione (come definite dall'articolo 3, paragrafo 2, lettera d) del Regolamento relativo agli abusi di mercato (UE/596/2014)) in relazione all'offerta degli strumenti finanziari di seguito descritta.

Strumenti finanziari:
Emittente	Philogen S.p.A.
Strumenti finanziari	Azioni ordinarie (ISIN: IT0005373789)
Dimensione dell'offerta	4.061.111 azioni ordinarie esclusa l'opzione di over-allotment
Totale aggregato delle	406.111 azioni ordinarie
azioni oggetto di
stabilizzazione
Stabilisation Manager	Mediobanca – Banca di Credito Finanziario S.p.A.

Ai sensi dell'articolo 6, paragrafo 3 del Regolamento Delegato (UE) 2016/1052 che integra il Regolamento (UE) n. 596/2014 del Parlamento europeo e del Consiglio per quanto riguarda le norme tecniche di regolamentazione sulle condizioni applicabili ai programmi di riacquisto di azioni proprie e alle misure di stabilizzazione, Philogen, sulla base di quanto comunicato da Mediobanca, comunica che l'attività di stabilizzazione è iniziata in data 3 marzo 2021 e che l'ultima operazione di stabilizzazione è avvenuta in data 5 marzo 2021.

La tabella che segue riporta i dati relativi alle operazioni compiute nel periodo di stabilizzazione.

Data	Numero totale delle azioni ordinarie acquistate	Numero delle operazioni	Intervallo di Prezzo (Euro)	Sede di Negoziazione
3 marzo 2021	320.000	722	16,288 – 17,00	Borsa Italiana – Mercato Telematico Azionario
4 marzo 2021	46.111	19	16,508 – 16,690	Borsa Italiana – Mercato Telematico Azionario

5 marzo 2021	40.000	59	15,004 – 16,300	Borsa Italiana –
				Mercato Telematico
				Azionario

Il presente comunicato è diffuso anche per conto di Mediobanca ai sensi dell'articolo 6, paragrafo 3, del Regolamento Delegato (UE) 2016/1052.

***

Philogen è un'azienda italo-svizzera attiva nel settore delle biotecnologie, specializzata nella ricerca e sviluppo di prodotti farmaceutici per il trattamento di patologie ad alto tasso di letalità. Di fatto, il Gruppo scopre e sviluppa principalmente farmaci antitumorali mirati, sfruttando ligandi ad alta affinità per markers tumorali (chiamati anche antigeni tumorali). Questi ligandi - anticorpi monoclonali umani o piccole molecole organiche - vengono identificati tramite le tecnologie di Antibody Phage Display Libraries e DNA-Encoded Chemical Libraries.

La principale strategia terapeutica del Gruppo per il trattamento di tali patologie è rappresentata dal c.d. tumor targeting. Questo approccio si basa sull'uso di ligandi capaci di veicolare in maniera selettiva principi attivi terapeutici molto potenti (come ad esempio citochine proinfiammatorie) presso la massa tumorale, risparmiando i tessuti sani. Nel corso degli anni Philogen ha principalmente sviluppato ligandi a base di anticorpi monoclonali, specifici per antigeni espressi nei vasi sanguigni associati ai tumori, ma non espressi nei vasi sanguigni associati ai tessuti sani. Questi antigeni sono solitamente più abbondanti e più stabili rispetto a quelli espressi direttamente sulla superficie delle cellule tumorali. Questo approccio, c.d. vascular targeting, è utilizzato per la maggior parte dei progetti perseguiti dal Gruppo.

L'obiettivo del Gruppo è quello di generare, sviluppare e commercializzare prodotti innovativi per il trattamento di malattie per le quali la scienza medica non ha ancora individuato terapie soddisfacenti. Ciò è possibile sfruttando (i) le tecnologie proprietarie per l'isolamento di ligandi che reagiscono con antigeni presenti in determinate patologie, (ii) l'esperienza nello sviluppo di prodotti mirati ai tessuti interessati dalla patologia, (iii) l'esperienza nella produzione e nello sviluppo di farmaci e (iv) l'ampio portafoglio di brevetti e diritti di proprietà intellettuale.

Nonostante i farmaci del Gruppo siano principalmente applicazioni oncologiche, l'approccio di targeting è potenzialmente applicabile anche ad altre patologie, quali alcune malattie infiammatorie croniche.

PER ULTERIORI INFORMAZIONI:

Philogen - Investor Relations

IR@philogen.com - Emanuele Puca | Investor Relator

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This announcement does not constitute or form part of any offer or invitation to sell or issue, or any solicitation of any offer to purchase or subscribe for any shares or any other securities, nor shall it (or any part of it) or the fact of its distribution form the basis of, or be relied on in connection with, any contract therefor. The offering of the Philogen's shares (the "Offering") and the distribution of this announcement and other information in connection with the Offering in certain jurisdictions may be restricted by law and persons into whose possession this announcement or any document or other information referred to herein comes should inform themselves about, and observe, any such restrictions. Any failure to comply with these restrictions may constitute a violation of the laws of any such jurisdiction.

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This announcement does not constitute an offer for sale of, or a solicitation of an offer to purchase or subscribe for, any securities in the United States. No securities of the Company have been registered under the U.S. Securities Act of 1933, as amended, and the Company does not intend to register any of the securities in the United States or to conduct a public offering of the securities in the United States. There will be no public offering of the securities in the United States or elsewhere.

This announcement does not constitute a recommendation concerning the Offering or the shares of the Company. The price and value of securities can go down as well as up. Past performance is not a guide to future performance. Information in this announcement or any of the documents relating to the Offering cannot be relied upon as a guide to future performance. Potential investors should consult, to the extent they deem necessary, a professional investment, business, tax, and/or legal advisor as to the suitability of the Offering for the person concerned.

None of the banks acting as joint global coordinators, joint bookrunners and/or co-bookrunner an/or stabilising manager in the contest of the Offering (the "Managers") or any of their respective directors, officers, employees, advisers or agents accepts any responsibility or liability whatsoever for or makes any representation or warranty, express or implied, as to the truth, accuracy or completeness of the information in this announcement (or whether any information has been omitted from the announcement) or any other information relating to the Company, its subsidiaries or associated companies, whether written, oral or in a visual or electronic form, and howsoever transmitted or made available or for any loss howsoever arising from any use of this announcement or its contents or otherwise arising in connection therewith. Nothing contained herein is, or shall be relied upon as, a promise or representation by the Managers or any of their respective directors, officers, employees, advisers or agents in this respect, whether as to the past or future.

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Solely for the purposes of the product governance requirements contained within: (a) EU Directive 2014/65/EU on markets in financial instruments, as amended ("MiFID II"); (b) Articles 9 and 10 of Commission Delegated Directive (EU) 2017/593 supplementing MiFID II; and (c) local implementing measures (together, the "MiFID II Product Governance Requirements''), (d) Regulation (EU) No 600/2014 as it forms part of United Kingdom domestic law by virtue of the EUWA ("UK MiFIR"); and (e) the FCA Handbook Product Intervention and Product Governance Sourcebook (together, the "Product Governance Requirements"), and disclaiming all and any liability, whether arising in tort, contract or otherwise, which any "manufacturer" (for the purposes of the Product Governance Requirements) may otherwise have with respect thereto, the Shares have been subject to a product approval process, which has determined that: (i) the target market for the Shares (a) in the EEA, eligible counterparties and professional clients only, each as defined in MiFID II; and (b) in the United Kingdom, eligible counterparties (as defined in the FCA Handbook Conduct of Business Sourcebook) and professional clients (as defined in UK MiFIR); and (ii) all channels for distribution of the Shares to eligible counterparties and professional clients are appropriate (the "Target Market Assessment"). Any person subsequently offering, selling or recommending the Shares (a "distributor") should take into consideration the manufacturers' Target Market Assessment; however, a distributor subject to MiFID II or the FCA Handbook Product Intervention and Product Governance Sourcebook is responsible for undertaking its own target market assessment in respect of the Shares (by either adopting or refining the manufacturers' target market assessment) and determining appropriate distribution channels. Notwithstanding the Target Market Assessment, distributors should note that: the price of the Shares may decline, and investors could lose all or part of their investment; the Shares offer no guaranteed income and no capital protection; and an investment in the Shares is compatible only with investors who do not need a guaranteed income or capital protection, who (either alone or in conjunction with an appropriate financial or other adviser) are capable of evaluating the merits and risks of such an investment and who have sufficient resources to be able to bear any losses that may result therefrom. The Target Market Assessment is without prejudice to the requirements of any contractual, legal or regulatory selling restrictions in relation to the offering. Furthermore, it is noted that, notwithstanding the Target Market Assessment, the Managers will only procure investors who meet the criteria of professional clients and eligible counterparties.

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