Oxurion NV — Major Shareholding Notification 2023

Feb 24, 2023

Oxurion Receives Transparency Notifications from Negma Group

February 24, 2023

Oxurion Receives Transparency Notifications from Negma Group

Leuven, BELGIUM, Boston, MA, US – February 24, 2022 – 7.00 PM CET Oxurion NV (Euronext Brussels: OXUR) a biopharmaceutical company developing next generation standard of care ophthalmic therapies, with clinical stage assets in vascular retinal disorders, today announced that, pursuant to Belgian Transparency legislation1 it has received a transparency notification as follows:

Oxurion received a transparency notification on February 21, 2023 from Negma Group Ltd. indicating that as of February 16, 2023, it held no shares of the then outstanding 564,210,937 shares, and therefore crossed below the threshold (3%) by virtue of disposal of voting securities. See Annex 1

Oxurion received a transparency notification on February 21, 2023 from Negma Group Ltd. indicating that as of February 15, 2023, it held 35,314,661 shares of the then outstanding 564,210,937 shares, and therefore crossed above the threshold (5%) by virtue of acquisition of voting securities. See Annex 2

About Oxurion

Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to improve and better preserve vision in patients with retinal disorders including diabetic macular edema (DME), the leading cause of vision loss in working-age people, as well as other conditions. Oxurion intends to play an important role in the treatment of retinal disorders, including the successful development of THR-149, its novel therapeutic for the treatment of DME. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the up to 50% of DME patients showing suboptimal response to anti-VEGF therapy. Oxurion is headquartered in Leuven, Belgium, with corporate operations in Boston, MA. More information is available at www.oxurion.com.

Important information about forward-looking statements

Certain statements in this press release may be considered "forward-looking". Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company's Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

For further information please contact:

Oxurion NV Tom Graney Chief Executive Officer Tel: +32 16 75 13 10	US Conway Communications Mary T. Conway mtconway@conwaycommsir.com
" tom.graney@oxurion.com	ICR Westwicke
Michael Dillen	Christopher Brinzey Tel: +1 617 835 9304
Chief Business Officer	Chris.Brinzey@westwicke.com
Tel: +32 16 75 13 10 michael.dillen@oxurion.com

1. Article 14, first paragraph, of the Law of 2 May 2007 on disclosure of major holdings.

________

FSMA	FINANCIAL SERVICES AND MARKETS AUTHORITY	Transparency notification Form TR-1 BE PART I
1) Status of the notification
	Final
2) Issuer
Identification number 0881-620-924	Name OXURION
3) Reason for the notification
	Acquisition or disposal of voting securities or voting rights
	Downward crossing of the lowest threshold
4) Notification by
	A parent undertaking or a controlling person
5) Persons subject to the notification requirement
	Name	Address (for legal entities)
	Elaf Gassam
	Negma Group Investment Ltd.	Unit 1 Level 28, ICD Brookfield Place, DIFC, Dubai (United Arab Emirates)
	Negma Group Ltd.	Craigmuir chambers, Road Town, Tortola, VG 1110 (British Virgin lslands)
	6) Persons that dispose of voting rights (only to be filled in if art. 7 of the Law applies)
	Name	Address (for legal entities)
19	Please continue entering the information in part # concerning the persons referred to in Sections 5 and 6	Part II
7) Date on which the threshold is crossed
		16/02/2023 (DD/MM/YYYY)
8) Threshold that is crossed (in %)

T

If the holding has fallen below the lowest threshold, you have the option of not entering any numbers in Section 10

3

9) Denominator

10) Notified details

A) Voting rights	Previous notification	After the transaction
	of voting rights		Il of voting rights	% of voting rights
Holders of voting rights		Linked to securities	Not linked to the securities	Linked to securities	Not linked to the securities
Elaf Gassam	0	0		0.00%
Negma Group Investment Ltd.	0	0		0.00%
Negma Group Ltd.	35,314,661	0		0.00%
Subtotal	35,314,661

+

TOTAL

Start with "groups" of holders. Add subtotals with Z, and then finish with the persons who are "alone".
For groups, start with the ultimate controlling natural person or l

0

0.00%

B) Equivalent financial instruments	After the transaction
Holders of equivalent financial instruments	Type of financial instrument	Expiration date	Exercise period or date	# of voting rights that may be acquired if the instrument is exercised	% of voting rights	Settlement
							+
	TOTAL
1 The totals will be updated once you have clicked on

TOTAL (A & B)			# of voting rights 1% of voting rights
	CALCULATE	o	0.00%

11) Full chain of controlled undertakings through which the holding is effectively held, it applicable

12) In case of proxy voting for only one GM

will cease to hold / Holder voting rights as of will hold again

13) Additional information

	Done at Dubai, United Arab Emirates
Ôn	21/02/2021	(DD/MM/YYYY)
	Name & capacity Elaf Gassam, Director	Signature	Charlesses 4

ANNEX 2

FSMA

1) Status of the notification_

		Final
2) Issuer
		Name OXURION
	Identification number 0881-620-924

3) Reason for the notification

|--|

+

+

4) Notification by

A parent undertaking or a controlling person
----------------------------------------------

5) Persons subject to the notification requirement_

Name	Address (for legal entities)
Elaf Gassam
Negma Group Investment Ltd.	Unit 1 Level 28, ICD Brookfield Place, DIFC, Dubai (United Arab Emirates)
Negma Group Ltd.	Craigmuir chambers, Road Town, Tortola, VG 1110 (British Virgin Islands)

ි) Persons that dispose of voting rights (only to be filled in if art. 7 of the Law applies)

	Name	Address (for legal entities)
			+
1	Please continue entering the information in part II concerning the persons referred to in Sections 5 and 6	Part II
7) Date on which the threshold is crossed
15/02/2023 (DD/MM/YYYY)
B) Threshold that is crossed (in %)
If the holding has fallen below the lowest threshold, you have the option of not entering any numbers in Section 10

9) Denominator

10) Notified details

A) Voting rights	Previous notification	After the transaction
	# of voting rights	# of voting rights		% of voting rights
Holders of voting rights		Linked to securities	Not linked to the securities	Linked to securities	Not linked to the securities
Elaf Gassam	0	D		0.00%
Negma Group Investment Ltd.	0	0		0.00%
Negma Group Ltd.	0	35,314,661		6.26%
Subtotal		35,314,661		6.26%

TOTAL		35,314,661	6.26%	0.00%
Start with "groups" of holders. Add subtotals with Z, and then finish with the persons who are "alone".

• ============================================================================================================================================================================

______________________________________________________________________________________________________________________________________________________________________________

For groups, start with the ultimate controlling natural person or legal entity.
The totals, subtotals and % will be updated once you have clicked on .

B) Equivalent financial instruments	After the transaction
Holders of equivalent financial instruments	Type of financial instrument	Expiration date	Exercise period or dato	# of voting rights that may be acquired if the Instrument is exercised	% of voting rights	Settlement
							+
TOTAL			0	0.00%

FOTAL (A & B)		# of voting rights % of voting rights
	CALCULATE	35,314,661	6.26%

Holder	will cease to hold / will hold again	voting rights as of

	Done at Dubai, United Arab Emirates
On		21/02/2023 (DD/MMYYYYY)
	Name & capacity Elaf Gassam, Director	Signature	Total Value of -

Attachments

• OXUR Transparency Notification (EN) 2023.2.24.FINAL
• OXUR Transparency Notification (NL) 2023.2.24.FINAL