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Oxurion NV Director's Dealing 2022

Nov 28, 2022

3987_mrq_2022-11-28_289640ca-9725-4c76-82a2-0e7281c187dc.pdf

Director's Dealing

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Oxurion Receives Transparency Notifications from Negma Group

Leuven, BELGIUM, Boston, MA, US – November 28, 2022 – 8.00 PM CET Oxurion NV (Euronext Brussels: OXUR) a biopharmaceutical company developing next generation standard of care ophthalmic therapies, with clinical stage assets in vascular retinal disorders, today announced that, pursuant to Belgian Transparency legislation1 it has received transparency notifications as follows:

Oxurion received transparency notification on November 28 from Negma Group Ltd. indicating that as of November 23, it held 19,475,880 shares of the then outstanding 168,949,714 shares, and therefore crossed below the 15% threshold by virtue of disposal of voting securities.

Oxurion received transparency notification on November 28 from Negma Group Ltd. indicating that as of November 22, it held 39,577,246 shares of the then outstanding 168,949,714 shares, and therefore crossed above the 20% threshold by virtue of acquisition of voting securities.

Oxurion received transparency notification on November 23 from Negma Group Ltd. indicating that as of November 21, it held 0 shares of the then outstanding 123,781,647 shares, and therefore crossed below the lowest (3%) threshold by virtue of disposal of voting securities.

Oxurion received transparency notification on November 22 from Negma Group Ltd. indicating that as of November 17, it held 14,705,882 shares of the then outstanding 123,781,647 shares, and therefore crossed above the 10% threshold by virtue of acquisition of voting securities.

Oxurion received transparency notification on November 18 from Negma Group Ltd. indicating that as of November 7, it held 16,250,000 shares of the then outstanding 109,075,765 shares, and therefore crossed above the 10% threshold by virtue of acquisition of voting securities.

The full transparency notices are available in the Investors section of the Oxurion website.

About Oxurion

Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to improve and better preserve vision in patients with retinal disorders including diabetic macular edema (DME), the leading cause of vision loss in working-age people, as well as other conditions. Oxurion intends to play an important role in the treatment of retinal disorders, including the successful development of THR-149, its novel therapeutic for the treatment of DME. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the up to 50% of DME patients showing suboptimal response to anti-VEGF therapy. Oxurion is headquartered in Leuven, Belgium, with corporate operations in Boston, MA. More information is available at www.oxurion.com.

Important information about forward-looking statements

Certain statements in this press release may be considered "forward-looking". Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forwardlooking statements will materialize and does not assume any obligation to update or revise any

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PRESS RELEASE

Regulated Information

forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company's Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

For further information please contact:

Oxurion NV US
Tom Graney Conway Communications
Chief Executive Officer Beth Kurth
Tel: +32 16 75 13 10 [email protected]
[email protected]
Michael Dillen ICR Westwicke
Chief Business Officer Christopher Brinzey
Tel: +32 16 75 13 10 Tel: +1 617 835 9304
[email protected] [email protected]
  1. Article 14, first paragraph, of the Law of 2 May 2007 on disclosure of major holdings.