OPKO Health Inc. — Proxy Solicitation & Information Statement 2021

May 1, 2021

Notice regarding the availability of proxy materials for Annual Meeting of Stockholders to be held on June 24, 2021����� ���� ������ ������ ������ � false

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OPKO HEALTH, INC
Corporation no: 2279206	13156
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	Israel Securities Authority			Tel Aviv Stock Exchange		C002 ( Public )		Reported via MAGNA:	01/05/2021
	www.isa.gov.il			www.tase.co.il				Reference:	2021-02-074934	Time of broadcast: 17:21 17:21

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Immediate ReportRegulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

	The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report onNotice regarding the availability of proxy materials for Annual Meeting of Stockholders to be held on June 24, 2021 ����� ���� ������ ������ ������ ����� ��� ������ ���� 24 �����, 2021

20210501Proxy_isa.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):
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Stock Exchange/Market: NASDAQ GSM	Date of revision of form structure: 20/04/2021
Address: Ashlegan 16 , Kiryat Gat 8211804   Israel , Tel: 08-9300051 , Fax: 08-9543101
E-mail address: gfaibish@opko.com   Company site: Www.Opko.Com
Previous names of reporting entity:
Name of the Signatory: Faibish Gabriel Position of Signatory in the reporting corporation: General Counsel Name of Employer Company:
Address: Ashlegan 16 , Kiryat Gat 8211804 Telephone: 08-9300051 Facsimile: 08-9300091 E-mail: gfaibish@opko.com 1