OPKO Health Inc. — Proxy Solicitation & Information Statement 2026

May 1, 2026

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934

Filed by the Registrant ☐ Filed by a party other than the Registrant ☐

Check the appropriate box:

☐ Preliminary Proxy Statement
☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☐ Definitive Proxy Statement
☑ Definitive Additional Materials
☐ Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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☑ No fee required
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☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

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Your Vote Counts!

OPKO HEALTH, INC.

2026 Annual Meeting

Vote by June 17, 2026

11:59 PM ET

OPKO HEALTH, INC.

PO. BOX 8016

CARV, NC 27512-9863

V89253-P40246

You invested in OPKO HEALTH, INC. and it's time to vote!

You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the stockholder meeting to be held on June 18, 2026.

Get informed before you vote

View the Notice and Proxy Statement, Annual Report and Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to June 4, 2026. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com to request such materials. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy.

For complete information and to vote, visit www.ProxyVote.com

Control #

Smartphone users

Point your camera here and vote without entering a control number

Vote Virtually at the Meeting*

June 18, 2026

10:00 a.m., Eastern Time

Virtually at:

www.virtualshareholdermeeting.com/OPK2026

*Please check the meeting materials for any special requirements for meeting attendance.

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Vote at www.ProxyVote.com

THIS IS NOT A VOTABLE BALLOT

This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters.

Voting Items	Board Recommends
1. To elect as directors the eleven nominees named in the attached proxy statement for a term of office expiring at the 2027 annual meeting of stockholders or until their respective successors are duly elected and qualified;
Nominees:
1a. Phillip Frost, M.D.	☑ For
1b. Jane H. Hsiao, Ph.D., MBA	☑ For
1c. Elias A. Zerhouni, M.D.	☑ For
1d. Steven D. Rubin	☑ For
1e. Gary J. Nabel, M.D., Ph.D.	☑ For
1f. Prem A. Lachman, M.D.	☑ For
1g. Roger J. Medel, M.D.	☑ For
1h. John A. Paganelli	☑ For
1i. Richard C. Pfenniger, Jr.	☑ For
1j. Subbarao V. Uppaluri, Ph.D.	☑ For
1k. Alice Lin-Tsing Yu, M.D., Ph.D.	☑ For
2. To approve the Company's 2026 Equity Incentive Plan;	☑ For
3. To approve a non-binding resolution regarding the compensation paid to the Company's named executive officers;	☑ For
4. The ratification of the appointment of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2026; and	☑ For
5. The transaction of such other business as may properly come before the Annual Meeting or any adjournments thereof.

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V89254-P40246