OPKO Health Inc. — Director's Dealing 2016

Mar 31, 2016

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C002����� ���', ����2PublicOPKO HEALTH, INC10802Corporation no: 2279206Stock Exchange/Market: NYSE2893380Golda Meir 7 , Nes Ziona 7414002 , Israel , IsraelTel: 08-9300051 , Fax: 08-9300091E.mail address: yphilip@opko.comReported via MAGNA: 31/03/2016              Time of broadcast: 14:54 14:53:27

Company site:		Www.Opko.Com

Reference: 2016-02-021585

Israel Securities Authority		Tel Aviv Stock Exchange
www.isa.gov.il		www.tase.co.il

Immediate ReportRegulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

The corporation is a foreign private issuer as defined by U.S. Securities Laws.
Attached hereto is a report on interested party transaction - Philip Frost
20160331Form4aSigned.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):
Previous names of reporting entity:
Date of revision of form structure: 03/03/2016
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Name of the Signatory: : Philip Yifat , Position of Signatory in the reporting corporation: General Counsel , Name of Employer Company: .
Golda Meir 7 Nes Ziona 7414002 Telephone: 08-9300051 , Facsimile: 08-9300091 , E-mail: yphilip@opko.com 1