OPKO Health Inc. — Director's Dealing 2015

Aug 21, 2015

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person Rubin Steven D

(Last) (First) (Middle) OPKO Health, Inc. 4400 Biscayne Blvd.

1. Date of Earliest Transaction (Month/Day/Year) 08/20/2015

2. If Amendment, Date Original Filed (Month/Day/Year)

3. Relationship of Reporting Person(s) to Issuer (Check all applicable) ___ X __ Director __ 10% Owner ___ X __ Officer (give title below) __ Other (specify below) Executive VP-Administration

4. Individual or Joint/Group Filing (Check Applicable Line) ___ X __ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1. Title of Security (Instr. 3)
2. Transaction Date (Month/Day/Year)
3. Transaction Code (Instr. 8)
4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)
7. Nature of Indirect Beneficial Ownership (Instr. 4)

Common Stock 08/20/2015 P 200 A $12.395 5,439,607 D

Common Stock 08/20/2015 P 1,800 A $12.4 5,441,407 D

Common Stock 20,091,062 I See Footnote(1)

Explanation of Responses: (1) These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.

Adam Logal, Attorney-In-Fact 08/20/2015

• If the form is filed by more than one reporting person, see Instruction 4(b)(v).

**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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