OPKO Health Inc. — Director's Dealing 2015

Oct 10, 2015

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

| 1. Name and Address of Reporting Person Yu, M.D., PhD. Alice Lin-Tsing | | | 2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [OPK] | 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) ☑ Director 10% Owner ☐ Officer (give title below) ☐ Other (specify below) | | --- | --- | --- | --- | --- | | (Last) (First) (Middle) OPKO Health, Inc. 4400 Biscayne Blvd. | | | 3. Date of Earliest Transaction (Month/Day/Year) 10/08/2015 | | | (Street) Miami FL 33137 | | | 4. If Amendment, Date Original Filed (Month/Day/Year) | | | (City) (State) (Zip) | | | | 6. Individual or Joint/Group Filing (Check Applicable Line) ☑ Form filed by One Reporting Person ☐ Form filed by More than One Reporting Person |

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

| 1. Title of Security (Instr. 3) | 2. Transaction Date (Month/Day/Year) | 2A. Deemed Execution Date, if any (Month/Day/Year) | 3. Transaction Code (Instr. 8) | | 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) | | | 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) | 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) | 7. Nature of Indirect Beneficial Ownership (Instr. 4) | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | Code | V | Amount | (A) or (D) | Price | | | | | Common Stock | 10/08/2015 | | M | | 20,000 | A | $3.43 | 80,000 | D | |

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Form 4 (continued)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$3.43	10/08/2015		M			20,000	06/09/2012	06/08/2018	Common Stock	20,000	$0	0	D

Explanation of Responses:

Adam Logal, Attorney-In-Fact Signature of Reporting Person

10/09/2015 Date

• If the form is filed by more than one reporting person, see Instruction 4(b)(v). ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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