OPKO Health Inc. — Director's Dealing 2013

Nov 17, 2013

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* 2. Issuer Name and Ticker or Trading Symbol 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) OPKO Health, Inc. Sorrento Therapeutics, Inc. (SRNE) Director 10% Owner (Last) (First) (Middle) 3. Date of Earliest Transaction (MM/DD/YYYY) Officer Other (give title below) (specify below) 4400 Biscayne Blvd. 11/13/2013 (Street) 4. If Amendment, Date Original Filed (MM/DD/YYYY) 6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person Miami FL 33137 Form filed by More than One Reporting Person (City) (State) (Zip) Table I — Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1. Title of Security 2. Transaction 2A. Deemed 3. Transaction 4. Securities Acquired (A) or Disposed of (D) 5. Amount of 6. Ownership 7. Nature of Indirect (Instr 3.) Date Execution Code (Instr. 3, 4 and 5) Securities Form: Beneficial (MM/DD/YYYY) Date, if any (Instr. 8) Beneficially Direct (D) Ownership (MM/DD/YYYY) Owned or (Instr. 4) Following Indirect (I) Reported (Instr. 4) Transactions (Instr. 3 and Code V Amount (A) or (D) Price 4) Common Stock 11/13/2013 S 13457 D $8.75 2208271 D

FORM 4 (continued)

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----- Start of picture text ----- Table II — Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)1. 2. 3. 3A. 4. 5. 6. 7. 8. 9. 10. 11.Title of Derivative Security Conversion Transaction Deemed Transaction Number of Date Exercisable and Title and Price of Number of Ownership Nature of(Instr.3) or Date Execution Date Code Derivative Expiration Date Amount of Derivative Derivative Form of IndirectExercise (MM/DD/YYYY) (MM/DD/YYYY) (Instr. 8) Securities (MM/DD/YYYY) Underlying Security Securities Derivative BeneficialPrice of Acquired Securities (Instr. 5) Beneficially Securities: OwnershipDerivative (A) or (Instr. 3 and Owned Direct (D) (Instr. 4)Security Disposed 4) Following orof (D) Reported Indirect (I)(Instr. 3, 4 Transaction(s) (Instr. 4)and 5) (Instr. 4)Amountor(A) Numberor Exercisable Expiration ofCode V Amount (D) Date Date Title Shares----- End of picture text -----

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• Adam Logal, Vice President-Finance, Chief Accounting Officer, and 11/14/2013 Treasurer

______ ___________________________________ Date

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