OMEROS CORP — Director's Dealing 2025

Oct 16, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: OMEROS CORP (OMER)
CIK: 0001285819
Period of Report: 2025-10-13

Reporting Person: Demopulos Gregory A MD (Director, Chairman, CEO & President)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-10-13	Common Stock	G	600000	—	Disposed	1426986	Direct
2025-10-13	Common Stock	G	300000	—	Acquired	300000	Indirect
2025-10-13	Common Stock	G	300000	—	Acquired	300000	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	123945	Indirect

Footnotes

F1: The reporting person made bona fide gifts of Omeros Corporation common stock, each of 300,000 shares, to separate irrevocable trusts established for the benefit of each of the reporting person's two minor children.

F2: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

F3: Shares held in the [Demopulos Child #1] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.

F4: Shares held in the [Demopulos Child #2] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.