OMEROS CORP — Director's Dealing 2026

Feb 21, 2026

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: OMEROS CORP (OMER)
CIK: 0001285819
Period of Report: 2026-02-18

Reporting Person: Demopulos Gregory A MD (Director, Chairman, CEO & President)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2026-02-18	Common stock	M	400000	$10.27	Acquired	1826986	Direct
2026-02-18	Common stock	F	357678	$11.93	Disposed	1469308	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2026-02-18	Stock option (right to buy)	$10.27	M	400000	Disposed	2026-02-19	Common stock (400000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common stock	300000	Indirect
Common stock	300000	Indirect
Common stock	123945	Indirect

Footnotes

F1: Represents shares withheld by Omeros Corporation ("Omeros") in connection with net share settlement to satisfy the exercise price and tax liability associated with the reporting person's exercise of stock options. The number of shares withheld was determined based on the closing price of Omeros' common stock on February 17, 2026. The transaction did not involve any open-market sale of securities, and all 357,678 withheld shares remained in the Omeros treasury.

F2: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

F3: Shares held in the [Demopulos Child #1] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.

F4: Shares held in the [Demopulos Child #2] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.

F5: This option vested and became exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2015.