OMEROS CORP — Director's Dealing 2011

May 16, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: OMEROS CORP (OMER)
CIK: 0001285819
Period of Report: 2011-05-13

Reporting Person: Demopulos Peter A MD (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-13	Common Stock	P	19000	$4.9957	Acquired	118421	Direct
2011-05-16	Common Stock	P	21000	$4.9506	Acquired	139421	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	164382	Indirect

Footnotes

F1: The price reported in Column 4 is a weighted-average price. These shares were purchased in multiple transactions at prices ranging from $4.85 to $5.11, inclusive. The reporting person undertakes to provide Omeros Corporation, any of its common stock holders, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1) and (2) to this Form 4.

F2: The price reported in Column 4 is a weighted-average price. These shares were purchased in multiple transactions at prices ranging from $4.90 to $4.98, inclusive.

F3: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.