MESOBLAST LTD — Major Shareholding Notification 2023

Aug 10, 2023

Form 605 Corporations Act 2001 Section 671B

Notice of ceasing to be a substantial holder

To Company Name/Scheme Mesoblast Limited ACN/ARSN 109 431 870 1. Details of substantial holder(1) Name M&G Plc and its subsidiary companies (please see annexure A)

ACN/ARSN (if applicable) The holder ceased to be a substantial holder on 09/08/2023 The previous notice was given to the company on 09/08/2023 The previous notice was dated 09/08/2023

2. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest (2) of the substantial holder or an associate (3) in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

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----- Start of picture text ----- Date of Person whose Nature of Consideration Class and number of Person'sChange relevant Change given in relation securities affected votes affectedinterest (6) to changechanged9-Aug-23 M&G Investment Sale AU $ 367,005 Ordinary 1,079,425 1,079,425ManagementLimited9-Aug-23 M&G Investment Sale AU $ 2,082,636 Ordinary 6,125,399 6,125,399ManagementLimited9-Aug-23 M&G Investment Sale AU $ 136,181 Ordinary 400,533 400,533ManagementLimited9-Aug-23 M&G Investment Sale AU $ 36,122 Ordinary 97,882 97,882ManagementLimited9-Aug-23 M&G Investment Sale AU $ 13,403 Ordinary 36,320 36,320ManagementLimited9-Aug-23 M&G Investment Sale AU $ 33,667 Ordinary 99,022 99,022ManagementLimited9-Aug-23 M&G Investment Sale AU $ 3,314 Ordinary 8,979 8,979ManagementLimited9-Aug-23 M&G Investment Sale AU $ 475,311 Ordinary 1,287,970 1,287,970ManagementLimited9-Aug-23 M&G Investment Sale AU $ 35,476 Ordinary 104,340 104,340ManagementLimited9-Aug-23 M&G Investment Sale AU $ 3,492 Ordinary 9,462 9,462ManagementLimited----- End of picture text -----

9-Aug-23	M&G InvestmentManagementLimited	Sale	AU $ 204,983	Ordinary 555,450	555,450
9-Aug-23	M&G InvestmentManagementLimited	Sale	AU $ 4,149,208	Ordinary 12,203,554	12,203,554

3. Changes in association

The persons who have become associates (3) of, ceased to be associates of, or have changed the nature of their association (7) with, the substantial holder in relation to voting

interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable) Nature of association

4. Addresses

The addresses of persons named in this form are as follows:

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----- Start of picture text ----- Name AddressM&G Investment Management Limited 10 Fenchurch Avenue, London,EC3M 5AG, EnglandM&G Investment Funds (3) 10 Fenchurch Avenue, London,EC3M 5AG, EnglandM&G Investment Funds (1) 10 Fenchurch Avenue, London,EC3M 5AG, EnglandM&G (Lux) Investment Funds 1 16 Boulevard Royal, 2449 LuxembourgHSBC Custody Nominees (Australia) HSBC Centre, Level 32, 580 George Street, Sydney, NSW 2000,AustraliaHongkong and Shanghai Banking Corporation Ltd Tower 1, International Tower Level 36, 100 Barangaroo AvenueSydney, NSW 2000 Australia----- End of picture text -----

Signature

print namesign here	Owen SmithcapacityRegulatory Reporting Manager
	date10/08/2023

This is annexure A of 1 page referred to in form 605 ‘Notice of ceasing to be a substantial holder’

Details of substantial holder

M&G plc is a British multinational life insurance and financial services company, incorporated and registered in England and Wales and headquartered in London. Please find below subsidiaries of the M&G Plc group of companies.

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----- Start of picture text ----- Wholly owned subsidiary of M&G Plc (the parent company)M&G Group Regulated Entity Holding Company LimitedM&G Group Limited Wholly owned subsidiary of M&G Group Regulated Entity Holding CompanyLimitedM&G FA Limited Wholly owned subsidiary of M&G Group LimitedM&G Investment Management Limited Wholly owned subsidiary of M&G FA LimitedM&G Securities Limited Wholly owned subsidiary of M&G FA LimitedM&G Luxembourg S.A. Wholly owned subsidiary of M&G FA LimitedM&G Alternatives Investment Management Limited Wholly owned subsidiary of M&G FA LimitedThe Prudential Assurance Company Limited Wholly owned subsidiary of M&G Group Regulated Entity Holding CompanyLimitedPrudential Pensions Limited Wholly owned subsidiary of The Prudential Assurance Company Limited----- End of picture text -----

The following are all open-ended investment companies with variable capital, incorporated in England & Wales and regulated by the Financial Conduct Authority. These are not M&G plc group companies but the Authorised Corporate Director (M&G Securities

Limited) and appointed fund manager (M&G Investment Management Limited) for each OEIC are wholly owned subsidiaries of M&G plc.

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----- Start of picture text ----- M&G Investment Funds (1) External Open Ended Investment CompanyM&G Investment Funds (2) External Open Ended Investment CompanyM&G Investment Funds (3) External Open Ended Investment CompanyM&G Investment Funds (4) External Open Ended Investment CompanyM&G Investment Funds (5) External Open Ended Investment CompanyM&G Investment Funds (7) External Open Ended Investment CompanyM&G Investment Funds (9) External Open Ended Investment CompanyM&G Investment Funds (11) External Open Ended Investment CompanyM&G Investment Funds (12) External Open Ended Investment CompanyM&G Investment Funds (14) External Open Ended Investment CompanyM&G Global Dividend Fund External Open Ended Investment Company----- End of picture text -----

The following are all société d'investissement à capital variable, incorporated in Luxembourg and regulated by the Commission de

Surveillance du Secteur Financier (CSSF). These are not M&G plc group companies but the Management Company (M&G Luxembourg S.A)

and appointed fund manager (M&G Investment Management Limited) for each SICAV are wholly owned subsidiaries of M&G plc.

M&G (Lux) Investment Funds 1 External Société d' Investissement à Capital Variable