MESOBLAST LTD — Director's Dealing 2026

Apr 15, 2026

Gregory George Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	MESOBLAST LIMITED
ABN	68 109 431 870

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Gregory George
Date of last notice	20 March 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Direct and indirect
Nature of indirect interest (including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	JP Morgan Nominees Australia Pty Limited (Interest in ordinary shares held in the form of American Depositary Shares (“ADS”) held by custodian JP Morgan Nominees Australia Pty Limited.) Each ADS represents a beneficial interest in 10 ordinary shares.
Certain shares and ADSs held by G to the Fourth Investments, LLC (“G4”) which is controlled by Gregory George.
Certain ADSs held by James George and Grant George, who have given power of attorney to Gregory George in respect of those ADSs.
Date of change	9 and 10 April 2026
No. of securities held prior to change	Direct
5 ordinary shares
12,829,328 ADSs.
200,000 warrants convertible into ADS.
1,600,000 warrants to acquire ordinary shares (or the applicable number of ADS at the holder’s election).
200,000 options to acquire ordinary shares
Indirect
5,644,192 ordinary shares.
14,415,410 ADS.
6,830,602 warrants to acquire ordinary shares

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Appendix 3Y

Change of Director's Interest Notice

Class	See above
Number acquired	70,000 ADS, each representing 10 ordinary shares; and 7,210,962 ordinary shares
Number disposed	Nil
Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation	US$11,429,969.84 for the ADS and ordinary shares purchased
No. of securities held after change	Direct
5 ordinary shares
12,829,328 ADSs.
200,000 warrants convertible into ADS.
1,600,000 warrants to acquire ordinary shares (or the applicable number of ADS at the holder’s election).
200,000 options to acquire ordinary shares
Indirect
12,855,154 ordinary shares.
14,485,410 ADS.
6,830,602 warrants to acquire ordinary shares
Nature of change
Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	On market purchases by James George of 70,000 ADS and 4,886,890 ordinary shares, and by Grant George of 2,324,072 ordinary shares.

Part 2 – Change of director's interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

Detail of contract	N/A
Nature of interest
Name of registered holder (if issued securities)
Date of change
No. and class of securities to which interest related prior to change
Note: Details are only required for a contract in relation to which the interest has changed
Interest acquired
Interest disposed

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 2

3437-3947-1947, v. 1

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Appendix 3Y
Change of Director's Interest Notice

Value/Consideration
Note: If consideration is non-cash, provide details and an estimated valuation

Interest after change

Part 3 – +Closed period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	No
If so, was prior written clearance provided to allow the trade to proceed during this period?
If prior written clearance was provided, on what date was this provided?

• See chapter 19 for defined terms.
  01/01/2011 Appendix 3Y Page 3
  3437-3947-1947, v. 1