MESOBLAST LTD — Major Shareholding Notification 2021

Jul 28, 2021

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29 July 2021

Manager Market Announcements Office ASX Limited Exchange Centre 20 Bridge Street Sydney NSW 2000

Dear Sir or Madam

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Release of shares from voluntary escrow

Mesoblast Limited (ASX Code: MSB) gives notice in accordance with ASX Listing Rule 3.10A that 212,244 ordinary shares, which are subject to voluntary escrow arrangements, will be released from escrow on 6 August 2021.

Yours sincerely

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Niva Sivakumar Company Secretary