MESOBLAST LTD — Director's Dealing 2025

Feb 23, 2025

Appendix 3X Initial Director’s Interest Notice

Rule 3.19A.1

Appendix 3X

Initial Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public. Introduced 30/9/2001.

Name of entity MESOBLAST LIMITED ABN 68 109 431 870

We (the entity) give ASX the following information under listing rule 3.19A.1 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Gregory George
Date of appointment	24 February 2025

Part 1 - Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

19,350,005 ordinary shares

200,000 warrants convertible into American Depositary Shares (“ADS”). Each ADS represents 10 ordinary shares.

• See chapter 19 for defined terms.

11/3/2002

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Appendix 3X Initial Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of Number & class of Securities interest

Note: Provide details of the circumstances giving rise to the relevant interest.

G to the Fourth Investments, LLC (Gregory George, is a member of HNP, LLC and is deemed to be the beneficial owner of these securities)

JP Morgan Nominees Australia Pty Limited (Interest in ordinary shares held in the form of American Depositary Shares held by custodian JP Morgan Nominees Australia Pty Limited. Interest in the ADSs held by Gregory George, G to the Fourth Investments, LLC, and Dr George’s sons’ James George and Grant George)

3 ordinary shares 6,830,602 warrants

22,414,606 ADS. Each ADS represents 10 ordinary shares.

Part 3 – Director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract Nature of interest Name of registered holder (if issued securities)

• See chapter 19 for defined terms.

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11/3/2002

Appendix 3X Initial Director’s Interest Notice

No. and class of securities to which interest relates

• See chapter 19 for defined terms.

11/3/2002

Appendix 3X Page 3