MESOBLAST LTD — Director's Dealing 2025

Sep 11, 2025

Gregory George Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity MESOBLAST LIMITED ABN 68 109 431 870

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Gregory George
Date of last notice	24 April 2025

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest		Direct and indirect
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.		JP Morgan Nominees Australia Pty Limited(Interest in ordinary shares held in the formof American Depositary Shares (“ADS”)held by custodian JP Morgan NomineesAustralia Pty Limited. Interest in the ADSsheld by G to the Fourth Investments, LLC)
Date of change		5 to 11 September 2025
No. of securities held prior to change		Direct19,350,005 ordinary shares200,000 warrants convertible into ADS. EachADS represents 10 ordinary shares.Indirect4,551,275 ordinary shares6,830,602 warrants to acquire ordinary shares23,022,084 ADS. Each ADS represents 10ordinary shares.
Class		See above
Number acquired		9,640,072 shares and 325,901 ADS, eachADS representing 10 ordinary shares

Appendix 3Y Change of Director’s Interest Notice

		Number disposed	Number disposed	Number disposed	Number disposed	Number disposed		Nil	Nil	Nil	Nil	Nil	Nil
		Value/ConsiderationNote: If consideration is non-cash, provide details and estimated valuation						US$18,848,476.86 for the shares and ADSpurchased
		No. of securities held after change						Direct19,350,005 ordinary shares200,000 warrants convertible into ADS. EachADS represents 10 ordinary shares.Indirect14,191,347 ordinary shares6830602 warrants to acuire ordinar shares
								,, q y23,347,985 ADS. Each ADS represents 10ordinary shares.
								23347985 ADS Eh ADS t
								,ordi	, .nary shares.	ac	represens
			Nature of chExample: on-marketsecurities under divid	angetrade, off-market traend reinvestment pla	de, exercise of optionn, participation in buy	s, issue of-back		OnInve325,	market purcstments, LLC901 ADS.	hase by G tof 9,640,07	o the Fou2 shares a	rthnd
PNd			art 2 – Chanote: In the case of a cisclosed in this part.	ge of directompany, interests wh	or’s interestich come within para	s in contractgraph (ii) of the defini			stion of “notifiable int	erest of a director” sh	ould be

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	N/A
Nature of interest
Name of registered holder(if issued securities)
Date of change
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract in relationto which the interest has changed
Interest acquired
Interest disposed
Value/ConsiderationNote: If consideration is non-cash, provide details and anestimated valuation
Interest after change

• See chapter 19 for defined terms.

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Appendix 3Y Change of Director’s Interest Notice

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailedabove traded during a+closed period where prior writtenclearance was required?	No
If so, was prior written clearance provided to allow thetrade to proceed during this period?
If prior written clearance was provided, on what date wasthis provided?

• See chapter 19 for defined terms.

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