MESOBLAST LTD — Director's Dealing 2023

Dec 11, 2023

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity Mesoblast Limited

ABN 68 109 431 870

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Silviu Itescu
Date of last notice	7 July 2023

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect interest
Nature of indirect interest	Josaka Investments Pty Ltd (the trustee of Dr
(including registered holder)Note: Provide details of the circumstances giving rise to the relevant	Itescu’s self-managed superannuation fund)
interest.
	Tamit Nominees Pty Ltd (Dr Itescu is the sole
	directorand shareholder)
Date of change	12 December 2023
No. of securities held prior to change	68,958,928 ordinary shares, held as
	follows:
	• Direct: 67,756,838 ordinary shares; and
	• Indirect: 1,202,090 ordinary shares
	6,960,334 options
Class	Ordinary shares
Number acquired	Josaka Investments Pty Ltd: 8,333,333
	ordinary shares
	Tamit Nominees Pty Ltd: 1,666,667 ordinary
	shares
Number disposed	Not applicable
Value/Consideration	A$3,000,000 (A$0.30 per share)
Note: If consideration is non-cash, provide details and estimated valuation

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	78,958,928 ordinary shares, held asfollows:• Direct: 67,756,838 ordinary shares; and• Indirect: 11,202,090 ordinary shares6,960,334 options
Nature of changeExample: on-market trade, off-market trade, exercise of options, issue ofsecurities under dividend reinvestment plan, participation in buy-back	Participation in entitlement offer announcedon 4 December 2023.

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	Not applicable
Nature of interest	Not applicable
Name of registered holder(if issued securities)	Not applicable
Date of change	Not applicable
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract in relationto which the interest has changed	Not applicable
Interest acquired	Not applicable
Interest disposed	Not applicable
Value/ConsiderationNote: If consideration is non-cash, provide details and anestimated valuation	Not applicable
Interest after change	Not applicable

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed above No traded during a[+] closed period where prior written clearance was required? If so, was prior written clearance provided to allow the trade to Not applicable proceed during this period? If prior written clearance was provided, on what date was this Not applicable provided?

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011