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Immuron Ltd Investor Presentation 2015

Aug 18, 2015

35121_rns_2015-08-18_91c873a1-cb83-4ec4-a8b8-094905dc2023.pdf

Investor Presentation

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Immuron Commences US Investor Roadshow

19 August 2015, Melbourne, Australia: Immuron Limited (ASX:IMC) today wishes to announce that the Company has commenced a US Investor Roadshow where the Company will showcase its technology platform and profile to US investment groups.

This US Roadshow comes off the back of recent market announcements detailing the Company’s advances in all product areas of the business, Travelan, NASH, ASH, C-Diff, and now Protectyn.

Travelan:

Immuron announced the execution of a 50,000 minimum annual order supply agreement for the Company’s flagship product, Travelan with the major US Travel Clinic supplier, Traveler’s Supply Inc.

NASH and ASH Clinical Trials:

The Company’s Clinical Trials are progressing well and have been further bolstered by the Company’s recent appointments of SVP of Innovation Dr Dan Peres, and Chief Operating and Scientific Officer Dr Jerry Kanellos.

A recent Deutsche Bank review of the NASH market suggests that there is a worldwide market for NASH of between $35 - $40 billion. The high prevalence of Type 2 diabetes and obesity, which lead to NASH and other non-alcoholic fatty liver diseases (NAFLD), boosts the prevalence of NASH and its market growth.

A copy of the US Investor Roadshow Presentation has been attached below.

Contacts:

Dr Roger Aston Amanda Loh Non-Executive Chairman Buchan Consulting +61 (0)3 9824 5254 +61 (0)3 9866 4722

ABOUT IMMURON

Immuron Ltd (ASX:IMC) is a Microbiom company focused on developing and commercialising oral immunotherapeutics for the treatment of a many gut mediated diseases. Immuron has a unique and safe technology platform that enables a shorter development therapeutic cycle. The company currently markets Travelan® for the prevention of travellers’ diarrhoea, its lead product candidate IMM-124E is in Phase 2 clinical trials for NASH and ASH, and it has a preclinical immunotherapy pipeline targeting immune-related diseases with unmet needs.

Immuron’s main scientific alliances are with Hadassah Medical Center (Israel), Monash University (Australia) and the Commonwealth Scientific and Industrial Research Organisation (CSIRO) (Australia).

Suite 1, 1233 High Street Armadale, Victoria AUSTRALIA 3143

www.immuron.com

Phone: + 61 (0)3 9824 5254 Facsimile: + 61 (0)3 9822 7735

ABN: 80 063 114 045

AUGUST 2015

HEALTH TO CHEW ON

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prevention of disease.
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NASH/ASH

SUMMARY

TRAVELAN

PIPELINE

2

TRAVELAN®

PIPELINE

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NASH/ASH
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SUMMARY
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Immuron presents the large upside Investor Potential of a biotech company.

It has a unique natural immune-technology platform with GRAS status that significantly reduces the research to product cycle timelines.

Immuron has a revenue-generating product with multiple revenue pathways

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TRAVELAN®

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NASH/ASH
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PIPELINE
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SUMMARY
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NASH: Two Phase II studies in progress with ASH: an increasingly alluring potential upside Travelan: Revenues growing and positioned to grow further with successful USA launch

Pipeline: Progressing and Strong Cap Pofile: Robust

Financials: Debt free, cash in the bank until after completion of NASH trial

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TRAVELAN®

NASH/ASH

PIPELINE

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SUMMARY
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AUD$19.5M

Listed Unlisted ASX Code: IMC Shares Options Options Securities currently on ~75M ~3M ~ 6M

Rank Shareholder Name
Qty Held % Ownership
Rank Shareholder Name
Qty Held % Ownership
1
2 AUTHENTICS AUSTRALIA PTY LTD
4,999,999
6.67%
3
4 MR PETER ANASTASIOU &
2,907,236
3.88%
5
6 FIFTY-FIFTH LEPRECHAUN PTY LTD
2,035,371
2.72%
7
8 INSYNC INVESTMENTS PTY LTD
1,534,432
2.05%
9
10 MR DAVID ANTHONY PLUSH &
1,334,075
1.78%
11
12 G & N LORD SUPERANNUATION PTY
1,237,994
1.65%
13
14 JOJO ENTERPRISES PTY LTD
918,898
1.23%
15
16 CAPITAL CONCERNS PTY LIMITED
654,716
0.87%
17
18 MR HAMISH SALMON &
575,000
0.77%
19
20 ADVANCE CLINICAL SYSTEMS
546,874
0.73%

5

NASH/ASH

TRAVELAN

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PIPELINE
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SUMMARY
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Targeting the human immune system with natural antibodies derived from bovine to address diseases of the gut and liver.

Why?

Acute and chronic infections in the gut have a major impact in human health, causing dis biosis and many metabolic diseases.

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TRAVELAN
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NASH
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PIPELINE
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SUMMARY
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  • Attractive risk-reward ratio – biotech upside with reduced risk profile

Immuron’s Platform Products

  • Natural product

  • High safety profile

  • Not a binary outcome.

  • If clinical end points not attained, there may still be a product that generates revenue

  • Low Cost

Other Products

� Synthetic product � Side effects occur

� Binary outcome: clinical trial failure means there is no product

� Antibodies typically very expensive to make

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TRAVELAN
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NASH PIPELINE
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SUMMARY
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Pathway with reduced risk

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Traditional model Immuron’s De-risked Platform
Pre-clinical
Phase I clinical
OR
OTC Consumers
Phase II clinical
OR
OTC Consumers
Phase III clinical
OR
Medical Food
Prescribed drug
on the market
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8
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2.

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TRAVELAN
Stop it before it starts
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SUMMARY

OVERVIEW

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NASH
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PIPELINE

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Without Travelan [®] : Bacteria With Travelan [®] : Bacteria
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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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http://www.travelan.com.au

`

Traveller’s diarrhoea global market estimate: US$600M - 1.2B

All-natural product; clinically proven with very high safety profile Available over-the-counter Strong brand loyalty

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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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Growing Australian brand

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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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Successfully Launched in the USA

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  • ** Note: first non-exclusive distribution contract signed for 50,000 units in July 2015 with major Traveller’s Supply company at full margin.

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OVERVIEW
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NASH PIPELINE
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SUMMARY
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Status in Nov 2013

Progress in 2015

Country Discussions Term Sheet Licensed Regulatory In Market Canada South Korea Other Asian Countries US (partnered) No regulatory process United States (direct) India China

  • Regulatory application preceding partnering engagement

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3.

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NASH/ASH
(INFLAMED
FATTY LIVER)
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OVERVIEW
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TRAVELAN
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Lipotoxicity

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PIPELINE
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SUMMARY
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Cirrhosis: Severe liver damage Liver Fibrosis: Scarring of liver tissue NASH: Inflamed Fatty Liver Liver: Fat accumulation We eat badly and are too sedentary

PIPELINE

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OVERVIEW
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TRAVELAN

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SUMMARY
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Population = 100%

Cirrhosis; 1 in 10

NASH > 5%

NAFL~ 25%

OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY

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= Estimated $40B Market in 2025
NASH - The Next Big Global Epidemic in 10 Years?
Deutsche Bank, Markets Research, 14 July 2014
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OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY

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IMM-124E chosen by NIH from
27 candidates for a phase II
study in ASH. Currently
recruiting.
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OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY

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OVERVIEW

TRAVELAN

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PIPELINE
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SUMMARY
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IMM-124E is safe and may be best in class
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Prevents bacterial spread

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OVERVIEW
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TRAVELAN
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PIPELINE
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SUMMARY
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2 Phase II trials started and recruiting

NASH- IMMURON FUNDED

ASH- NIH FUNDED

Phase II trial has begun:

Phase II trial has begun:

NIH funded,

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Princess Alexandra Hospital, Brisbane, QLD

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Westmead Hospital, Sydney, NSW Nepean Hospital, Sydney, NSW Box Hill Hospital Melbourne, VIC

Alfred Hospital

Swedish MC Seattle, WA

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U.Colorado, Denver, CO

Cleveland Clinic, OH

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Kansas City GE&H, MO

UVA, Charlottesville VA VCU, Richmond VA Bon Secours, Richmond/NN, VA

Duke Liver Center, Durham NC

U Florida, Gainesville, FL

Baylor St Luke’s Houston, TX

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OVERVIEW

TRAVELAN

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PIPELINE
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SUMMARY

Bile Acid

Shire - LUM-002

Intercept - Obeticholic acid, modified bile acid

Galmed - Aramchol, Conjugate of Fatty acid and Fatty bile acid

Anti-fibrotic

Gilead - Simtuzumab, anti-fibrotic

Galectin - galectin proteins

Anti-Inflammatory + (anti-inflammatory, anti-diabetic, cholesterol control, FFA)

Immuron - Hyperimmune colostrum enriched with Anti-LPS Abs

Conatus - Emricassan, caspase protease inhibitor

Genfit - Peroxisome proliferator - activated receptor alpha

� IMM-124E is safe and may be best in class

4.

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ROBUST
PIPELINE
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TRAVELAN
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NASH
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PIPELINE
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SUMMARY
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Indication Research Pre-clinical Phase I Phase II Phase III

Traveller’s Diarrhea NASH (IMM-124E) ASH (IMM-124E)

Clostridium difficile infection Other Projects:

  • Trial funded by NIH

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  • diabetes • Colitis/Crohn’s Disease

  • Fibrosis

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OVERVIEW
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TRAVELAN
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NASH/ASH
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SUMMARY
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US Hospitalisations Skyrocket Annually due to C.diff

  • superbug

  • more than US$3.2 billion in health care

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85,700
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Source: Agency for Healthcare Research and Quality 28

Comparative Values- Nasdaq Peers

  • Immuron is significantly undervalued relative to peers listed on NASDAQ who are currently undertaking a Phase II study in NASH

Average Value for these Companies is over $100 Million

  • Immuron is significantly undervalued relative to its peers listed on NASDAQ that currently have a C-Diff program in place.

Average Value of these companies is over $200 Million, although several are in Phase II or Phase III clinical trials.

At $20 Million Immuron represents a strong Value case with Two phase II studies, a C- Diff program, Travelan sales and a strong pipeline and safe platform.

5.

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SUMMARY
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TRAVELAN®

PIPELINE

OVERVIEW

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NASH
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SUMMARY
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The Board and Management

Chairman

Non-Executive Director

Non-Executive Director

Director

Senior VP of Innovation

Clinical Director

Dr. Yaron Ilan Medical Officer

Dr. Yaron Ilan, MD, is a Director-Inpatient Medicine Department at Hadassah Medical Center. He holds more than 50 patents and co-authored more than 240 articles.

Chief Scientific Officer

Development Manager

Manufacturing Quality Director

THANK YOU

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