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Immuron Ltd — Investor Presentation 2015
Aug 18, 2015
35121_rns_2015-08-18_91c873a1-cb83-4ec4-a8b8-094905dc2023.pdf
Investor Presentation
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Immuron Commences US Investor Roadshow
19 August 2015, Melbourne, Australia: Immuron Limited (ASX:IMC) today wishes to announce that the Company has commenced a US Investor Roadshow where the Company will showcase its technology platform and profile to US investment groups.
This US Roadshow comes off the back of recent market announcements detailing the Company’s advances in all product areas of the business, Travelan, NASH, ASH, C-Diff, and now Protectyn.
Travelan:
Immuron announced the execution of a 50,000 minimum annual order supply agreement for the Company’s flagship product, Travelan with the major US Travel Clinic supplier, Traveler’s Supply Inc.
NASH and ASH Clinical Trials:
The Company’s Clinical Trials are progressing well and have been further bolstered by the Company’s recent appointments of SVP of Innovation Dr Dan Peres, and Chief Operating and Scientific Officer Dr Jerry Kanellos.
A recent Deutsche Bank review of the NASH market suggests that there is a worldwide market for NASH of between $35 - $40 billion. The high prevalence of Type 2 diabetes and obesity, which lead to NASH and other non-alcoholic fatty liver diseases (NAFLD), boosts the prevalence of NASH and its market growth.
A copy of the US Investor Roadshow Presentation has been attached below.
Contacts:
Dr Roger Aston Amanda Loh Non-Executive Chairman Buchan Consulting +61 (0)3 9824 5254 +61 (0)3 9866 4722
ABOUT IMMURON
Immuron Ltd (ASX:IMC) is a Microbiom company focused on developing and commercialising oral immunotherapeutics for the treatment of a many gut mediated diseases. Immuron has a unique and safe technology platform that enables a shorter development therapeutic cycle. The company currently markets Travelan® for the prevention of travellers’ diarrhoea, its lead product candidate IMM-124E is in Phase 2 clinical trials for NASH and ASH, and it has a preclinical immunotherapy pipeline targeting immune-related diseases with unmet needs.
Immuron’s main scientific alliances are with Hadassah Medical Center (Israel), Monash University (Australia) and the Commonwealth Scientific and Industrial Research Organisation (CSIRO) (Australia).
Suite 1, 1233 High Street Armadale, Victoria AUSTRALIA 3143
www.immuron.com
Phone: + 61 (0)3 9824 5254 Facsimile: + 61 (0)3 9822 7735
ABN: 80 063 114 045
AUGUST 2015
HEALTH TO CHEW ON
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prevention of disease.
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NASH/ASH
SUMMARY
TRAVELAN
PIPELINE
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TRAVELAN®
PIPELINE
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NASH/ASH
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SUMMARY
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Immuron presents the large upside Investor Potential of a biotech company.
It has a unique natural immune-technology platform with GRAS status that significantly reduces the research to product cycle timelines.
Immuron has a revenue-generating product with multiple revenue pathways
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TRAVELAN®
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NASH/ASH
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PIPELINE
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SUMMARY
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NASH: Two Phase II studies in progress with ASH: an increasingly alluring potential upside Travelan: Revenues growing and positioned to grow further with successful USA launch
Pipeline: Progressing and Strong Cap Pofile: Robust
Financials: Debt free, cash in the bank until after completion of NASH trial
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TRAVELAN®
NASH/ASH
PIPELINE
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SUMMARY
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AUD$19.5M
Listed Unlisted ASX Code: IMC Shares Options Options Securities currently on ~75M ~3M ~ 6M
| Rank Shareholder Name Qty Held % Ownership |
Rank Shareholder Name Qty Held % Ownership |
|---|---|
| 1 | |
| 2 | AUTHENTICS AUSTRALIA PTY LTD 4,999,999 6.67% |
| 3 | |
| 4 | MR PETER ANASTASIOU & 2,907,236 3.88% |
| 5 | |
| 6 | FIFTY-FIFTH LEPRECHAUN PTY LTD 2,035,371 2.72% |
| 7 | |
| 8 | INSYNC INVESTMENTS PTY LTD 1,534,432 2.05% |
| 9 | |
| 10 | MR DAVID ANTHONY PLUSH & 1,334,075 1.78% |
| 11 | |
| 12 | G & N LORD SUPERANNUATION PTY 1,237,994 1.65% |
| 13 | |
| 14 | JOJO ENTERPRISES PTY LTD 918,898 1.23% |
| 15 | |
| 16 | CAPITAL CONCERNS PTY LIMITED 654,716 0.87% |
| 17 | |
| 18 | MR HAMISH SALMON & 575,000 0.77% |
| 19 | |
| 20 | ADVANCE CLINICAL SYSTEMS 546,874 0.73% |
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NASH/ASH
TRAVELAN
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PIPELINE
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SUMMARY
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Targeting the human immune system with natural antibodies derived from bovine to address diseases of the gut and liver.
Why?
Acute and chronic infections in the gut have a major impact in human health, causing dis biosis and many metabolic diseases.
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TRAVELAN
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NASH
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PIPELINE
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SUMMARY
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- Attractive risk-reward ratio – biotech upside with reduced risk profile
Immuron’s Platform Products
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Natural product
-
High safety profile
-
Not a binary outcome.
-
If clinical end points not attained, there may still be a product that generates revenue
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Low Cost
Other Products
� Synthetic product � Side effects occur
� Binary outcome: clinical trial failure means there is no product
� Antibodies typically very expensive to make
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TRAVELAN
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NASH PIPELINE
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SUMMARY
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Pathway with reduced risk
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Traditional model Immuron’s De-risked Platform
Pre-clinical
Phase I clinical
OR
OTC Consumers
Phase II clinical
OR
OTC Consumers
Phase III clinical
OR
Medical Food
Prescribed drug
on the market
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2.
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TRAVELAN
Stop it before it starts
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SUMMARY
OVERVIEW
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NASH
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PIPELINE
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Without Travelan [®] : Bacteria With Travelan [®] : Bacteria
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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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http://www.travelan.com.au
`
Traveller’s diarrhoea global market estimate: US$600M - 1.2B
All-natural product; clinically proven with very high safety profile Available over-the-counter Strong brand loyalty
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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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Growing Australian brand
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OVERVIEW
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NASH
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PIPELINE
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SUMMARY
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Successfully Launched in the USA
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- ** Note: first non-exclusive distribution contract signed for 50,000 units in July 2015 with major Traveller’s Supply company at full margin.
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OVERVIEW
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NASH PIPELINE
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SUMMARY
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Status in Nov 2013
Progress in 2015
Country Discussions Term Sheet Licensed Regulatory In Market Canada South Korea Other Asian Countries US (partnered) No regulatory process United States (direct) India China
- Regulatory application preceding partnering engagement
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3.
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NASH/ASH
(INFLAMED
FATTY LIVER)
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OVERVIEW
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TRAVELAN
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Lipotoxicity
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PIPELINE
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SUMMARY
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Cirrhosis: Severe liver damage Liver Fibrosis: Scarring of liver tissue NASH: Inflamed Fatty Liver Liver: Fat accumulation We eat badly and are too sedentary
PIPELINE
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OVERVIEW
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TRAVELAN
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SUMMARY
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Population = 100%
Cirrhosis; 1 in 10
NASH > 5%
NAFL~ 25%
OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY
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= Estimated $40B Market in 2025
NASH - The Next Big Global Epidemic in 10 Years?
Deutsche Bank, Markets Research, 14 July 2014
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OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY
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IMM-124E chosen by NIH from
27 candidates for a phase II
study in ASH. Currently
recruiting.
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OVERVIEW TRAVELAN NASH/ASH PIPELINE SUMMARY
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OVERVIEW
TRAVELAN
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PIPELINE
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SUMMARY
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�
IMM-124E is safe and may be best in class
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Prevents bacterial spread
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OVERVIEW
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TRAVELAN
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PIPELINE
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SUMMARY
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2 Phase II trials started and recruiting
NASH- IMMURON FUNDED
ASH- NIH FUNDED
Phase II trial has begun:
Phase II trial has begun:
NIH funded,
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Princess Alexandra Hospital, Brisbane, QLD
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Westmead Hospital, Sydney, NSW Nepean Hospital, Sydney, NSW Box Hill Hospital Melbourne, VIC
Alfred Hospital
Swedish MC Seattle, WA
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U.Colorado, Denver, CO
Cleveland Clinic, OH
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Kansas City GE&H, MO
UVA, Charlottesville VA VCU, Richmond VA Bon Secours, Richmond/NN, VA
Duke Liver Center, Durham NC
U Florida, Gainesville, FL
Baylor St Luke’s Houston, TX
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OVERVIEW
TRAVELAN
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PIPELINE
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SUMMARY
Bile Acid
Shire - LUM-002
Intercept - Obeticholic acid, modified bile acid
Galmed - Aramchol, Conjugate of Fatty acid and Fatty bile acid
Anti-fibrotic
Gilead - Simtuzumab, anti-fibrotic
Galectin - galectin proteins
Anti-Inflammatory + (anti-inflammatory, anti-diabetic, cholesterol control, FFA)
Immuron - Hyperimmune colostrum enriched with Anti-LPS Abs
Conatus - Emricassan, caspase protease inhibitor
Genfit - Peroxisome proliferator - activated receptor alpha
� IMM-124E is safe and may be best in class
4.
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ROBUST
PIPELINE
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TRAVELAN
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NASH
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PIPELINE
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SUMMARY
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Indication Research Pre-clinical Phase I Phase II Phase III
Traveller’s Diarrhea NASH (IMM-124E) ASH (IMM-124E)
Clostridium difficile infection Other Projects:
- Trial funded by NIH
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diabetes • Colitis/Crohn’s Disease
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Fibrosis
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OVERVIEW
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TRAVELAN
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NASH/ASH
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SUMMARY
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US Hospitalisations Skyrocket Annually due to C.diff
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superbug
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more than US$3.2 billion in health care
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85,700
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Source: Agency for Healthcare Research and Quality 28
Comparative Values- Nasdaq Peers
- Immuron is significantly undervalued relative to peers listed on NASDAQ who are currently undertaking a Phase II study in NASH
Average Value for these Companies is over $100 Million
- Immuron is significantly undervalued relative to its peers listed on NASDAQ that currently have a C-Diff program in place.
Average Value of these companies is over $200 Million, although several are in Phase II or Phase III clinical trials.
At $20 Million Immuron represents a strong Value case with Two phase II studies, a C- Diff program, Travelan sales and a strong pipeline and safe platform.
5.
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SUMMARY
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TRAVELAN®
PIPELINE
OVERVIEW
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NASH
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SUMMARY
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The Board and Management
Chairman
Non-Executive Director
Non-Executive Director
Director
Senior VP of Innovation
Clinical Director
Dr. Yaron Ilan Medical Officer
Dr. Yaron Ilan, MD, is a Director-Inpatient Medicine Department at Hadassah Medical Center. He holds more than 50 patents and co-authored more than 240 articles.
Chief Scientific Officer
Development Manager
Manufacturing Quality Director
THANK YOU
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