Immuron Ltd — Investor Presentation 2026

Mar 4, 2026

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Immuron CEO, Steven Lydeamore presentation at Coffee Microcaps Conference

Melbourne, Australia, March 5, 2026: Immuron Limited (ASX: IMC; NASDAQ: IMRN) is pleased to advise our Chief Executive Officer, Steven Lydeamore is presenting virtually at the Coffee Microcaps Conference on Thursday 5[th] March 2026 (11:00am – 11:30am Australian Eastern Time).

A copy of the presentation made is included below.

This release has been authorised by the directors of Immuron Limited.

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COMPANY CONTACT: Steven Lydeamore Chief Executive Officer steve@immuron.com

About Immuron

Immuron Limited (ASX: IMC, NASDAQ: IMRN), is an Australian biopharmaceutical company focused on developing and commercializing orally delivered targeted polyclonal antibodies for the treatment of infectious diseases.

About Travelan®

Travelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting travelers’ diarrhea, a digestive tract disorder that is commonly caused by pathogenic bacteria and the toxins they produce. Travelan® is a highly purified tabletized preparation of hyper immune bovine antibodies and other factors, which when taken with meals bind to diarrhea-causing bacteria and prevent colonization and the pathology associated with travelers’ diarrhea. In Australia, Travelan® is a listed medicine on the Australian Register for Therapeutic Goods (AUST L 106709) and is indicated to reduce the risk of Travelers’ Diarrhea, reduce the risk of minor gastro-intestinal disorders and is antimicrobial. In Canada, Travelan® is a licensed natural health product (NPN 80046016) and is indicated to reduce the risk of Travelers’ Diarrhea. In the U.S., Travelan® is sold as a dietary supplement for digestive tract protection.

Travelers’ diarrhea (TD)

TD is generally defined as the passage of ≥ 3 unformed stools per 24 hours plus at least one additional symptom (such as nausea, vomiting, abdominal cramps, fever, blood/mucus in the stools, or fecal urgency) that develop while abroad or within 10 days of returning from any resource-limited destinations (Leung et al., 2006). Diarrhea continues to be the most frequent health problem among travelers to destinations in lower- and middle-income regions (Steffen, 2017). Deployed US military personnel, essentially representing a long-term traveller population, are particularly affected given their population dynamics and the context in which they seek care and treatment (Connor et al., 2012). Diarrhea is the leading infectious disease threat to the overall health and preparedness of deployed US armed forces, with diarrheagenic E. coli, Campylobacter spp., and Shigella spp. among the most commonly reported etiologies (Riddle et al., 2006).

Immuron Platform Technology

Immuron’s proprietary technology is based on polyclonal immunoglobulins (IgG) derived from engineered hyper-immune bovine colostrum. Immuron has the capability of producing highly specific immunoglobulins to any enteric pathogen and our products

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are orally active. Bovine IgG can withstand the acidic environment of the stomach and is resistant to proteolysis by the digestive enzymes found in the Gastrointestinal (GI) tract. Bovine IgG also possesses this unique ability to remain active in the human GI tract delivering its full benefits directly to the bacteria found there. The underlying nature of Immuron’s platform technology enables the development of medicines across a large range of infectious diseases. The platform can be used to block viruses or bacteria at mucosal surfaces such as the Gastrointestinal tract and neutralize the toxins they produce.

IMM-124E (Travelan®)

IMM-124E was developed using Immuron’s platform technology. IMM-124E is produced from the colostrum of birthing cattle that have been immunised during pregnancy with a vaccine containing the outer antigens of multiple human derived ETEC. A total of 13 ETEC strains are used in the vaccine to produce high levels of antibodies against selected surface antigens from the most common strains of ETEC. (Otto et al., 2011)

The resultant hyperimmune colostrum IMM-124E from ETEC vaccinated cows contains significant levels of polyclonal antibodies specific for ETEC antigens LPS, CFA-I and Flagellin (Sears et al., 2017).

The antibodies produced in IMM-124E have been found to have a stronger binding and neutralizing activity (than the antibodies of unvaccinated cattle) against a wide range of LPS antigens including both the variable O-polysaccharide region and the preserved oligosaccharide core ‘R’ region of LPS from the 13 serotypes used in the ETEC vaccine.

IMM-124E is manufactured into a tablet form referred to as Travelan®.

IMM-529

Immuron is developing IMM-529 as an adjunctive therapy in combination with standard of care antibiotics for the prevention and/or treatment of recurrent Clostridioides difficile infection (CDI). IMM-529 antibodies targeting Clostridioides difficile (C. diff) may help to clear CDI infection and promote a quicker re-establishment of normal gut flora, providing an attractive oral preventative for recurrent CDI.

Immuron is collaborating with Dr. Dena Lyras and her team at Monash University, Australia to develop vaccines to produce bovine colostrum-derived antibodies. Dairy cows were immunised to generate hyperimmune bovine colostrum (HBC) that contains antibodies targeting three essential C. diff virulence components. IMM-529 targets Toxin B (TcB), the spores and the surface layer proteins of the vegetative cells.

This unique 3-target approach has yielded promising results in pre-clinical infection and relapse models, including (1) Prevention of primary disease (80% P =0.0052); (2) Protection of disease recurrence (67%, P <0.01) and (3) Treatment of primary disease (78.6%, P<0.0001; TcB HBC). Importantly IMM-529 antibodies cross-react with whole cell lysates of many different human strains of C. diff including hypervirulent strains.

To our knowledge, IMM-529 is, to date, the only investigational drug that has shown therapeutic potential in all three phases of the disease (Hutton et al., 2017).

ProIBS®

Immuron has an exclusive distribution agreement with Calmino goup AB for the territories of Australia and New Zealand for ProIBS®. ProIBS® - to help patients treat IBS symptoms ProIBS® is a certified medical device for the treatment of IBS symptoms such as abdominal pain, bloating and unsettled bowel movements (diarrhoea and/or constipation). ProIBS® contains AVH200®, derived from the plant Aloe barbadensis. Mill. AVH200® has gel forming components which support the intestinal mucosal barrier. As IBS is known to affect individuals for a long period of time, it is essential to have a treatment appropriate for longterm use –as ProIBS® is. The product is safe, and no interactions with other medications are known. Science-driven innovative Calmino group AB, the developer of ProIBS®, conducted a usability study among 1,003 users. PROIBS® was helpful for 94% of them. 91% of the users experienced an improvement in daily life and 98% would recommend PROIBS® to someone else. To learn more please check: www.proibs.eu.

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Irritable bowel syndrome (IBS) is a common condition where you experience symptoms related to your digestive system. This is sometimes linked to certain foods, lifestyle habits and stress levels or mood. IBS affects around 3 out of every 10 people. Females are more likely than males to be affected. Some key symptoms of IBS include: abdominal pain or discomfort; stomach bloating and wind; chronic diarrhoea or constipation, or alternating between the two.(healthdirect.gov.au) According to available data, the IBS treatment market in Australia is estimated to be a part of the broader "Digestives & Intestinal Remedies" market, generating a revenue of around AU$221.14 million in 2025, with a projected annual growth rate of 3.28%.(Statista)

References

Connor P, Porter CK, Swierczewski B and Riddle MS. Diarrhea during military deployment: current concepts and future directions. Curr Opin Infect Dis. 25(5): 546-54; 2012.

Hutton, M.L., Cunningham, B.A., Mackin, K.E. et al. Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative. Sci Rep 7, 3665 (2017). https://doi.org/10.1038/s41598-017-03982-5

Leung AK, Robson WL, Davies HD. Travelers’ diarrhea. Adv Ther. Jul-Aug; 23(4): 519-27; 2006

Otto W, Najnigier B, Stelmasiak T and Robins-Browne RM. Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers Scandinavian Journal of Gastroenterology 46: 862– 868; 2011.

Riddle MS, Sanders JW, Putnam SD, and Tribble DR. Incidence, etiology, and impact of diarrhea among long-term travelers’ (US military and similar populations): A systematic review. American Journal of Tropical Medicine and Hygiene. 74(5): 891-900; 2006.

Sears KT, Tennant SM, Reymann MK, Simon R, Konstantopolos N, Blackwelder WC, Barry EM and Pasetti MF. Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum products. Clinical and Vaccine Immunology. 24 (8) 1-14; 2017.

Steffen R. Epidemiology of travelers' diarrhea. J Travel Med. 24(suppl_1): S2-S5; 2017.

For more information visit: https://www.immuron.com.au/ and https://www.travelan.com Subscribe to Immuron’s InvestorHub: Here

FORWARD-LOOKING STATEMENTS:

This press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions, or circumstances on which any such statement is based, except as required by law.

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NASDAQ: IMRN ASX: IMC

Investor Presentation

Steven Lydeamore Chief Executive Officer

SAFE HARBOR STATEMENT

Certain statements made in this presentation are forward-looking statements and are based on Immuron’s current expectations, estimates and projections. Words such as “anticipates,” “expects,” “intends,” “plans,” “believes,” “seeks,” “estimates,” “guidance” and similar expressions are intended to identify forward-looking statements.

Although Immuron believes the forward-looking statements are based on reasonable assumptions, they are subject to certain risks and uncertainties, some of which are beyond Immuron’s control, including those risks or uncertainties inherent in the process of both developing and commercializing technology. As a result, actual results could materially differ from those expressed or forecasted in the forward-looking statements.

The forward-looking statements made in this presentation relate only to events as of the date on which the statements are made. Immuron will not undertake any obligation to release publicly any revisions or updates to these forward-looking statements to reflect events, circumstances or unanticipated events occurring after the date of this presentation except as required by law or by any appropriate regulatory authority.

FY2026 results in this presentation are subject to audit review.

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Immuron Ltd is an Australian integrated biopharmaceutical company with global scale, focused on developing, and commercialising, oral products for the treatment of gut mediated diseases

Technology Research & Platform Development Safe and potentially 2 pipeline assets to be transformational partnered for approach to gut development and infections commercialization

Our Products

Global footprint Australia, US, Canada and expanding

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Corporate Research Independent Buy recommendation

Technology Platform

• Immuron’s core strength lies in its ability to program cows to produce high levels of specific polyclonal antibodies (immunoglobulins) through vaccination.

• Orally Active: Unlike many biologics that require injection, Immuron’s bovine antibodies are naturally hardy. They survive the harsh acidic environment of the human stomach to work directly in the Gastrointestinal (GI) tract.

• Precision Targeting: The platform can be "tuned" to target specific bacteria, viruses, or toxins by changing the vaccine.

• Dual-Action Mechanism: The products don't just target the pathogens; they prevent them from sticking to the gut wall and neutralize the inflammatory toxins they release.

• Reduce the risk of Traveller’s Diarrhoea

• Sold in pharmacies Australia-wide

• • Available in Australia, USA and Canada

• Treatment of symptoms associated with Irritable Bowel Syndrome (IBS)

• • Sold in pharmacies Australia-wide • Available in Australia

• No reported serious adverse events or safety signals. Safety demonstrated in repeat-dose animal toxicity studies, immunohistochemical assessments showing no off-target cross-reactivity and bacterial reverse-mutation testing confirming it is nonmutagenic.

Executive summary Immuron Ltd (NASDAQ:IMRN) (ASX:IMC) is a globally integrated biopharmaceutical company focused on developing, and commercialising, oral immunotherapeutics for the treatment of gut mediated diseases

Company Overview

Three commercial products: Travelan® (traveler’s diarrhea), Protectyn® and ProIBS (irritable bowel syndrome) Two clinical assets : Travelan®: IMC: eligible for end of Phase 2 meeting with U.S. FDA

IMM-529 (CDI): U.S. FDA investigational new drug (IND) application approval to proceed with Phase 2 clinical trial

Clinical:

Business Update

IMM-529 (CDI): U.S. FDA approval of investigational new drug (IND) application in November 2025

Commercial:

Uniformed Services University IMM-124E trial reported topline results in December 2025 ; secondary analysis pending

Continued quarter on quarter analysis pending growth of Travelan® New research agreement signed in December 2025 funded by a U.S. Department of Defense sub ProIBS launch stock launched in award with the Naval Medical Research Command and Walter Reed Army Institute of Research October 2025 IMM-986 (VRE): pre-clinical mouse study completed; Immuron decision not to progress; to focus efforts on partnering IMM-124E and IMM-529 for development and commercialization

1H FY 26 Results

EBITDX (ex-R&D)[1] for HY26 was -A$1.1m, up A$0.1m on HY25 and up A$0.7m on 2H FY25

1H FY26 Results:

HY26 Global Sales Revenue of A$4.2 million up 5% on prior year

Cash of A$10.0 million, up A$7.2 million on 30 June 2025; equivalent to 22.5 months of cash used in operating activities in 1H FY26

HY26 Australian Sales of A$3.3 million, up 13%

HY26 North American Sales of A$0.9 million, down 18%

HY26 U.S. Sales of A$0.9 million, up 17%

R&D Tax Incentive A$1.1 million received in February 2026

Continued quarter on quarter growth of Travelan® from growth drivers

1 Earnings before Interest, Tax, Depreciation, Foreign Exchange and Net R&D (R&D expenses less R&D income)

Financial Snapshot

	Financial Snapshot
	Shares on Issue 326,653,609
	Total Options 13,707,599
	Last Traded Price IMC: A$0.028
	52 week High/Low IMC: A$0.11/0.054 IMRN: $2.87/1.50 Market Cap IMC: A$9.14m Cash (31 December 2025) A$10.0m

Major Shareholders

	Major Shareholders
	Holder Units % of CSO
	BNY Mellon Asset Management 135,013,184 41.33 %
	Board and Employees 6,566,869 2.01%
	Authentics Australia Pty. Ltd. 5,500,000 1.68 % Grandlodge 3,846,712 1.18 %

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Immuron strategic reset provides clearer path to profitability

Immuron has taken a strategic decision to partner clinical assets IMM-124E and IMM-529 for development and commercialization.

• IMM-124E is eligible for an end of Phase 2 meeting with the U.S. FDA (indication: traveler’s diarrhea) • Lumanity[1] peak U.S. sales estimate of US$102 million

• IMM-529 has an investigational new drug (IND) application approved by the U.S. FDA and is ready to go into Phase 2 clinical trials (indication: Clostridioides difficile infection)

• Lumanity[1] peak U.S. sales estimate of US$400 million

• Under a partnering model, the licensee typically funds development, registration and commercialization costs and pays the licensor an upfront licensing fee, milestone payments and royalties on sales

• This partnering strategy removes the uncertainty of how Immuron would fund these assets through to commercialization

• Partnering has the potential to bring forward monetization of these assets

• The reduction in R&D expenses (net of R&D Tax Incentive) will improve profitability and decrease cash burn

• Immuron has sufficient cash ($10 million @ 31 December 2025) to fund commercial operations (over the counter (OTC) sales of Travelan® and PROIBS®

• Immuron continues to evaluate opportunities to broaden distribution and to add complementary products to its OTC portfolio

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1. Lumanity global healthcare consulting

IMM-124EMarket Potential

TAM (Total Addressable Market)

The global Traveler’s Diarrhea (TD) market, including all treatments (antibiotics, anti-diarrhea agents) and prevention (vaccines, probiotics).

• Global Value : The global Traveler's Diarrhea treatment market is estimated at $3.31 billion for 2026, growing at a CAGR of ~6.8%.

• Pathogen Burden : Bacterial pathogens (E. coli, etc.) cause ~80% of cases, which is the specific target for Travelan’s hyper-immune bovine colostrum technology.

SAM (Serviceable Addressable Market)

The specific segment of travelers visiting high-risk regions who seek prophylactic (preventative) and OTC/Natural solutions rather than acute treatment.

• Prevention vs. Treatment : Historically, the "prevention" segment accounts for roughly 25% of the total market, as many travelers rely on acute treatment (antibiotics/Imodium) only after falling ill.

• High-Risk Travel : Approximately 20-40% of international arrivals (1.52 billion in 2025) are traveling from developed nations to high-risk zones (Africa, SE Asia, Latin America), which constitutes the primary customer base.

SOM (Serviceable Obtainable Market)

15-20% penetration rate of the “addressable travelers” segment by shifting Travelan from a "niche discovery" to a "standard of care" through the following marketing resources:

• The "Treatment to Prevention" Pivot : High-spend marketing (SEO/SEM targeting "Bali belly," "Mexico travel tips," etc.) captures the user at the booking phase, effectively moving them from the Treatment TAM to the Prevention SAM.

• Pharmacy & Clinical Detailing : An "appropriate" resource allocation includes a field force to educate pharmacists (who drive the majority of OTC sales). In Australia, where this is already partially active, Travelan accounts for nearly 75% of the niche market; duplicating this in the US/UK is the primary driver of this SOM growth.

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IMM-529 Market Potential

The Disease: C. difficile is the leading cause of healthcare-associated infection causing 400,000 cases and 30,000 deaths in the US annually

Disease spectrum:

• Mild-to-moderate : Watery persistent diarrhea, cramping

• Severe/Pseudomembranous Colitis (PMC) : Colon wall plaques

• • Fulminant CDI : Toxic megacolon, sepsis, and potential bowel perforation, death

Who’s at risk: Adults 65+, immunocompromised patients, antibiotic users, and Proton Pump Inhibitors users.

Problem with current treatment: Antibiotics eliminate pathogens, indiscriminately disrupt the gut microbiome, hinder flora regeneration, and leave 25% patients vulnerable to recurrent infection within 30 days, rising to 65% after multiple episodes

Market opportunity: The diagram represents the funnel from the clinical burden to Immuron's target revenue:

• TAM (Total Addressable Market): 100% of all recurrent CDI patients globally at regional pricing.

• SAM (Serviceable Addressable Market): The subset of patients expected to be treated with advanced therapy (e.g., FMT, Vowst, Rebyota, or IMM-529).

• SOM (Serviceable Obtainable Market): The peak revenue based on Immuron capturing 30% of the advanced therapy segment.

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IMM-529 Deal Potential

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Year	Licensor / Asset Owner	Licensee / Acquirer	Licensed Asset	Financial terms (public)	Stage at deal	Status update (as of March 2026)
2024	Seres Therapeutics	Nestlé Health Science	VOWST (SER-109) business (oral microbiota spores)	Asset sale signed Aug 2024 (public reporting indicates deal structure included upfront and additional payments; exact totals vary by source and filings). (BioSpace )	Marketed	FDA approved (Apr 2023) and commercialized by Nestlé Health Science; global rights consolidated under Nestlé via the 2024 transaction. ( U.S. Food and Drug Administration )
2023	Destiny Pharma	Sebela Pharmaceuticals	NTCD-M3 (non toxigenic C. difficile strain, live biotherapeutic)	Upfront $1M; up to $570M milestones (incl. $19M development and up to $550M sales) plus royalties. (FT Markets )	Phase 3 ready	Phase 3 preparation continues, including work on a more patient friendly capsule formulation and regulatory alignment on Phase 3 design. (AMR Bio )
2021	Seres Therapeutics	Nestlé Health Science	SER-109 (later VOWST)	$175M upfront; $125M on FDA approval; up to $225M sales milestones; profit share structure. (Business Wire )	Phase 3	Became FDA approved Apr 2023; subsequently commercialized and later moved into the 2024 asset sale to Nestlé (row above). ( U.S. Food and Drug Administration )
2018	Rebiotix	Ferring Pharmaceuticals	RBX2660 (later REBYOTA), microbiota suspension	Acquisition (terms not fully disclosed publicly). (Ferring Global )	Phase 3	FDA approved Nov 2022 for prevention of recurrent CDI; marketed as REBYOTA. (Ferring Global )
2017	Summit Therapeutics	Eurofarma	Ridinilazole (small molecule antibiotic)	$2.5M upfront; up to $25M milestones plus royalties. (BioSpace )	Phase 2/3	Phase 3 program did not meet superiority vs vancomycin; Summit later focused its strategy on oncology (ivonescimab).(Fierce Biotech )
2017	Assembly Biosciences	Allergan (later AbbVie)	Microbiome GI programs (often cited as ABI-M201, ABI- M301; not CDI specific)	$50M upfront plus milestones and royalties (per deal announcement coverage). (BioSpace )	Preclinical	Partnership was later unwound and the microbiome candidates returned; Assembly ultimately exited microbiome work. Note: public deal descriptions emphasize UC and Crohn’s, not CDI. (Fierce Biotech )

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1. FINANCIAL & OPERATIONAL HIGHLIGHTS

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HY26 Financial Summary

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Global Sales Australian Sales
Revenue Revenue
$4.2m $3.3m
Up 5% Up 13%
EBITDX (ex-R&D) [2]
Gross Profit
$(1.1)m
Margin
Up $0.1m
63%
Up $0.7m
on H2 FY25
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North American
Sales Revenue
$0.9m
Down [1] 18%
USA Up 17%
Cash $10.0m
Up $7.2m [3]
on 30 Jun 25
≈ 23.5 months cash [4]
(calculated on 1H FY26 net
cash used in operating
activities)
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1 Due to Canada. During FY25 we had a Q1 pipeline fill into over a thousand Canada retail doors on the back of securing listings within key pharmacy and grocery retail groups. As expected, sales picked up on the back of consumer promotions in Q2 FY26 (+191% on prior quarter).

2 Earnings before Interest Tax Depreciation and FX and ex-R&D: Research & Development expenses, R&D Tax Incentive and R&D grants

• 3 Excludes 30 June 2025 Term Deposit of $3.0m; adjusted increase $4.1m 4 Calculation for illustration; not a forecast

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Continued strong sales growth

Global

• • HY2026 AUD$4.2 million up 5% on prior year

Australia

• • HY2026 AUD$3.3 million up 13% on prior year

North America

• • HY2026 AUD$0.9 million down 18% on prior year
• • USA HY2026 AUD$0.9 million up 17% on prior year
• • Post HY, secured distribution with Jean Coutu in Canada, the largest pharmacy chain in Quebec

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Commercial – Operational Highlights

2H FY24 1H FY25

1H FY26 and 2H FY25 Outlook

Travelan ® / Protectyn®

• • • •

• $2.55m global sales $3.99m global sales $3.29m global sales $4.18m global sales

• • • • •

• Revenue $1.87m Australia $2.89m Australia $2.36m Australia $3.27m Australia • • • • $0.67m North America $1.11m North America $0.93m North America $0.91m North America • Australia: 3,700 pharmacies; 27m

• Marketing & • peopleCanada: 10,000 pharmacies; 39m Distribution people • USA: 342m people

Commentary

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1 Refer Safe Harbor Statement
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• Sigma PROIBS® • Launched ProIBS® in Australia with HY26 sales of AUD$72,000.

• • Sigma orders decreased ( one-off ) by 1 month’s sales due to Chemist

• • 4 x monthly sales • Exclusive distribution of ProIBS® for the treatment of symptoms related • Warehouse/Sigma merger initiativeSecured distribution with Jean Coutu, ordered to support new to IBS in Australia and New largest pharmacy chain in Quebec,

• distribution obtained Zealand. Canada • Projecting 2H FY26 and FY26 Net Sales to both exceed pcp and Net Sales, Net Profit and EBITDX (ex-R&D) all to exceed pcp[1]

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STEVEN LYDEAMORE CHIEF EXECUTIVE OFFICER IMMURON LIMITED CONTACT INFORMATION:

EMAIL: STEVE@IMMURON.COM PHONE: AUSTRALIA: +61 438 027 172

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