EXELIXIS, INC. — Director's Dealing 2025

May 17, 2025

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: EXELIXIS, INC. (EXEL)
CIK: 0000939767
Period of Report: 2025-05-14

Reporting Person: Haley Patrick J. (EVP, Commercial)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2025-05-14	Common Stock	S	10000	$42.68	Disposed	491164	Direct
2025-05-15	Common Stock	F	34705	$44.65	Disposed	456459	Direct
2025-05-15	Common Stock	S	10000	$46.95	Disposed	446459	Direct
2025-05-15	Common Stock	M	116383	$18.80	Acquired	562842	Direct
2025-05-15	Common Stock	S	116383	$48.05	Disposed	446459	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-05-15	Option (right to buy)	$18.80	M	116383	Disposed	2025-09-09	Common Stock (116383)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	23539	Indirect
Common Stock	10648	Indirect

Footnotes

F1: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 19, 2024.

F2: Includes 374,029 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based
restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of
one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

F3: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F4: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $48.05 to $48.16. Reporting Person undertakes to provide Exelixis, Inc., any security
holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in
footnote 4 to this Form 4.

F5: Represents shares of Common Stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of May 14, 2025.

F6: The option, representing the right to purchase a total of 116,383 shares of Common Stock, became fully exercisable on September 10, 2022.