CRYOSITE LIMITED — Director's Dealing 2008

Oct 30, 2008

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ASX RELEASE - FRIDAY, 31 OCTOBER 2008 RESIGNATION OF NON-EXECUTIVE DIRECTOR – Appendix 3Z

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As announced at the Annual General Meeting held on the 29[th] October 2008, Ms Catherine Brenner did not stand for re-election as a director at that meeting and has ceased to be a director of the Company.

As set out in the Chairman’s address of that meeting, the Chairman thanked Catherine for her participation in the Company during her time as a director.

Ms Brenner’s Appendix 3Z - ceasing to be a Director Notice - is attached.

In the preparation of the appendix 3Z is was noted that an appendix 3Y for the issue of unlisted options to Ms Brenner have not been lodged due to an administrative oversight at the time of the issue of the options This appendix 3y is now attached.

It is noted that all other compliance documents deriving from the issues of these options had been lodged - Notice of Shareholder meeting to approve the options, results of the meeting and appendix 3b Issue of new securities.

It is also noted that the Company is aware of its disclosure obligations under listings rules 3.19A and 3.19B “obligation to notify ASX within 5 business days of the notifiable interests in securities held by each director” and has appropriate systems in place to meet its requirements particularly in relation to tradeable securities where we receive a daily report from the share registry if there is any movement in a directors direct holding or their relevant interest. Directors are also aware of their responsibility to notify the Company of any changes that may occur in their holdings.

Bryan Dulhunty Company Secretary

9 Sirius Road Lane Cove NSW 2066 Australia phone +61 2 9420 1400 fax +61 2 9420 1414 email corporate@cryosite.com www.cryosite.com Cryosite Ltd ABN 86 090 919 476

Appendix 3Z Final Director’s Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity Cryosite Limited ABN 86 090 919 476

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	Ms Catherine Brenner
Date of last notice	7 November 2007
Date that director ceased to be director	29 October 2008

Part 1 – Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

300,000 unlisted options

Granted by shareholders at the November 07 Annual General Meeting. 3 tranches 100,000 exercise price 20 cents. vest 7 Nov 08, 100,000 exercise price 30 cents vest 7 Nov 09, 100,000 exercise price 40 cents vest 7 Nov10

Condition of vesting is Ms Brenner is a director of the Company at each vesting date.

These options will now lapse.

Appendix 3Z Page 1

Appendix 3Z Final Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

	Name of holder & nature of interest Note: Provide details of the circumstances giving rise to the relevant interest	Number & class of securities

Part 3 – Director’s interests in contracts

Detail of contract Nature of interest Name of registered holder (if issued securities) No. and class of securities to which interest relates

• See chapter 19 for defined terms.

Appendix 3Z Page 2

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity Cryosite Limited

ABN 86 090 919 476

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Ms Catherine Brenner
Date of last notice	28 September 2006

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest (including registered holder) Note: Provide details of the circumstances giving rise to the relevant interest.
Date of change	7 November 2007
No. of securities held prior to change	Nil
Class	Unlisted options
Number acquired	300,000
Number disposed
Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation	Nil
No. of securities held after change	300,000 unlisted options

• See chapter 19 for defined terms.

Appendix 3Y Page 1

11/3/2002

Appendix 3Y Change of Director’s Interest Notice

Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	Granted by shareholders at the November 07 Annual General Meeting. 3 tranches 100,000 exercise price 20 cents. vest 7 Nov 08, 100,000 exercise price 30 cents vest 7 Nov 09, 100,000 exercise price 40 cents vest 7 Nov10 Condition of vesting is Ms Brenner is a director of the Company at each vesting date

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract Nature of interest Name of registered holder (if issued securities) Date of change No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed Interest acquired Interest disposed Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation Interest after change

• See chapter 19 for defined terms.

Appendix 3Y Page 2

11/3/2002