BOTANIX PHARMACEUTICALS LTD — Investor Presentation 2021

May 3, 2021

==> picture [114 x 50] intentionally omitted <==

4 May 2021

Botanix update on BTX 1801 clinical development

Key highlights

• Recent Phase 2a study data demonstrated BTX 1801 was safe, well tolerated, clinically effective and successful at achieving decolonisation of Staph aureus in the nose

• Botanix has launched the next phase of BTX 1801 development, targeting the nasal decolonisation of Staph aureus in haemodialysis patients to prevent bloodstream infections

• Limited current preventative measures mean there is an urgent need and significant market opportunity for novel approaches to prevent bloodstream infections in haemodialysis patients

• Botanix’s approach enables a rapid clinical development pathway, with the opportunity to apply for key FDA incentives to accelerate development and increase exclusivity

• Plans for a Phase 2b clinical study are well advanced and fully funded with existing capital reserves

Philadelphia PA and Perth Australia, 4 May 2021 : Clinical dermatology and antimicrobial company, Botanix Pharmaceuticals Limited (ASX:BOT, “Botanix” or “the Company”), is pleased to announce a clinical development update of its antimicrobial platform with the identification of a new indication, targeting the prevention of bloodstream infections in haemodialysis patients. A presentation providing key takeaways of the recent positive Phase 2a study data, summary of the target indication identified, significant market opportunity and clinical development plan is attached to this release.

Vince Ippolito, President and Executive Chairman, commented: “We are very excited to announce the clinical development update for our BTX 1801 antimicrobial platform. Our assessment indicates that haemodialysis patients with central venous catheters are at considerable risk of bloodstream infections, with no currently approved treatments.

BTX 1801’s novel mechanism of action has been shown to rapidly kill Staph aureus and MRSA without generating resistance, and the recent positive Phase 2a study data demonstrated the clinical utility of BTX 1801 as a nasal decolonisation agent. This represents a potential novel approach for removing sources of bacteria to prevent bloodstream infections in haemodialysis patients, representing a valuable market opportunity to significantly lower the health system impact of haemodialysis infections.”

Clinical data generated to date by Botanix indicates that synthetic cannabidiol has a unique bactericidal mechanism of action that rapidly kills Staphylococcus aureus (Staph aureus) and drug-resistant Staph aureus (MRSA) without generating antimicrobial resistance. In addition, Botanix recently announced positive top-line data from its BTX 1801 Phase 2a study, with efficacy of BTX 1801 demonstrated by nasal decolonisation of Staph aureus.

In the BTX 1801 Phase 2a study, the bacterial killing effect was demonstrated to be sustained in a proportion of patients without further treatment for up to 3 weeks and none of the analysed bacteria developed resistance to BTX 1801 during the 28-day study period. In addition, data generated to date

==> picture [113 x 50] intentionally omitted <==

has shown that BTX 1801 is safe and generally well tolerated, providing Botanix the confidence that BTX 1801 has the potential to be used as a nasal decolonisation agent for prolonged periods to prevent recolonisation (from other parts of the subject’s body) over time.

Following an extensive assessment of clinical data generated to date with key opinion leaders and after a thorough review of potential market opportunities, Botanix has identified its target indication for next phase of clinical development for BTX 1801 – nasal decolonisation of Staph aureus in patients undergoing haemodialysis treatment in order to reduce the incidence of life-threatening bloodstream infections.

Dialysis largely replicates the functions of the kidneys in patients with chronic kidney failure, with dialysis taking over the key functions of the kidneys (including filtering and removing waste materials from the body). Haemodialysis patients undergoing ongoing dialysis regularly (e.g. three to five times per week), are at a high risk of bloodstream infections, due to their treatment requiring frequent use of catheters which in the first year are routinely central lines with direct access to the heart. As a result, infection is a leading cause of death in haemodialysis patients with 20% to 40% of patients eventually dying from an infection[i] . Despite the significant health risks, the treatment to prevent bloodstream infections are essentially limited to the application of antiseptics at the catheter site[ii,iii] . Other issues with the use of antiseptics including the potential degradation of the catheter’s plastic construction and potential to cause patient toxicities[iii] (especially if antiseptics enters the opening of the catheter). No topical antibiotic creams or gels are recommended for catheter sites, primarily due to fungal growth and antimicrobial resistance concerns[iv] .

The potential benefit of BTX 1801 in haemodialysis patients to prevent bloodstream infection is supported by previous studies using mupirocin. These studies indicated that mupirocin was able to reduce Staph aureus bloodstream infections by as much as 60% to 70% among patients undergoing haemodialysis[v] . However, despite these successful studies, mupirocin was never approved and is not expected to be a suitable long-term solution for haemodialysis patients, given the level of resistance to mupirocin (e.g. up to 95% in some hospitals[vi] ) and the fact that mupirocin is now generic (so there is no economic motivation to develop it for this indication).

The health system impact of haemodialysis infections is significant – with the estimated annual cost of treating bacteraemia in haemodialysis patients with central venous catheters to be approximately US$1bn[vii] and approximately 60% of staph aureus-related hospital admissions occurring within the first year of the initiation of dialysis therapy[viii] .

Botanix intends to leverage a range of existing US Food and Drug Administration (FDA) programs (e.g. Qualified Infection Disease Product, Fast Track and Limited Population Pathway for Antimicrobial and Antifungal Drugs status) to accelerate BTX 1801 clinical development, reduce clinical costs and increase the exclusivity period. Botanix is finalizing plans to progress BTX 1801 into a Phase 2b study to assess how effective BTX 1801 is at killing Staph aureus over a 3 month treatment period, with three times weekly treatment of the nose. Planning is well advanced to optimise the study design and the Company plans to initiate this Phase 2b study in 4Q CY2021.

==> picture [113 x 50] intentionally omitted <==

Release authorised by

Vince Ippolito

President and Executive Chairman

About Botanix Pharmaceuticals

Botanix Pharmaceuticals Limited (ASX:BOT) is a dermatology focused company based in Perth (Australia) and Philadelphia (USA) committed to the development of pharmaceutical products that are underpinned by science and supported by well-controlled randomised clinical trials. The Company has two separate development platforms, dermatology and antimicrobial products, both of which currently leverage the unique anti-inflammatory, immune modulating and antimicrobial properties of cannabinoids, particularly synthetic cannabidiol. Botanix has an exclusive license to use a proprietary drug delivery system (Permetrex) for direct skin delivery of active pharmaceuticals in all skin diseases, which it utilises in its existing development programs and is being explored with a number of other product opportunities.

The Company is developing a pipeline of product candidates with recent positive data from its BTX 1801 Phase 2a antimicrobial study and plans for an upcoming Phase 2b study. For the dermatology platform, the Company has received ethics approval to commence its Phase 1b rosacea study and following a successful meeting with the FDA, the Company has confirmed a drug development plan for the BTX 1503 acne program to support registration. To learn more please visit: https://www.botanixpharma.com/

For more information, please contact:

General enquiries Investor enquiries Media enquiries Corporate Communications Joel Seah Haley Chartres Botanix Pharmaceuticals Vesparum Capital H^CK P: +61 8 6555 2945 P: +61 3 8582 4800 P: +61 423 139 163 investors@botanixpharma.com botanixpharma@vesparum.com haley@hck.digital

Cautionary Note on Forward-Looking Statements

Any statements in this press release about future expectations, plans and prospects for the Company, the Company’s strategy, future operations, and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” ”potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the Company’s ability to successfully develop its product candidates and timely complete its planned clinical programs and the Company’s ability to obtain marketing approvals for is product candidates. In addition, the forward-looking statements included in this press release represent the Company’s views as of the date hereof. The

==> picture [113 x 50] intentionally omitted <==

Company anticipates that subsequent events and developments will cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date hereof.

i ‘Mortality in dialysis patients: analysis of the causes of death’, Mailloux LU, Bellucci AG, Wilkes BM, Napolitano B, Mossey RT, Lesser M, Bluestone PA. AJKD. 1991 Sep;18(3):326-35

ii CDC recommends the use of antiseptics greater than 0.5% chlorhexidine with alcohol, 70% alcohol, or 10% povidoneiodine.

iii ‘Hemodialysis Central Venous Catheter Scrub-the-Hub Protocol’, CDC, 2016, https://www.cdc.gov/dialysis/preventiontools/scrub-protocols.html

iv O’Grady NP, Alexander M, Burns LM, et al. Guideline for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011; 52:e162-e193. CDC Guidelines for Central Venous Catheters, updated 2017

v ‘Mupirocin Prophylaxis to Prevent Staphylococcus aureus Infection in Patients Undergoing Dialysis: A Meta-analysis’ (2003) Tacconnelli, E. et al Clinical Infectious Diseases, Volume 37, Issue 12, 15 December 2003, Pages 1629–1638

vi Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus Jan 2010, Bode et al N Engl J Med 2010; 362:9-17

vii ‘Following CDC Protocols Cuts Dialysis Bloodstream Infection in Half’, CDC, May 2013, https://www.cdc.gov/media/releases/2013/p0513-dialysis-infections.html

viii ‘Clinical and Economic Outcomes of Staphylococcus aureus Septicemia in ESRD Patients Receiving Hemodialysis’, Nissenson A et al, American Journal of Kidney Diseases, Vol 46, No 2 (August), 2005: pp 301-308

BTX 1801 Development Update May 2021

www.botanixpharma.com

Executive summary

==> picture [32 x 32] intentionally omitted <==

New generation Synthetic cannabidiol (CBD) with a novel mechanism of action rapidly kills Staphylococcus aureus antimicrobial (Staph aureus) and drug-resistant Staph aureus (MRSA) without generating resistance

==> picture [32 x 32] intentionally omitted <==

Demonstrated BTX 1801 demonstrated in recent Phase 2a study to effectively and safely achieve bacterial clinical efficacy decolonisation of Staph aureus in the nose

==> picture [32 x 32] intentionally omitted <==

Target indication Nasal decolonisation of Staph aureus in patients undergoing haemodialysis treatment to prevent life identified threatening bloodstream infections

==> picture [32 x 32] intentionally omitted <==

Significant market Hospitalisations due to bloodstream infections among haemodialysis patients with central venous opportunity catheters cost the US health system ~US$1bn p.a.[2]

==> picture [32 x 33] intentionally omitted <==

Efficient clinical Targeting haemodialysis patients as the first indication, allows a streamlined pathway to FDA development approval in an attractive market , with the opportunity to efficiently expand into other infection types

==> picture [112 x 50] intentionally omitted <==

‘Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis’, Fisher, M. Golestaneh, L. Allon, M. Abreo, K. and Mokrzycki, MH. CJASN January 2020, 15 (1) 132-151 ‘Following CDC Protocols Cuts Dialysis Bloodstream Infection in Half’, CDC, May 2013, https://www.cdc.gov/media/releases/2013/p0513-dialysis-infections.html

2

www.botanixpharma.com

New generation antimicrobial

BTX 1801 has remarkable activity against bacteria without inducing resistance

MIC daily variability[1]

==> picture [876 x 229] intentionally omitted <==

----- Start of picture text -----

12
26x fold increase from Day 1
8 An increase in MIC over time
shows MRSA can develop
resistance to the drug
4
1.5x fold increase from Day 1
-
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Days
Daptomycin Cannabidiol
MIC (µg/mL)
----- End of picture text -----

Repeat challenge experiments demonstrate that MRSA bacteria develop resistance to commonly-used antibiotics such as daptomycin, but not easily to synthetic CBD

==> picture [112 x 50] intentionally omitted <==

1. The Antimicrobial Potential of Cannabidiol, Communications Biology 4, Article number: 7 (2021) Blaskovich, M et al

3

www.botanixpharma.com

New generation antimicrobial

Unique mechanism of action – bactericidal CBD rapidly kills MRSA bacteria by targeting all 5 macromolecular pathways

==> picture [15 x 50] intentionally omitted <==

Mupirocin – targets only protein synthesis[1]

==> picture [288 x 129] intentionally omitted <==

==> picture [83 x 68] intentionally omitted <==

==> picture [15 x 50] intentionally omitted <==

CBD – affects all macromolecular pathways[1]

==> picture [284 x 129] intentionally omitted <==

==> picture [82 x 67] intentionally omitted <==

CBD – MRSA bacteria dead within 10 minutes[2]

CBD (1xMIC)

CBD (2xMIC)

CBD (5xMIC)

Control

==> picture [224 x 87] intentionally omitted <==

==> picture [223 x 85] intentionally omitted <==

==> picture [223 x 85] intentionally omitted <==

==> picture [224 x 87] intentionally omitted <==

==> picture [112 x 50] intentionally omitted <==

Based on testing conducted by HD Biosciences – BOT data on file Based on testing conducted by Linnaeus Bioscience – BOT data on file

4

www.botanixpharma.com

Demonstrated clinical efficacy

Efficacy of BTX 1801 demonstrated by nasal decolonisation of Staph aureus in Phase 2a study

==> picture [432 x 73] intentionally omitted <==

----- Start of picture text -----

Study design
----- End of picture text -----

• Double-blind, vehicle-controlled, Phase 2a clinical study

• 4 dose groups: 66 healthy volunteers:

  • Safe and generally well tolerated at doses of active drug up to 20%

  • All 66 participants successfully

  • Safety & completed the BTX 1801 study

  • tolerability  No severe adverse events reported[1]

• BTX 1801 Formulation A

• BTX 1801 Formulation B

• Vehicle A

• Vehicle B

• Sites: single Australian centre

• Patients: adults: 18 ≥years with positive nasal Staph aureus

• Treatment: twice daily for 5-days

• Primary endpoints: safety and local tolerability, proportion of volunteers with Staph aureus/ MRSA carriage at Day 12

 Efficacy of ointment and gel formulations demonstrated for primary endpoint at Day 12  Eradication rates as high as 76.2% at Day 7, with eradication effects Efficacy extending through to Day 28, despite no treatment after Day 5

==> picture [112 x 50] intentionally omitted <==

2. BTX 1801 Phase 2a Clinical Study - BOT data on file

The incidence of adverse events was low, mild in severity and occurred at similar rates across the different treatment groups with no severe events reported

5

www.botanixpharma.com

Demonstrated clinical efficacy

6

Phase 2a study data: Staph aureus eradication

BTX 1801: Staph aureus eradication rates (% of participants)[1]

Study observations

==> picture [839 x 278] intentionally omitted <==

----- Start of picture text -----

80%  Significant eradication of Staph aureus 2 days after
5 day 76.2%
1 completion of treatment period
treatment
68.8%
period  Large difference between active groups / vehicle control
60%
 After 7 days of no treatment with BTX 1801 – significant %
2
of subjects maintained eradication of Staph aureus
40%
38.1%
27.8%
25.0% 23.8%  After 23 days of no treatment with BTX 1801 – significant
20% 3
16.7% 18.8% % of subjects maintained eradication of Staph aureus
12.5%
•
The BTX 1801 Phase 2a study did not include a full body chlorhexidine
0%
wash, that has been used in other clinical studies to remove bacterial
0 5 7 12 28
reservoirs in other parts of the body (that recolonize the nose)
Days • Bacterial detection was with high accuracy PCR testing rather than less
BTX 1801 Ointment BTX 1801 Gel Combined Vehicle Groups accurate culture methods
----- End of picture text -----

• After 7 days of no treatment with BTX 1801 – significant % of subjects maintained eradication of Staph aureus

After 23 days of no treatment with BTX 1801 – significant % of subjects maintained eradication of Staph aureus

• Bacterial detection was with high accuracy PCR testing rather than less accurate culture methods

==> picture [112 x 50] intentionally omitted <==

First human data demonstrating clinical utility of synthetic CBD as an antimicrobial agent

BTX 1801 Phase 2a Clinical Study Data announced 3 February 2021

www.botanixpharma.com

Demonstrated clinical efficacy

==> picture [224 x 421] intentionally omitted <==

BTX 1801 for nasal decolonisation: key takeaways

• BTX 1801 is safe and generally well tolerated

• BTX 1801 kills Staph aureus

• The bacterial killing effect can be sustained in a proportion of patients without further treatment for up to 3 weeks

• None of the analysed bacteria developed resistance to BTX 1801 during the 28 day study period

• BTX 1801 has the potential to be used as a nasal decolonisation agent for prolonged periods to prevent recolonisation over time

• Very low systemic blood levels of active drug – provides a targeted and localised effect

==> picture [112 x 50] intentionally omitted <==

Note: BTX 1801 Phase 2a Clinical Study BOT data on file.

7

www.botanixpharma.com

Target indication identified

Haemodialysis patients with central venous catheters at risk of bloodstream infections

==> picture [223 x 325] intentionally omitted <==

Significant health risks

Disease overview

• There are more than 468k[2] patients in the US currently receiving dialysis with more than 100,000 new patients added annually[3]

• Dialysis largely replicates the functions of the kidneys in patients with chronic kidney failure – haemodialysis takes over the key tasks of the kidneys, removing waste materials from the body

• the kidneys, removing waste materials from  80% of patients start haemodialysis with a the body central venous catheter which is generally

• Patients undergoing dialysis 3 times per week replaced after 12 months, by a ‘fistula’ or graft are at a high risk for bloodstream infections access port in the arm[4] due to the frequent use of catheters to access  Some studies have found that risks for central the blood stream venous catheter-related complications were

• Infection is a leading cause of death in as high as 30% and 38%, at 1 and 2 years haemodialysis patients respectively[5]

• 20% to 40% of haemodialysis patients will  The central venous catheter population eventually die from an infection[1] (approx. 160,000 patients) is responsible for more than 70% of blood infections in the total dialysis population[4]

==> picture [112 x 50] intentionally omitted <==

1. ‘Mortality in dialysis patients: analysis of the causes of death’, Mailloux LU, Bellucci AG, Wilkes BM, Napolitano B, Mossey RT, Lesser M, Bluestone PA. AJKD. 1991 Sep;18(3):326-35

2. United States Renal Data Service 2019 Annual Data Report, https://www.usrds.org/media/2371/2019-executive-summary.pdf

4. ‘Kidney Disease Statistics for the United States’, NIH, 29 April 2020, https://www.niddk.nih.gov/health information/health-statistics/kidney-disease

6. ’Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis Fisher’, M. Golestaneh, L. Allon, M. Abreo, K. and Mokrzycki, MH. CJASN January 2020, 15 (1) 132-151

7. ‘Complications From Tunneled Hemodialysis Catheters: A Canadian Observational Cohort Study’, (2019) Poinen, K. et al AJKD Volume 73 Issue 4 Pages 467-475

8

www.botanixpharma.com

Significant market opportunity

Limited preventative measure: nasal decolonisation is not widely utilised

==> picture [42 x 219] intentionally omitted <==

CDC currently focuses on the catheter site

CDC only recommends disinfecting the catheter hub with appropriate antiseptics prior to accessing it[1,2]

These antiseptics can degrade the plastic of catheters and are not widely used[3]

No topical antibiotic creams or gels are recommended for catheter sites due to fungal growth and antimicrobial resistance concerns[3]

If antiseptics enters the lumen (opening) of the catheter, they can potentially cause toxicities to the patient[2]

==> picture [282 x 183] intentionally omitted <==

Multiple publications suggest the utility of addressing nasal decolonisation to prevent bloodstream infections

==> picture [112 x 50] intentionally omitted <==

CDC recommends the use of antiseptics greater than 0.5% chlorhexidine with alcohol, 70% alcohol, or 10% povidone-iodine.

‘Hemodialysis Central Venous Catheter Scrub-the-Hub Protocol’, CDC, 2016, https://www.cdc.gov/dialysis/prevention-tools/scrub-protocols.html

O’Grady NP, Alexander M, Burns LM, et al. Guideline for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011; 52:e162-e193. CDC Guidelines for Central Venous Catheters, updated 2017

9

www.botanixpharma.com

Significant market opportunity

Potential benefits of BTX 1801 in haemodialysis: supported by previous studies using mupirocin (but never approved)

Overview

• Mupirocin was evaluated in clinical studies in the 1990s as a potential nasal decolonisation therapy in haemodialysis patients

• Studies indicate that mupirocin was able to reduce Staph aureus bloodstream infections by as much as 60% to 70% among patients undergoing haemodialysis[1]

• Despite these successful studies, mupirocin was never pursued for FDA approval for use in haemodialysis patients (and is now generic - so no incentive to try)

• In addition, mupirocin is not a suitable long-term solution for haemodialysis patients considering the levels of bacterial resistance to mupirocin (up to 95% in some hospitals[2] )

==> picture [280 x 107] intentionally omitted <==

==> picture [132 x 84] intentionally omitted <==

“Severalstudieshavedemonstratedareducedriskof[catheter relatedbloodstreaminfections]whenmupirocinointmentwas applied nasally…However, enthusiasm for this measure has been dampened by the rapid emergence of mupirocin resistance observed at some centers and the potential degrading effect that mupirocin has on polyurethane catheters.”

==> picture [112 x 50] intentionally omitted <==

1. ‘Mupirocin Prophylaxis to Prevent Staphylococcus aureus Infection in Patients Undergoing Dialysis: A Meta-analysis’ (2003) Tacconnelli, E. et al Clinical Infectious Diseases, Volume 37, Issue 12, 15 December 2003, Pages 1629–1638

2. Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus Jan 2010, Bode et al N Engl J Med 2010; 362:9-17

www.botanixpharma.com

Significant market opportunity

==> picture [224 x 424] intentionally omitted <==

Haemodialysis: population characteristics and risks of infection

==> picture [649 x 289] intentionally omitted <==

----- Start of picture text -----

 An estimated 40% to 60% of haemodialysis patients have diabetes
Weakened immune
 Diabetes is a known risk factor for developing infections, due to
system
compromised circulation and immune systems
High hospitalisation  Patient population is hospitalised on average once per year with a
rates serious bloodstream infection
 …to get a bloodstream infection from a common resistant bacteria,
100x More likely…
such as MRSA, than other people [1]
 catheter access related bloodstream infections for patients with a
8x Higher risk of… central venous catheter compared with a fistula or graft access port [2]
----- End of picture text -----

New approaches for removing sources of bacteria are urgently required

==> picture [112 x 50] intentionally omitted <==

‘‘Following CDC Protocols Cuts Dialysis Bloodstream Infection in Half’, CDC, May 2013, https://www.cdc.gov/media/releases/2013/p0513-dialysis-infections.html ‘Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis’ Fisher, M. Golestaneh, L. Allon, M. Abreo, K. and Mokrzycki, MH. CJASN January 2020, 15 (1) 132-151

11

www.botanixpharma.com

Significant market opportunity

==> picture [268 x 270] intentionally omitted <==

----- Start of picture text -----

Patients
Hospitals
----- End of picture text -----

==> picture [268 x 135] intentionally omitted <==

----- Start of picture text -----

Government
----- End of picture text -----

==> picture [112 x 50] intentionally omitted <==

Health system impact of haemodialysis infections

~US$32k

US$1bn

~60%

of Staph aureus–related Mean cost (per episode) of hospital admissions occur treating Staph within the first year of the aureus bloodstream infections, initiation of dialysis therapy[1] including re-admissions and outpatient costs[1]

Estimated annual cost of treating bacteraemia in haemodialysis patients with central venous catheters[2]

13 days Average length of stay for the index admission[1]

11.8%

of patients were readmitted within 12 weeks of hospitalisation related to Staph aureus infections[1]

‘Clinical and Economic Outcomes of Staphylococcus aureus Septicemia in ESRD Patients Receiving Hemodialysis’, Nissenson A et al, American Journal of Kidney Diseases, Vol 46, No 2 (August), 2005: pp 301-308 ‘Following CDC Protocols Cuts Dialysis Bloodstream Infection in Half’, CDC, May 2013, https://www.cdc.gov/media/releases/2013/p0513-dialysis-infections.html

12

www.botanixpharma.com

Significant market opportunity

Significant market with further upside potential

Market for nasal decolonisation of haemodialysis patients with central venous catheters

Potential to expand into other vascular access methods

==> picture [435 x 275] intentionally omitted <==

----- Start of picture text -----

An estimated ~15% to ~25% of
haemodialysis patients continue to
remain with central venous catheter
usage after the first year
Represents an additional revenue
opportunity of
~US$78m to US$130m [1]
----- End of picture text -----

==> picture [430 x 286] intentionally omitted <==

----- Start of picture text -----

~$734m
~$521m by 2030 [1]
by 2025 [1]
Market benchmarked against GSK Bactroban Nasal where the
total cost of 1 Year of treatment course costs ~$5,184 [2]
----- End of picture text -----

==> picture [112 x 50] intentionally omitted <==

1. Using GSK Bactroban Nasal Pricing/BTX 1801 pricing to be developed following analyses of potential impact on healthcare system; assumes 5% YOY pricing following product approval/launch in 2025

13

www.botanixpharma.com

1. https://www.goodrx.com/bactroban-nasal

Efficient clinical development

BTX 1801: rapid clinical development

Next Study

Phase 1 Phase 2b Safe and delivers Effective at killing Staph aureus synthetic cannabidiol over 3 months, with three times effectively weekly treatment of the nose

==> picture [433 x 85] intentionally omitted <==

Phase 2a

Phase 3

BTX 1801 effectively kills BTX 1801 is effective at killing Staph aureus after 5 days of Staph aureus for up to 12 continuous treatment months, with three times weekly treatment of the nose

FDA incentives provide accelerated development and increase exclusivity

• Extra 5 years (total of 8 years) exclusivity from generic competition

QIDP[1] generic competition status  Attractive economic benefits from FDA approval  Following IND submission, allows increased Fast track consultation with FDA status  De-risks clinical trials and accelerates

• Attractive economic benefits from FDA approval

• De-risks clinical trials and accelerates development pathway

==> picture [47 x 14] intentionally omitted <==

----- Start of picture text -----

LPAD [2]
----- End of picture text -----

• Allows smaller, fewer and / or shorter clinical trials for FDA approval

status

Botanix plans to apply for all three programs to accelerate development, reduce clinical costs and increase exclusivity

==> picture [112 x 50] intentionally omitted <==

1. QIDP: Qualified Infections Disease Product 2. LPAD: Limited Population Pathway for Antimicrobial and Antifungal Drugs

14

www.botanixpharma.com

Summary

New generation antimicrobial Novel mechanism of action rapidly kills without resistance

Demonstrated efficacy Effectively and safely achieves bacterial decolonisation

Target indication identified New indication with significant morbibity and mortality

Significant market opportunity

==> picture [46 x 39] intentionally omitted <==

Large market with significant financial burden on healthcare system

==> picture [42 x 45] intentionally omitted <==

Efficient clinical development

Streamlined pathway to FDA approval with ability to expand to other infection types

==> picture [112 x 50] intentionally omitted <==

15

www.botanixpharma.com

DISCLAIMER

Any statements in this press release about future expectations, plans and prospects for the Company, the Company’s strategy, future operations, and other statements containing the words “anticipate,” “believe,” “estimate, ”expect,” “intend,” “may,” “plan,” “predict,” “project,” “target, ”potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the Company’s ability to successfully develop its product candidates and timely complete its planned clinical programs and the Company’s ability to obtain marketing approvals for is product candidates. In addition, the forward-looking statements included in this release the views as of the date hereof. The that press represent Company’s Company anticipates subsequent events and developments will cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These statements should not be relied as the views as of date to the date forward-looking upon representing Company’s any subsequent hereof.

==> picture [112 x 50] intentionally omitted <==

16

www.botanixpharma.com

General enquiries Botanix Pharmaceuticals Corporate communications +61 8 6555 2945 investors@botanixpharma.com

==> picture [203 x 36] intentionally omitted <==

==> picture [112 x 50] intentionally omitted <==

==> picture [227 x 101] intentionally omitted <==

www.botanixpharma.com