BOTANIX PHARMACEUTICALS LTD — Director's Dealing 2026

Apr 23, 2026

Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Botanix Pharmaceuticals Ltd
ABN	70 009 109 755

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Vincent Ippolito
Date of last notice	17 April 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Direct and Indirect
Nature of indirect interest (including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	Vincent Peter Ippolito and Karen Ann Ippolito - trustee and beneficiary of the trust
Date of change	20 April 2026
No. of securities held prior to change	Vincent Peter Ippolito
16,000,000 Performance Rights (expiring 2 December 2029)
Vincent Peter Ippolito and Karen Ann Ippolito - trustee and beneficiary of the trust
16,668,311 Fully Paid Ordinary Shares
Class	Unquoted options exercisable at $0.06, expiring on 31 January 2027
Number acquired	1,666,667
Number disposed	Nil
Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation	Nil – Corresponding offer of options alongside participation in Share placement

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| No. of securities held after the change | Vincent Peter Ippolito
16,000,000 Performance Rights (expiring 2 December 2029)

Vincent Peter Ippolito and Karen Ann Ippolito - trustee and beneficiary of the trust
16,668,311 Fully Paid Ordinary Shares

1,666,667 unquoted options exercisable at $0.06, expiring on 31 January 2027 |
| --- | --- |
| Nature of change
Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back | Corresponding grant of options alongside Director participation in Tranche 2 of the Placement, following shareholder approval granted at a general meeting held on 1 April 2026. |

Part 2 – Change of director’s interests in contracts – N/A

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder (if issued securities)	N/A
Date of change	N/A
No. and class of securities to which interest related prior to change
Note: Details are only required for a contract in relation to which the interest has changed	N/A
Interest acquired	N/A
Interest disposed	N/A
Value/Consideration
Note: If consideration is non-cash, provide details and an estimated valuation	N/A
Interest after change	N/A

Part 3 – ${}^{+}$ Closed period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	Yes
If so, was prior written clearance provided to allow the trade to proceed during this period?	Yes. Subscription for shares under the Placement was approved by the Board and shareholders.
If prior written clearance was provided, on what date was this provided?	7 March 2026

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Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity	Botanix Pharmaceuticals Ltd
ABN	70 009 109 755

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Dr Henry William Bosch
Date of last notice	17 April 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest (including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	N/A
Date of change	20 April 2026
No. of securities held prior to change	20,503,369 Fully Paid Ordinary Shares
3,000,000 Performance Rights (expiring 2 December 2029)
Class	Unquoted options exercisable at $0.06, expiring on 31 January 2027
Number acquired	1,666,667
Number disposed	Nil
Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation	Nil – Corresponding offer of options alongside participation in Share placement
No. of securities held after change	20,503,369 Fully Paid Ordinary Shares
3,000,000 Performance Rights (expiring 2 December 2029)
1,666,667 unquoted options exercisable at $0.06, expiring on 31 January 2027

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Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	Corresponding grant of options alongside Director participation in Tranche 2 of the Placement, following shareholder approval granted at a general meeting held on 1 April 2026.

Part 2 – Change of director's interests in contracts – N/A

Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part.

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder (if issued securities)	N/A
Date of change	N/A
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed	N/A
Interest acquired	N/A
Interest disposed	N/A
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation	N/A
Interest after change	N/A

Part 3 – ${}^{+}$ Closed period

Were the interests in the securities or contracts detailed above traded during a ( {}^{ + } ) closed period where prior written clearance was required?	Yes
If so, was prior written clearance provided to allow the trade to proceed during this period?	Yes. Subscription for shares under the Placement was approved by the Board and shareholders.
If prior written clearance was provided, on what date was this provided?	7 March 2026

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Appendix 3Y
Change of Director's Interest Notice
Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

Name of entity	Botanix Pharmaceuticals Ltd
ABN	70 009 109 755

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Daniel Sharp
Date of last notice	17 April 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Indirect
Nature of indirect interest (including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	DJMB Corporate Pty Ltd -
Mr Sharp is a director of DJMB Corporate Pty Ltd
Mr Sharp is a beneficiary
Date of change	20 April 2026
No. of securities held prior to change	DJMB Corporate Pty Ltd - Mr Sharp is a director of DJMB Corporate Pty Ltd
2,131,313 Fully Paid Ordinary Shares
4,000,000 Unlisted Options exercisable at 0.094 each, expiring 22 March 2025
333,333 Performance Rights (expiring 30 November 2026)
3,000,000 Performance Rights (expiring 2 December 2029)
Mr Sharp is a beneficiary
833,333 Fully Paid Ordinary Shares

• See chapter 19 for defined terms.

Appendix 3Y Page 1

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Appendix 3Y

Change of Director's Interest Notice

Class	Unquoted options exercisable at $0.06, expiring on 31 January 2027
Number acquired	833,333
Number disposed	Nil
Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation	Nil – Corresponding offer of options alongside participation in Share placement
No. of securities held after change	DJMB Corporate Pty Ltd - Mr Sharp is a director of DJMB Corporate Pty Ltd
2,131,313 Fully Paid Ordinary Shares
4,000,000 Unlisted Options exercisable at 0.094 each, expiring 22 March 2025
333,333 Performance Rights (expiring 30 November 2026)
3,000,000 Performance Rights (expiring 2 December 2029)
Mr Sharp is a beneficiary
833,333 Fully Paid Ordinary Shares
833,333 unquoted options exercisable at $0.06, expiring on 31 January 2027
Nature of change
Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	Corresponding grant of options alongside Director participation in Tranche 2 of the Placement, following shareholder approval granted at a general meeting held on 1 April 2026.

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder (if issued securities)	N/A
Date of change	N/A
No. and class of securities to which interest related prior to change
Note: Details are only required for a contract in relation to which the interest has changed	N/A

• See chapter 19 for defined terms.

Appendix 3Y Page 2

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Appendix 3Y
Change of Director's Interest Notice

Interest acquired	N/A
Interest disposed	N/A
Value/Consideration
Note: If consideration is non-cash, provide details and an estimated valuation	N/A
Interest after change	N/A

Part 3 Closed Period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	Yes
If so, was prior written clearance provided to allow the trade to proceed during this period?	Yes. Subscription for shares under the Placement was approved by the Board and shareholders.
If prior written clearance was provided, on what date was this provided?	7 March 2026

• See chapter 19 for defined terms.

Appendix 3Y Page 3

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Appendix 3Y
Change of Director's Interest Notice
Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

Name of entity	Botanix Pharmaceuticals Ltd
ABN	70 009 109 755

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Dr Patricia Walker
Date of last notice	17 April 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Direct
Nature of indirect interest (Including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	N/A
Date of change	20 April 2026
No. of securities held prior to change	1,666,667 Fully Paid Ordinary Shares
1,000,000 unquoted options exercisable at $0.145, expiring on 22 August 2026
4,000,000 unquoted options exercisable at $0.19, expiring on 22 August 2028
4,000,000 unquoted options exercisable at $0.28, expiring on 12 July 2027
Class	Unquoted options exercisable at $0.06, expiring on 31 January 2027
Number acquired	1,666,667
Number disposed	Nil

• See chapter 19 for defined terms.

Appendix 3Y Page 1

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Appendix 3Y

Change of Director's Interest Notice

Value/Consideration Note: If consideration is non-cash, provide details and estimated valuation	Nil – Corresponding offer of options alongside participation in Share placement
No. of securities held after change	1,666,667 Fully Paid Ordinary Shares 1,000,000 unquoted options exercisable at $0.145, expiring on 22 August 2026 4,000,000 unquoted options exercisable at $0.19, expiring on 22 August 2028 4,000,000 unquoted options exercisable at $0.28, expiring on 12 July 2027 1,666,667 unquoted options exercisable at $0.06, expiring on 31 January 2027
Nature of change Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back	Corresponding grant of options alongside Director participation in Tranche 2 of the Placement, following shareholder approval granted at a general meeting held on 1 April 2026.

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder (if issued securities)	N/A
Date of change	N/A
No. and class of securities to which interest related prior to change Note: Details are only required for a contract in relation to which the interest has changed	N/A
Interest acquired	N/A
Interest disposed	N/A
Value/Consideration Note: If consideration is non-cash, provide details and an estimated valuation	N/A
Interest after change	N/A

• See chapter 19 for defined terms.

Appendix 3Y Page 2

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Appendix 3Y
Change of Director's Interest Notice

Part 3 Closed Period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	Yes
If so, was prior written clearance provided to allow the trade to proceed during this period?	Yes. Subscription for shares under the Placement was approved by the Board and shareholders.
If prior written clearance was provided, on what date was this provided?	7 March 2026

• See chapter 19 for defined terms.

Appendix 3Y Page 3

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Appendix 3Y
Change of Director's Interest Notice
Rule 3.19A.2

Appendix 3Y

Change of Director's Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX's property and may be made public.

Introduced 30/9/2001.

Name of entity	Botanix Pharmaceuticals Ltd
ABN	70 009 109 755

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Stewart Washer
Date of last notice	17 April 2026

Part 1 - Change of director's relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part.

Direct or indirect interest	Indirect
Nature of indirect interest (Including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.	Dr Stewart James Washer + Dr Patrizia Derna Washer "
Date of change	20 April 2026
No. of securities held prior to change	Dr Stewart James Washer + Dr Patrizia Derna Washer - Dr Washer is a trustee and beneficiary of the trust.
• 654,884 Fully Paid Ordinary Shares
• 5,000,000 Unlisted Options exercisable at 0.102 each, expiring 22 March 2025
• 333,333 Performance Rights (expiring 30 November 2026) *
• 3,000,000 Performance Rights (expiring 2 December 2029)
Mal Washer Nominees Pty Ltd - Dr Washer is a Director.
• 1,515,151 Fully Paid Ordinary Shares

• See chapter 19 for defined terms.

Appendix 3Y Page 1

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Appendix 3Y

Change of Director's Interest Notice

| | Dr Stewart James Washer + Dr Patrizia Derna Washer - Dr Washer is a trustee and beneficiary of the trust.
• 1,666,667 Fully Paid Ordinary Shares |
| --- | --- |
| Class | Unquoted options exercisable at $0.06, expiring on 31 January 2027 |
| Number acquired | 1,666,667 |
| Number disposed | Nil |
| Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation | Nil – Corresponding offer of options alongside participation in Share placement |
| No. of securities held after change | Dr Stewart James Washer + Dr Patrizia Derna Washer - Dr Washer is a trustee and beneficiary of the trust.
• 654,884 Fully Paid Ordinary Shares
• 5,000,000 Unlisted Options exercisable at 0.102 each, expiring 22 March 2025
• 333,333 Performance Rights (expiring 30 November 2026) *
• 3,000,000 Performance Rights (expiring 2 December 2029)
Mal Washer Nominees Pty Ltd - Dr Washer is a Director.
• 1,515,151 Fully Paid Ordinary Shares
Dr Stewart James Washer + Dr Patrizia Derna Washer - Dr Washer is a trustee and beneficiary of the trust.
1,666,667 Fully Paid Ordinary Shares
1,666,667 unquoted options exercisable at $0.06, expiring on 31 January 2027 |
| Nature of change
Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back | Corresponding grant of options alongside Director participation in Tranche 2 of the Placement, following shareholder approval granted at a general meeting held on 1 April 2026. |

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

• See chapter 19 for defined terms.

Appendix 3Y Page 2

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Appendix 3Y
Change of Director's Interest Notice

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder (if issued securities)	N/A
Date of change	N/A
No. and class of securities to which interest related prior to change
Note: Details are only required for a contract in relation to which the interest has changed	N/A
Interest acquired	N/A
Interest disposed	N/A
Value/Consideration
Note: If consideration is non-cash, provide details and an estimated valuation	N/A
Interest after change	N/A

Part 3 Closed Period

Were the interests in the securities or contracts detailed above traded during a +closed period where prior written clearance was required?	Yes
If so, was prior written clearance provided to allow the trade to proceed during this period?	Yes. Subscription for shares under the Placement was approved by the Board and shareholders.
If prior written clearance was provided, on what date was this provided?	7 March 2026

• See chapter 19 for defined terms.

Appendix 3Y Page 3