BOTANIX PHARMACEUTICALS LTD — Capital/Financing Update 2023

Jul 26, 2023

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27 July 2023

ASX Market Announcements Office ASX Compliance Pty Ltd Level 40, Central Park 152-158 St Georges Terrace Perth WA 6000

Dear Sir/Madam,

NOTICE UNDER SECTION 708A(5)(e) OF THE CORPORATIONS ACT 2001 (CTH)

Botanix Pharmaceuticals Limited (ASX: BOT, Botanix or the Company ) advises that it today issued 104,166,667 new fully paid ordinary shares ( New Shares ) at an issue price of $0.12 each under the placement announced to ASX on 21 July 2023.

The Company hereby provides notification under section 708A(5)(e) of the Corporations Act 2001 (Cth) ( Corporations Act ) of the issue of the New Shares. The Corporations Act restricts the on-sale of securities issued without disclosure unless the sale is exempt under section 708 or 708A of the Corporations Act. By the Company giving this notice ( Notice ), a sale of the New Shares will fall within the exemption in section 708A(5) of the Corporations Act and they will be able to be traded immediately.

For the purposes of section 708A(6) of the Corporations Act, the Company gives notice that:

• (a) the Company issued the New Shares without disclosure to investors under Part 6D.2 of the Corporations Act;

• (b) this Notice is being given under section 708A(5)(e) of the Corporations Act;

• (c) as at the date of this Notice, the Company has complied with:

  • (i) the provisions of Chapter 2M of the Corporations Act as they apply to the Company; and

  • (ii) sections 674 and 674A of the Corporations Act; and

• (d) as at the date of this Notice, there is no excluded information, within the meanings of section 708A(7) and 708A(8) of the Corporations Act.

By order of the Board

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Susan Park Company Secretary

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Release authorised by the Board of Directors.

About Botanix Pharmaceuticals

Botanix Pharmaceuticals Limited (ASX:BOT) is a dermatology company based in Philadelphia and Phoenix (US) which is committed to the development of novel treatments for a range of common skin diseases. The Company has a mature dermatology pipeline with its first product, Sofpironium Bromide, for the treatment of primary axillary hyperhidrosis, filed for FDA approval in Q3 CY2022 with approval expected in Q3 2023. The Company also has a pipeline of other products in late-stage clinical studies for the treatment of moderate to severe rosacea (successful Phase 1b/2 study in 4Q 2022), dermatitis and acne respectively. Botanix is also developing a topical antimicrobial product for the eradication of bacteria on the skin surface, initially in patients who are undergoing hemodialysis.

Botanix leverages its proprietary drug delivery system (Permetrex[TM] ) for direct skin delivery of active pharmaceuticals in all skin diseases, which is utilised in its existing development programs and is being explored with a view to being utilized in a number of other product opportunities. To learn more please visit: http://www.botanixpharma.com/

For more information, please contact:

General enquiries Investor enquiries Corporate Communications Hannah Howlett Botanix Pharmaceuticals WE Communications P: +61 8 6555 2945 P: +61 450 648 064 investors@botanixpharma.com hhowlett@we-worldwide.com

Media enquiries Haley Chartres H^CK P: +61 423 139 163 haley@hck.digital

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