Biorem Inc. — Proxy Solicitation & Information Statement 2022

May 25, 2022

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TSX TRUST COMPANY

VIA ELECTRONIC TRANSMISSION

May 24, 2022

TO ALL APPLICABLE EXCHANGES AND COMMISSIONS:

RE: BIOREM INC

We are pleased to confirm that copies of the following proxy-related materials were mailed on May 20, 2022 to the Registered Securityholders:

1 Proxy

2 Notice of Meeting Combined with Information Circular

3 Virtual Meeting Guide Form

4 Proxy Return Envelope

Yours truly,

TSX Trust Company

''Kieran Webb'' Senior Relationship Manager kieran.webb@tmx.com

VANCOUVER

650 West Georgia Street, Suite 2700 Vancouver, BC V6B 4N9

T 604 689-3334

CALGARY

300-5th Avenue SW, 10th floor Calgary, AB T2P 3C4

MONTRÉAL

TORONTO

301 - 100 Adelaide Street West 1800 - 1190, avenue des Toronto ON M5H 4H1 Canadiens-de-Montréal, C. P. 37 Montréal (Québec) H3B 0G7

Toll Free 1-866-600-5869 T 416 361-0930

T 514 395-5964

T 403 218-2800