Biorem Inc. — Proxy Solicitation & Information Statement 2026

May 13, 2026

TMX THE FUTURE IS YOURS TO SEE.

TSX TRUST COMPANY

VIA ELECTRONIC TRANSMISSION

May 13, 2026

TO ALL APPLICABLE EXCHANGES AND COMMISSIONS:

RE: BIOREM INC.

We are pleased to confirm that copies of the following proxy-related materials were mailed on May 12, 2026 to the Registered Securityholders and to the Non-Objecting Beneficial Owners ("NOBO"):

1. Proxy with Request for Financial Statements - Registered Securityholders
2. Voting Instruction Form with Request for Financial Statements - NOBOs
3. Notice of Meeting Combined with Information Circular
4. Virtual Meeting Guide Form
5. Proxy Return Envelope

Yours truly,

TSX Trust Company

VANCOUVER

2310 - 733 Seymour Street, Vancouver, BC V6B 0S6

T 604 689-3334

CALGARY

300-5th Avenue SW, 10th floor Calgary, AB T2P 3C4

T 403 218-2800

TORONTO

301 - 100 Adelaide Street West Toronto ON M5H 4H1

Toll Free 1-866-600-5869

T 416 361-0930

MONTRÉAL

1800 - 1190, avenue des Canadiens-de-Montréal, C. P. 37 Montréal (Québec) H3B 0G7

T 514 395-5964