Biorem Inc. — AGM Information 2021

Mar 31, 2021

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TSX TRUST COMPANY

VIA ELECTRONIC TRANSMISSION

March 31, 2021

TO ALL APPLICABLE EXCHANGES AND COMMISSIONS:

RE: BIOREM INC Confirmation of Notice of Record and Meeting Dates

We are pleased to confirm that Notice of Record and Meeting Dates was sent to The Canadian Depository for Securities.

We advise the following with respect to the upcoming Annual General Meeting of Security Holders for the subject issuer:

1 ISIN: CA09068G1046 CUSIP: 09068G104 2 Date Fixed for the Meeting: June 15, 2021 3 Record Date for Notice: April 26, 2021 4 Record Date for Voting: April 26, 2021 5 Beneficial Ownership Determination Date: April 26, 2021 6 Classes or Series of Securities that entitle COMMON the holder to receive Notice of the Meeting: 7 Classes or Series of Securities that entitle COMMON the holder to vote at the meeting: 8 Business to be conducted at the meeting: Annual General 9 Notice-and-Access: Registered Shareholders: NO Beneficial Holders: NO Stratification Level: Not Applicable 10 Reporting issuer is sending proxy-related materials directly to Non-Objecting Beneficial Owners: NO 11 Issuer paying for delivery to Objecting Beneficial Owners: NO

Yours truly, TSX Trust Company

• " Kieran Webb " Relationship Manager kieran.webb@tmx.com

VANCOUVER

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