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Capital/Financing Update • Jan 31, 2024

Half-year liquidity contract statement for Valerio Therapeutics

Paris (France), January 25, 2024 – Valerio Therapeutics S.A. (Euronext Growth Paris: ALVIO)

Under the liquidity contract entered into between Valerio Therapeutics and Kepler Cheuvreux, the following resources appeared on the liquidity account on December 31st 2023:

• 368,174 shares
• € 144,918.05
• Number of executions on buy side on semester: 324
• Number of executions on sell side on semester: 244
• Traded volume on buy side on semester: 304,205 shares for € 69,976.87
• Traded volume on sell side on semester: 223,191 shares for € 56,117.81

As a reminder :

• the following resources appeared on the last half year statement on 30 June 2023 on the liquidity account:
• 287,160 shares
• € 156,554.06
• Number of executions on buy side on semester: 509
• Number of executions on sell side on semester: 492
• Traded volume on buy side on semester: 634,648 shares for € 258,705.74
• Traded volume on sell side on semester: 923,185 shares for € 402,719.91
• the following resources appeared on the liquidity account when the activity started:
• 87,612 shares
• € 196,423.24

The implementation of this report is carried out in accordance with AMF Decision N°2021-01 of June 22nd 2021 renewing the implementation of liquidity contracts for shares as an accepted market practice.