Matricelf Ltd.

Investor Presentation • Feb 14, 2023

Autologous 3D Engineered Tissues

(TASE:MTLF) Corporate Presentation February 2023

Statement Looking Forward and Disclosure

This presentation was prepared by Matricelf Ltd. ("The Company"), as a general presentation about The Company, as such, the information it includes is only an extract, and does not cover all of the information about The Company and its operations. Therefore, this presentation does not describe The Company's operations fully and detail, and it is not intended to replace the need to review The Company's reports to the public, including the supplementary prospectus of The Company. The information included in this presentation does not purport to survey or include all of the information that could be relevant for the purpose of reaching any conclusion related to investment in the securities of The Company. The Company is also not obligated to update or change the information included in the presentation so that it reflects events or editing, processing or segmentation that differ from the current depiction in the presentation, or change that take the place after the date of its preparation. This presentation includes forward looking information, as defined in the Securities Law 1968 including outlooks, evaluations, estimates and other information related to the events and matters that will take place or may take place in the future, including with regard to the outlook on income and profitability, whose occurrence is not certain and is not under the exclusive control of The Company. Forward looking in the presentation is based on estimates and assumptions of the management of The Company as of the date of that presentation was prepared, which are uncertain by their nature, due to their dependence on the risks inherent in The Company's operations, and which are not under The Company's control, each of which, or a combination thereof, is liable to harm the results of The Company and, consequentially, the realization of this estimates and outlook. The presentation includes statistical data and publications that were published by third parties, the content of which was not examined by The Company, and The Company is not responsible for their validity. The information included in the presentation does not constitute a proposal or invitation to make an offer to purchase The Company's securities.

Company Vision

Curing the Incurable

Innovative regenerative medicine company,

helping millions of patients worldwide

Matricelf Introduction

• Regenerative Medicine company
• Developing 3D engineered tissue implants
• Spin-out company from Tel Aviv University (Dvir Lab, Nanotechnology Center: more than 10 years of academic research & USD ~12M in research grants)
• Established April 2019

Proprietary Technologies

Autologous 3D implants:

• Integration of autologous matrix and cells
  • Matrix Thermo-responsive autologous hydrogel
  • Cells In-gel differentiation of autologous induced Pluripotent Stem Cells (iPSC)
• Engineered tissues for numerous medical indications

3D bioprinting of tissues and organs:

• Proprietary medium for 3D printing of biomaterials
• Enables biocompatible structuring of volumetric tissues and organs

Spinal Cord Injury (SCI)

SCI Program Highlights

Unmet need • No available treatment for SCI - irreversible loss of motor/sensory/autonomic functions

• • Most potential therapies are synthetic/allogeneic which may lead to immune rejection
• Our solution • 100% autologous tissue engineered product

opportunity

timelines

• Personalized treatment, reduced potential immune response
• Market and • Approximately 17,000 new SCI cases per year in the US
  • ~300,000 SCI patients in the US today
  • Huge economic impact on society and healthcare systems
• Regulation Classification: Advanced Therapy Medicinal Product (ATMP)
  • Pre-IND meeting with FDA, March 2021

Status and • Current status – R&D, preclinical studies, feasibility trials in mice - completed

• First in Human (FIH) clinical trial – 2025, Israel

Matricelf Platform Genetares Autologous Functioning 3D Neural Implants for SCI

Functional Neural Implant

• ✓ Incorporation of iPSCs within extracellular matrix followed by controlled differentiation
• ✓ New synapses and neurons generate a neural network
• ✓ Matured 3D tissue formed

Neural Implants Restore Function

• Follow up: 2 months post spinal hemisection in mice
• "Cat walk" four limbs motor function and gait analysis
• Control group hemiparesis (circled in red)
• Mice treated with neural implants regained their walking abilities

Lior Wertheim, Adv. Sci. 2022

Control

Competitive Therapeutic Landscape

Matricelf develops a one-of-a-kind technology that produces functioning, completely autologous, 3D neural implants

Company Roadmap

Key Achievements: 2022

• ✓ Development of human hydrogel
• ✓ Development of human iPSC lines
• ✓ Development of human neural implant
• ✓ Usability study in pigs in collaboration with Johns Hopkins Medical school
• ✓ Three granted patents, two new patents application submitted
• ✓ Completed technology transfer of 3D bioprinting support medium from Tel Aviv University to Matricelf
• ✓ MTA with a multinational technology corporation 3D bioprinting support medium to explore future cooperation
• ✓ PIPE on TASE for ~ USD 6M

Projected Milestones: 2023

• Completion of pilot efficacy study
• Completion of pilot safety study
• Completion of formulation development
• Initiation of POC efficacy study
• Pipeline broadening New indication

The Team

ASAF TOKER, MD

CEO

TAL BEN NERIAH, MSc VP of Operations

TAL DVIR, PhD Founder, CSO

SIGAL RUSSO, CPA

CFO

TAMAR HAREL ADAR, PhD VP R&D

ALON SINAI

Founder, Deputy CEO

Board of Directors

DORON BIRGER

Chairman

RUTH ARNON, PhD Board member

TAL DVIR, PhD Board member

NEOMI ENOCH, CPA Board member

STANLEY HIRSCH, PhD Board member

SUZANA NAHUM-ZILBERBERG, CPA

Board member

ALON SINAI Board member

Scientific Advisory Board

KAPIL BHARTI, PhD

Senior researcher at the National Institutes of Health ("NIH"), an expert in the use of induced pluripotent stem cells (iPSC) in regenerative medicine and the development of cellular therapies.

NICHOLAS THEODORE, MD

Professor of Neurosurgery and the Director of the Johns Hopkins Neurosurgical Spine Center.

ECKHARD VON KEUTZ, PhD

Chairman of the Advisory Board of the Fraunhofer Institute of Toxicology and Experimental Medicine Member of the Executive Council at Center of Healthcare Innovation (US); Member of the Industrial Advisory Board (IAB) of the European Organ-on-Chip Society (EUROoCS).

Sr. Director of Business Development at Stryker Spine.

MARK TUSZYNSKI, MD PhD

Director of The Center for Neural Repair, University of California, San Diego

BROCK REEVE, PhD

Advisor to the Petit Institute at Georgia Tech University and on the Board of the Pioneer Charter School of Science in Everett, MA.

Summary
Unique advantages	• Autologous treatment
	• 3D engineered tissue implants (cells and matrix)
	• Cell/iPSC differentiation within a 3D structure
	• Support medium enabling 3D bioprinting
Main programs	• Spinal Cord Injury (SCI)
	• 3D bioprinting
IP status	• 3 granted patents, 7 pending applications, extensive knowhow
Market opportunity	• Address unmet medical need in a multibillion-dollar market
Financial position	• NIS ~33 million in cash and cash equivalents as of December 31st, 2022
Market capitalization	• NIS ~75 million as of December 31st, 2022

Watch our corporate video at:

https://youtu.be/XUGfveypuAs

Thank you www.matricelf.com info@matricelf.com