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Grifols S.A.

Annual / Quarterly Financial Statement Feb 28, 2019

1834_10-k_2019-02-28_9281ab39-dbb3-4860-9656-33bc9afa54b3.pdf

Annual / Quarterly Financial Statement

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Impairment of Goodwill
See note 7 to the consolidated annual accounts
Key Audit Matter How the Matter was Addressed in Our Audit
The Group has recognised goodwill allocated to
the corresponding cash generating units (CGU)
of Euros 5,209,230 thousand.
The Group calculates the recoverable amount
of goodwill on an annual basis to determine
whether they have been impaired.
These recoverable amounts are determined by
applying valuation techniques which require
judgement by the Directors and the use of
assumptions and estimates in relation to the
financial projections and cash flow discounts
used.
Due to the high level of judgement, the
uncertainty associated with these estimates
and the significance of the carrying amount of
these goodwill, this has been considered a key
matter of our audit for the current year.
Our audit procedures comprised the following:
assessing the design and implementation of
$\bullet$
the controls linked to the process of
evaluating the impairment of goodwill.
assessing the reasonableness of the
۰
methodology used to calculate the
recoverable amount and the main
assumptions, with the involvement of our
valuation specialists.
comparing the coherence of the estimates
$\bullet$
of growth of future cash flows of each CGU
included in the calculation of recoverable
amount with the business plans approved
by the Group's governing bodies. We have
also compared the cash flow forecasts of
the cash generating units estimated in prior
years with the actual cash flows obtained.
assessing the sensitivity to reasonably
$\bullet$
possible changes in certain assumptions.
evaluating whether the disclosures in the
$\bullet$
consolidated annual accounts meet the
requirements of the financial reporting
framework applicable to the Group.

Consolidated Annual Accounts

31 December 2018 and 2017

SUMMARY

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Consolidated financial statements

  • Consolidated Balance Sheets
  • Consolidated Statement of Profit or Loss
  • Consolidated Statements of Comprehensive Income
  • Consolidated Statements of Cash Flows
  • Consolidated Statements of Changes in Equity

Notes

  • (1) Nature, Principal Activities and Subsidiaries
  • (2) Basis of Presentation
  • (3) Business Combinations
  • (4) Significant Accounting Policies
  • (5) Financial Risk Management Policy
  • (6) Segment Reporting
  • (7) Goodwill
  • (8) Other Intangible Assets
  • (9) Property, Plant and Equipment
  • (10) Equity Accounted Investees
  • (11) Financial Assets
  • (12) Inventories
  • (13) Trade and Other Receivables
  • (14) Cash and Cash Equivalents
  • (15) Equity
  • (16) Earnings per Share
  • (17) Non-Controlling Interests
  • (18) Grants
  • (19) Provisions
  • (20) Financial Liabilities
  • (21) Trade and Other Payables
  • (22) Other Current Liabilities
  • (23) Net Revenues
  • (24) Personnel Expenses
  • (25) Expenses by Nature
  • (26) Finance Result
  • (27) Taxation
  • (28) Operating Leases
  • (29) Other Commitments with Third Parties and Other Contingent Liabilities
  • (30) Financial Instruments
  • (31) Balances and Transactions with Related Parties
  • (32) Environmental Issues
  • (33) Other Information

Consolidated Annual Accounts

31 December 2018 and 2017

SUMMARY

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Appendices

  • Appendix I Information on Group Companies, Associates and Others
  • Appendix II Operating Segments
  • Appendix III Changes in Other Intangible Assets
  • Appendix IV Movement in Property, Plant and Equipment
  • Appendix V Statement of Liquidity for Distribution of Interim Dividend

Consolidated Balance Sheets

at 31 December 2018 and 2017

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Assets 31/12/18 31/12/17
Goodwill (note 7) 5,209,230 4,590,498
Other intangible assets (note 8) 1,385,537 1,269,342
Property, plant and equipment (note 9) 1,951,983 1,760,053
Investments in equity-accounted investees (note 10) 226,905 219,009
Non-current financial assets
Non-current financial assets measured at fair value 7 47,046
Non-current financial assets not measured at fair value 107,594 22,843
Total non-current financial assets (note 11) 107,601 69,889
Deferred tax assets (note 27) 112,539 66,157
Total non-current assets 8,993,795 7,974,948
Inventories (note 12) 1,949,360 1,629,293
Trade and other receivables
Trade receivables 269,167 286,198
Other receivables 92,418 40,681
Current income tax assets 42,205 59,531
Trade and other receivables (note 13) 403,790 386,410
Other current financial assets (note 11)
Current financial assets measured at fair value 19,934 0
Current financial assets not measured at fair value 34,031 10,738
Total current financial assets (note 11) 53,965 10,738
Other current assets 42,344 32,354
Cash and cash equivalents (note 14) 1,033,792 886,521
Total current assets 3,483,251 2,945,316
Total assets 12,477,046 10,920,264

Consolidated Balance Sheets

at 31 December 2018 and 2017

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Equity and liabilities 31/12/18 31/12/17
Share capital 119,604 119,604
Share premium 910,728 910,728
Reserves 2,441,931 2,027,648
Treasury stock (55,441) (62,422)
Interim dividend (136,747) (122,986)
Profit for the year attributable to the Parent 596,642 662,700
Total equity 3,876,717 3,535,272
Available for sale financial assets -- 4,926
Other comprehensive Income (554) (656)
Translation differences 349,391 89,537
Other comprehensive expenses 348,837 93,807
Equity attributable to the Parent (note 15) 4,225,554 3,629,079
Non-controlling interests (note 17) 471,050 4,886
Total equity 4,696,604 3,633,965
Liabilities
Grants (note 18) 11,845 11,822
Provisions (note 19) 6,114 5,763
Non-current financial liabilities (note 20) 6,099,463 5,901,815
Other non-current liabilities 1,301 --
Deferred tax liabilities (note 27) 404,398 388,912
Total non-current liabilities 6,523,121 6,308,312
Provisions (note 19) 80,055 106,995
Current financial liabilities (note 20) 277,382 155,070
Current debts with related companies 7,079 --
Trade and other payables
Suppliers
561,883 423,096
Other payables 159,816 141,720
Current income tax liabilities 1,917 6,709
Total trade and other payables (note 21) 723,616 571,525
Other current liabilities (note 22) 169,189 144,397
Total current liabilities 1,257,321 977,987
Total liabilities 7,780,442 7,286,299
Total equity and liabilities 12,477,046 10,920,264

for the years ended 31 December 2018, 2017 and 2016 Consolidated Statements of Profit and Loss

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/18 31/12/17 31/12/16
Continuing Operations
Net revenue (notes 6 and 23) 4,486,724 4,318,073 4,049,830
Cost of sales (2,437,164) (2,166,062) (2,137,539)
Gross Profit 2,049,560 2,152,011 1,912,291
Research and Development (240,661) (288,320) (197,617)
Selling, General and Administration expenses (814,775) (860,348) (775,266)
Operating Expenses (1,055,436) (1,148,668) (972,883)
Operating Result 994,124 1,003,343 939,408
Finance income 13,995 9,678 9,934
Finance costs (293,273) (263,344) (244,829)
Change in fair value of financial instruments -- (3,752) (7,610)
Impairment and gains /(losses) on disposal of financial
instruments
30,280 (18,844) --
Exchange differences (8,246) (11,472) 8,916
Finance result (note 26) (257,244) (287,734) (233,589)
Share of losses of equity accounted investees (note 10) (11,038) (19,887) 6,933
Profit before income tax from continuing operations 725,842 695,722 712,752
Income tax expense (note 27) (131,436) (34,408) (168,209)
Profit after income tax from continuing operations 594,406 661,314 544,543
Consolidated profit for the year 594,406 661,314 544,543
Profit attributable to the Parent 596,642 662,700 545,456
Loss attributable to non-controlling interest (note 17) (2,236) (1,386) (913)
Basic earnings per share (Euros) (see note 16) 0.87 0.97 0.80
Diluted earnings per share (Euros) (see note 16) 0.87 0.97 0.80

Consolidated Statements of Comprehensive Income

for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/18 31/12/17 31/12/16
Consolidated profit for the year 594,406 661,314 544,543
Items for reclassification to profit or loss
Translation differences 268,557 (532,389) 103,833
Translation differences / Cash Flow Hedge -- -- (6,809)
Available for sale financial Assets -- 10,145 (5,219)
Equity accounted investees (note 10) / Translation differences (9,270) (27,134) 10,671
Cash flow hedges - effective part of changes in fair value -- -- 14,501
Cash flow hedges - amounts taken to profit or loss -- -- (7,426)
Other comprehensive income 102 (14) (4,810)
Tax effect -- -- (2,462)
Other comprehensive income for the year, after tax 259,389 (549,392) 102,279
Total comprehensive income for the year 853,795 111,922 646,822
Total comprehensive income attributable to the Parent 856,598 113,441 647,667
Total comprehensive expense attributable to the non-controlling interests (2,803) (1,519) (845)

Consolidated Statements of Cash Flows for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/2018 31/12/2017 31/12/2016
Cash flows from operating activities
Profit before tax 725,842 695,722 712,752
Adjustments for: 454,378 556,792 391,986
Amortization and depreciation (note 25) 228,609 215,490 201,869
Other adjustments: 225,769 341,302 190,117
(Profit) / losses on equity accounted investments (note 10) 11,038 19,888 (6,933)
Impairment of assets and net provision charges (23,657) 66,047 (23,079)
(Profit) / losses on disposal of fixed assets (note 8 and 9) (6,700) 1,551 (2,987)
Government grants taken to income (note 18) (1,166) (286) (1,681)
Finance cost / (income) 232,962 263,657 236,034
Other adjustments 13,292 (9,555) (11,237)
Change in operating assets and liabilities (112,639) (65,800) (164,319)
Change in inventories (231,670) (165,508) (173,003)
Change in trade and other receivables (13,141) 80,112 (25,180)
Change in current financial assets and other current assets (3,092) (2,691) (2,610)
Change in current trade and other payables 135,264 22,287 36,474
Other cash flows used in operating activities (330,153) (344,968) (387,141)
Interest paid (225,146) (207,079) (180,497)
Interest recovered 6,862 9,492 8,685
Income tax (paid) / received (111,585) (147,015) (215,329)
Other recovered (paid) (284) (366) --
Net cash from operating activities 737,428 841,746 553,278
Cash flows from investing activities
Payments for investments (852,536) (2,209,667) (509,078)
Group companies, associates and business units (notes 3, 2 (b) and 10) (524,081) (1,857,210) (202,727)
Property, plant and equipment and intangible assets (307,722) (322,973) (292,690)
Property, plant and equipment (231,983) (251,507) (249,416)
Intangible assets (75,739) (71,466) (43,274)
Other financial assets (20,733) (29,484) (13,661)
Proceeds from the sale of investments 70,669 23,787 2,426
Property, plant and equipment 550 762 2,426
Other financial assets 70,119 23,025 --
Net cash used in investing activities (781,867) (2,185,880) (506,652)
Cash flows from financing activities
Proceeds from and payments for equity instruments -- -- (11,766)
Payments for treasury stock (note 15 (d)) -- -- (12,686)
Sales of treasury stock (note 15 (d)) -- -- 920
Proceeds from and payments for financial liability instruments 37,418 1,808,771 (80,149)
Issue 179,350 1,912,615 81,513
Redemption and repayment (141,932) (103,844) (161,662)
Dividends and interest on other equity instruments (275,783) (218,260) (216,151)
Dividends paid (278,841) (218,260) (216,151)
Dividends received 3,058 -- --
Other cash flows from / (used in) financing activities 4,661 (156,446) (21,492)
Financing costs included on the amortised costs of the debt -- (142,288) --
Other amounts from / (used in) financing activities 4,661 (14,158) (21,492)
Transaction with minority interests with no loss of control (note 3) 386,207 -- --
Net cash from/(used in) financing activities 152,503 1,434,065 (329,558)
Effect of exchange rate fluctuations on cash 39,207 (98,419) 35,441
Net increase in cash and cash equivalents 147,271 (8,488) (247,491)
Cash and cash equivalents at beginning of the year 886,521 895,009 1,142,500
Cash and cash equivalents at year end 1,033,792 886,521 895,009

Statement of Changes in Consolidated Equity for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Attributable to shareholders of the Parent
--------------------------------------------
Accumulated other comprehensive income
Share
capital
Share
premium
Reserves Profit attributable
to
Parent
Interim
dividend
Treasury
stock
Translation
differences
Available for sale
financial assets
Other comprehensive
income
Cash flow
hedges
Equity
attributable
to
Parent
Non-controlling
interests
Equity
Balance at 31 December 2015 119,604 910,728 1,371,061 532,145 (119,615) (58,575) 534,491 -- 3,035 3,329 3,296,203 5,187 3,301,390
Translation differences -- -- -- -- -- -- 114,436 -- -- -- 114,436 68 114,504
Available for sale financial assets -- -- -- -- -- -- -- (5,219) -- -- (5,219) -- (5,219)
Cash flow hedges (note 15 (f)) -- -- -- -- -- -- -- -- -- (3,329) (3,329) -- (3,329)
Other comprehensive income -- -- -- -- -- -- -- -- (3,677) -- (3,677) -- (3,677)
Other comprehensive income / (expense) for the year -- -- -- -- -- -- 114,436 (5,219) (3,677) (3,329) 102,211 68 102,279
Profit/(loss) for the year -- -- -- 545,456 -- -- -- -- -- -- 545,456 (913) 544,543
Total comprehensive income / (expense) for the year -- -- -- 545,456 -- -- 114,436 (5,219) (3,677) (3,329) 647,667 (845) 646,822
Net change in treasury stock (note 15 (d)) -- -- (182) -- -- (10,135) -- -- -- -- (10,317) -- (10,317)
Acquisition of non-controlling interests (note 15 (c)) -- -- (2,737) -- -- -- -- -- -- -- (2,737) 2,737 --
Other changes -- -- 6,816 -- -- -- -- -- -- -- 6,816 (582) 6,234
Interim dividend -- -- -- -- (122,908) -- -- -- -- -- (122,908) -- (122,908)
Distribution of 2015 profit
Reserves
Dividends
--
--
--
--
319,287
--
(319,287)
(93,243)
--
--
--
--
--
--
--
--
--
--
--
--
--
(93,243)
--
--
--
(93,243)
Interim dividend -- -- -- (119,615) 119,615 -- -- -- -- -- -- -- --
Operations with shareholders or owners -- -- 323,184 (532,145) (3,293) (10,135) -- -- -- -- (222,389) 2,155 (220,234)

Statement of Changes in Consolidated Equity for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Attributable to shareholders of the Parent

Accumulated other comprehensive income
Share
capital
Share
premium
Reserves Profit attributable
to
Parent
Interim
dividend
Treasury
stock
Translation
differences
Available for sale
financial assets
Other comprehensive
income
Cash flow
hedges
Equity
attributable
to
Parent
Non-controlling
interests
Equity
Balance at 31 December 2016 119,604 910,728 1,694,245 545,456 (122,908) (68,710) 648,927 (5,219) (642) -- 3,721,481 6,497 3,727,978
Translation differences -- -- -- -- -- -- (559,390) -- -- -- (559,390) (133) (559,523)
Available for sale financial assets -- -- -- -- -- -- -- 10,145 -- -- 10,145 -- 10,145
Other comprehensive income -- -- -- -- -- -- -- -- (14) -- (14) -- (14)
Other comprehensive income / (expense) for the year -- -- -- -- -- -- (559,390) 10,145 (14) -- (549,259) (133) (549,392)
Profit/(loss) for the year -- -- -- 662,700 -- -- -- -- -- -- 662,700 (1,386) 661,314
Total comprehensive income / (expense) for the year -- -- -- 662,700 -- -- (559,390) 10,145 (14) -- 113,441 (1,519) 111,922
Net change in treasury stock (note 15 (d))
Acquisition of non-controlling interests (note 15 (c))
Other changes
Interim dividend
--
--
--
--
--
--
--
--
--
(346)
6,475
--
--
--
--
--
--
--
(122,986)
6,288
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
6,288
(346)
6,475
(122,986)
--
(43)
(49)
--
6,288
(389)
6,426
(122,986)
Distribution of 2016 profit
Reserves
Dividends
Interim dividend
--
--
--
--
--
--
422,548
(95,274)
--
(422,548)
--
(122,908)
--
--
122,908
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
--
(95,274)
--
--
--
--
--
(95,274)
--
Operations with shareholders or owners -- -- 333,403 (545,456) (78) 6,288 -- -- -- -- (205,843) (92) (205,935)
Balance at 31 December 2017 119,604 910,728 2,027,648 662,700 (122,986) (62,422) 89,537 4,926 (656) -- 3,629,079 4,886 3,633,965
Impact of new IFRS (note 2) -- -- 29,562 -- -- -- -- (4,926) -- -- 24,636 -- 24,636
Balance at 31 December 2017 adjusted 119,604 910,728 2,057,210 662,700 (122,986) (62,422) 89,537 0 (656) 0 3,653,715 4,886 3,658,601
Translation differences -- -- -- -- -- -- 259,854 -- -- -- 259,854 (567) 259,287
Other comprehensive income -- -- -- -- -- -- -- -- 102 -- 102 -- 102
Other comprehensive income / (expense) for the year -- -- -- -- -- -- 259,854 -- 102 -- 259,956 (567) 259,389
Profit/(loss) for the year -- -- -- 596,642 -- -- -- -- -- -- 596,642 (2,236) 594,406
Total comprehensive income / (expense) for the year -- -- -- 596,642 -- -- 259,854 -- 102 -- 856,598 (2,803) 853,795
Net change in treasury stock (note 15 (d))
Acquisition / Divestment of non-controlling interests (note 15
-- -- -- -- -- 6,981 -- -- -- -- 6,981 -- 6,981
(c))
Other changes
--
--
--
--
(3,462)
(9,437)
--
--
--
--
--
--
--
--
--
--
--
--
--
--
(3,462)
(9,437)
469,010
(43)
465,548
(9,480)
Interim dividend -- -- -- (136,747) -- -- -- -- -- (136,747) -- (136,747)
Distribution of 2017 profit:
Reserves -- -- 539,714 (539,714) -- -- -- -- -- -- -- -- --
Dividends -- -- (142,094) -- -- -- -- -- -- -- (142,094) -- (142,094)
Interim dividend -- -- -- (122,986) 122,986 -- -- -- -- -- -- -- --
Operations with shareholders or owners -- -- 384,721 (662,700) (13,761) 6,981 -- -- -- -- (284,759) 468,967 184,208
Balance at 31 December 2018 119,604 910,728 2,441,931 596,642 (136,747) (55,441) 349,391 -- (554) -- 4,225,554 471,050 4,696,604

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(1) Nature, Principal Activities and Subsidiaries

Grifols, S.A. (hereinafter the Company) was incorporated with limited liability under Spanish law on 22 June 1987. Its registered and tax offices are in Barcelona. The Company's statutory activity consists of providing corporate and business administrative, management and control services, as well as investing in assets and property. Its principal activity involves rendering administrative, management and control services to its subsidiaries.

On 17 May 2006 the Company completed its flotation on the Spanish securities market, which was conducted through the public offering of 71,000,000 ordinary shares of Euros 0.50 par value each and a share premium of Euros 3.90 per share. The total capital increase (including the share premium) amounted to Euros 312.4 million, equivalent to a price of Euros 4.40 per share.

The Company's shares were floated on the Spanish stock exchange IBEX-35 index on 2 January 2008.

All of the Company's shares are listed on the Barcelona, Madrid, Valencia and Bilbao securities markets and on the Spanish Automated Quotation System (SIBE/Continuous Market). On 2 June 2011, Class B non-voting shares were listed on the NASDAQ (USA) and on the Spanish Automated Quotation System (SIBE/Continuous Market).

Grifols, S.A. is the Parent of the subsidiaries listed in Appendix I of this note to the consolidated annual accounts.

Grifols, S.A. and subsidiaries (hereinafter the Group) act on an integrated basis and under common management and their principal activity is the procurement, manufacture, preparation and sale of therapeutic products, especially haemoderivatives.

The main factory locations of the Group's Spanish companies are in Parets del Vallés (Barcelona) and Torres de Cotilla (Murcia), while the US companies are located in Los Angeles (California), Clayton (North Carolina), Emeryville (California), and San Diego (California).

The Company aims to reinforce its strategic presence in China. In this regards, Grifols is currently in talks with Shangai RAAS Blood Products to explore a possible corporate transaction and reached an agreement with Boya-Pharmaceutical to open plasma centers in China.

(2) Basis of Presentation

The consolidated annual accounts have been prepared on the basis of the accounting records of Grifols, S.A. and of the Group companies. The consolidated annual accounts for 2018 have been prepared under International Financial Reporting Standards as adopted by the European Union (IFRS-EU) which for Grifols Group purposes, are identical to the standards as endorsed by the International Accounting Standard Board (IFRS-IASB) to present fairly the consolidated equity and consolidated financial position of Grifols, S.A. and subsidiaries at 31 December 2018, as well as the consolidated results from their operations, consolidated cash flows and consolidated changes in equity for the year then ended.

These consolidated annual accounts for 2018 show comparative figures for 2017 and voluntarily show figures for 2016 from the consolidated statement of profit and loss, consolidated statement of comprehensive income, consolidated statement of changes in equity and consolidated statement of cash flows and their corresponding notes thereto.

The Group adopted IFRS-EU for the first time on 1 January 2004 and has been preparing its annual accounts under International Financial Reporting Standards, as adopted by the European Union (IFRS-EU) as required by capital market regulations governing the presentation of financial statements by companies whose debt or own equity instruments are listed on a regulated market.

The Board of Directors of Grifols, S.A. considers that these consolidated annual accounts of 2018 authorized for issue at their meeting held on 22 February 2019, will be approved by the shareholders without any modifications.

In accordance with the provision of section 357 of the Irish Companies Act 2014, the Company has irrevocably

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

guaranteed all liabilities of an Irish subsidiary undertaking, Grifols Worldwide Operations Limited (Ireland) (see Appendix I), for the financial year ended 31 December 2018 as referred to in subsection 1(b) of that Act, for the purposes of enabling Grifols Worldwide Operations Limited to claim exemption from the requirement to file their own annual accounts in Ireland.

(a) Relevant accounting estimates, assumptions and judgments used when applying accounting principles

The preparation of the consolidated annual accounts in conformity with IFRS-EU requires management to make judgments, estimates and assumptions that affect the application of Group accounting policies. The following notes include a summary of the relevant accounting estimates and judgments used to apply accounting policies which have the most significant effect on the amounts recognized in the consolidated annual accounts.

  • Assumptions used to test non-current assets and goodwill for impairment. Relevant cash generating units are tested annually for impairment. These are based on risk-adjusted future cash flows discounted using appropriate interest rates. The key assumptions used are specified in note 7. Assumptions relating to riskadjusted future cash flows and discount rates are based on business forecasts and are therefore inherently subjective. Future events could cause a change in business forecasts, with a consequent adverse effect on the future results of the Group. To the extent considered a reasonably possible change in key assumptions could result in an impairment of goodwill, a sensitivity analysis has been disclosed to show the effect of changes to these assumptions and the effect of the cash generating unit (CGU) on the recoverable amount.
  • Determination the fair value of assets, liabilities and contingent liabilities related to business combinations. Details of the fair value methods used by the Group are provided in note 3.
  • Evaluation of the capitalization of development costs (see note 4(h)). The key assumption is related to the estimation of sufficient future economic benefits of the projects.
  • Evaluation of provisions and contingencies. Key assumptions relate to the evaluation of the likelihood of an outflow of resources due to a past event, as well as to the evaluation of the best estimate of the likely outcome. These estimates take into account the specific circumstances of each dispute and relevant external advice and therefore are inherently subjective and could change substantially over time as new facts arise and each dispute progresses. Details of the status of various uncertainties involved in significant unresolved disputes are set out in note 29.
  • Evaluation of the recoverability of tax credits, including tax loss carryforwards and rights for deductions. Deferred tax assets are recognized to the extent that future taxable profits will be available against which the temporary differences can be utilized, based on management's assumptions relating to the amount and timing of future taxable profits (see notes 4(t) and 27).
  • Analysis that the refinancing of debt and bonds does not result in a new financial liability.

No changes have been made to prior year judgments relating to existing uncertainties.

The Group is also exposed to interest rate and currency risks. Refer to sensitivity analysis in note 30.

(b) Basis of consolidation

Appendix I shows details of the percentages of direct or indirect ownership of subsidiaries by the Company at 31 December 2018, 2017 and 2016, as well as the consolidation method used in each case for preparation of the accompanying consolidated annual accounts.

Subsidiaries in which the Company directly or indirectly owns the majority of equity or voting rights have been fully consolidated. Associates in which the Company owns between 20% and 50% of share capital and over which it has no control but does have significant influence, have been accounted for under the equity method.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Although the Group holds 30% of the shares with voting rights of Grifols Malaysia Sdn Bhd, it controls the majority of the economic and voting rights of Grifols Malaysia Sdn Bhd through a contract with the other shareholder and a pledge on its shares. As a consequence it has been fully consolidated.

Grifols (Thailand) Ltd. has two classes of shares and it grants the majority of voting rights to the class of shares held by the Group. As a consequence it has been fully consolidated.

Changes in associates and jointly controlled entities are detailed in note 10.

Changes in subsidiaries

In 2018:

  • On 28 December 2018, Grifols sold Biotest US Corporation and Haema AG to Scranton Enterprises B.V. for a global amount of US Dollars 538,014 thousand. Scranton is an existing shareholder of Grifols (see note 3(b)).
  • On 1 August 2018, Grifols, through its subsidiary Grifols Shared Services North America, Inc. has completed the acquisition of 100% of the shares in Biotest US Corporation for a price of US Dollars 286,454 thousand, after obtaining the consent of the US Federal Trade Commission (see note 3).
  • On 19 March 2018, Grifols entered into an agreement with Aton GmbH for the purchase of 100% of the shares of German based pharmaceutical company Haema AG, in exchange for a purchase price of Euros 220,191 thousand on a debt free basis. The closing of this transaction took place in June 2018 (see note 3).
  • On 26 January 2018, Grifols through its subsidiary Grifols Shared Services North America, Inc, suscribed a capital increase in the amount of US Dollars 98 million in the U.S company Goetech LLC, based in Denver, Colorado, trading as Medkeeper. As a result, Grifols holds a 54.76% interest in Medkeeper. Grifols and a majority position on the board of directors.
  • On 12 January 2018 the Group acquired the remaining 50% of the voting rights of Aigües Minerals de Vilajuïga, S.A. and consequently Grifols holds 100% of the voting rights for a total amount of Euros 550 thousand.

In 2017:

  • On 4 December 2017, Progenika Biopharma, S.A., transferred the total shares of Abyntek Biopharma, S.L. to a third party. No profit or loss was recognized on this transaction.
  • On 11 October 2017, Grifols Diagnostic Solutions, Inc. acquired an additional 0.98% interest in Progenika Biopharma, S.A. from its non-controlling interests for a total amount of Euros 644 thousand in the form of a cash payment. As a result, Grifols owed 90.23% of Progenika's share capital at 31 December 2017.
  • On 24 July 2017, Grifols acquired an additional 40% interest in Kiro Grifols, S.L. for a purchase price of Euros 12.8 million. With this new acquisition, Grifols reached a 90% interest in equity of Kiro Grifols S.L. (see note 3(b)).
  • On 13 March 2017, Progenika Latina, S.A. de C.V., was wound up. The assets and liabilities of Progenika Latina. S.A. de C.V were integrated into Progenika Biopharma, S.A.
  • On 31 January 2017, Grifols closed the transaction for the asset purchase agreement to acquire Hologic's business of NAT (Nucleic Acid Testing) donor screening unit, previously agreed on 14 December 2016, for a total amount of US Dollars 1,865 million (see note 3(a)).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • On 5 January 2017, the Group incorporated a new company called Chiquito Acquisition Corp.
  • With effect as of 1 January 2017, Grifols Diagnostic Solutions, Inc. and Progenika, Inc. entered into a merger agreement. The surviving company was Grifols Diagnostic Solutions, Inc.

In 2016 Grifols incorporated the following companies:

  • PBS Acquisition Corp. (USA)
  • Grifols Diagnostics Equipment Taiwan Limited (Taiwan)
  • Grifols Innovation and New Technologies Limited (Ireland)
  • On 12 December 2016, the Group company Grifols Innovation and New Technologies Limited subscribed to an increase in the share capital of VCN Biosciences, S.L. amounting to Euros 5 million. Following this capital increase, Grifols' interest rose to 81.34% in 2016. Grifols subscribed to another capital increase on 16 November 2015 through the Group company Gri-Cel, S.A. for an amount of Euros 2,549 thousand (see note 3 (d)).
  • With effect as of 1 November 2016, Grifols Brasil, Lda. and Gri-Cei, S.A. Produtos para Trasfusao entered into a merger agreement. The surviving company was Grifols Brasil, Lda.
  • In August 2016 and July 2015 Araclon Biotech, S.L. carried out two share capital increases of Euros 6.7 million and Euros 6 million, respectively. After the latter capital increase Grifols' interest rose to 73.22% (see note 15 (c)).
  • In July 2016 the Group acquired an additional 20% of the assets of Medion Diagnostics AG. in exchange for 59,951 treasury stocks (Class B Shares) from its non-controlling interests. After this acquisition, Grifols' interest rose to 100%.
  • On 3 March, 2016 the Group executed the call option on 32.93% of the shares in Progenika Biopharma, S.A. for Euros 25 million following the exercise of call and put options agreed in February 2013. Grifols paid 50% of this investment in Grifols B shares (876,777 shares) and the remaining 50% in cash. The Group guaranteed the selling shareholders the option to repurchase the Class B shares during the first five days following the sale date. As a result of this transaction, Grifols owns 89.25% of Progenika Biopharma, S.A.'s share capital at 31 December 2016.
  • With effect as of 1 January 2016, Progenika Biopharma, S.A. and Brainco Biopharma, S.L. entered into a merger agreement. The surviving company was Progenika Biopharma, S.A.

(c) Amendments to IFRS in 2018, 2017 and 2016

In accordance with IFRS, the following should be noted in connection with the scope of application of IFRS and the preparation of these consolidated annual accounts of the Group.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Effective date in 2016

Mandatory application for annual periods
beginning on or after:
Standards IASB effective date EU effective date
IAS 16
IAS 38
Clarification of Acceptable Methods of Depreciation and
Amortisation (issued on 12 May 2014)
1 January 2016 1 January 2016
IFRS 11 Accounting for Acquisitions of Interests in Joint Operations
(issued on 6 May 2014)
1 January 2016 1 January 2016
IAS 27 Equity Method in Separate Financial Statements (issued on 12
August 2014)
1 January 2016 1 January 2016
Various Annual Improvements to IFRSs 2012-2014 cycle (issued on 25
September 2014)
1 January 2016 1 January 2016
IAS 1 Disclosure Initiative (issued on 18 December 2014) 1 January 2016 1 January 2016
Effective date in 2017
Mandatory application for annual periods
beginning on or after:
Standards IASB effective date EU effective date
IAS 12 Recognition of Deferred Tax Assets for Unrealized Losses
(issued on 19 January 2016)
1 January 2017 1 January 2017
IAS 7 Disclosure Initiative (issued on 29 January 2016) 1 January 2017 1 January 2017
Various Annual improvements to IFRSs 2014 - 2016 cycle (issued on 8
December 2016) - IFRS 12
1 January 2017 1 January 2017

Effective date in 2018

Mandatory application for annual periods
beginning on or after:
Standards IASB effective date EU effective date
IFRS 15 Revenue from contracts with Customers (issued on 28 May 2014) 1 January 2018 1 January 2018
IFRS 15 Clarification to IFRS15 Revenue from Contracts with Customers
(issued on 12 April 2016)
1 January 2018 1 January 2018
IFRS 9 Financial instruments (issued on 24 July 2014) 1 January 2018 1 January 2018
IFRS 2 Classification and Measurement of Share-based Payment
Transactions (issued on 20 June 2016)
1 January 2018 1 January 2018
IFRS 4
IFRS 9
Applying IFRS 9 Financial Instruments with IFRS 4 Insurance
Contracts (issued on 12 September 2016)
1 January 2018 1 January 2018
IFRIC 22 IFRIC 22 Interpretation: Foreign currency translations and
Advance Consideration (issued on 8 December 2016)
1 January 2018 1 January 2018
IAS 40 Amendments to IAS 40: Transfers of Investment Property
(issued on 8 December 2016)
1 January 2018 1 January 2018
Various Annual improvements to IFRSs 2014 - 2016 cycle (issued on 8
December 2016)
1 January 2018 1 January 2018

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The application of these standards and interpretations has had some impacts on these consolidated annual accounts, which are detailed below:

IFRS 9 Financial Instruments

IFRS 9 Financial Instruments was applied on 1 January, 2018 without any restatements of the comparative figures relative for the prior year. The impacts of the first-time adoption, recognized directly in equity, are as follows:

  • Classification and measurement of financial assets:

In general terms, based on the analysis of the new classification based on the business model, the majority of financial assets have continued to be measured at amortized cost, the main exception being equity instruments, which are measured at fair value through profit or loss.

  • Impairment of financial assets:

For trade receivables the Group uses the simplified approach, estimating lifetime expected credit losses, while for all other financial assets the Group has used the general approach for calculating expected credit losses. In both cases, due to the customers' credit rating, as well as the internal classification systems currently in place for new customers, and considering that collection periods are mostly under 30 days, the adoption of IFRS 9 does not have a significant impact.

- Modification or exchanges of financial liabilities that do not result in derecognition of liabilities

According to the IASB's interpretation published in October 2017, when a financial liability measured at amortized cost is modified or exchanged and does not result in the derecognition of the financial liability, a gain or loss should be recognized in profit or loss, calculated as the difference between the original contractual cash flows from the liability and the new modified cash flows, discounted at the original effective interest rate of the liability.

IFRS 9 must be applied retrospectively as of 1 January 2018, therefore any gains or losses from the modification of financial liabilities that arise from applying the new standard in years prior to 1 January 2018 have been recognized in reserves at that date and the comparative period has not been re-expressed. Grifols has retrospectively calculated the impact of adopting IFRS 9 on the refinancing of its senior debt and unsecured senior corporate notes in 2014 and 2017. As a result of these new calculations, the 2014 refinancing of both debts did not cause the derecognition of the respective liabilities, therefore generating an adjustment to profit and loss in that year. Considering the retroactive adjustment generated in 2014, the 2017 refinancing of senior debt did not result in the derecognition of the financial liability either. However, the refinancing of the unsecured senior corporate notes led to derecognition of the liability as it did not pass the new quantitative test. The adoption of IFRS 9 has entailed a positive impact on reserves of Euros 24,636 thousand.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details of the impacts on reserves due to the application of IFRS 9 application are as follows:

Thousand of Euros
Senior Unsecured Noted IAS 39 IFRS 9 Impact
01/01/2018
Total Debt 853,667 1,000,000 146,333
Deferred Expenses (41,035)
Negative Impact in reserves 105,298
Thousand of Euros
Senior Secured Debt IAS 39 IFRS 9 Impact
01/01/2018
Total Debt 3,375,157 3,226,244 (148,913)
Deferred Expenses 18,979
Positive impact in reserves (129,934)
Thousand of Euros
Total Impact IAS 39 IFRS 9 Impact
01/01/2018
Total Debt 4,228,824 4,226,244 (2,580)
Deferred Expenses (22,056)
Positive impact in reserves (24,636)

IFRS 15 Revenue from Contracts with Customers.

IFRS 15 provides a framework that replaces the previous guides on revenue recognition. According to the new criteria, a five-step model should be used to determine the timing and amounts of revenue recognition:

Step 1: Identify the contract.

Step 2: Identify the performance obligations in the contract.

Step 3: Determine the transaction price.

Step 4: Allocate the transaction price to the performance obligations in the contract.

Step 5: Recognize revenue.

This new model specifies that revenue should be recognized when (or as) control of the goods or services is transferred from an entity to customers, for the amount the entity expects to be entitled to receive. Depending on whether certain criteria are met, revenue is recognized over time, reflecting that the entity has satisfied the performance obligation, or at a point in time, when control of the goods or services is transferred to customers.

Based on the analysis and implementation at 1 January 2018, there has been no impact from adopting IFRS 15 Revenue from Contracts with Customers.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Standards issued but not effective in 2018

Mandatory application for annual periods
beginning on or after:
Standards IASB effective date EU effective date
IFRS 16 Leases (Issued on 13 January 2016) 1 January 2019 1 January 2019
IFRIC 23 Uncertainty over Income Tax Treatments (issued on 7
June 2017)
1 January 2019 1 January 2019
IFRS 9 Amendment to IFRS 9: Prepayment Features with
Negative Compensation (issued on 12 October 2017)
1 January 2019 1 January 2019
IAS 28 Amendment to IAS 28: Long-term interests in Associates
and Joint Ventures (issued on 12 October 2017)
1 January 2019 pending
Various Annual Improvements to IFRS Standards 2015-2017 Cycle
(issued on 12 December 2017)
1 January 2019 pending
IFRS 17 Insurance Contracts (issued on 18 May 2017) 1 January 2021 pending
IAS 19 Amendment to IAS19: Plan Amendment, Curtailment or
Settlemet (issued on 7 February 2018)
1 January 2019 pending
IFRS 3 Amendment to IFRS 3: Definition of a business (issued on
22 October 2018)
1 January 2020 pending
IAS 1
IAS 8
Amendments to IAS 1 and IAS 8: Definition of material
(issued on 31 October 2018)
1 January 2020 pending
IFRS 1 Amendments to the Conceptual Framework for Financial
Reporting (issued on 29 March 2018)
1 January 2020 pending

The application of these standards and interpretations, except for IFRS 16 "Leases", is not expected to have any significant impacts on the consolidated annual accounts.

IFRS 16 "Leases"

IFRS 16 brings in a single model for lease accounting by lessees in the statement of financial position. A lessee recognises a right-of-use asset representing its right to use the underlying asset and a lease liability representing its obligation to make lease payments. There are optional exemptions for short-term leases and leases of low value items. Lessor accounting remains similar to the current standard. Lessors continue to classify leases as finance or operating leases.

IFRS 16 replaces existing guidance on leases, including IAS 17 Leases, IFRIC 4 Determining whether an arrangement contains a lease, SIC-15 Operating leases-Incentives and SIC-27 Evaluating the substance of transactions involving the legal form of a lease.

IFRS 16 is mandatory for all financial years starting on or after 1 January 2019. It may be adopted in advance by companies that already use IFRS 15 Revenue from contracts with customers prior to the date of first-time application of IFRS 16. The Group will first-time adopt IFRS 16 on 1 January 2019 and is in the process of estimating the impact on the consolidated annual accounts. The main policies, estimates and criteria for the application of IFRS 16 are as follows:

  • Scope: this IFRS 16 evaluation considers all the contracts in which the Group acts as lessee, except for the contracts between Group companies and the cancelable contracts.
  • Transition approach: The Group has opted to implement IFRS 16 using the modified retrospective approach, whereby the right-of-use asset is measured at an amount equal to the lease liability, adjusted by the amount of any prepaid or accrued lease payments relating to that lease recognized in the consolidated statement of financial position immediately before the date of initial application. When applying this modified retrospective approach, the Group does not re-express the comparative information.
  • Discount rates: For financial lease contracts, Grifols will discount lease payments using the implicit interest rate. For operating lease agreements, lease payments will be discounted using the incremental

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

borrowing rate. The incremental borrowing rate is the rate of interest that a lessee would have to pay to borrow over a similar term, and with a similar security, the funds necessary to obtain an asset of a similar value to the right-of-use asset in a similar economic environment.

An incremental effective interest rate has been applied and varies from 2.07% to 8.18% depending on the geographical area and the term of the lease agreement at the date of initial application.

• Lease term for each agreement: The term considered for the leases depends, fundamentally, on whether or not the lease contract contains a period of mandatory compliance, as well as unilateral termination and or renewal clauses that grant the Group the right to terminate early or to extend the agreements.

The Group leases several buildings, equipment and vehicles. Leases agreements are usually made for fixed periods, as shown below:

Average lease term
Real Estate and land 10 to 15 years
Donor centers 13 to 15 years
PC's and hardware 3 to 5 years
Machinery 4 to 5 years
Vehicles 3 to 5 years

The lease terms of the agreements are negotiated on an individual basis and contain a wide range of terms and conditions.

  • Accounting policies applied during transition: The Group has employed the following practical solutions when applying the simplified method to leases previously carried as operating leases under IAS 17 Leases:
  • o Non-application of IFRS 16 to agreements that were not previously deemed to contain a lease under IAS 17 and IFRIC 4 "Determining whether an arrangement contains a lease".
  • o Exclusion of the initial direct costs from the measurement of the right-of-use asset on the date of first-time adoption.
  • o Exclusion of leases that expire within 12 months as from the date of first-time adoption.
  • o Exclusion of leases in which the underlying asset has a low value.
  • Estimated effect of adoption: At 1 January 2019, the Group has non-cancellable operating lease commitments of Euros 400,579 thousand for buildings and warehouses (see note 28). Of these commitments, approximately Euros 4,822 thousand of these commitments relate to short-term leases which will be recognized on a straight-line basis as expense in profit and loss. For the remaining lease commitments, the Group expects to recognise right-of-use assets of approximately Euros 648,345 thousand at 1 January, 2019 (after adjustments for prepayments, dismantling costs and accrued lease payments recognized as at 31 December 2018 by an amount of approximately Euros 16,898 thousand) and lease liabilities of Euros 664,948 thousand.
  • Total net assets will be approximately Euros 16,603 thousand lower, and net current assets will be Euros 43,318 thousand lower due to, mainly, the presentation of a portion of the liability as a current liability.

The Group expects net profit before tax to fall by approximately Euros 15,500 thousand in 2019 due to the adoption of the new Standard for the lease agreements for buildings and warehouses. EBITDA is expected to increase by approximately Euros 60,281 thousand, as the operating lease payments were included in EBITDA but the amortisation charges on right-of-use assets and interest on the lease liability are excluded from this measurement.

Operating cash flows will increase and cash flows from financing will decrease by approximately Euros 60,281 thousand, since the repayment of principal on the lease liabilities and interest will be classified as cash flows from financing activities.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

In addition, Grifols has performed the reconciliation of lease liabilities for buildings and warehouses in relation to leases which had previously been classified as operating leases under IAS 17 (related to non-cancelable agreements and renewals) and lease liabilities under IFRS 16:

01/01/2019
Thousands of Euros
Operating lease commitments existing as at 31 December 2018 400,579
Periods covered by an option to extend the lease by the Group 579,261
Discounting using the Group's incremental borrowing rate (311,116)
finance lease liabilities recognised as at 31 December 2018 1,395
Short-term leases recognised on a straight-line basis as expense (4,822)
Others (349)
Lease liability recognised as at 1 January 2019 664,948

The Group's activities as a lessor are immaterial, and therefore the Group does not expect any significant impact on the consolidated annual accounts.

(3) Business Combinations

2018

(a) Acquisition of assets used in donor centers from Kedplasma

In August and December of 2018, Grifols through its company Biomat USA, Inc. acquired the assets used in the operation of six donor centers from Kedplasma LLC. The purchase price agreed was Euros 20,939 thousand and Euros 21,841 thousand, respectively. These amounts have been provisionally allocated to goodwill in the consolidated balance sheet, considering that the initial accounting has not been completed at the end of the reporting period.

(b) Biotest Acquisition

On 1 August 2018, Grifols, through its subsidiary Grifols Shared Services North America, Inc. completed the acquisition of 100% of the shares in Biotest US Corporation for a price of US Dollars 286,454 thousand, after obtaining the consent of the US Federal Trade Commission. Grifols has acquired the shares from Biotest Divestiture Trust.

Biotest USA owns a plasma collection business in the USA with 24 plasma collection centers throughout the territory. In the preceding financial year, it obtained approximately 850,000 liters of plasma.

Details of the aggregate business combination cost, the fair value of the net assets acquired and goodwill at the acquisition date are provided below:

Thousands of Euros Thousands of US Dollars
Total business combination cost 245,126 286,454
Fair value of net assets acquired 114,463 133,761
Goodwill (excess of the cost of the business combination over
the fair value of net assets acquired)
130,663 152,693

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The amounts determined at the date of acquisition of assets, liabilities and contingent liabilities were as follows:

Fair value
Thousands of Euros Thousands of US Dollars
Cash and cash equivalents 5,876 6,867
Trade and other receivables 15,114 17,663
Inventories 18,235 21,309
Other assets 2,438 2,849
Intangible assets (note 8) 19,511 22,800
Goodwill 5,571 6,510
Property, Plant and equipment (note 9) 22,190 25,931
Deferred tax assets 33,917 39,635
Financial assets 10,975 12,825
Total assets 133,827 156,389
Trade and other payables (5,322) (6,219)
Other liabilities (4,249) (4,965)
Deferred tax liability (4,878) (5,700)
Long-term liabilities (4,915) (5,744)
Total liabilities and contingent liabilities (19,364) (22,628)
Total net assets acquired 114,463 133,761
Goodwill (note 7) 130,663 152,693
Total business combination cost 245,126 286,454

The resulting goodwill has been allocated to the Bioscience segment.

If the acquisition had taken place on 1 January 2018, the net amount of the Group´s revenue and profit would have increased by Euros 90,216 thousand and Euros 5,592 thousand, respectively.

The revenue and profit of Biotest between the acquisition date and 31 December 2018 amounted to Euros 73,747 thousand and Euros 7,473 thousand, respectively.

On 28 December 2018, Grifols sold Biotest US Corporation and Haema AG to Scranton Enterprises B.V. for the global amount of US Dollars 538,014 thousand (see note 1), Scranton is an existing shareholder of Grifols (see note 31). The current sale of Biotest and Haema to Scranton took place for the same price, at the current US Dollar/Euro exchange rate, and under the same terms and conditions existing when Grifols acquired both companies.

The sale of Biotest and Haema has not resulted in a loss of control for the Group. In assessing the existence of control, Grifols has considered the potential voting rights to determine whether it has power and therefore control. The Group holds potential voting rights arising from the repurchase options of the shares and they are substantive, based on the following:

  • The sale contract includes a call option for Grifols which grants the irrevocable and exclusive right (not an obligation) to be able to acquire the shares sold to Scranton (both at the same time) at any time from the effective date of sale.
  • The purchase option has been negotiated jointly in the same sale agreement of the entities.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • The price of exercising the call option will be equal to the higher of: a) the price at which Grifols sold them plus costs incurred in the transaction and plus the increase in working capital and (b) the amount of the debt that Scranton owns the date on which Grifols exercises the option (principal plus interest plus any other cost to be able to cancel said loan). Considering that the projections for the entities are for growth and an improvement in their results is expected, it is concluded that said call option is "in the money" since their market price is estimated to be higher than that agreed in the call option.
  • Even if a nullity clause on the call option is included in the case of default by the buyer (standard clause included in financing agreements), it has been considered remote since Grifols will have the capacity to exercise said call option in the remediation period of 90 days.
  • There are no agreements between shareholders that establish that the relevant decisions are approved in a different manner than by majority vote.
  • There is a commitment from Grifols to provide support services in the plasma collection business of the donation centers for their subsequent sale and thus ensure that these companies will continue to operate effectively, as well as ensuring the continuity and growth of said entities. Likewise, there is a "Plasma Supply Agreement" agreement whereby the plasma to be produced by these entities will be almost entirely to meet the needs of Grifols. There is no exclusivity of sale.

The aforementioned are indicators of Grifols' power over these entities, even after their sale, considering that the repurchase options are susceptible to being exercised and Grifols would have the financial capacity to carry them out.

Consequently, the sale of the entities does not result in a loss of control, which is why the entities continue to consolidate, recording the sale as a transaction in equity without any impact on the consolidated statements of profit and loss.

(c) Haema AG

On 19 March 2018, Grifols has entered into an agreement with Aton GmbH for the purchase of 100% of the shares of the German based pharmaceutical company Haema AG, in exchange for a purchase price of Euros 220,191 thousand on a debt free basis. This transaction was closed in June 2018.

With this acquisition, and subject to the conditions being met, Grifols will acquire Haema's business, based on the collection of plasma for fractionation, which includes 35 plasma collection centers located throughout Germany, and three more centers under construction. Haema's headquarters are located in Leipzig measuring approximately 24,000 m² (which include administration, production, storage and power station buildings) and also has a central laboratory in Berlin.

Haema employs about 1,100 people and collected almost 800,000 liters of plasma in the preceding financial year, coming from approximately 1 million donations.

Details of the aggregate business combination cost, the fair value of the net assets acquired and goodwill at the acquisition date are provided below:

Thousands of Euros
Total business combination cost 220,191
Fair value of net assets acquired 49,057
Goodwill (excess of the cost of the business combination over the fair value of net assets
acquired)
171,134

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The amounts determined at the date of acquisition of assets, liabilities and contingent liabilities were as follows:

Fair value
Thousands of Euros
Cash and cash equivalents 7,727
Trade and other receivables 10,321
Inventories 5,535
Other assets 836
Intangible assets (note 8) 1,518
Property, Plant and equipment (note 9) 25,407
Total assets 51,344
Trade and other payables (1,795)
Contingent liabilities (492)
Total liabilities and contingent liabilities (2,287)
Total net assets acquired 49,057
Goodwill (note 7) 171,134
Total business combination cost 220,191

The resulting goodwill has been allocated to the Bioscience segment.

If the acquisition had taken place on 1 January, 2018, the net amount of the Group´s revenue would have increased by Euros 39,517 thousand and the Group´s profit would not have deferred significantly.

The revenue and profit of Haema AG between the acquisition date and 31 December 2018 amounted to Euros 46,758 thousand and Euros 53 thousand, respectively.

On 28 December 2018, Grifols sold Haema AG to Scranton Enterprises B.V (see note 3 (b) for more details).

(d) Goetech, LLC Acquisition ("MedKeeper")

On 26 January 2018, Grifols through its subsidiary Grifols Shared Services North America, Inc, suscribed a capital increase for an amount of US Dollars 98 million in the U.S company Goetech LLC, with headquarters in Denver, Colorado, and trading as Medkeeper. As a result of this transaction, Grifols held 51% interest in Medkeeper and also holds a majority position on the board of directors.

The acquisition agreement includes the repurchase of own shares by Medkeeper from the non-controlling shareholder in the amount of US Dollars 14 million (in 2 business days) and US Dollars 20 million (in two years). The agreement grants a call option to Grifols to acquire the remaining non-controlling stake for a term of three years and Medkeeper has a put option to sell this stake to Grifols, which may be executed at the end of the three-year period.

As the non-controlling shareholders do not currently have access to the economic rewards associated with the underlying ownership interests related to shares under the put and call commitment, we have applied the advance-acquisition method. Under this method we recognize the agreement as an advance acquisition of the underlying non-controlling interest, as if the put option had already been exercised by the non-controlling shareholders.

Medkeeper´s core business is the development and distribution of web and mobile-based platforms for hospital pharmacies that improve quality standards, productivity in the processes, control systems and monitoring different preparations, while increasing patient safety.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

This investment will enhance the activity of the Grifols Hospital Division and it is part of the strategy to underpin this division into the U.S. market.

Details of the aggregate business combination cost, the fair value of the net assets acquired and goodwill at the acquisition date are provided below:

Thousands of Euros Thousands of US Dolla
Cost of the business combination
First repurchase of non-controlling interests 11,475 14,000
Second repurchase of non-controlling interests (discounted amount) 14,952 18,241
Purchase of remaining non-controlling interests 42,998 52,458
Total business combination cost 69,425 84,699
Fair value of net assets acquired 14,104 17,207
Goodwill (excess of the cost of the business combination over the
fair value of net assets acquired) (note 7)
55,321 67,492

The amounts determined at the date of acquisition of assets, liabilities and contingent liabilities were as follows:

Fair value
Thousands of EurosThousands of US Dollars
Intangible assets (note 8) 30,561 37,285
Property, Plant and equipment (note 9) 67 82
Other non-current assets 2,350 2,867
Other current assets 4,453 5,433
Total assets 37,432 45,667
Non-current liabilities (2,186) (2,667)
Current liabilities (7,711) (9,407)
Deferred tax liability (13,431) (16,386)
Total liabilities and contingent liabilities (23,328) (28,460)
Total net assets acquired 14,104 17,207

The resulting goodwill has been allocated to the Hospital segment.

If the acquisition had taken place on 1 January, 2018, the net amount of the Group´s revenue and profit would not have deferred significantly.

The revenue and profit of Goetech LLC between the acquisition date and 31 December 2018 amounted to Euros 9,210 thousand and Euros 1,778 thousand, respectively.

(e) Plasmavita Healthcare GmbH

In 2017, Grifols incorporated PLASMAVITA GmbH, a joint venture between Grifols (50%) and two European partners (50%). The company aims to set up at least 10 plasma centers in Germany. The share capital amounts to Euros 25,000, divided into 25,000 nominal shares of Euro 1 each, subscribed by both parties at Euros 12,500 each. During 2018, Grifols contributes an amount of Euros 10,000 thousand, which can be increased by an additional Euros 10 million, which will be used to finance the project.

(f) Aigües Minerals de Vilajuïga, S.A.

On 1 June 2017 the Group announced the acquisition of 50% of the voting rights in Aigües Minerals de Vilajuïga, S.A. a company based in Vilajuïga, Girona, Spain.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

On 12 January 2018 the Group acquired the remaining 50% of the voting rights and consequently Grifols holds 100% of the voting rights for a total amount of Euros 550 thousand.

Aigües Minerals de Vilajuïga, S.A.'s principal activity is the collection and use of mineral-medicinal waters and the procurement of all necessary administrative concessions in order to facilitate the extraction of these waters and find the best way to exploit them.

2017

(a) Hologic Acquisition

On 14 December 2016 Grifols entered into an asset purchase agreement to acquire assets corresponding to Hologic's NAT (Nucleic Acid Testing) business donor screening unit for US Dollars 1,865 million. The transaction was closed on 31 January 2017. The agreement encompasses the acquisition of the Hologic business engaged in research, development and manufacture of assays and instruments based on NAT technology for transfusion and transplantation screening. In addition, it was agreed to cancel the existing jointcollaboration agreement for the commercialization of NAT donor screening products by Grifols. NAT technology makes it possible to detect the presence of infectious agents in blood and plasma donations, contributing to greater transfusion safety.

The transaction is structured through the purchase of assets by Grifols Diagnostic Solutions, Inc., a U.S. incorporated and wholly-owned subsidiary of Grifols, S.A.

The assets acquired comprise a plant in San Diego, California (United States) as well as development rights, licenses to patents and access to product manufacturers.

Grifols consolidates itself as one of the only vertically integrated providers capable of offering comprehensive solutions to blood and plasma donation centers.

This acquisition strengthens cash flows and positively impacts the Group's margins. The sales revenues of the Diagnostic Division will not change as a result of the acquisition due to the existing commercialization agreement between Grifols and Hologic in place since 2014, under which Grifols commercializes this line of business.

It is expected that this acquisition will strengthen the position of the Grifols Diagnostic Division in transfusion medicine and will increase significantly the profitability of Grifols Diagnostic Division having a direct impact on the Group's EBITDA margin. By streamlining and integrating the NAT business, operational efficiency will be in terms of production, R&D, overheads and administrative expenses.

Details of the aggregate business combination cost, the fair value of the net assets acquired and goodwill at the acquisition date are provided below:

Thousands of Euros Thousands of US Dollars
Cost of the business combination
Payment in cash 1,734,077 1,865,000
Result of the cancellation of the existing contract 41,894 45,057
Total business combination cost 1,775,971 1,910,057
Fair value of net assets acquired 309,551 332,923
Goodwill (excess of the cost of the business combination over the fair
value of net assets acquired) (see note 7)
1,466,420 1,577,134

As part of the purchase price allocation, the Company determined that the identifiable intangible assets were developed technology and IPR&D. The fair value of the intangible assets was estimated using the income approach. The cash flows were based on estimates used to price the transaction and the discount rates applied

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

were benchmarked with reference to the implied rate of return from the transaction model and the weighted average cost of capital.

The developed technology assets are comprised of know-how, patents and technologies embedded in revenue. The Company applied the Relief-from-Royalty Method to determine its fair value. IPR&D projects relate to inprogress projects that have not reached technological feasibility as of the acquisition date. All of the IPR&D assets were valued using the Multiple-Period Excess Earnings Method approach.

The excess of the purchase price over the estimated fair value of the net assets acquired was recorded as goodwill. The factors contributing to the recognition of the amount of goodwill were the acquired workforce, cost savings and benefits arising from the vertical integration of the business that will lead to efficiencies in R&D, commercial and manufacturing activities.

The expenses incurred in this transaction in 2017 amounted to approximately Euros 13 million (Euros 5.1 million in 2016).

The amounts determined at the date of acquisition of assets, liabilities and contingent liabilities were as follows:

Fair Value
Thousands of Euros Thousands of US
Dollars
R&D in progress
Other Intangible assets
137,756
142,174
148,157
152,908
Property, plant and equipment
Deferred Tax Assets (note 27)
Inventories
24,569
16,736
30,157
26,424
18,000
32,434
Total Assets 351,392 377,923
Current Provisions (note 19 (b)) 41,841 45,000
Total liabilities and contingent liabilities 41,841 45,000
Total net assets acquired 309,551 332,923

The resulting goodwill has been allocated to the Diagnostic segment.

(b) Kiro Grifols, S.L.

On 25 July 2017 the Group acquired an additional 40% interest in Kiro Grifols, S.L for an amount of Euros 12.8 million. In September 2014 the Group subscribed a capital increase in Kiro Grifols, S.L for an amount of Euros 21 million, by virtue of which Grifols acquired 50% of Kiro Grifols, S.L.'s economic and voting rights.

As a result, Grifols owns a 90% interest in Kiro Grifols. S.L. The remaining 10% will continue to be held by Socios Fundadores Kiro, S.L. a company wholly owned by cooperatives of the Mondragon Corporation.

Grifols also entered into a joint venture & shareholders' agreement (the "Joint Venture Agreement") with Kiro Grifols' partners: Mondragon Innovacion S.P.E, S.A.; Mondragon Assembly, S.Coop. and Agrupación de Fundición y Utillaje, S.Coop.. This agreement governs, among other matters, the capital increase subscribed by Grifols and the managing and governing bodies of Kiro Grifols, whether these are the Board of Directors or any other internal managing and governing bodies.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(c) Kedplasma

On 27 December 2016 Grifols entered into an agreement to acquire six new Plasma Donor Centers to the company Kedplasma, LLC, with a purchase price of US Dollars 47 million. These centers were handed over in February 2017.

Aggregate details of the combination cost, fair value of the net assets acquired and goodwill at the acquisition date are as follows:

Thousands of Euros Thousands of US Dollars
Cost of the business combination
Payment in cash 44,238 47,083
Total business combination cost 44,238 47,083
Fair value of net assets acquired 4,137 4,403
Goodwill (excess of the cost of the business combination over
the fair value of net assets acquired) (note 7)
40,101 42,680

The fair value of net assets acquired includes property, plant and equipment amounting to Euros 3,698 thousand.

Goodwill is allocated to the Bioscience segment and includes the plasma donor data base, FDA licenses and workforce retained.

At 31 December 2016, the Group advanced the sum of US Dollars 15 million related to this acquisition.

2016

During 2016, no significant business combinations were made for the Group.

(4) Significant Accounting Policies

(a) Subsidiaries and associates

Subsidiaries are entities, including special purpose entities (SPE), over which the Group exercises control, either directly or indirectly, through subsidiaries. The Group controls a subsidiary when it has the substantive rights in force that provide the ability to manage relevant activities. The Group is exposed or has the right to variable returns for its involvement in the subsidiaries when the returns obtained vary depending on the economic performance of the subsidiaries.

The income, expenses and cash flows of subsidiaries are included in the consolidated annual accounts from the date of acquisition, which is when the Group takes control. Subsidiaries are excluded from the consolidated Group from the date on which control is lost.

Transactions and balances with Group companies and unrealized gains or losses have been eliminated upon consolidation.

The accounting policies of subsidiaries have been adapted to those of the Group for transactions and other events in similar circumstances.

The annual accounts of consolidated subsidiaries have been prepared as of the same date and for the same reporting period as the annual accounts of the Company.

Associates are entities over which the Company, either directly or indirectly through subsidiaries, exercises significant influence. Significant influence is the power to participate in the financial and operating policy decisions of the investee but is not control or joint control over those entities. The existence of potential voting

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

rights that are exercisable or convertible at the end of each reporting period, including potential voting rights held by the Group or other entities, are considered when assessing whether an entity has significant influence.

Investments in associates are initially recognized at acquisition cost, including any cost directly attributable to the acquisition and any consideration receivable or payable contingent on future events or on compliance with certain conditions.

Subsequently, investments in associates are accounted for using the equity method from the date that significant influence commences until the date that significant influence ceases.

The excess of the cost of the investment over the Group's share of the fair values of the identifiable net assets is recognized as goodwill, which is included in the carrying amount of the investment. Any shortfall, once the cost of the investment and the identification and measurement of the associate's net assets have been evaluated, is recognized as income when determining the investor's share of the profit and loss of the associate for the year in which it was acquired.

The accounting policies of associates have been harmonized in terms of timing and measurement, applying the policies described for subsidiaries.

The Group's share of the profit and loss of an associate from the date of acquisition is recognized as an increase or decrease in the value of the investments, with a credit or debit to share of the profit and loss for the year of "equity-accounted investees" in the consolidated statement of profit and loss (consolidated statement of comprehensive income). The Group's share of other comprehensive income of associates from the date of acquisition is recognized as an increase or decrease in the investments in associates with a balancing entry recognized by type in other comprehensive income. The distribution of dividends is recognized as a decrease in the value of the investment. The Group's share of profit and loss, including impairment losses recognized by the associates, is calculated based on income and expenses arising from application of the acquisition method.

When the Group's share of the losses in an investment accounted for using the equity method equals or exceeds its interest in the entity, the Group does not recognize additional losses, unless it has incurred in obligations or made payments on behalf of the other entity.

The Group's share of the profit and loss of an associate and changes in equity is calculated to the extent of the Group's interest in the associate at year end and does not reflect the possible exercise or conversion of potential voting rights. However, the Group's share is calculated taking into account the possible exercise of potential voting rights and other derivative financial instruments which, in substance, currently allow access to the economic benefits associated with the interests held, such as entitlement to a share in future dividends and changes in the value of associates.

Information on the subsidiaries and associates included in the consolidated Group is presented in Appendix I.

(b) Business combinations

On the date of transition to IFRS-EU, 1 January 2004, the Group applied the exception permitted under IFRS 1 "First-time adoption of International Financial Reporting Standards", whereby only those business combinations performed as from 1 January 2004 have been recognized using the acquisition method. Entities acquired prior to that date were recognized in accordance with accounting prevailing at that time, taking into account the necessary corrections and adjustments at the transition date.

The Group applies the revised IFRS 3 "Business combinations" in transactions made subsequent to 1 January 2010.

The Group applies the acquisition method for business combinations.

The acquisition date is the date on which the Group obtains control of the acquiree.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Business combinations made subsequent to 1 January 2010

The cost of the business combination is calculated as the sum of the acquisition-date fair values of the assets transferred, the liabilities incurred or assumed, equity instruments issued and any additional consideration contingent on future events or the fulfilment of certain conditions, in exchange for control of the acquiree.

The consideration paid excludes all amounts that do not form part of the exchange for the acquired business. Acquisition-related costs are accounted for as expenses when incurred. Share increase costs are recognized as equity when the increase takes place and borrowing costs are deducted from the financial liability when it is recognized.

At the acquisition date the Group recognizes at fair value the assets acquired and liabilities assumed. Liabilities assumed include any contingent liabilities that represent present obligations arising from past events for which the fair value can be reliably measured. The Group also recognizes indemnification assets transferred by the seller at the same time and following the same measurement criteria as the item that is subject to indemnification from the acquired business, taking into consideration, where applicable, the insolvency risk and any contractual limit on the indemnity amount.

This criterion does not include non-current assets or disposal groups of assets which are classified as held for sale, long-term defined benefit employee benefit liabilities, share-based payment transactions, deferred tax assets and liabilities and intangible assets arising from the acquisition of previously transferred rights.

Assumed assets and liabilities are classified and designated for subsequent measurement in accordance with the contractual terms, economic conditions, operating or accounting policies and other factors that exist at the acquisition date, except for leases and insurance contracts.

The excess between the consideration transferred and the value of net assets acquired and liabilities assumed, less the value assigned to non-controlling interests, is recognized as goodwill. Where applicable, any shortfall, after evaluating the consideration transferred, the value assigned to non-controlling interests and the identification and measurement of net assets acquired, is recognized in profit and loss.

When a business combination has been provisionally determined, net identifiable assets have initially been recognized at their provisional value, and any adjustments made during the measurement period have been recorded as if they had been known at that date. Where applicable, comparative figures for the prior year have been restated. Adjustments to the provisional values only reflect information relating to events and circumstances existing at the acquisition date and which, had they been known, would have affected the amounts recognized at that date. Once this period has elapsed, adjustments are only made to initial values when errors must be corrected. Any potential benefits arising from tax losses and other deferred tax assets of the acquiree that have not been recorded as they did not qualify for recognition at the acquisition date, are accounted for as income tax revenue, provided the adjustments were not made during the measurement period.

The contingent consideration is classified in accordance with underlying contractual terms as a financial asset or financial liability, equity instrument or provision. Provided that subsequent changes to the fair value of a financial asset or financial liability do not relate to an adjustment of the measurement period, they are recognized in consolidated profit and loss. The contingent consideration classified, where applicable, as equity is not subject to subsequent change, with settlement being recognized in equity. The contingent consideration classified, where applicable, as a provision is recognized subsequently in accordance with the relevant measurement standard.

Business combinations made prior to 1 January 2010

The cost of the business combination is calculated as the sum of the acquisition-date fair values of the assets transferred, the liabilities incurred or assumed, and equity instruments issued by the Group, in exchange for control of the acquiree, plus any costs directly attributable to the business combination. Any additional consideration contingent on future events or the fulfilment of certain conditions is included in the cost of the combination provided that it is probable that an outflow of resources embodying economic benefits will be required and the amount of the obligation can be reliably estimated. Subsequent recognition of contingent

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

considerations or subsequent variations to contingent considerations is recognized as a prospective adjustment to the cost of the business combination.

Where the cost of the business combination exceeds the Group's interest in the fair value of the identifiable net assets of the entity acquired, the difference is recognized as goodwill, whilst the shortfall, once the costs of the business combination and the fair values of net assets acquired have been reconsidered, is recognized in profit and loss.

(c) Non-controlling interests

Non-controlling interests in subsidiaries acquired after 1 January 2004 are recognized at the acquisition date at the proportional part of the fair value of the identifiable net assets. Non-controlling interests in subsidiaries acquired prior to the transition date were recognized at the proportional part of the equity of the subsidiaries at the date of first consolidation.

Non-controlling interests are disclosed in the consolidated balance sheet under equity separately from equity attributable to the Parent. Non-controlling interests' share in consolidated profit and loss for the year (and in consolidated comprehensive income for the year) is disclosed separately in the consolidated statement of profit and loss (consolidated statement of comprehensive income).

The consolidated profit and loss for the year, consolidated comprehensive income and changes in equity of the subsidiaries attributable to the Group and non-controlling interests after consolidation adjustments and eliminations, is determined in accordance with the percentage ownership at year end, without considering the possible exercise or conversion of potential voting rights. However, Group and non-controlling interests are calculated taking into account the possible exercise of potential voting rights and other derivative financial instruments which, in substance, currently allow access to the economic benefits associated with the interests held, such as entitlement to a share in future dividends and changes in the value of subsidiaries.

Profit and loss and each component of other comprehensive income are assigned to equity attributable to shareholders of the Parent and to non-controlling interests in proportion to their interest, although this implies a balance receivable from non-controlling interests. Agreements signed between the Group and the noncontrolling interests are recognized as a separate transaction.

The increase and reduction of non-controlling interests in a subsidiary in which control is retained is recognized as an equity instrument transaction. Consequently, no new acquisition cost arises on increases, nor is a gain recorded on reductions; rather, the difference between the consideration transferred or received and the carrying amount of the non-controlling interests is recognized in the reserves of the investor, without prejudice to reclassifying consolidation reserves and reallocating other comprehensive income between the Group and the non-controlling interests. When a Group's interest in a subsidiary diminishes, non-controlling interests are recognized at their share of the net consolidated assets, including goodwill.

(d) Joint arrangements

Joint arrangements are those in which there is a contractual agreement to share the control over an economic activity, in such a way that the decisions over relevant activities require the unanimous consent of the Group and the remaining venturers. Under IFRS 11 "Joint arrangements" investments in joint arrangements are classified as joint operations or joint ventures. The classification depends on the contractual rights and obligations of each investor, rather than on the legal structure of the joint agreement.

Interests in joint ventures are accounted for using the equity method, after initially being recognized at cost in the consolidated balance sheet.

The acquisition cost of investments in joint arrangements is determined consistently with that established for investments in associates.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(e) Foreign currency transactions and balances

(i) Functional and presentation currency

The consolidated annual accounts are presented in thousands of Euros, which is the functional and presentation currency of the Parent.

(ii) Foreign currency transactions, balances and cash flows

Foreign currency transactions are translated into the functional currency using the previous month's exchange rate for all transactions performed during the current month. This method does not differ significantly from applying the exchange rate at the date of the transaction.

Monetary assets and liabilities denominated in foreign currencies have been translated into thousands of Euros at the closing rate, while non-monetary assets and liabilities measured at historical cost have been translated at the exchange rate prevailing at the transaction date. Non-monetary assets measured at fair value have been translated into thousands of Euros at the exchange rate at the date that the fair value was determined.

In the consolidated statement of cash flows, cash flows from foreign currency transactions have been translated into thousands of Euros at the exchange rates prevailing at the dates the cash flows occur. The effect of exchange rate fluctuations on cash and cash equivalents denominated in foreign currencies is recognized separately in the statement of cash flows as "Effect of exchange rate fluctuations on cash and cash equivalents".

Exchange gains and losses arising on the settlement of foreign currency transactions and the translation into thousands of Euros of monetary assets and liabilities denominated in foreign currencies are recognized in profit and loss.

(iii) Translation of foreign operations

The translation into thousands of Euros of foreign operations for which the functional currency is not the currency of a hyperinflationary economy is based on the following criteria:

  • Assets and liabilities, including goodwill and net asset adjustments derived from the acquisition of the operations, including comparative amounts, are translated at the closing rate at the reporting date;
  • Income and expenses, including comparative amounts, are translated using the previous month's exchange rate for all transactions performed during the current month. This method does not differ significantly from using the exchange rate at the date of the transaction;
  • Translation differences resulting from application of the above criteria are recognized in other comprehensive income.

(f) Borrowing costs

In accordance with IAS 23 "Borrowing Costs", since 1 January 2009 the Group recognizes borrowing costs directly attributable to the purchase, construction or production of qualifying assets as an increase in the value of these assets. Qualifying assets are those which require a substantial period of time before they can be used or sold. To the extent that funds are borrowed specifically for the purpose of obtaining a qualifying asset, the amount of borrowing costs eligible for capitalization is determined as the actual borrowing costs incurred, less any investment income on the temporary investment of those funds. Capitalized borrowing costs corresponding to general borrowing are calculated as the weighted average of the qualifying assets without considering specific funds. The amount of borrowing costs capitalized cannot exceed the amount of borrowing costs incurred during that period. The capitalized borrowing costs include adjustments to the carrying amount of financial liabilities arising from the effective portion of hedges entered into by the Group.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Group begins capitalizing borrowing costs as part of the cost of a qualifying asset when it incurs expenditure for the asset, interest is accrued, and it undertakes activities that are necessary to prepare the asset for its intended use or sale, and ceases capitalizing borrowing costs when all or substantially all the activities necessary to prepare the qualifying asset for its intended use or sale are complete. Nevertheless, capitalization of borrowing costs is suspended when active development is interrupted for extended periods.

The remaining interest costs are recognized as an expense in the year in which they are incurred.

(g) Property, plant and equipment

(i) Initial recognition

Property, plant and equipment are recognized at cost or deemed cost, less accumulated depreciation and any accumulated impairment losses. Land is not subject to depreciation. The cost of self-constructed assets is determined using the same principles as for an acquired asset, while also considering the criteria applicable to production costs of inventories. Capitalized production costs are recognized by allocating the costs attributable to the asset to "Self-constructed non-current assets" in the consolidated statement of profit and loss.

(ii) Depreciation

Property, plant and equipment are depreciated by allocating the depreciable amount of an asset on a systematic basis over its useful life. The depreciable amount is the cost or deemed cost of an asset, less its residual value. The Group determines the depreciation charge separately for each item for a component of property, plant and equipment with a cost that is significant in relation to the total cost of the asset.

Property, plant and equipment are depreciated using the following criteria:

Depreciation method Rates
Buildings Straight line 1% - 3%
Other property, technical equipment and machinery Straight line 4%-10%
Other property, plant and equipment Straight line 7% - 33%

The Group reviews residual values, useful lives and depreciation methods at each financial year end. Changes to initially established criteria are accounted for as a change in accounting estimates.

(iii) Subsequent recognition

Subsequent to initial recognition of the asset, only those costs incurred which will probably generate future profits and for which the amount may reliably be measured are capitalized. Costs of day-to-day servicing are recognized in profit and loss as incurred.

Replacements of property, plant and equipment which qualify for capitalization are recognized as a reduction in the carrying amount of the items replaced. Where the cost of the replaced items has not been depreciated independently and it is not possible to determine the respective carrying amount, the replacement cost is used as indicative of the cost of items at the time of acquisition or construction.

(iv) Impairment

The Group tests for impairment and reversals of impairment losses on property, plant and equipment based on the criteria set out in note 4(i) below.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(h) Intangible assets

(i) Goodwill

Goodwill is generated on the business combinations and is calculated using the criteria described in the section on business combinations.

Goodwill is not amortized, but is tested for impairment annually or more frequently whenever there is an indication that goodwill may be impaired. Goodwill acquired in business combinations is allocated to the cash-generating units (CGUs) or groups of CGUs which are expected to benefit from the synergies of the business combination and the criteria described in note 7 are applied. After initial recognition, goodwill is measured at cost less any accumulated impairment losses. Gains and losses on the sale of an entity include the carrying amount of the goodwill related to the entity sold.

(ii) Internally generated intangible assets

Any research and development expenditure incurred during the research phase of projects is recognized as an expense when incurred.

Costs related with development activities are capitalized when:

  • The Group has technical studies that demonstrate the feasibility of the production process;
  • The Group has undertaken a commitment to complete production of the asset, to make it available for sale or internal use;
  • The asset will generate sufficient future economic benefits;
  • The Group has sufficient technical and financial resources to complete development of the asset and has devised budget control and cost accounting systems that enable monitoring of budgetary costs, modifications and the expenditure actually attributable to the different projects.

The cost of internally generated assets by the Group is calculated using the same criteria established for determining production costs of inventories. The production cost is capitalized by allocating the costs attributable to the asset to self-constructed non-current assets in the consolidated statement of profit and loss.

Expenditure on activities that contribute to increasing the value of the different businesses in which the Group as a whole operates is expensed when incurred. Replacements or subsequent costs incurred on intangible assets are generally recognized as an expense, except where they increase the future economic benefits expected to be generated by the assets.

Development costs previously recognized as an expense are not recognized as an asset in a subsequent period.

(iii) Other intangible assets

Other intangible assets are carried at cost, or at fair value if they arise on business combinations, less accumulated amortization and impairment losses.

Intangible assets with indefinite useful lives are not amortized but tested for impairment at least annually.

(iv) Intangible assets acquired in business combinations

The cost of the identifiable intangible assets acquired in Biotest's business combination includes the fair value of the current contracts.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The cost of identifiable intangible assets acquired in the business combination of Hologic includes the fair value of the R&D projects and the Intellectual Property-Patents.

The cost of identifiable intangible assets acquired in the business combination of Novartis includes the fair value of the existing royalty agreements.

The cost of identifiable intangible assets acquired in the Progenika business combination includes the fair value of currently marketed products sold and which are classified under "Other intangible assets"and "Research and Development".

The cost of identifiable intangible assets acquired in the Talecris business combination includes the fair value of currently marketed products sold and which are classified under "Other intangible assets".

(v) Useful life and amortization rates

The Group assesses whether the useful life of each intangible asset acquired is finite or indefinite. An intangible asset is regarded as having an indefinite useful life when there is no foreseeable limit to the period over which the asset will generate net cash inflows.

Intangible assets with finite useful lives are amortized by allocating the depreciable amount of an asset on a systematic basis over its useful life, by applying the following criteria:

Amortisation method
Rates
Development expenses Straight line 10%
Concessions, patents, licences, trademarks and similar Straight line 4% - 20%
Computer software Straight line 33%
Currently marketed products Straight line 3% - 10%

The depreciable amount is the cost or deemed cost of an asset, less its residual value.

The Group does not consider the residual value of its intangible assets to be material. The Group reviews the residual value, useful life and amortization method for intangible assets at each financial year end. Changes to initially established criteria are accounted for as a change in accounting estimates.

(i) Impairment of goodwill, other intangible assets and other non-financial assets subject to depreciation or amortization

The Group evaluates whether there are indications of possible impairment losses on non-financial assets subject to amortization or depreciation, to verify whether the carrying amount of these assets exceeds the recoverable amount.

The Group tests goodwill, intangible assets with indefinite useful lives and intangible assets with finite useful lives that are not available for use for potential impairment at least annually, irrespective of whether there is any indication that the assets may be impaired.

The recoverable amount of the assets is the higher of their fair value less costs of disposal and their value in use. An asset's value in use is calculated based on an estimate of the future cash flows expected to derive from the use of the asset, expectations about possible variations in the amount or timing of those future cash flows, the time value of money, the price for bearing the uncertainty inherent in the asset and other factors that market participants would reflect in pricing the future cash flows deriving from the asset.

Negative differences arising from comparison of the carrying amounts of the assets with their recoverable amounts are recognized in the consolidated statement of profit and loss. Recoverable amount is determined for each individual asset, unless the asset does not generate cash inflows that are largely independent of those from

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

other assets or groups of assets. If this is the case, recoverable amount is determined for the cash-generating unit (CGU) to which the asset belongs.

Impairment losses recognized for cash-generating units are first allocated to reduce, where applicable, the carrying amount of goodwill allocated to the CGU and then to the other assets of the CGU pro rata on the basis of the carrying amount of each asset. The carrying amount of each asset may not be reduced below the highest of its fair value less costs of disposal, its value in use and zero.

At the end of each reporting period the Group assesses whether there is any indication that an impairment loss recognized in prior periods may no longer exist or may have decreased. Impairment losses on goodwill are not reversible. Impairment losses on other assets are only reversed if there has been a change in the estimates used to calculate the recoverable amount of the asset.

A reversal of an impairment loss is recognized in consolidated profit and loss. The increased carrying amount of an asset attributable to a reversal of an impairment loss may not exceed the carrying amount that would have been determined, net of depreciation or amortization, had no impairment loss been recognized.

A reversal of an impairment loss for a CGU is allocated to the assets of each unit, except goodwill, pro rata with the carrying amounts of those assets. The carrying amount of an asset may not be increased above the lower of its recoverable amount and the carrying amount that would have been disclosed, net of amortization or depreciation, had no impairment loss been recognized.

(j) Leases

(i) Lessee accounting records

The Group has rights to use certain assets through lease contracts.

Leases in which the Group assumes substantially all the risks and rewards incidental to ownership are classified as finance leases, otherwise they are classified as operating leases.

• Finance leases

At the commencement of the lease term, the Group recognizes finance leases as assets and liabilities at the lower of the fair value of the leased asset and the present value of the minimum lease payments. Initial direct costs are added to the asset's carrying amount. Minimum lease payments are apportioned between the finance charge and the reduction of the outstanding liability. The finance charge is allocated to each period during the lease term so as to produce a constant periodic rate of interest on the remaining balance of the liability. Contingent rents are recognized as an expense in the years in which they are incurred. Property, plant and equipment acquired through a finance lease is amortized over the useful life of the asset or within the term of the lease, whichever is less, if there is no reasonable certainty that the group will obtain the property at the end of the term of the lease.

• Operating leases

Lease payments under an operating lease (excluding incentives) are recognized as an expense on a straight-line basis unless another systematic basis is representative of the time pattern of the user's benefit.

(ii) Leasehold investments

Non-current investments in properties leased from third parties are recognized on the basis of the same criteria for property, plant and equipment. Investments are amortized over the lower of their useful lives and the term of the lease contract. The lease term is consistent with that established for recognition of the lease.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(iii) Sale and leaseback transactions

Any profit on sale and leaseback transactions that meet the conditions of a finance lease is deferred over the term of the lease.

When the leaseback is classified as an operating lease:

  • If the transaction is established at fair value, any profit and loss on the sale is recognized immediately in the consolidated statement of profit and loss for the year;
  • If the sale price is below fair value, any profit and loss is recognized immediately in the consolidated statement of profit and loss. However, if the loss is compensated for by future lease payments at below market price, it is deferred in proportion to the lease payments over the period for which the asset is to be used.

(k) Financial instruments

(i) Classification of the financial instruments

Financial instruments are classified at the time of their initial recognition as a financial asset, a financial liability or an equity instrument, in accordance with the economic substance of the contractual agreement and with the definitions of financial assets, financial liabilities or equity instruments indicated in IAS 32 "Financial instruments: Presentation".

For purposes of its valuation, the Group classifies financial instruments in the categories of financial assets and financial liabilities at fair value through profit or loss, separating those initially designated from those held for trading or mandatorily measured at fair value through profit or loss, financial assets and financial liabilities valued at amortized cost and financial assets measured at fair value through other comprehensive income, separating the equity instruments designated as such, from other financial assets. The classification depends on the Group's business model to manage the financial assets and the contractual terms of the cash flows.

The Group classifies a financial asset at amortized cost if it is held in the framework of a business model whose objective is to hold financial assets to obtain contractual cash flows and the contractual terms of the financial asset give rise, on specified dates, to cash flows which are only principal and interest payments on the outstanding principal amount (OPIP).

The Group classifies a financial asset at fair value through changes in other comprehensive income, if it is maintained in the framework of a business model whose objective is achieved by obtaining contractual cash flows and selling financial assets and the contractual conditions of the financial asset give rise to, at specified dates, to cash flows that are OPIP.

The business model is determined by the key personnel of the Group and at a level that reflects the way in which they jointly manage groups of financial assets to achieve a specific business objective. The Group's business model represents the way in which it manages its financial assets to generate cash flows.

Financial assets that are part of a business model whose objective is to hold assets to receive contractual cash flows are managed to generate cash flows in the form of contractual collections during the life of the instrument. The Group manages the assets held in the portfolio to receive these specific contractual cash flows. To determine whether cash flows are obtained through the collection of contractual cash flows from financial assets, the Group considers the frequency, value and timing of sales in prior years, the reasons for those sales and expectations in relation to with the future sales activity. However, the sales themselves do not determine the business model and, therefore, cannot be considered in isolation. Instead, it is the information on past sales and future sales expectations that provides indicative data on how to achieve the stated objective of the Group with respect to the management of financial assets and, more specifically, the way where cash flows are obtained.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

For assets measured at fair value, losses and gains will be recognized in profit or loss or other comprehensive income. For investments in equity instruments that are not held for trading, it will depend on whether the Group has made an irrevocable election at the time of initial recognition to account for investments in equity at fair value through other comprehensive income (COCI).

The Group reclassifies investments in debt when and only when its business model to manage those assets changes.

(ii) Measurement

At the time of initial recognition, the Group values a financial asset at its fair value plus, in the case of a financial asset that is not at fair value through profit or loss, the costs of the transaction that are directly attributable to the acquisition. The transaction costs of financial assets at fair value through profit or loss are taken to results.

In order to determine the fair value of financial assets or liabilities, the Group uses market data as much as possible. Based on the factors used for the measurement, the fair values are hierarchized based on the following levels:

  • Level 1: quoted prices (unadjusted) within current markets for assets or liabilities identical to those under consideration.
  • Level 2: factors other than the prices considered in Level 1 that come directly from the asset or liability in question, such as those that may derive directly from the price.
  • Level 3: factors not based on data directly from the market.

In the event that the factors used to determine the fair value of an asset or liability are included in different levels of hierarchy, the fair value will be determined in its entirety based on the significant component located at the lowest level of hierarchy.

(iii) Offseting principles

A financial asset and a financial liability are offset only when the Group has the legally enforceable right to set off the recognized amounts and intends either to settle on a net basis, or to realize the asset and settle the liability simultaneously.

(iv) Financial assets and liabilities at fair value through profit or loss

Financial assets or liabilities at fair value through profit or loss are those that are classified as held for trading or have been designated from the moment of initial recognition.

A financial asset or liability is classified as held for trading if:

• It is acquired or incurred mainly for the purpose of selling it or repurchasing it in the near term.

• On initial recognition it is part of a portfolio of identified financial instruments that are managed together and for which there is evidence of a recent pattern of short-term profit-taking, or

• It is a derivative, except for a derivative that is a financial guarantee contract or a designated and effective hedging instrument.

Financial assets and liabilities at fair value through profit or loss are initially recognized at fair value. Transaction costs directly attributable to the purchase or issue are recognized as an expense as incurred.

After initial recognition, they are recognized at fair value through profit or loss. The fair value is not reduced by the transaction costs that may be incurred by their eventual sale or disposal by other means.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Group does not reclassify any financial asset or liability to or from this category as long as it is recognized in the consolidated statement of financial position.

(v) Financial assets at amortized cost

Financial assets at amortized cost are initially recognized at their fair value, including the transaction costs incurred, and are subsequently valued at amortized cost, using the effective interest rate method.

(vi) Debt instruments

The subsequent valuation of the debt instruments depends on the Group's business model to manage the asset and the characteristics of the cash flows of the asset. The Group's debt instruments consist mainly of trade and other receivables, which the Group classifies as financial assets at amortized cost.

Financial assets at amortized cost are assets that the Group holds for the collection of contractual cash flows when these cash flows represent only payments of principal and interest, and are valued at amortized cost. Interest income from these financial assets is included in finance income in accordance with the effective interest rate method.

(vii) Equity instruments

The Group holds financial assets owned, mainly equity instruments, which are measured at fair value. When Group management has chosen to present the gains and losses on the fair value of the equity investments in other comprehensive income, after the initial recognition, the equity instruments are measured at fair value, recognizing the loss or gain in other comprehensive income. The amounts recognized in other comprehensive income are not subject to reclassification to profit or loss, without prejudice to reclassification to reserves at the time when the instruments are derecognized. Dividends from such investments continue to be recognized in income for the year as other income when the Group's right to receive payments is established.

(viii) Impairment

As of 1 January, 2018, the Group evaluates, on a prospective basis, the expected credit losses associated with its debt instruments recorded at amortized cost. The Group uses the practical solutions permitted by IFRS 9 to assess the expected credit losses related to commercial accounts using a simplified approach, eliminating the need to evaluate when there has been a significant increase in credit risk. The simplified approach requires that the expected losses be recorded from the initial recognition of receivables, so that the Group determines expected credit losses as a probability-weighted estimate of such losses over the expected life of the financial instrument.

The practical solution applied is the use of a provision matrix based on the segmentation into groups of homogeneous assets, applying the historical information of percentages of non-payment for said groups and applying reasonable information about the future economic conditions.

The percentage of non-payment is calculated according to the current experience of non-payment during the last year, as it is a very dynamic market and is adjusted for the differences between current and historical economic conditions and considering projected information, which is reasonably available.

(ix) Derecognition of financial assets

The Group applies the criteria for the derecognition of financial assets to a part of a financial asset or to a part of a group of similar financial assets or to a financial asset or a group of similar financial assets.

Financial assets are derecognised when the rights to receive cash flows related to them have expired or have been transferred and the Group has substantially transferred the risks and rewards derived from their ownership.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(x) Financial liabilities at amortized cost

Financial liabilities, including trade payables and other accounts payable, that are not classified at fair value through profit or loss, are initially recognized at their fair value, less, if applicable, the transaction costs that are directly attributable to the issue. Subsequent to the initial recognition, liabilities classified under this category are valued at amortized cost using the effective interest rate method.

(xi) Derecognition and modification of financial liabilities

The Group derecognises a financial liability or part thereof when it has complied with the obligation contained in the liability, or is legally exempt from the main liability contained in the liability, either by virtue of a judicial process or by the creditor.

The Group considers that the conditions are substantially different if the present value of the discounted cash flows under the new conditions, including any commission paid net of any commission received, and using the original effective interest rate to make the discount, differs at least at 10 percent of the discounted present value of the cash flows that still remain of the original financial liability.

If the exchange is recorded as a cancellation of the original financial liability, the costs or commissions are recognized in consolidated results forming part of the result of the same. Otherwise, the costs or commissions adjust the carrying amount of the liability and are amortized by the amortized cost method during the remaining life of the modified liability.

The Group recognizes the difference between the carrying amount of the financial liability or a part of it that is canceled or assigned to a third party and the consideration paid, including any assigned asset different from the cash or liability assumed in profit or loss.

(l) Equity instruments

The Group's acquisition of equity instruments of the Parent is recognized separately at cost of acquisition in the consolidated balance sheet as a reduction in equity, regardless of the motive of the purchase. Any gains or losses on transactions with treasury equity instruments are not recognized in consolidated profit and loss.

The subsequent redemption of Parent shares, where applicable, leads to a reduction in share capital in an amount equivalent to the par value of such shares. Any positive or negative difference between the cost of acquisition and the par value of the shares is debited or credited to reserves. Transaction costs related with treasury equity instruments, including issue costs related to a business combination, are accounted for as a reduction in equity, net of any tax effect.

(m) Inventories

Inventories are measured at the lower of cost and net realizable value. The cost of inventories comprises all costs of purchase, costs of conversion and other costs incurred in bringing the inventories to their present location and condition.

The costs of conversion of inventories include costs directly related to the units of production and a systematic allocation of fixed and variable production overheads that are incurred in converting materials into finished goods. The allocation of fixed indirect overheads is based on the higher of normal production capacity or actual production.

The raw material used to produce haemoderivatives is human plasma, which is obtained from our donation centers using the plasmapheresis method. The cost of inventories includes the amount paid to plasma donors, or the amount billed by the seller when purchased from third parties, as well as the cost of products and devices used in the collection process, rental expenses and storage. This plasma has to be stored before use, which is an essential part of the production process. During the storage period, the plasma undergoes various virological tests and should be kept in quarantine in accordance with FDA and European Medicines Agency regulations, in order to guarantee that all the plasma is suitable for use in the production process.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

To the extent that plasma storage costs are necessary to the production process, they are included as cost of inventories.

Indirect costs such as general management and administration costs are recognized as expenses in the period in which they are incurred.

The cost of raw materials and other supplies and the cost of merchandise are allocated to each inventory unit on a weighted average cost basis.

The transformation cost is allocated to each inventory unit on a FIFO (first-in, first-out) basis.

The Group uses the same cost model for all inventories of the same nature and with a similar use.

Volume discounts extended by suppliers are recognized as a reduction in the cost of inventories when it is probable that the conditions for discounts to be received will be met. Discounts for prompt payment are recognized as a reduction in the cost of the inventories acquired.

When the cost of inventories exceeds net realizable value, materials are written down to net realizable value, which is understood to be:

  • For raw materials and other supplies, replacement cost. Nevertheless, raw materials and other supplies are not written down below cost if the finished goods into which they will be incorporated are expected to be sold at or above cost of production;
  • Merchandise and finished goods, estimated selling price less costs to sell;
  • Work in progress, the estimated selling price of related finished goods, less the estimated costs of completion and the estimated costs necessary to make the sale.

The previously recognized write-down is reversed against profit and loss when the circumstances that previously caused inventories to be written down no longer exist or when there is clear evidence of an increase in net realizable value because of changed economic circumstances. The reversal of the write-down is limited to the lower of the cost and revised net realizable value of the inventories. Write-downs may be reversed with a credit to "Cost of Sales".

(n) Cash and cash equivalents

Cash and cash equivalents include cash on hand and demand deposits in financial institutions. They also include other short-term, highly liquid investments that are readily convertible to known amounts of cash and which are subject to an insignificant risk of changes in value. An investment normally qualifies as a cash equivalent when it has a maturity of less than three months from the date of acquisition.

The Group classifies cash flows relating to interest received and paid as operating activities, and dividends received and distributed are classified under investing and financing activities, respectively.

(o) Government grants

Government grants are recognized when there is reasonable assurance that they will be received and that the Group will comply with the conditions attached.

(i) Capital grants

Outright capital grants are initially recognized as deferred income in the consolidated balance sheet. Income from capital grants is recognized in the consolidated statement of profit and loss in line with the depreciation of the corresponding financed assets.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(ii) Operating grants

Operating grants received to offset expenses or losses already incurred, or to provide immediate financial support not related to future disbursements, are recognized in the consolidated statement of profit and loss.

(iii) Interest rate grants

Financial liabilities comprising implicit assistance in the form of below-market interest rates are initially recognized at fair value. The difference between this value, adjusted where necessary for the issue costs of the financial liability and the amount received, is recognized as a government grant based on the nature of the grant awarded.

(p) Employee benefits

(i) Defined contribution plans

The Group recognizes the contributions payable to a defined contribution plan in exchange for a service in the period in which contributions are accrued. Accrued contributions are recognized as an employee benefit expense in the corresponding consolidated statement of profit and loss in the year that the contribution was made.

(ii) Termination benefits

Termination benefits are recognized at the earlier of the date when the Group can no longer withdraw the offer of those benefits and when the Group recognizes costs for a restructuring that involves the payment of termination benefits.

For termination benefits payable as a result of an employee's decision to accept an offer of benefits, the time when the Group can no longer withdraw the offer of termination benefits is the earlier of when the employee accepts the offer and when a restriction on the Group's ability to withdraw the offer takes effect.

For termination benefits payable as a result of the Group's decision to make an employee redundant, the Group can no longer withdraw the offer when it has informed the affected employees or union representatives of the plan and the actions required to complete the plan indicate that it is unlikely that significant changes to the plan will be made. The plan must identify the number of employees to be made redundant, their job classifications or functions and their locations and the expected completion date. The plan must also establish the termination benefits that employees will receive in sufficient detail that employees can determine the type and amount of benefits they will receive when their employment is terminated.

If the Group expects to settle the termination benefits in full more than twelve months after year end, the liability is discounted using the market yield on high quality corporate bonds.

(iii) Short-term employee benefits

The Group recognizes the expected cost of short-term employee benefits in the form of accumulating compensated absences when the employees render service that increases their entitlement to future compensated absences. In the case of non-accumulating compensated absences, the expense is recognized when the absences occur.

The Group recognizes the expected cost of profit-sharing and bonus plans when it has a present legal or constructive obligation to make such payments as a result of past events and a reliable estimate of the obligation can be made.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(iv) Restricted Share Unit Retention Plan (RSU)

The Group gives share-based payments to certain employees who render services to the Company. The fair value of the services received is determined based on the estimated fair value of the shares given at the grant date. Because the equity instruments granted do not vest until the employees complete a specified period of service, those services are accounted for during the vesting period in the income statement as an expense for the year, with the corresponding increase in equity. The amount recognized corresponds to that settled once the agreed terms have been met and it will not be adjusted or revalued during the accrual period, as the commitment is settled in the form of shares.

The total amount recognized is calculated based on the incentive payable in shares, increasing in line with percentages agreed by the Group. If an employee decides to leave his/her job prior to the end of the accrual period, he/she will only receive the agreed incentive in the form of shares and the Company will be able to choose whether to settle in cash or using equity instruments.

(q) Provisions

Provisions are recognized when the Group has a present obligation (legal or implicit) as a result of a past event; it is probable that an outflow of resources embodying economic benefits will be required to settle the obligation; and a reliable estimate can be made of the amount of the obligation. No provisions are recognized for future operating losses.

The amount recognized as a provision is the best estimate of the expenditure required to settle the present obligation at the end of the reporting period, taking into account all risks and uncertainties surrounding the amount to be recognized as a provision and, where the time value of money is material, the financial effect of discounting provided that the expenditure to be made each period can be reliably estimated. The discount rate used to determine the present value is a pre-tax rate that reflects the evaluations that the current market is making of the time value of money and the specific risks of the obligation. The increase in the provision due to the passage of time is recognized as an interest expense.

If it is not probable that an outflow of resources embodying economic benefits will be required to settle the obligation, the provision is reversed against the consolidated statement of profit and loss item where the corresponding expense was recognized.

(r) Revenue recognition

Revenue from the sale of goods or services is recognized at an amount that reflects the consideration that the Group expects to be entitled to receive in exchange for transferring goods or services to a customer, at the time when the customer obtains control of the goods or services rendered. The consideration that is committed in a contract with a client can include fixed amounts, variable amounts, or both. The amount of the consideration may vary due to discounts, reimbursements, incentives, performance bonuses, penalties or other similar items. Contingent consideration is included in the transaction price when it is highly probable that the amount of revenue recognized is not subject to future significant reversals. Revenue is presented net of the value added tax and any other amount or tax, which in substance corresponds to amounts received on behalf of third parties.

(i) Sale of goods

Revenue from the sale of goods is recognized when the Group meets the performance obligation by transferring the assets committed to the customer. An asset is transferred when the customer obtains control of that asset. When evaluating the satisfaction of the performance obligation, the Group considers the following indicators of the transfer of control, which include, but are not limited to the following:

  • The Group has a present right to payment for the asset
  • The customer has the legal right to the asset
  • The Group has transferred the physical possession of the asset
  • The customer has the significant risks and rewards of ownership of the asset
  • The customer has accepted the asset

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Group participates in the government-managed Medicaid programs in the United States, accounting for Medicaid rebates by recognizing an accrual at the time a sale is recorded for an amount equal to the estimated claims for Medicaid rebates attributable to the sale. Medicaid rebates are estimated based on historical experience, legal interpretations of the applicable laws relating to the Medicaid program and any new information regarding changes in the program regulations and guidelines that would affect rebate amounts. Outstanding Medicaid claims, Medicaid payments and inventory levels are analyzed for each distribution channel and the accrual is adjusted periodically to reflect actual experience. While rebate payments are generally made in the following or subsequent quarter, any adjustments for actual experience have not been material.

As is common practice in the sector, the purchase contracts signed by some customers with the Group entitle these customers to price discounts for a minimum purchase volume, volume discounts or prompt payment discounts. The Group recognizes these discounts as a reduction in sales and receivables in the same month that the corresponding sales are invoiced based on the customer's actual purchase figures or on past experience when the customer's actual purchases will not be known until a later date.

In the USA, the Group enters into agreements with certain customers to establish contract pricing for the products, which these entities purchase from the authorized wholesaler or distributor (collectively, wholesalers) of their choice. Consequently, when the products are purchased from wholesalers by these entities at the contract price which is less than the price charged by the Group to the wholesaler, the Group provides the wholesaler with a credit referred to as a chargeback. The Group records the chargeback accrual at the time of the sale. The allowance for chargebacks is based on Group's estimate of the wholesaler inventory levels, and the expected sell-through of the products by the wholesalers at the contract price based on historical chargeback experience and other factors. The Group periodically monitors the factors that influence the provision for chargebacks, and makes adjustments when it considers that actual chargebacks may differ from established allowances. These adjustments occur in a relatively short period of time. As these chargebacks are typically settled within 30 to 45 days of the sale, adjustments for actual experience have not been material.

(ii) Services rendered

Revenues associated with the rendering of service transactions are recognized by reference to the stage of completion at the consolidated balance sheet date when the outcome of the transaction can be estimated reliably. The outcome of a transaction can be estimated reliably when revenues, the stage of completion, the costs incurred and the costs to complete the transaction can be estimated reliably and it is probable that the economic benefits derived from the transaction will flow to the Group.

When the outcome of the transaction involving the rendering of services cannot be estimated reliably, revenue is recognized only to the extent of costs incurred that are recoverable.

(iii) Interest income

Until June 2012 the Group has been recognizing interest receivable from the different Social Security affiliated bodies in Spain, to which it provides goods or services, on an accrual basis, and only for those bodies to which historically claims have been made and from which interest has been collected. As a result of the terms imposed by the Spanish Government in 2012 regarding the waiver of late payment interest on overdue receivables, the Group modified its estimate regarding late payment interest. Since June 2012 the Group has only been recognizing late payment interest on receivables from Social Security affiliated bodies on the date on which delayed invoices are collected, as it is highly likely that they will be collected as of that date provided.

(s) Income taxes

The income tax expense or tax income for the year comprises current tax and deferred tax.

Current tax is the amount of income taxes payable or recoverable in respect of the consolidated taxable profit or consolidated tax loss for the year. Current tax assets or liabilities are measured at the amount expected to be

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

paid to or recovered from the taxation authorities, using the tax rates and tax laws that have been enacted or substantially enacted at the reporting date.

Deferred tax liabilities are the amounts of income taxes payable in future periods in respect of taxable temporary differences, whereas deferred tax assets are the amounts of income taxes recoverable in future periods in respect of deductible temporary differences, the carryforward of unused tax losses, and the carryforward of unused tax credits. Temporary differences are differences between the carrying amount of an asset or liability in the balance sheet and its tax base.

Current and deferred tax are recognized as income or an expense and included in profit and loss for the year, except to the extent that the tax arises from a transaction or event which is recognized, in the same or a different year, directly in equity, or from a business combination.

(i) Taxable temporary differences

Taxable temporary differences are recognized in all cases except where:

• They arise from the initial recognition of goodwill or an asset or liability in a transaction that is not a business combination and, at the time of the transaction, affects neither accounting profit nor taxable income;

• They are associated with investments in subsidiaries over which the Group is able to control the timing of the reversal of the temporary difference and it is not probable that the temporary difference will reverse in the foreseeable future.

(ii) Deductible temporary differences

Deductible temporary differences are recognized provided that:

• It is probable that sufficient taxable income will be available against which the deductible temporary difference can be utilized, unless the differences arise from the initial recognition of an asset or liability in a transaction that is not a business combination and, at the time of the transaction, affects neither accounting profit nor taxable income;

• The temporary differences are associated with investments in subsidiaries to the extent that the difference will reverse in the foreseeable future and sufficient taxable income is expected to be generated against which the temporary difference can be offset.

Tax planning opportunities are only considered when assessing the recoverability of deferred tax assets and if the Group intends to use these opportunities or it is probable that they will be utilized.

(iii) Measurement

Deferred tax assets and liabilities are measured at the tax rates that are expected to apply to the years when the asset is realized or the liability is settled, based on tax rates and tax laws that have been enacted or substantively enacted. The tax consequences that would follow from the manner in which the Group expects to recover or settle the carrying amount of its assets or liabilities are also reflected in the measurement of deferred tax assets and liabilities.

At year end the Group reviews the fair value of deferred tax assets to write down the balance if it is not probable that sufficient taxable income will be available to apply the tax asset.

Deferred tax assets which do not meet the above conditions are not recognized in the consolidated balance sheet. At year end the Group assesses whether deferred tax assets which were previously not recognized now meet the conditions for recognition.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(iv) Offset and classification

The Group only offsets current tax assets and current tax liabilities if it has a legally enforceable right to set off the recognized amounts and intends either to settle on a net basis, or to realize the asset and settle the liability simultaneously.

The Group only offsets deferred tax assets and liabilities where it has a legally enforceable right, where these relate to income taxes levied by the same taxation authority and where the taxation authority permits the entity to settle on a net basis, or to realize the asset and settle the liability simultaneously for each of the future years in which significant amounts of deferred tax assets or liabilities are expected to be settled or recovered.

Deferred tax assets and liabilities are recognized in the consolidated balance sheet under non-current assets or liabilities, irrespective of the expected date of recovery or settlement.

(t) Segment reporting

An operating segment is a component of the Group that engages in business activities from which it may earn revenues and incur expenses, whose operating results are regularly reviewed by the Group's chief operating decision maker to make decisions about resources to be allocated to the segment, assess its performance and, based on which, differentiated financial information is available.

(u) Classification of assets and liabilities as current and non-current

The Group classifies assets and liabilities in the consolidated balance sheet as current and non-current. Current assets and liabilities are determined as follows:

• Assets are classified as current when they are expected to be realized or are intended for sale or consumption in the Group's normal operating cycle, they are held primarily for the purpose of trading, they are expected to be realized within twelve months after the reporting date or are cash or a cash equivalent, unless the assets may not be exchanged or used to settle a liability for at least twelve months after the reporting date.

• Liabilities are classified as current when they are expected to be settled in the Group's normal operating cycle, they are held primarily for the purpose of trading, they are due to be settled within twelve months after the reporting date or the Group does not have an unconditional right to defer settlement of the liability for at least twelve months after the reporting date.

• Financial liabilities are classified as current when they are due to be settled within twelve months after the reporting date, even if the original term was for a period longer than twelve months, and an agreement to refinance, or to reschedule payments, on a long-term basis is completed after the reporting date and before the consolidated annual accounts are authorized for issue.

(v) Environmental issues

The Group takes measures to prevent, reduce or repair the damage caused to the environment by its activities. Property, plant and equipment acquired by the Group for long-term use to minimize the environmental impact of its activity and protect and improve the environment, including the reduction and elimination of future pollution from the Group's operations, are recognized as assets applying the measurement, presentation and disclosure criteria described in note 4(g).

(5) Financial Risk Management Policy

(a) General

The Group is exposed to the following risks associated with the use of financial instruments:

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • Credit risk
  • Liquidity risk
  • Market risk: includes interest rate risk, currency risk and other price risks.

This note provides information on the Group's exposure to each of these risks, the Group's objectives and procedures to measure and mitigate this risk, and the Group's capital management strategy. More exhaustive quantitative information is disclosed in note 30 to the consolidated annual accounts.

The Group's risk management policies are established to identify and analyse the risks faced by the Group, define appropriate risk limits and controls and to control risks and comply with limits. Risk management policies and procedures are reviewed regularly so that they reflect changes in market conditions and the Group's activities. The Group's management procedures and rules are designed to create a strict and constructive control environment in which all employees understand their duties and obligations.

The Group's Audit Committee supervises how management controls compliance with the Group's risk management procedures and policies and reviews whether the risk management policy is suitable considering the risks to which the Group is exposed. This committee is assisted by Internal Audit which acts as supervisor. Internal Audit performs regular and ad hoc reviews of the risk management controls and procedures and reports its findings to the Audit Committee.

Credit risk

Credit risk is the risk to which the Group is exposed in the event that a customer or counterparty to a financial instrument fails to discharge a contractual obligation, and mainly results from trade receivables and the Group's investments in financial assets.

Trade receivables

The Group does not predict any significant insolvency risks as a result of delays in receiving payment from some European countries due to their current economic situation. The main risk in these countries is that of late payments, which is mitigated through the possibility of claiming interest as foreseen by prevailing legislation. No significant bad debt or late payment issues have been detected for sales to private entities.

The Group recognizes impairment based on its best estimate of the expected losses on trade and other receivables. The main impairment losses recognized are due to specific losses relating to individually identified risks. At year end, these impairment losses are immaterial.

Details of exposure to credit risk are disclosed in note 30.

Liquidity risk

Liquidity risk is the risk that the Group cannot meet its financial obligations as they fall due. The Group's approach to managing liquidity is to ensure where possible, that it always has sufficient liquidity to settle its obligations at the maturity date, both in normal conditions and in times of tension, to avoid incurring unacceptable losses or tarnishing the Group's reputation.

The Group manages liquidity risk on a prudent basis, based on availability of cash and sufficient committed unused long-term credit facilities, enabling the Group to implement its business plans and carry out operations using stable and secure sources of financing.

At 31 December 2018 the Group has total cash and cash equivalents of Euros 1,033,792 thousand (Euros 886,521 thousand at 31 December 2017). The Group also has approximately Euros 404,808 thousand in unused credit facilities (Euros 381,165 thousand at 31 December 2017), including Euros 262,008 thousand on the revolving credit facility (Euros 250,146 thousand at 31 December 2017).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The structure of the Group's debt consists mainly of a non-current loan of US Dollars 5,992 million with institutional investors and banks divided into two tranches (Tranche A and Tranche B), in a US Dollars 300 million undrawn revolving credit facility and unsecured senior corporate notes for an amount of Euros 1,000 million.

As in previous years, the Group continues with its quarterly program for optimization of working capital, which is mainly based on contracts to sell receivables without recourse.

2018:

In September 2018 the Group received an additional non-current loan from the European Investment Bank totaling Euros 85,000 thousand. The loan will be used to support certain investments in R&D which are mainly focused on searching for new therapeutic for plasmatic proteins. Financial terms include a fixed interest rate for a period of 10 years with a grace period of two years. At 31 December 2018, the carrying amount of the loans obtained from the European Investment Bank is Euros 244,375 thousand (Euros 170,000 thousand at 31 December 2017).

2017:

On 5 December 2017 the Group received an additional loan from the European Investment Bank of up to Euros 85,000 thousand at a fixed interest rate for a period of 10 years with a grace period of 2 years. The loan will be used to support certain investments in R&D which are mainly focused on searching for new applications for plasmatic proteins. On 28 October 2015, the Group received its first loan from the same entity under the same terms, for a total amount of Euros 100,000 thousand.

On 18 April 2017 the Group concluded the refinancing process of the Senior Unsecured Notes. The total note issuance amounted to Euros 1,000 million.

On 6 February 2017 the Group concluded the refinancing process of its senior debt. The total debt refinanced amounts to US Dollars 6,300 million (Euros 5,800 million), including the US Dollars 1,816 million loan obtained for the acquisition of Hologic's transfusional diagnostics unit. Following the refinancing process, Grifols' debt structure consisted of a US Dollars 6,000 million long-term loan with institutional investors and banks segmented in two tranches (Term Loan A and Term Loan B), and a US Dollars 300 million undrawn revolving credit facility.

Market risk

Market risk comprises the risk of changes in market prices, for example, exchange rates, interest rates, or the prices of equity instruments affecting the Group's revenues or the value of financial instruments it holds. The objective of managing market risk is to manage and control the Group's exposure to this risk within reasonable parameters at the same time as optimising returns.

(i) Currency risk

The Group operates internationally and is therefore exposed to currency risk when operating with foreign currencies, especially with regard to the US Dollar which is used in a significant percentage of transactions in foreign functional currencies. Currency risk is associated with future commercial transactions, recognized assets and liabilities, and net investments in foreign operations.

The Group holds significant investments in foreign operations, the net assets of which are exposed to currency risk. The conversion risk affecting net assets of the Group's foreign operations in US Dollars is mitigated primarily through borrowings in this foreign currency.

The Group's main exposure to currency risk is with regard to the US Dollar, which is used in a significant percentage of transactions in foreign functional currencies.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details of the Group's exposure to currency risk at 31 December 2018 and 2017 of the most significant financial instruments are shown in note 30.

(ii) Interest rate risk

The Group's interest rate risks arise from current and non-current borrowings. Borrowings at variable interest rates expose the Group to cash flow interest rate risks. Fixed-rate borrowings expose the Group to fair value interest rate risk.

The objective of the management of interest rate risk is to achieve a balance in the structure of the debt, keeping part of the external resources issued at a fixed rate and covering part of the variable rate debt through hedges.

A significant part of the financing obtained accrues interest at fixed rates. This fixed interest debt (Senior Unsecured Notes) amounts to Euros 1,000 million, which represents approximately 54% of the Group's total debt in Euros. The additional loans of Euros 244,375 thousand received from the European Investment Bank represent approximately 13% of the Group's total debt in Euros.

Senior debt in Euros represents approximately 12% of the Group's total Senior debt at 31 December 2018 and 31 December 2017.

Total fixed-interest debt represents 19% of total debt at 31 December 2018 (19% at 31 December 2017).

(iii) Market price risk

Price risk affecting raw materials is mitigated by the vertical integration of the haemoderivatives business in a highly-concentrated sector.

(b) Capital management

The directors' policy is to maintain a solid capital base in order to ensure investor, creditor and market confidence and sustain future business development. The board of directors defines and proposes the level of dividends paid to shareholders.

The directors consider various arguments to calculate capital structure:

• The directors control capital performance using rates of returns on equity (ROE). At 31 December 2018 the ROE stood at 14% (18% at 31 December 2017). The ROE is calculated by dividing profit attributable to the Parent by the equity attributable to the Parent.

Thousand of Euros
2018
2017
Profit attributable to the parent 596,642 662,700
Equity attributable to the Parent 4,225,554 3,629,079
ROE 14% 18%
  • In accordance with the senior secured debt contract, the Group is subject to compliance with some covenants. At 31 December 2018 and 2017, the Group complies with the covenants.
  • Consideration of the Company's credit rating (see note 20 (d)).

The Parent held Class A and B treasury stock equivalent to 0.6% of its capital at 31 December 2018 (0.6% at 31 December 2017). The Group does not have a formal plan for repurchasing shares.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(6) Segment Reporting

In accordance with IFRS 8 "Operating Segments", financial information for operating segments is reported in the accompanying Appendix II, which forms an integral part of this note to the consolidated annual accounts.

Group companies are divided into four areas: companies from the industrial area, companies from the commercial area, companies from the services area and companies from the research area. Within each of these areas, activities are organized based on the nature of the products and services manufactured and marketed.

Assets, liabilities, income and expenses for segments include directly and reliably attributable items. Items which are not attributed to segments by the Group are:

  • Balance sheet: cash and cash equivalents, current income tax assets and liabilities, deferred tax assets and liabilities and loans and borrowings.
  • Statement of profit and loss: finance result and income tax.

(a) Operating segments

The operating segments defined by the steering committee are as follows:

  • Bioscience: including all activities related with products derived from human plasma for therapeutic use.
  • Hospital: comprising all non-biological pharmaceutical products and medical supplies manufactured by Group companies earmarked for hospital pharmacy. Products related with this business which the Group does not manufacture but markets as supplementary to its own products are also included.
  • Diagnostic: including the marketing of diagnostic testing equipment, reagents and other equipment, manufactured by Group or other companies.
  • Bio Supplies: since January 2017, the company is including all transactions related to biological products for non-therapeutic use, Kedrion production agreements, and third-party plasma sales channeled through Haema and Biotest in the new Bio Supplies Division resulting in a reclassification from Bioscience Division to Bio Supplies Division.
  • Others: including the rendering of manufacturing services to third party companies.

As a result of the creation of the new Bio Supplies segment and the Intersegments, the Group has reviewed the allocation of balances and transactions by segments. The comparative figures for 2016 have been restated accordingly.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details of net sales by groups of products for 2018, 2017 and 2016 are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Bioscience
Haemoderivatives 3,516,704 3,429,785 3,228,275
Diagnostic
Transfusional medicine 650,180 679,692 640,443
Other diagnostic 19,797 23,377 23,540
Hospital
Fluid therapy and nutrition 52,574 47,699 46,210
Hospital supplies 58,014 52,466 52,373
Bio supplies 167,004 66,791 24,387
Others 22,451 18,263 34,602
Total 4,486,724 4,318,073 4,049,830

The Group has concluded that hemoderivative products are sufficiently alike to be considered as a whole for the following reasons:

  • All these products are human plasma derivatives and are manufactured in a similar way.
  • The customers and methods used to distribute these products are similar.
  • All these products are subject to the same regulations regarding production and the same regulatory environment.

(b) Geographical information

Geographical information is grouped into four areas:

  • United States of America and Canada
  • Spain
  • Rest of the European Union
  • Rest of the world

The definition of these four segments is mainly due to the geographical level that the Group sets to manage its revenue as they respond to specific economic scenarios. The main framework of the Group is consistent with this geographical segment grouping, including the monitoring of its commercial operations and its information systems.

The financial information reported for geographical areas is based on sales to third parties in these markets as well as the location of assets.

(c) Main customers

In 2018 the revenue of two Bioscience segment customers represents approximately 23.1% of the Group's total revenues. For 2017 and 2016 one Bioscience segment customer represented 11.0% and 10.7% of the Group's total revenue, respectively.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(7) Goodwill

Details of and movement in this caption of the consolidated balance sheet at 31 December 2017 are as follows:

Thousands of Euros
Balance at Business Translation Balance at
Segment 31/12/2016 Combination differences 31/12/2017
Net value
Grifols UK.Ltd. (UK) Bioscience 8,025 -- (280) 7,745
Grifols Italia.S.p.A. (Italy) Bioscience 6,118 -- -- 6,118
Biomat USA, Inc.(USA) Bioscience 193,039 40,101 (27,886) 205,254
Grifols Australia Pty Ltd.
(Australia) / Medion Diagnostics AG (Switzerland)
Diagnostic 10,134 -- (591) 9,543
Grifols Therapeutics, Inc. (USA) Bioscience 2,108,139 -- (255,234) 1,852,905
Araclon Biotech, S.L. (Spain) Diagnostic 6,000 -- -- 6,000
Progenika Biopharma, S.A. (Spain) Diagnostic 40,516 -- -- 40,516
Grifols Diagnostic (Novartis & Hologic) (USA, Spain and
Hong Kong)
Diagnostic 1,272,024 1,466,420 (302,537) 2,435,907
Kiro Grifols S.L. (Spain) Hospital -- 26,510 -- 26,510
3,643,995 1,533,031 (586,528) 4,590,498

(See note 3)

Details of and movement in this caption of the consolidated balance sheet at 31 December 2018 are as follows:

Thousands of Euros
Balance at Business Translation Balance at
Segment 31/12/2017 Combination Disposals differences 31/12/2018
Net value
Grifols UK.Ltd. (UK) Bioscience 7,745 -- -- (63) 7,682
Grifols Italia.S.p.A. (Italy) Bioscience 6,118 -- -- -- 6,118
Biomat USA, Inc.(USA) Bioscience 205,254 42,780 (2,827) 9,907 255,114
Grifols Australia Pty Ltd.
(Australia) / Medion Diagnostics AG
(Switzerland)
Diagnostic 9,543 -- -- (272) 9,271
Grifols Therapeutics, Inc. (USA) Bioscience 1,852,905 -- -- 87,871 1,940,776
Araclon Biotech, S.L. (Spain) Diagnostic 6,000 -- -- -- 6,000
Progenika Biopharma, S.A. (Spain) Diagnostic 40,516 -- -- -- 40,516
Grifols Diagnostic (Novartis & Hologic)
(USA, Spain and Hong Kong)
Diagnostic 2,435,907 -- -- 114,349 2,550,256
Kiro Grifols S.L. (Spain) Hospital 26,510 (2,134) -- -- 24,376
Goetech LLC (USA) Hospital -- 55,321 -- 3,624 58,945
Haema AG (Germany) Bioscience -- 171,134 -- -- 171,134
Biotest Pharma Corp (USA) Bioscience -- 136,234 -- 2,808 139,042
4,590,498 403,335 (2,827) 218,224 5,209,230

(See note 3)

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Impairment testing:

As a result of the acquisition of Talecris in 2011, and for impairment testing purposes, the Group combines the CGUs allocated to the Bioscience segment, grouping them together at segment level, because substantial synergies were expected to arise on the acquisition of Talecris, and due to the vertical integration of the business and the lack of an independent organized market for the products. Because the synergies benefit the Bioscience segment globally they cannot be allocated to individual CGUs. The Bioscience segment represents the lowest level to which goodwill is allocated and is subject to control by Group management for internal control purposes.

Since the acquisition of Novartis' Diagnostic business unit in 2014, the Group combines Araclon, Progenika, Australia and Hologic's share of NAT donor screening unit acquisition into a single CGU for the Diagnostic business as the acquisition is supporting not only the vertically integration business but also cross-selling opportunities. In addition, for management purposes, the Group's management is focused on the business more than geographical areas or individual companies.

Due to the acquisition of an additional 40% stake of Kiro Grifols S.L. and a 51% stake of Goetech LLC (Medkeeper), the Group decided to group Kiro Grifols S.L., Laboratorios Grifols S.L. and Medkeeper into a single CGU for the Hospital business since the acquisitions are supporting cross-selling opportunities.

The CGUs established by Management are:

  • Bioscience
  • Diagnostic
  • Hospital

The recoverable amount of the Bioscience CGU was calculated based on its value in use calculated as the present value of the future cash flows discounted at a discount rate considering the related inherent risk.

The recoverable amount of the Diagnostic CGU was calculated based on its fair value less costs of disposal calculated as the present value of the future cash flows discounted at a discount rate considering the related inherent risk.

The recoverable amount of the Hospital CGU was calculated based on its fair value less costs of disposal calculated as the present value of the future cash flows discounted at a discount rate considering the related inherent risk.

This value in use and fair value less costs of disposal calculations use cash flow projections for five years based on the financial budgets approved by management. Cash flows estimated as of the year in which stable growth in the CGU has been reached are extrapolated using the estimated growth rates indicated below.

The key assumptions used in calculating impairment of the CGUs for 2017 were as follows:

Perpetual Growth rate Pre-tax discount rate
Bioscience 2% 9.50%
Diagnostic 2% 10.60%
Hospital 1.40% 13.30%

The key assumptions used in calculating impairment of the CGUs for 2018 have been as follows:

Perpetual Growth rate Pre-tax discount rate
Bioscience 2% 8.90%
Diagnostic 2% 9.40%
Hospital 1.50% 13.10%

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Management determined budgeted gross margins based on past experience, investments in progress which would imply significant growth in production capacity and its forecast international market development. Perpetual growth rates are coherent with the forecasts included in industry reports. The discount rate used reflects specific risks related to the CGU.

As the recoverable amount of the Bioscience CGU is much higher than the carrying amount of the Bioscience segment's assets, specific information from the impairment test sensitivity analysis is not included.

At 31 December 2018 Grifols' stock market capitalization totals Euros 13,978 million (Euros 15,379 million at 31 December 2017).

(8) Other Intangible Assets

Details of other intangible assets and movement during the years ended 31 December 2018 and 2017 are included in Appendix III, which forms an integral part of these notes to the consolidated annual accounts.

Intangible assets acquired from Talecris mainly include currently marketed products. Identifiable intangible assets correspond to Gamunex and have been recognized at fair value at the acquisition date of Talecris and classified as currently marketed products. Intangible assets recognized comprise the rights on the Gamunex product, its commercialization and distribution license, trademark, as well as relations with hospitals. Each of these components is closely linked and fully complementary, are subject to similar risks and have a similar regulatory approval process.

Intangible assets acquired from Progenika mainly include currently marketed products. Identifiable intangible assets correspond to blood, immunology and cardiovascular genotyping. These assets have been recognized at fair value at the acquisition date of Progenika and classified as currently marketed products.

The cost and accumulated amortization of currently marketed products acquired from Talecris and Progenika at 31 December 2017 is as follows:

Thousands of Euros
Balance at
31/12/2016
Additions Translation
differences
Balance at
31/12/2017
Cost of currently marketed products - Gamunex 1,138,412 -- (137,828) 1,000,584
Cost of currently marketed products - Progenika 23,792 -- -- 23,792
Accumulated amortisation of currently marketed products -
Gamunex
(211,871) (35,837) 28,136 (219,572)
Accumulated amortisation of currently marketed products -
Progenika
(9,117) (2,379) -- (11,496)
Carrying amount of currently marketed products 941,216 (38,216) (109,692) 793,308

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The cost and accumulated amortization of currently marketed products acquired from Talecris and Progenika at 31 December 2018 is as follows:

Thousands of Euros
Balance at
31/12/2017
Additions Translation
differences
Balance at
31/12/2018
Cost of currently marketed products - Gamunex 1,000,584 -- 47,451 1,048,035
Cost of currently marketed products - Progenika 23,792 -- -- 23,792
Accumulated amortisation of currently marketed products -
Gamunex
(219,572) (33,775) (11,573) (264,920)
Accumulated amortisation of currently marketed products -
Progenika
(11,496) (2,379) -- (13,875)
Carrying amount of currently marketed products 793,308 (36,154) 35,878 793,032

The estimated useful life of the currently marketed products acquired from Talecris is considered limited, has been estimated at 30 years on the basis of the expected life cycle of the product (Gamunex) and is amortized on a straight-line basis.

At 31 December 2018 the residual useful life of currently marketed products is 22 years and 5 months (23 years and 5 months at 31 December 2017).

The estimated useful life of the currently marketed products acquired from Progenika is considered limited, has been estimated at 10 years on the basis of the expected life cycle of the product and is amortized on a straight-line basis.

At 31 December 2018 the residual useful life of currently marketed products acquired from Progenika is 4 years and 2 months (5 years and 2 months at 31 December 2017).

(a) Self – constructed intangible assets

At 31 December 2018 the Group has recognized Euros 58,254 thousand as self-constructed intangible assets (Euros 49,782 thousand at 31 December 2017).

(b) Purchase commitments

At 31 December 2018 the Group has intangible asset purchase commitments amounting to Euros 589 thousand (Euros 1,199 thousand at 31 December 2017).

(c) Intangible assets with indefinite useful lives and other intangibles in progress

At 31 December 2018 the Group recognizes plasma center licenses with indefinite useful lives under intangible assets for a carrying amount of Euros 26,917 thousand (Euros 26,631 thousand at 31 December 2017).

The Group has also an amount of Euros 206,087 thousand as development costs in progress (Euros 183,281 thousand at 31 December 2017).

(d) Result on disposal of intangible assets

Total profit on disposals of intangible assets in 2018 amount to Euros 8,101 thousand (Euros 83 thousand of loss in 2017) and mainly corresponds to the sale of plasma centers to Kedplasma.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(e) Impairment testing

Indefinite-lived intangible assets have been allocated to the cash-generating unit (CGU) of the Bioscience segment. These assets have been tested for impairment together with goodwill (see note 7).

Impairment testing has been analyzed for each of the intangible assets in progress by calculating its recoverable amount based on their fair value.

On 29 January 2018 (prior to the date that the 2017 consolidated annual accounts were authorized for issued) Aradigm communicated that it had not obtained the approval of the Antimicrobial Drugs Advisory Committee of the US Food and Drug Administration (FDA) for LinahiqTM. As the Committee did not recommend it as a treatment for non-cystic fibrosis bronchiectasis patients with chronic lung Pseudomonas aeruginosa infections, the intangible assets related to the product have been totally impaired and recognized as R&D expense in the statement of profit and loss for 2017 for an amount of Euros 63,675 thousand. In 2017 the investment in this company and the bonds that the Group held with the company were impaired.

(9) Property, Plant and Equipment

Details of property, plant and equipment and movement in the consolidated balance sheet at 31 December 2018 and 2017 are included in Appendix IV, which forms an integral part of this note to the consolidated annual accounts. Property, plant and development under construction at 31 December 2018 and 2017 mainly comprise investments made to extend the companies' equipment and to increase their productive capacity.

In 2018, the Group has capitalized interests for a total amount of Euros 8,955 thousand (Euros 8,839 thousand in 2017)

a) Insurance

Group policy is to contract sufficient insurance coverage for the risk of damage to property, plant and equipment. At 31 December 2018 the Group has a combined insurance policy for all Group companies, which more than adequately covers the carrying amount of all the Group's assets.

b) Losses on disposal of property, plant and equipment

Total losses incurred on disposals of property, plant and equipment for 2018 amount to Euros 1,401 thousand (Euros 1,468 thousand of loss in 2017).

c) Assets under finance lease

The Group contracted the following types of property, plant and equipment under finance leases at 31 December 2017:

Thousands of Euros
Cost Accumulated
depreciation
Carrying amount
Land and buildings 2,545 (815) 1,730
Plant and machinery 14,249 (6,564) 7,685
16,794 (7,379) 9,415

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Group has contracted the following types of property, plant and equipment under finance leases at 31 December 2018:

Thousands of Euros
Cost Accumulated
depreciation
Carrying amount
Land and buildings 2,389 (898) 1,491
Plant and machinery 15,690 (7,237) 8,453
18,079 (8,135) 9,944

Details of minimum lease payments and the present value of finance lease liabilities, disclosed by maturity date, are detailed in note 20 (c).

d) Self – constructed property, plant and equipment

At 31 December 2018 the Group has recognized Euros 66,995 thousand as self -constructed property, plant and equipment (Euros 52,218 thousand at 31 December 2017).

e) Purchase commitments

At 31 December 2018 the Group has property, plant and equipment purchase commitments amounting to Euros 47,148 thousand (Euros 39,675 thousand at 31 December 2017).

f) Impairment

A group of assets forming part of the Hospital segment has been tested for impairment due to the decrease in the results of the segment and no impairment has been observed. The recoverable amount of the aforementioned assets is calculated based on the fair value less cost of disposal, using cash flow projections based on five-year financial budgets approved by management. Cash flows estimated as of the year in which stable growth has been reached by the assets are extrapolated using a pre-tax discount rate of 10.1% and a perpetual growth rate of 2% (12.2% and 2% respectively in fiscal year 2017).

(10) Equity Accounted Investees

Details of this caption in the consolidated balance sheet at 31 December 2018 and 2017 are as follows:

Thousands of Euros Thousands of Euros
% ownership 31/12/2018 % ownership 31/12/2017
Alkahest, Inc. 47.58% 28,336 47.58% 30,559
Albajuna Therapeutics, S.L 30.00% 1,106 30.00% 1,956
Interstate Blood Bank, Inc. 49.19% 29,595 49.19% 27,936
Bio Blood Components Inc. 48.97% 38,223 48.97% 32,960
Plasma Biological Services, LLC 48.90% 21,809 48.90% 23,010
Singulex, Inc. 19.33% 19,256 19.33% 29,322
GigaGen, Inc 43.96% 28,363 43.96% 29,047
Access Biologicals LLC 49.00% 47,742 49.00% 44,219
Aigües de Vilajuïga, S.A. -- -- 50.00% --
Plasmavita HealthCare 50.00% 9,920 -- --
Mecwins, S.A. 24.99% 2,555 -- --
226,905 219,009

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in the investments in equity-accounted investees for the years ended at 31 December 2018, 2017 and 2016 have been as follows:

Thousands of Euros
2018 2017 2016
Balance at 1 January 219,009 201,345 76,728
Acquisitions 12,222 80,685 136,072
Transfers 500 (16,000) (29,059)
Share of profit / (losses)
Share of other comprehensive income / translation
(11,038) (13,195) 6,933
differences 9,270 (27,134) 10,671
Losses for Impairment -- (6,692) --
Collected dividends (3,058) -- --
Balance at 31 December 226,905 219,009 201,345

Mecwins, S.A.

On 22 October, 2018 Grifols has allocated Euros 2 million to the capital increase of Mecwins through Progenika Biopharma, reaching 24.99% of the total capital.

Mecwins is a spin-off of the Institute of Micro and Nanotechnology of the Center for Scientific Research (CSIC), specialized in the development of innovative nanotechnological analysis tools for the diagnosis and prognosis of diseases.

Mecwins has developed ultrasensitive optical reading immunoassay technology from nanosensors for the detection of protein biomarkers in blood. This technology has potential applications in fields such as oncology, cardiovascular and infectious diseases.

The injection of capital, in which CRB Inverbio has also participated with an additional Euros 2 million, will enable Mecwins to start developing pre-commercial prototypes of this technology and for Grifols to position itself in the field of nanotechnology applied to diagnosis.

Plasmavita Healthcare GmbH

Refer to note 3 for details of this investment.

GigaGen Inc.

On 5 July 2017, Grifols through its 100% subsidiary Grifols Innovation and New Technologies Limited ("GIANT") acquired a 43.96% shareholding in GigaGen, Inc., a company based in San Francisco (USA) for the amount of US Dollars 35 million.

GIANT and GigaGen entered into a Research and Collaboration Agreement whereby in exchange of a collaboration fee of US Dollars 15 million in the aggregate, GigaGen will commit to carry out research activities to develop recombinant polyclonal immunoglobulin therapies derived from human B cells for the treatment of human diseases.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in Gigagen's equity-accounted investment for the years ended 31 December 2018 and 2017 is as follows:

Thousand of Euros
31/12/2018 31/12/2017
Balance at 1 January 29,047 --
Acquisitions -- 31,752
Share of profit / (losses) (1,562) (804)
Share of other comprehensive income / translation differences 878 (1,595)
Pérdidas por deterioro de valor -- (306)
Balance at 31 December 28,363 29,047

Access Biologicals LLC.

On 12 January 2017, the group announced the acquisition of 49% of the voting rights in Access Biologicals LLC, a company based in San Diego, California, USA, for the amount of US Dollars 51 million. Grifols entered into an option agreement to purchase the remaining 51% voting rights in five years, in 2022. Grifols alsosigned a supply agreement to sell to Access Biologicals biological products not meant for therapeutic use.

The principal business activity of Access Biologicals is the collection and manufacturing of an extensive portfolio of biologicals products. Combined with closed-loop material sourcing, it provides critical support for various markets such as in-vitro diagnostic manufacturing, biopharmaceutical, cell culture and diagnostic research & development.

Movement in Access Biological's equity-accounted investment for the years ended 31 December 2017 and 2018 is as follows:

Thousand of Euros
31/12/2018 31/12/2017
Balance at 1 January 44,219 --
Acquisitions -- 48,383
Share of profit / (losses) 3,039 1,830
Share of other comprehensive income / translation differences 2,073 (5,994)
Collected dividends (1,589) --
Balance at 31 December 47,742 44,219

Singulex, Inc.

On 17 May 2016 Grifols subscribed and paid a capital increase for an amount of US Dollars 50 million (Euros 44,107 thousand) in the US company Singulex, Inc. ("Singulex"). As a result, Grifols holds a 19.33% common stock interest in Singulex on a fully diluted basis at a pre-money valuation of US Dollars 200 million. Grifols will be entitled to appoint a director to serve the board of directors of Singulex. As a result, Singulex granted Grifols an exclusive worldwide license for the use and sale of Singulex' technology for the blood donor and plasma screening to further ensure the safety of blood and plasma products.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in Singulex, Inc.'s equity-accounted investment for the years ended 31 December 2018 and 2017 is as follows:

Thousand of Euros
31/12/2018 31/12/2017
Balance at 1 January 29,322 43,329
Share of profit / (losses) (10,975) (9,335)
Share of other comprehensive income / translation differences 909 (4,672)
Balance at 31 December 19,256 29,322

Interstate Blood Bank, Inc., Bio-Blood Components, Inc. and Plasma Biological Services, Llc.

On 11 May 2016 Grifols acquired a 49.19% stake in Interstate Blood Bank, Inc. (IBBI), 48.97% of Bio-Blood Components, Inc. (Bio-Blood) and 48.90% of Plasma Biological Services, LLC. (PBS) ("IBBI Group"), a group based in Memphis, USA, for the price of US Dollars 100 million (Euros 88,215 thousand). GWWO also entered into an option agreement to purchase the remaining stakes for a price of US Dollars 100 million for an option price of US Dollars 10 million (Euros 9,007 thousand) (see notes 11 and 30). The purchase price and the call right were paid upon signature of the contract. The principal business activity of IBBI and its affiliates is the collection of plasma for the plasma fractionation industry, with 23 plasma collection centers, 9 blood donation centers and one laboratory.

Movement in Interstate Blood Bank, Inc., Bio-blood Components, Inc. and Plasma Biological Services, LLC.'s equity-accounted investment for the years ended 31 December 2017 and 2018 is as follows:

Thousands of Euros Thousands of Euros
31/12/2018 31/12/2017
IBBI Bio-Blood PBS IBBI Bio-Blood PBS TOTAL 2018 TOTAL 2017
Balance at 1 January 27,936 32,960 23,010 31,090 38,725 25,890 83,906 95,705
Share of profit / (losses) 1,830 3,492 (2,181) 635 (1,181) 270 3,141 (276)
Share of other comprehensive income /
translation differences
1,298 1,771 980 (3,789) (4,584) (3,150) 4,049 (11,523)
Collected dividend (1,469) -- -- -- -- -- (1,469) --
Balance at 31 December 29,595 38,223 21,809 27,936 32,960 23,010 89,627 83,906

Kiro Grifols, S.L.

On 25 July 2017 the Group acquired an additional 40% interest in Kiro Grifols, S.L (formerly Kiro Robotics, S.L.) for an amount of Euros 12.8 million. With this new acquisition, Grifols owns 90% in Kiro Grifols S.L., which is now considered part of the group, and starts using the global consolidation method instead of the equity method (see note 3(b)).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(11) Financial Assets

Details of non-current financial assets on the consolidated balance sheet at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Non-current derivatives (see note 30) -- 8,338
Financial investments in shares with stock market (a) 7 38,708
Total Non-current financial assets measured at fair value 7 47,046
Non-current guarantee deposits 5,566 4,820
Other non-current financial assets 1,908 1,346
Non-current loans to related parties (see note 31) 82,969 --
Non-current loans to EEAA (c) (see note 31) 17,151 16,677
Total Non-current financial assets measured at amortized cost 107,594 22,843

Details of other current financial assets on the consolidated balance sheet at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Current derivatives (b) (see note 30) 19,934 --
Total Non-current financial assets measured at fair value 19,934 --
Thousands of Euros
31/12/2018 31/12/2017
Deposits and guarantees 822 702
Current loans to third parties 56 59
Current loans to associates (c) (see note 31) 33,153 9,977
Total other current financial assets 34,031 10,738

(a) Financial investments in quoted shares

Within the framework of its integrated R & D & I strategy, which assesses the adequacy of the various projects, Grifols made the decision to divest in TiGenix and participated in the takeover bid by Takeda in the first half of 2018. Divestment has generated a cash inflow of Euros 70.1 million and a positive impact on the consolidated profit of Euros 32 million (see note 26).

(b) Current derivatives

At 31 December 2018, current derivatives correspond to the purchase options described below:

  • Option to purchase the non-acquired shares of Interstate Blood Bank, Inc., Bio-Blood Components, Inc. and Plasma Biological Services, LLC. The purchase option may be exercised by the Group by written notification at any time between 1 February 2019 and 30 April 2019 (see note 30).
  • Option to purchase Biotest Pharmaceuticals Corporation over two donation centers of ADMA Centers. The execution of the purchase option was executed on 1 January 2019 (see note 30).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(c) Non-current loans to EEAA

On 2 October 2017 the Group's subsidiary Grifols Diagnostic Solutions, Inc. granted a loan of US Dollars 20,000 thousand (Euros 16,676 thousand), that bear at an interest rate of 5% and mature on 19 September 2019. In the first half of 2018, the Group made an additional contribution amounting to US Dollars 12,339 (Euros 11,063 thousand). The Group owns 19.33 % of the common stock of Singulex Inc.

On 8 February 2017, the subsidiary Grifols Worldwide Operations granted a loan of US Dollars 11,000 thousand (Euros 10,809 thousand) to Interstate Blood Bank Inc, with interest at a rate of 4% and due on 6 February 2022. The Group owns 49.19% of the capital of Interstate Blood Bank Inc.

(12) Inventories

Details of inventories at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Goods for resale 118,876 105,013
Raw materials and supplies 647,399 454,371
Work in progress and semi-finished goods 744,436 592,612
Finished goods 438,649 477,297
1,949,360 1,629,293

Movement in the inventory provision was as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Balance at 1 January 35,764 33,069 22,614
Net charge for the year 10,398 8,232 8,878
Cancellations for the year (558) (357) (20)
Translation differences 3,236 (5,180) 1,597
Balance at 31 December 48,840 35,764 33,069

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(13) Trade and Other Receivables

Details at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Trade receivables 289,316 302,685
Receivables from associates (note 31) 382 3,219
Bad debt provision (note 30) (20,531) (19,706)
Trade receivables 269,167 286,198
Other receivables (note 30) 9,901 7,485
Personnel 2,082 566
Advance payments (note 30) 35,426 11,181
Taxation authorities, VAT recoverable 42,707 20,105
Other public entities 2,302 1,344
Other receivables 92,418 40,681
Current income tax assets 42,205 59,531
403,790 386,410

Other receivables

During 2018, 2017 and 2016 certain companies of the Grifols Group have sold receivables from several public entities, without recourse, to certain financial institutions. Under some of these contracts, the Group receives an initial payment which usually amounts to 90% of the nominal amount of the receivables sold less the associated sale and purchase costs. The deferred collection (equivalent to the rest of the nominal amount) will be made by the Group once the financial institution has collected the nominal amount of the receivables (or the interest, if the balances are received after more than 36 months, depending on the terms of each particular contract) and this amount is recognized in the consolidated balance sheet as a balance receivable from the financial institution. The deferred amount (equivalent to the continuing involvement) totals Euros 1,220 thousand at 31 December 2018 (Euros 1,800 thousand at 31 December 2017), which does not differ significantly from its fair value and coincides with the amount of maximum exposure to losses. The financial institution makes the initial payment when the sale is completed and therefore, the bad debt risk associated with this part of the nominal amount of the receivables is transferred. The Group has transferred the credit risk and control of the receivables to certain financial institutions and has therefore derecognized the asset transferred in the consolidated balance sheet, as the risks and rewards inherent to ownership have not been substantially retained.

Certain foreign Group companies have also entered into a contract to sell receivables without recourse to various financial institutions.

Total balances receivable without recourse sold to financial institutions through the aforementioned contracts in 2018 amount to Euros 1,188,216 thousand (Euros 912,204 thousand in 2017 and Euros 870,324 thousand in 2016).

The finance cost of these operations for the Group totals approximately Euros 6,053 thousand which has been recognized under finance costs in the consolidated statement of profit and loss for 2018 (Euros 3,973 thousand in 2017 and Euros 4,885 thousand in 2016) (see note 26).

Details of balances with related parties are shown in note 31.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(14) Cash and Cash Equivalents

Details of this caption of the consolidated balance sheet at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Current deposits 441,614 655,463
Cash in hand and at banks 592,178 231,058
Total cash and cash equivalents 1,033,792 886,521

(15) Equity

Details of consolidated equity and movement are shown in the consolidated statement of changes in equity.

(a) Share capital

At 31 December 2018 and 2017, the Company's share capital amounts to Euros 119,603,705 and comprises:

  • Class A shares: 426,129,798 ordinary shares of Euros 0.25 par value each, subscribed and fully paid and of the same class and series.
  • Class B shares: 261,425,110 non-voting preference shares of 0.05 Euros par value each, of the same class and series, and with the preferential rights set forth in the Company's by-laws.

The main characteristics of the Class B shares are as follows:

  • Each Class B share entitles its holder to receive a minimum annual preferred dividend out of the distributable profits at the end of each year equal to Euros 0.01 per Class B share provided that the aggregate preferred dividend does not exceed the distributable profits of that year and a distribution of dividends has been approved by the Company's shareholders. This preferred dividend is not cumulative if sufficient distributable profits are not obtained in the period.
  • Each Class B share is entitled to receive, in addition to the above-mentioned preferred dividend, the same dividends and other distributions as for one Grifols ordinary share.
  • Each Class B share entitles the holder to its redemption under certain circumstances, if a takeover bid for all or part of the shares in the Company has been made, except if holders of Class B shares have been entitled to participate in the bid on the same terms as holders of Class A shares. The redemption terms and conditions reflected in the Company's by-laws limit the amount that may be redeemed, requiring that sufficient distributable reserves be available, and limit the percentage of shares to be redeemed in line with the ordinary shares to which the bid is addressed.
  • In the event the Company were to be wound up and liquidated, each Class B share entitles the holder to receive, before any amounts are paid to holders of ordinary shares, an amount equal to the sum of (i) the par value of the Class B share, and (ii) the share premium paid for the Class B share when it was subscribed. In addition to the Class B liquidation preference amount, each holder is entitled to receive the same liquidation amount that is paid for each ordinary share.

These shares are freely transferable.

Since 23 July 2012 the ADSs (American Depositary Shares) representing Grifols' Class B shares (non-voting shares) have had an exchange ratio of 1:1 in relation to Class B shares, ie.1 ADS represents 1 Class B share. The previous rate was 2 ADS per 1 Class B share.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Company's knowledge of its shareholders is based on information provided voluntarily or in compliance with applicable legislation. According to the information available to the Company, there are no interests representing more than 10% of the Company's total capital at 31 December 2018 and 2017.

At 31 December 2018 and 2017, the number of outstanding shares is equal to the total number of Company shares, less treasury stock.

Movement in outstanding shares during 2017 is as follows:

Class A shares Class B shares
Balance at 1 January 2017 426,129,798 256,694,375
(Acquisition) / disposal of treasury stock (note 15 (d)) -- 432,929
Balance at 31 December 2017 426,129,798 257,127,304
Movement in outstanding shares during 2018 is as follows:
Class A shares Class B shares
Balance at 1 January 2018 426,129,798 257,127,304
(Acquisition) / disposal of treasury stock (note 15 (d)) -- 479,355
Balance at 31 December 2018 426,129,798 257,606,659

(b) Share premium

Movement in the share premium is described in the consolidated statement of changes in equity, which forms an integral part of this note to the consolidated annual accounts.

(c) Reserves

The drawdown of accumulated gains is subject to legislation applicable to each of the Group companies. At 31 December 2018, Euros 35,613 thousand equivalent to the carrying amount of development costs pending amortization of certain Spanish companies (Euros 40,061 thousand at 31 December 2017) (see note 8) are, in accordance with applicable legislation, restricted reserves which cannot be distributed until these development costs have been amortized.

In July 2016 the Group acquired an additional 20% of the assets of Medion Diagnostics AG in exchange for 59,951 treasury stocks (Class B Shares) from its non-controlling interests. After these capital increases, Grifols' interest rose to 100% in 2016. The difference between the share capital increase carried out by the Group and the non-controlling interest was recognized as a Euros 0.6 million decrease in reserves.

In August 2016 Araclon Biotech, S.L. increased capital by an amount of Euros 6.7 million. As a result, the Group increased its investment from 70.83% to 73.22%. The difference between the share capital increase carried out by the Group and the non-controlling interest was recognized as a Euros 1.7 million decrease in reserves.

On 12 December 2016, the Group subscribed a share capital increase in the capital of VCN Biosciences, S.L. of Euros 5 million. After this capital increase, Grifols interest rose to 81.34% in 2016. The difference between the share capital increase carried out by the Group and the non-controlling interest was recognized as a Euros 1 million decrease in reserves.

In October 2017, the Group acquired 12,020 Progenika Biopharma, S.A. shares As a result, the Group has increased its investment from 89.25% to 90.23%. The difference between the share capital increase carried out by the Group and the non-controlling interest has been recognized as a Euros 374 thousand decrease in reserves.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

In June 2018, Grifols made the decision to divest in TiGenix and participated in the takeover bid made by Takeda in the first half of 2018. This divestment has generated a positive impact on reserves of Euros 4,900 thousand and a negative impact of Euros 4,900 thousand in "Other comprehensive income".

In June 2018, Grifols executed the purchase option for 6.41% of the shares of Progenika owned by Ekarpen Private Equity, S.A. for an amount of Euros 5,300 thousand. As a result, the Group increased its interest from 90.23% to 96.64%. The difference between the acquisition carried out by the Group and the non-controlling interest was recognized in reserves.

In September 2018, the Group acquired 41,387 shares of Progenika Biopharma, S.A for an amount of Euros 4,333 thousand. As a result, the Group increased its interest from 96.64% to 99.99%. The difference between the acquisition carried out by the Group and the non-controlling interest was recognized against reserves.

At 31 December 2018 and 2017 reserves include the IFRS-EU first-time adoption revaluation reserves and legal reserve of certain Group companies.

Legal reserve

Companies in Spain are obliged to transfer 10% of each year's profits to a legal reserve until this reserve reaches an amount equal to 20% of share capital. This reserve is not distributable to shareholders and may only be used to offset losses if no other reserves are available. Under certain conditions it may be used to increase share capital provided that the balance left on the reserve is at least equal to 10% of the nominal value of the total share capital after the increase.

At 31 December 2018 and 2017 the legal reserve of the Company amounts to Euros 23,921 thousand, which corresponds to 20% of the share capital.

Distribution of the legal reserves of Spanish companies is subject to the same restrictions as those of the Company and at 31 December 2018 the balance of the legal reserve of other Spanish companies amounts to Euros 2,527 thousand (Euros 2,416 thousand at 31 December 2017).

Other foreign Group companies have a legal reserve amounting to Euros 843 thousand at 31 December 2018 (Euros 731 thousand at 31 December 2017).

(d) Treasury stock

At 31 December 2018 and December 2017 the Company does not have any Class A treasury stock.

Movement in Class B treasury stock during 2017 was as follows:

No. of Class B shares Thousands of Euros
Balance at 1 January 2017 4,730,735 68,710
Disposal Class B shares (432,929) (6,288)
Balance at 31 December 2017 4,297,806 62,422

Movement in Class B treasury stock during 2018 is as follows:

No. of Class B shares Thousands of Euros
Balance at 1 January 2018 4,297,806 62,422
Disposal Class B shares (479,355) (6,981)
Balance at 31 December 2018 3,818,451 55,441

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

In March 2018 the Group delivered 480,661 treasury stocks (Class B shares) to eligible employees as compensation for the Restricted Share Unit Retention Plan (see note 29).

In March 2017 the Group delivered 432,929 treasury stocks (Class B shares) to eligible employees as a compensation for the Restricted Share Unit Retention Plan (see note 29).

The Parent held Class B treasury stock equivalent to 0.6% of its capital at 31 December 2018 (0.6% at 31 December 2017).

(e) Distribution of profit

The profits of Grifols, S.A. and subsidiaries will be distributed as agreed by respective shareholders at their general meetings.

The proposed distribution of profit of the Parent Grifols, S.A. for the years ended 31 December 2018, and the distribution of profit approved for 2017, presented at the general meeting held on 25 May 2018, is as follows:

Thousands of Euros
31/12/2018 31/12/2017
Voluntary reserve 91,059 76,247
Dividends 238,659 265,080
Profit of the Parent 329,718 341,327

The following dividends were paid in 2017:

31/12/2017
% of par value Euros per share Thousands of Euros
Ordinary shares 54% 0.14 57,790
Non-voting shares 271% 0.14 34,870
Non-voting shares (preferred dividend) 20% 0.01 2,614
Total dividends paid 95,274
31/12/2017
% of par value Euros per share Thousands of Euros
Ordinary shares (interim dividend) 72% 0.18 76,703
Non-voting shares (interim dividend) 360% 0.18 46,283
Total interim dividends paid 122,986
The following dividends were paid in 2018:
31/12/2018
% of par value Euros per share Thousands of Euros
82% 0.20 86,929
408% 0.20 52,551
20% 0.01 2,614
142,094

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/2018
% of par value Euros per share Thousands of Euros
Ordinary shares (interim dividend) 80% 0.2 85,226
Non-voting shares (interim dividend) 400% 0.2 51,521
Total interim dividends paid 136,747

At the meeting held on 26 October, 2018, the Board of Directors of Grifols approved the distribution of interim dividend for 2018, of Euros 0.20 for each Class A and B share, recognizing a total of Euros 136,747 thousand as interim dividend.

At the meeting held on 27 October 2017, the Board of Directors of Grifols approved the distribution of interim dividend for 2017 of Euros 0.18 for each Class A and B share, recognizing a total of Euros 122,986 thousand as interim dividend.

These amounts to be distributed did not exceed the profits generated by the Company since the end of the last reporting period, less the estimated income tax payable on these profits, in accordance with article 277 of the Revised Spanish Companies Act.

The Statement of Liquidity for Distribution of Interim Dividend of Grifols, S.A. prepared in accordance with legal requirements and which shows the existence of sufficient liquidity to be able to distribute the aforementioned interim dividend is provided in Appendix V.

At a general meeting held on 25 May 2018 the shareholders approved the distribution of a preferred dividend of Euros 0.01 for every Class B non-voting share.

The distribution of the profit for the years ended 31 December 2017 and 2018 is presented in the consolidated statement of changes in equity.

(f) Restricted Share Unit Retention Plan

The Group has set up a Restricted Share Unit Retention Plan (hereinafter RSU Plan) for certain employees (see note 29). This commitment will be settled using equity instruments and the cumulative accrual amounts to Euros 12,652 thousand at 31 December 2018 (Euros 13,871 thousand at 31 December 2017).

(16) Earnings Per Share

The calculation of basic earnings per share is based on the profit for the year attributable to the shareholders of the Parent divided by the weighted average number of ordinary shares in circulation throughout the year, excluding treasury stock.

Details of the calculation of basic earnings per share are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Profit for the year attributable to shareholders of the Parent
(thousands of Euros)
596,642 662,700 545,456
Weighted average number of ordinary shares outstanding 684,709,377 684,197,276 683,225,815
Basic earnings per share (Euros per share) 0.87 0.97 0.80

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The weighted average of the ordinary shares outstanding (basic) has been calculated taking into consideration the share split carried out on 4 January 2016 as follows:

Number of shares
31/12/2018 31/12/2017 31/12/2016
Issued shares outstanding at 1 January 684,346,294 683,854,491 683,516,338
Effect of shares issued -- -- --
Effect of treasury stock 363,083 342,785 (290,523)
Average weighted number of ordinary shares outstanding
(basic) at 31 December
684,709,377 684,197,276 683,225,815

Diluted earnings per share are calculated by dividing profit for the year attributable to shareholders of the Parent by the weighted average number of ordinary shares in circulation considering the diluting effects of potential ordinary shares.

The RSU Plan granted by the Group and payable in shares, assumes the existence of dilutive potential shares. Diluted earnings per share have been calculated as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Profit for the year attributable to shareholders of the Parent
(thousands of Euros)
Weighted average number of ordinary shares outstanding
596,642
684,686,164
662,700
684,243,891
545,456
684,170,887
(diluted)
Diluted earnings per share (Euros per share) 0.87 0.97 0.80

The weighted average number of ordinary shares outstanding diluted has been calculated as follows:

Number of shares
31/12/2018 31/12/2017 31/12/2016
Issued shares outstanding at 1 January 684,346,294 683,854,491 683,988,460
Effect of RSU shares (23,213) 46,615 472,950
Effect of shares issued -- -- --
Effect of treasury stock 363,083 342,785 (290,523)
Average weighted number of ordinary shares outstanding
(diluted) at 31 December
684,686,164 684,243,891 684,170,887

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(17) Non-Controlling Interests

Details of non-controlling interests and movement at 31 December 2017 are as follows:

Thousands of Euros
Balance at
31/12/2016
Additions Disposals Business
Combination /
Additions to
Consolidated Group
Translation
differences
Balance at
31/12/2017
Grifols (Thailand) Pte Ltd 3,354 433 (77) -- (131) 3,579
Grifols Malaysia Sdn Bhd 1,172 229 -- -- (29) 1,372
Araclon Biotech, S.A. 140 (1,617) -- -- -- (1,477)
Progenika Biopharma, S.A. 1,211 (60) (298) -- 27 880
Abyntek Biopharma, S.L. (73) 45 28 -- -- --
VCN Bioscience, S.L 693 (272) -- -- -- 421
Kiro Grifols , S.L. -- (144) -- 255 -- 111
6,497 (1,386) (347) 255 (133) 4,886

Details of non-controlling interests and movement at 31 December 2018 are as follows:

Thousands of Euros
Balance at
31/12/2017
Additions Disposals Business
Combination /
Additions to
Consolidated
Group
Translation
differences
Balance at
31/12/2018
Grifols (Thailand) Pte Ltd 3,579 193 (43) -- 206 3,935
Grifols Malaysia Sdn Bhd 1,372 326 -- -- 37 1,735
Araclon Biotech, S.A. (1,477) (2,011) -- -- -- (3,488)
Progenika Biopharma, S.A. 880 -- (871) -- -- 9
VCN Bioscience, S.L 421 (281) -- -- -- 140
Kiro Grifols , S.L. 111 (463) -- -- -- (352)
Haema AG -- -- -- 220,190 -- 220,190
Biotest Pharma Corp -- -- -- 249,691 (810) 248,881
4,886 (2,236) (914) 469,881 (567) 471,050

(18) Grants

Details are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Capital grants 11,149 11,010
Interest rate grants (preference loans) (See note 20 (e)) 696 812
11,845 11,822

Interest-rate grants (preference loans) reflect the implicit interest on loans extended by the Spanish Ministry of Science and Technology as these are interest free.

Grants totaling Euros 1,166 thousand have been recognized in the consolidated statement of profit and loss for the year ended at 31 December 2018 (Euros 323 thousand for the year ended at 31 December 2017).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(19) Provisions

Details of provisions at 31 December 2018 and 2017 are as follows:

Thousands of Euros
Non-current provisions (a) 31/12/2018 31/12/2017
Provisions for pensions and similar obligations 5,296 4,742
Other provisions 818 1,021
Non-current provisions 6,114 5,763
Thousands of Euros
Current provisions (b) 31/12/2018 31/12/2017
Trade provisions 80,055 106,995
Current provisions 80,055 106,995

(a) Non-current provisions

At 31 December 2018, 2017 and 2016 provisions for pensions and similar obligations mainly comprise a provision made by certain foreign subsidiaries in respect of labor commitments with certain employees.

Movement in provisions during 2016 was as follows:

Thousands of Euros
Balance at
31/12/2015
Net charge Cancellations Reclassifications Translation
differences
Balance at
31/12/2016
Non-current provisions 4,980 (399) (281) 814 4 5,118
4,980 (399) (281) 814 4 5,118

Movement in provisions during 2017 was as follows:

Thousands of Euros
Balance at
31/12/2016
Business
combination
Net charge Cancellations Reclassifications Translation
differences
Balance at
31/12/2017
Non-current
provisions
5,118 23 422 (23) 290 (67) 5,763
5,118 23 422 (23) 290 (67) 5,763

Movement in provisions during 2018 is as follows:

Thousands of Euros
Balance at
31/12/2017
Net charge Cancellations Reclassifications Translation
differences
Balance at
31/12/2018
Non-current provisions 5,763 635 (565) 277 4 6,114
5,763 635 (565) 277 4 6,114

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(b) Current provisions

Movement in trade provisions during 2016 was as follows:

Translation differences Balance at
31/12/2016
1,437 89,588
89,588
1,437

Movement in trade provisions during 2017 was as follows:

Thousands of Euros
Balance at
31/12/2016
Business
Combination
Net charge Cancellations Reclassification Translation differences Balance at
31/12/2017
Trade provisions 89,588 41,841 (4,812) (2,886) (2,600) (14,136) 106,995
89,588 41,841 (4,812) (2,886) (2,600) (14,136) 106,995

Movement in trade provisions during 2018 is as follows:

Thousands of Euros
Balance at
31/12/2017
Net charge Cancellations Translation differences Balance at
31/12/2018
106,995 (30,668) (290) 4,018 80,055
106,995 (30,668) (290) 4,018 80,055

(20) Financial Liabilities

This note provides information on the contractual conditions of the Group's financial liabilities, which are measured at amortized cost. For further information on exposure to interest rate risk, currency risk and liquidity risk and the fair values of financial liabilities, please refer to note 30.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details at 31 December 2018 and 2017 are as follows:

Thousands of Euros
Financial liabilities 31/12/2018 31/12/2017
Non-current obligations (a) 1,000,000 853,667
Senior secured debt (b) 4,771,285 4,849,882
Other loans (b) 239,686 169,214
Finance lease liabilities (c) 9,537 5,415
Other non-current financial liabilities (e) 78,955 23,637
Total non-current financial liabilities 6,099,463 5,901,815
Current obligations (a) 102,978 95,538
Senior secured debt (b) 129,955 4,057
Other loans (b) 24,839 29,527
Finance lease liabilities (c) 3,348 3,945
Other current financial liabilities (e) 16,262 22,003
Total current financial liabilities 277,382 155,070

In September 2018, Grifols obtained a new non-current loan from the European Investment Bank totaling Euros 85,000 thousand that will be used by Grifols to support its investments in R&D, mainly focused on the search for new therapeutic indications for plasma-derived protein therapies. The financial terms include a fixed interest rate, a maturity of 10 years with a grace period of 2 years. At 31 December 2018, the carrying amount of the loans obtained from the European Investment Bank amounts to Euros 244,375 thousand (Euros 170,000 thousand at 31 December, 2017).

On 5 December 2017 the Group received a loan from the European Investment Bank totaling Euros 85 million, falling due in 10 years, at a fixed rate and with a grace period of 2 years. The loan will be used to support certain investments the Group's R&D which are mainly focused on searching for new applications for plasmatic proteins.

On 28 October 2015, the Group received its first loan from the same entity and with the same terms for a total amount of Euros 100 million.

On 18 April 2017 the Group concluded the refinancing process of the Senior Unsecured Notes. The total note issuance amounted to Euros 1,000 million.

On 6 February 2017 the Group concluded the refinancing process of its senior debt. The total debt refinanced amounts to US Dollars 6,300 million (Euros 5,800 million), including the US Dollars 1,816 million loan obtained for the acquisition of Hologic's transfusional diagnostics unit. Following the refinancing process, Grifols' debt structure consisted of a US Dollars 6,000 million non-current loan from institutional investors and banks segmented in two tranches (Term Loan A and Term Loan B), and a US Dollars 300 million undrawn revolving credit facility.

Retrospectively as of 1 January 2018, Grifols has calculated the impact of the entry into force of the new IFRS 9 on the refinancing process of the Senior Unsecured Notes and the Senior debt, concluding that the refinancing of the notes caused a derecognition of the liability as they did not pass the new quantitative test, whereas the senior debt did not result in a derecognition of the liability.

According to the IASB's interpretation published in October 2017, when a financial liability measured at amortized cost is modified or exchanged and does not result in the derecognition of the financial liability, a gain or loss should be recognized in profit or loss, calculated as the difference between the original contractual cash flows from the liability and the modified cash flows, discounted at the original effective interest rate of the liability. Due to the retrospective effect of IFRS 9, any gains or losses from the modification of financial liabilities that arise from

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

applying the new standard in years prior to 1 January 2018 have been recognized in reserves, generating a positive net impact of Euros 24,636 thousand (see note 2 (c)).

(a) Senior Unsecured Notes

On 18 April 2017, Grifols, S.A., issued US Dollars 1,000 million of Senior Unsecured Notes (the "Notes") that will mature in 2025 and will bear annual interest at a rate of 3.20%. These notes replaced 97.1 % of the Senior Unsecured Notes issued in 2014 by Grifols Worldwide Operations Limited, a wholly-owned subsidiary of Grifols S.A., amounting to US Dollars 1,000 million, with a maturity in 2022 and with interest rate of 5.25% that was owned by a financial institution. The remaining 2.9% of the existing notes was redeemed before the exchange by an amount of Euros 26,618 thousand. The corresponding deferred costs of the notes have been recognized in profit and loss in 2017. On 2 May 2017 the Notes were admitted to listing on the Irish Stock Exchange.

Due to the implementation of IFRS 9, the refinancing of unsecured corporate notes has resulted in the decrease of liabilities by not passing the new quantitative test (see note 2).

Details of movement in the Senior Unsecured Notes at 31 December 2017 are as follows:

Thousands of Euros
Opening outstanding Refinancing
Repayments
Translation Closing outstanding
balance 01/01/17 differences balance 31/12/17
Senior Unsecured Notes
(nominal amount)
948,677 108,597 (26,618) (30,656) 1,000,000
Total 948,677 108,597 (26,618) (30,656) 1,000,000

At 31 December 2018 and 2017 the current obligations caption includes the issue of bearer promissory notes to Group employees, as follows:

31/12/2017
Issue date Maturity date Nominal amount
of promissory
notes (Euros)
Interest
rate
Promissory
notes subscribed
(Thousands of
Euros)
Buy back
(Thousands of
Euros)
Interest
pending accrual
(Thousands of
Euros)
Issue of bearer
promissory notes
05/05/17 04/05/18 3,000 3.00% 92,109 (906) (909)
31/12/2018
Issue date Maturity date Nominal amount
of promissory
notes (Euros)
Interest
rate
Promissory
notes subscribed
(Thousands of
Euros)
Buy back
(Thousands of
Euros)
Interest
pending accrual
(Thousands of
Euros)
Issue of bearer
promissory notes
05/05/18 04/05/19 3,000 4.00% 99,990 (1,041) (1,304)

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(b) Loans and borrowings

Details of loans and borrowings at 31 December 2018 and 2017 are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Credit Currency Interest rate Date awarded Maturity date Amount extended Carrying amount Amount extended Carrying amount
Senior debt - Tranche A US Dollars Libor + 1.75% 31/01/2017 31/01/2023 2,052,403 1,949,782 1,959,476 1,959,476
Senior debt - Tranche A Euros Euribor + 1.75% 31/01/2017 31/01/2023 607,000 576,650 607,000 607,000
Senior debt - Tranche B US Dollars Libor + 2.25% 31/01/2017 31/01/2025 2,620,087 2,548,035 2,501,459 2,457,684
Total senior debt 5,279,490 5,074,467 5,067,935 5,024,160
EIB Loan Euros 2.40% 20/11/2015 20/11/2025 100,000 63,750 100,000 74,375
EIB Loan Euros 2.02% 22/12/2017 22/12/2027 85,000 85,000 85,000 85,000
EIB Loan Euros 2.15% 25/09/2018 25/09/2028 85,000 85,000 -- --
Total EIB Loan 270,000 233,750 185,000 159,375
Revolving Credit US Dollars Libor + 1.75% 31/01/2017 31/01/2023 262,009 -- 250,146 --
Total Revolving Credit 262,009 -- 250,146 --
Other non-current loans Euros Euribor
Euribor+2.30%
25/03/2010 30/09/2024 26,680 5,936 33,180 9,839
Loan transaction costs -- (303,182) -- (174,278)
Non-current loans and borrowings 5,838,179 5,010,971 5,536,261 5,019,096

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Thousands of Euros
31/12/2018 31/12/2017
Credit Currency Interest rate Date awarded Maturity date Amount extended Carrying amount Amount extended Carrying amount
Senior debt - Tranche A US Dollars Libor + 1.75% 31/01/2017 31/01/2023 (*) 102,621 (*) --
Senior debt - Tranche A Euros Euribor + 1.75% 31/01/2017 31/01/2023 (*) 30,350 (*) --
Senior debt - Tranche B US Dollars Libor + 2.25% 31/01/2017 31/01/2025 (*) 26,201 (*) 25,015
Total senior debt -- 159,172 -- 25,015
EIB Loan Euros 2.40% 20/11/2015 20/11/2025 (*) 10,625 (*) 10,625
Total EIB Loan -- 10,625 -- 10,625
Other current loans 0,10% - 4,62% 144,571 14,214 131,700 18,902
Loan transaction costs -- (29,217) -- (20,958)
Current loans and borrowings 144,571 154,794 131,700 33,584

(*) See amount granted under non-current debt

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Current loans and borrowings include accrued interest amounting to Euros 2,546 thousand at 31 December 2018 (Euros 1,713 thousand at 31 December 2017).

On 6 February 2017 the Group refinanced its Senior Secured Debt with the existing lenders and obtained the additional debt for the acquisition of Hologic by an amount of US Dollars 1,816 million. The new senior debt consisted of a Term Loan A ("TLA"), which amounted US Dollars 2,350 million and Euros 607 million with a 1.75% margin over Libor and Euribor respectively and maturity in 2023 and quasi-bullet amortization structure, and a Term Loan B ("TLB") which amounted US Dollars 3,000 million with a 2.25% margin over Libor and maturity in 2025. The borrowers of the total debt are Grifols Worldwide Operations Limited and Grifols, S.A. for the Term Loan A and Grifols Worldwide Operations USA, Inc. for the Term Loan B.

The present value discounted from cash flows under the new agreement, including any fees paid and discounted using the original effective interest rate differed by less than 10% of the present value discounted from cash flows remaining in the original debt, whereby it is considered that the debt instrument has not been substantially modified.

The costs of refinancing the senior debt amounted to Euros 84.8 million. Based on an analysis of the quantitative and qualitative factors, the Group concluded that the renegotiation of the terms of the senior debt did not imply a derecognition of the liability. The difference between the amortized cost of the debt applying the new IFRS 9 is Euros 332,399 thousand less than its nominal amount.

The terms and conditions of the senior secured debt are as follows:

  • o Tranche A: six year loan divided into two tranches: US Tranche A and Tranche A in Euros.
  • US Tranche A :
    • Original principal amount of US Dollars 2,350 million.
    • Applicable margin of 175 basis points (bp) linked to US Libor.
    • Quasi-bullet amortization structure.
    • Maturity in 2023.

Tranche A in Euros :

  • Original principal amount of Euros 607 million.
  • Applicable margin of 175 basis ponts (bp) linked to Euribor.
  • Quasi-bullet amortization structure.
  • Maturity in 2023.

Details of Tranche A by maturity at 31 December 2018 are as follows:

US Tranche A Tranche A in Euros
Principal in thousands of US Dollars Principal in thousands of Euros Principal in thousands of Euros
Maturity
2019 117,500 102,621 30,350
2020 235,000 205,240 60,700
2021 235,000 205,240 60,700
2022 1,321,875 1,154,476 341,437
2023 440,625 384,826 113,813
Total 2,350,000 2,052,403 607,000

o Tranche B: Senior Debt Loan repayable in eight years.

US Tranche B :

  • Original principal amount of US Dollars 3,000 million.
  • Applicable margin of 225 basis points (bp) linked to US Libor.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • Quasi-bullet amortization structure.
  • Maturity in 2025.

Details of Tranche B by maturity at 31 December 2018 are as follows:

US Tranche B
Currency Principal in thousands
of US Dollars
Principal in thousands
of Euros
Maturity
2019 US Dollars 30,000 26,201
2020 US Dollars 30,000 26,201
2021 US Dollars 30,000 26,201
2022 US Dollars 30,000 26,201
2023 US Dollars 30,000 26,201
2024 US Dollars 30,000 26,201
2025 US Dollars 2,767,500 2,417,030
Total US Dollars 2,947,500 2,574,236

o US Dollars 300 million committed credit revolving facility: Amount maturing on 2023 and applicable margin of 175 basis points (bp) pegged to US Libor. At 31 December 2018 and 2017 no amount has been drawn down on this facility.

The issue of senior unsecured notes and senior secured debt is subject to compliance with a leverage ratio covenant. At 31 December 2018 the Group complies with this covenant.

Both the Senior Term Loans and the Revolving Loans are guaranteed by Grifols, S.A. and certain significant subsidiaries of Grifols, S.A. that together with Grifols, S.A. represent, in the aggregate, at least 80% of the consolidated assets and consolidated EBITDA of Grifols, S.A. and its subsidiaries.

The Notes have been issued by Grifols S.A. and are guaranteed on a senior unsecured basis by subsidiaries of Grifols, S.A. that are guarantors and co-borrower under the New Credit Facilities. The guarantors are Grifols Worldwide Operations Limited, Biomat USA, Inc., Grifols Biologicals Inc., Grifols Shared Services North America, Inc., Grifols Diagnostic Solutions Inc., Grifols Therapeutics, Inc., Instituto Grifols, S.A., Grifols Worldwide Operations USA, Inc and Grifols USA, Llc.

(c) Finance lease liabilities

Details of minimum payments and the present value of finance lease liabilities, by maturity date, are as follows:

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Thousands of Euros
31/12/2018 31/12/2017
Minimum
payments
Interest Present Value Minimum
payments
Interest Present Value
Maturity at:
Less than one year 3,576 228 3,348 4,305 360 3,945
Two years 3,339 123 3,216 2,636 179 2,457
Three years 2,606 82 2,524 1,461 88 1,373
Four years 1,971 53 1,918 814 60 754
Five years 1,578 32 1,546 369 42 327
More than five years 351 18 333 550 46 504
Total 13,421 536 12,885 10,135 775 9,360

(d) Credit rating

In December 2018 and December 2017 Moody's Investors Service has confirmed the 'Ba3' corporate family rating, 'Ba2' rating to the senior secured bank debt and 'B2' rating to the unsecured notes that were used to refinance the existing debt structure. The outlook is confirmed as stable.

In December 2018 and December 2017 Standard & Poor's has confirmed its 'BB' rating on Grifols and has assigned 'BB+' and 'B+' issue ratings to Grifols' senior secured debt and senior unsecured notes that were used to refinance the existing debt structure. The outlook for the rating is stable.

(e) Other financial liabilities

At 31 December 2018 "other financial liabilities" include interest-free loans extended by governmental institutions amounting to Euros 16,559 thousand (Euros 20,306 thousand at 31 December 2017). The portion of the loans considered a grant and still to be taken to profit and loss amounts to Euros 696 thousand (Euros 812 thousand at 31 December 2017) (see note 18).

At 31 December 2017, "other current financial liabilities" included an amount of Euros 5,000 thousand related to the remaining call option extended by the Group and the shareholders of Progenika with maturity in 2018. This option was executed in June 2018.

At 31 December 2018 and 2017 "other current financial liabilities" also include approximately Euros 6,704 thousand and Euros 3,056 thousand, respectively, which have been collected directly from Spanish Social Security affiliated bodies and transferred to financial institutions (see note 13).

Details of the maturity of other financial liabilities are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Maturity at:
Up to one year 16,262 22,003
Two years 21,460 10,818
Three years 49,602 3,787
Four years 2,916 2,794
Five years 1,799 2,247
Over five years 3,178 3,991
95,217 45,640

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(f) Changes in liabilities derived from financing activities

Thousand of Euros
Obligations Senior Secured
debt & Other
loans
Finance lease
liabilities
Other financial
liabilities
Total
Book value at January 1, 2017 926,941 3,948,154 9,945 57,096 4,942,136
New financing 1,092,109 5,666,300 -- 8,661 6,767,070
Refunds (1,003,104) (3,936,799) (780) (21,838) (4,962,521)
Bear of interests 61,944 198,588 505 1,020 262,057
Other movements (57,484) (84,917) -- -- (142,401)
Collection / Payment of interests (44,432) (162,647) -- -- (207,079)
Business combination -- -- -- 2,163 2,163
Foreign exchange differences (26,769) (575,999) (310) (1,462) (604,540)
Balance at December 31, 2017 949,205 5,052,680 9,360 45,640 6,056,885
New financing 99,990 85,000 -- 6,789 191,779
Refunds (92,244) (45,225) (1,001) (20,041) (158,511)
Bear of interests 31,694 253,673 409 865 286,641
Other movements (note 2) 146,333 (141,998) -- -- 4,335
Collection / Payment of interests (32,000) (193,146) -- -- (225,146)
Business combination -- -- 4,007 57,816 61,823
Foreign exchange differences -- 154,781 110 4,148 159,039
Balance at December 31, 2018 1,102,978 5,165,765 12,885 95,217 6,376,845

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(21) Trade and Other Payables

Details are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Suppliers 561,883 423,096
VAT payable 8,954 8,827
Taxation authorities, withholdings payable 26,299 24,084
Social security payable 12,787 11,741
Other public entities 111,776 97,068
Other payables 159,816 141,720
Current income tax liabilities 1,917 6,709
723,616 571,525

Suppliers

Details of balances with related parties are shown in note 31.

The Group's exposure to currency risk and liquidity risk associated with trade and other payables is described in note 30.

In accordance with the second final provision of Law 31/2014 that amends Law 15/2010 of 5 July 2010, for fiscal years 2018 and 2017 information concerning the average payment period to suppliers is included.

Days
31/12/2018 31/12/2017
Average payment period to suppliers 72.6 72.9
Paid invoices ratio 74.2 74.0
Outstanding invoices ratio 63.4 62.2
Thousands of Euros
31/12/2018 31/12/2017
Total invoices paid 454,995 460,699
Total outstanding invoices 82,740 49,339

(22) Other Current Liabilities

Details at 31 December are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Salaries payable 153,160 129,519
Other payables 504 649
Deferred income 8,912 4,284
Advances received 6,613 9,945
Other current liabilities 169,189 144,397

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(23) Net Revenues

Net revenues are mainly generated from the sale of goods.

The distribution of net consolidated revenues for 2018, 2017 and 2016 by segment is as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Bioscience 3,516,704 3,429,785 3,195,424
Diagnostic 702,265 732,369 691,701
Hospital 119,454 105,649 102,251
Bio supplies 167,004 66,791 57,239
Others 22,451 18,263 34,601
Intersegments (41,154) (34,784) (31,386)
4,486,724 4,318,073 4,049,830

As a result of the creation of Bio Supplies segment and the Intersegments in 2017 , the Group has reviewed the allocation of balances and transactions by segments. The comparative figures for 2016 have been restated accordingly.

The geographical distribution of net consolidated revenues is as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
USA and Canada 2,974,429 2,896,505 2,707,579
Spain 264,913 242,894 225,273
European Union 535,361 444,089 426,223
Rest of the world 712,021 734,585 690,755
Consolidated 4,486,724 4,318,073 4,049,830

Details of discounts and other reductions in gross income are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Gross sales 5,588,257 5,322,618 4,882,615
Chargebacks (923,023) (826,775) (652,564)
Cash discounts (62,518) (57,512) (51,953)
Volume rebates (46,922) (43,274) (51,242)
Medicare and Medicaid (40,343) (41,722) (47,820)
Other discounts (28,727) (35,262) (29,206)
Net sales 4,486,724 4,318,073 4,049,830

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in discounts and other reductions in gross income during 2016 were as follows:

Thousands of Euros
Chargebacks Cash
discounts
Volume
rebates
Medicare /
Medicaid
Other
discounts
Total
Balance at 31 December 2015 126,178 5,902 29,680 12,468 5,367 179,595
Current estimate related to sales made in
current and prior year
652,564 51,953 51,242 47,820 29,206 832,785 (1)
(Actual returns or credits in current period
related to sales made in current period)
(693,458) (51,733) (27,409) (24,988) (27,243) (824,831) (2)
(Actual returns or credits in current period
related to sales made in prior periods)
-- (248) (27,732) (14,401) (2,986) (45,367) (3)
Translation differences 1,965 758 726 858 98 4,405
Balance at 31 December 2016 87,249 6,632 26,507 21,757 4,442 146,587

Movement in discounts and other reductions to gross income during 2017 were as follows:

Thousands of Euros
Chargebacks Cash
discounts
Volume
rebates
Medicare /
Medicaid
Other
discounts
Total
Balance at 31 December 2016 87,249 6,632 26,507 21,757 4,442 146,587
Current estimate related to sales made in
current and prior year
826,775 57,512 43,274 41,722 35,262 1,004,545 (1)
(Actual returns or credits in current period
related to sales made in current period)
(795,449) (52,270) (28,976) (28,198) (26,072) (930,965) (2)
(Actual returns or credits in current period
related to sales made in prior periods)
31 (6,024) (20,210) (16,659) (2,864) (45,726) (3)
Translation differences (12,716) (736) (2,604) (2,418) (625) (19,099)
Balance at 31 December 2017 105,890 5,114 17,991 16,204 10,143 155,342

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in discounts and other reductions to gross income during 2018 were as follows:

Thousands of Euros
Chargebacks Cash
discounts
Volume
rebates
Medicare /
Medicaid
Other
discounts
Total
Balance at 31 December 2017 105,890 5,114 17,991 16,204 10,143 155,342
Current estimate related to sales made in
current and prior year
923,023 62,518 46,922 40,343 28,727 1,101,533 (1)
(Actual returns or credits in current period
related to sales made in current period)
(957,695) (56,568) (24,648) (21,324) (26,493) (1,086,728) (2)
(Actual returns or credits in current period
related to sales made in prior periods)
-- (4,909) (16,384) (13,232) (3,781) (38,306) (3)
Translation differences 3,957 286 916 950 241 6,350
Balance at 31 December 2018 75,175 6,441 24,797 22,941 8,837 138,191

(1) Net impact in income statement: estimate for the current year plus prior years' adjustments. Adjustments made during the year corresponding to prior years' estimates have not been significant.

(2) Amounts credited and posted against provisions for current period

(3) Amounts credited and posted against provisions for prior period

(24) Personnel Expenses

Details of personnel expenses by function are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Cost of sales 810,512 731,192 635,577
Research and development 93,817 90,495 77,988
Selling, general & administration expenses 345,224 323,880 314,348
1,249,553 1,145,567 1,027,913

Details by nature are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Wages and salaries 1,000,682 917,810 822,384
Contributions to pension plans (see note 29) 21,363 20,347 18,486
Other social charges 29,055 27,679 25,074
Social Security 198,453 179,731 161,969
1,249,553 1,145,567 1,027,913

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The average headcount during 2018 and 2017, by department, was approximately as follows:

Average headcount
31/12/2018 31/12/2017
Manufacturing 14,576 12,194
R&D - technical area 945 905
Administration and others 1,316 1,070
General management 212 201
Marketing 184 180
Sales and Distribution 1,223 1,211
18,456 15,761

The headcount of the Group employees and the Company's directors at 31 December 2017, by gender, was as follows:

31/12/2017
Male Female Total number of
employees
Directors 9 4 13
Manufacturing 5,933 8,644 14,577
Research&development - technical area 373 590 963
Administration and others 631 481 1,112
General management 119 111 230
Marketing 78 109 187
Sales and Distribution 647 580 1,227
7,790 10,519 18,309

The headcount of the Group employees and the Company's directors at 31 December 2018, by gender, is as follows:

31/12/2018
Male Female Total number of
employees
Directors 9 4 13
Manufacturing 6,591 10,556 17,147
Research&development - technical area 368 616 984
Administration and others 842 554 1,396
General management 129 125 254
Marketing 76 108 184
Sales and Distribution 658 607 1,265
8,673 12,570 21,243

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(25) Expenses by Nature

(a) Amortization and depreciation

Expenses for the amortization and depreciation of intangible assets and property, plant and equipment, incurred during 2018, 2017 and 2016 classified by functions are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Cost of sales 146,530 135,186 126,998
Research and development 19,836 14,721 13,050
Selling, general & administration expenses 62,243 65,583 61,821
228,609 215,490 201,869

(b) Other operating income and expenses

Other operating income and expenses incurred during 2018, 2017 and 2016 by function are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Cost of sales 432,803 416,020 454,097
Research and development 152,670 129,579 113,078
Selling, general & administration expenses 410,753 460,959 393,523
996,226 1,006,558 960,698

Details by nature are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Changes in trade provisions (23,125) 3,648 (22,069)
Professional services 211,305 211,579 190,003
Commissions 21,941 18,473 20,147
Supplies and auxiliary materials 149,831 131,932 119,014
Operating leases (note 28) 84,299 80,136 74,945
Freight 112,340 105,292 96,680
Repair and maintenance expenses 107,806 103,518 89,797
Advertising 44,659 49,893 51,233
Insurance 22,632 21,529 20,008
Royalties 10,726 11,241 9,217
Travel expenses 51,428 58,171 53,239
External services 53,391 82,699 43,231
R&D Expenses 100,889 89,977 78,379
Other 48,104 38,470 136,874
Other operating income&expenses 996,226 1,006,558 960,698

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(26) Finance Result

Details are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Finance income 13,995 9,678 9,934
Finance cost from Senior Unsecured Notes (35,471) (65,189) (73,491)
Finance cost from senior debt (247,646) (193,183) (168,332)
Finance cost from sale of receivables (note 13) (6,053) (3,973) (4,885)
Capitalized interest 8,955 8,839 13,019
Other finance costs (13,058) (9,838) (11,140)
Finance costs (293,273) (263,344) (244,829)
Change in fair value of financial derivatives (note 30)
Impairment and gains / (losses) on disposal of financial
-- (3,752) (7,610)
instruments 30,280 (18,844) --
Exchange differences (8,246) (11,472) 8,916
Finance result (257,244) (287,734) (233,589)

On 29 January 2018 (prior to the date on which the 2017 consolidated annual accounts were authorized to issue) Aradigm communicated that it had not obtained the approval of the Antimicrobial Drugs Advisory Committee of the US Food and Drug Administration for LinahiqTM. As a result, the financial assets related to the convertible note of Aradigm have been totally impaired totaling Euros 14,477 thousand at 31 December 2017. This amount was recognized in "Impairment and gains/(losses) on disposal of financial instruments" in the consolidated statement of profit and loss.

During 2018 the Group has capitalized interest at a rate of between 4.61% and 5.18% based on the financing received (between 4.26% and 4.87% during 2017) (see note 4 (f)).

(27) Taxation

Grifols, S.A. is authorized to file consolidated tax returns in Spain with Diagnostic Grifols, S.A., Grifols Movaco, S.A., Laboratorios Grifols, S.A., Instituto Grifols, S.A., Grifols Worldwide Operations Spain, S.A. (formerly Logister, S.A), Biomat, S.A., Grifols Viajes, S.A., Grifols International, S.A., Grifols Engineering, S.A., Gri-Cel, S.A., Gripdan Invest, S.L. and VCN Biosciences, S.L. Grifols, S.A., in its capacity as Parent, is responsible for the filing and settlement of the consolidated tax return. Under prevailing tax law, Spanish companies pay 25% tax, which may be reduced by certain deductions.

The North American company Grifols Shared Services North America, Inc. is also authorized to file consolidated tax returns in the USA with Grifols Biologicals Inc., Grifols USA, LLC., Biomat USA, Inc., Grifols Therapeutics Inc. and Talecris Plasma Resources, Inc. The profits of the companies domiciled in the USA, determined in accordance with prevailing tax legislation, are subject to tax of approximately 22.4% of taxable income, which may be reduced by certain deductions.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(a) Reconciliation of accounting and taxable income

Details of the income tax expense and income tax related to profit for the year are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Profit before income tax from continuing
operations
725,842 695,722 712,752
Tax at 25% 181,461 173,931 178,188
Permanent differences (2,000) 17,163 8,019
Effect of different tax rates (29,543) 40,981 14,509
Tax credits (deductions) (18,226) (16,092) (20,163)
Impact related to the US tax legistation
modifications
-- (171,169) --
Prior year income tax expense 381 (8,614) 928
Other income tax expenses/(income) (637) (1,792) (13,272)
Total income tax expense 131,436 34,408 168,209
Deferred tax (21,189) (149,444) (40,161)
Current tax 152,625 183,851 208,370
Total income tax expense 131,436 34,407 168,209

The effect of the different tax rates is basically due to a change of country mix in profits

On 22 December 2017, a tax reform was approved in the United States that took effect on 1 January 2018.

The Group carried out an exercise to identify changes in the tax reform affecting its subsidiaries in the USA and an assessment of the impact that these changes will have on the manner in which the deferred taxes will revert as of 31 December 2017. In the analysis performed, the main impact comes from the change in tax rates to be applied to deferred taxes as of 31 December 2017, which have fallen from a rate of 35% to 21% for fiscal years beginning on or after 1 January 2018. The impact recorded in the "income tax expense" caption amounted to Euros 171 million in 2017.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(b) Deferred tax assets and liabilities

Details of deferred tax assets and liabilities are as follows:

Miles de Euros
Efecto impositivo
31/12/2018 31/12/2017 31/12/2016
Activos
Provisiones 7,936 4,564 3,696
Existencias 41,029 35,619 39,297
Derechos por deducciones 57,357 49,467 37,685
Créditos por pérdidas a compensar 32,769 6,179 10,717
Otros 8,611 7,513 3,393
Subtotal Activos 147,702 103,342 94,788
Fondo de comercio (24,691) (22,346) (19,136)
Activos fijos y amortización (3,922) (7,780) (7,062)
Activos intangibles (6,550) (7,059) (1,371)
Subtotal Pasivos neteados (35,163) (37,185) (27,569)
Activos diferidos netos 112,539 66,157 67,219
Pasivos
Fondo de comercio (150,644) (105,963) (131,039)
Activos intangibles (220,752) (201,921) (392,388)
Activos fijos (99,819) (95,029) (158,060)
Costes amortización deuda (42,319) (70,503) (64,762)
Existencias -- -- (1,175)
Subtotal Pasivos (513,534) (473,416) (747,424)
Créditos por pérdidas a compensar 20,833 15,384 40,358
Existencias 5,644 5,063 --
Provisiones 53,290 47,404 61,252
Otros 29,369 16,653 45,168
Subtotal Activos neteados 109,135 84,504 146,778
Pasivos diferidos netos (404,398) (388,912) (600,646)

Movement in deferred tax assets and liabilities is as follows:

Thousands of Euros
Deferred tax assets and liabilities 31/12/2018 31/12/2017 31/12/2016
Balance at 1 January (322,755) (533,427) (564,771)
Movements during the year 21,189 149,444 40,161
Movements in equity during the year -- -- --
Business combination (note 3) 21,328 16,736 --
Translation differences (11,621) 44,492 (8,817)
Balance at 31 December (291,859) (322,755) (533,427)

The Spanish companies have opted to apply accelerated depreciation to certain additions to property, plant and equipment, which has resulted in the corresponding deferred tax liability.

The remaining assets and liabilities recognized in 2018, 2017 and 2016 were recognized in the statement of profit and loss.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Estimated net deferred tax assets to be reversed in a period of less than 12 months amount to Euros 27,097 thousand at 31 December 2018 (Euros 51,930 thousand at 31 December 2017).

The majority of the tax deductions pending application from Spanish companies related mainly to research and development, mature in 18 years.

Tax credits derived from the US companies are available for 20 years from their date of origin whilst tax credits from Spanish companies registered in the Basque Country are available for 15 and other remaining Spanish companies have no maturity date.

The Group has not recognized as deferred tax assets the tax effect of the unused tax loss carryforwards of Group companies, which amount to Euros 55,282 thousand (Euros 51,169 thousand at 31 December 2017).

The commitments from Spanish companies from the reversal of deferred tax related to provisions of investments in subsidiaries are not significant.

(c) Years open to inspection

Under prevailing legislation, taxes cannot be considered to be definitively settled until the returns filed have been inspected by the taxation authorities, or the prescription period has elapsed.

The main tax audits currently open in the Group are as follows:

  • Grifols Shared Services North America, Inc. and subsidiaries: notification of an inspection of State Income Tax in North Carolina and New York states (fiscal years 2012 to 2015). During 2017, this inspection was closed and the Group without any significant adjustment.
  • Grifols Shared Services North America, Inc. and subsidiaries: In 2018 has been notified of an inspection related to the State Income Tax of the fiscal year 2016.

Group management does not expect any significant liability to derive from these inspections.

(28) Operating Leases

(a) Operating leases (as lessee)

At 31 December 2018, 2017 and 2016 the Group leases buildings and warehouses from third parties under operating leases.

Operating lease instalments of Euros 84,299 thousand were recognized as an expense in 2018 (Euros 80,136 thousand in 2017 and Euros 74,945 thousand in 2016) and fully comprise minimum lease payments.

Future minimum payments on non-cancellable operating leases at 31 December 2018, 2017 and 2016 are as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Maturity at:
Up to 1 year 63,959 46,541 56,869
Between 1 and 5 years 200,156 156,897 181,076
More than 5 years 136,464 58,905 112,986
Total future minimum payments 400,579 262,343 350,931

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(b) Operating leases (as lessor)

At 31 December 2018, 2017 and 2016 the Group has no lease contracts as lessor.

(29) Other Commitments with Third Parties and Other Contingent Liabilities

(a) Guarantees

The Group has no significant guarantees extended to third parties.

(b) Guarantees committed with third parties

The Group has no significant guarantees extended to third parties, except for those described in note 20.

(c) Obligations with personnel

The Group's annual contribution to defined contribution pension plans of Spanish Group companies for 2018 has amounted to Euros 777 thousand (Euros 725 thousand for 2017).

In successive years this contribution will be defined through labor negotiations.

In the event that control is taken of the Company, the Group has agreements with 69 employees/directors whereby they can unilaterally rescind their employment contracts with the Company and are entitled to termination benefits ranging from 2 to 5 years' salary.

The Group has contracts with six executives entitling them to termination benefits ranging from one to four years of their salary in different circumstances.

Restricted Share Unit Retention Plan

For the annual bonus, the Group established a Restricted Share Unit Retention Plan (RSU Plan), for eligible employees. Under this plan, employees can choose to receive up to 50% of their yearly bonus in non-voting Class B ordinary shares (Grifols Class B Shares) or Grifols American Depositary Shares (Grifols ADS), and the Group will match this with an additional 50% of the employee's choice of RSUs.

Grifols Class B Shares and Grifols ADS are valued at grant date.

These RSU's will have a vesting period of 2 years and 1 day and, subsequently, the RSU's will be exchanged for Grifols Class B Shares or Grifols ADS (American Depositary Share representing 1 Class B Share).

If an eligible employee leaves the Company or is terminated before the vesting period, he/she will not be entitled to the additional RSU's.

At 31 December 2018, the Group has settled the RSU plan of 2015 for an amount of Euros 7,914 thousand.

This commitment is treated as equity instrument and the amount totals Euros 12,652 thousand at 31 December 2018 (Euros 13,871 thousand at 31 December 2017).

Savings plan and profit-sharing plan

The Group has a defined contribution plan (savings plan), which qualifies as a deferred salary arrangement under Section 401 (k) of the Internal Revenue Code (IRC). Once eligible, employees may elect to contribute a portion of their salaries to the savings plan, subject to certain limitations. The Group matches 100% of the first 3% of employee contributions and 50% of the next 2%. Group and employee contributions are fully vested when contributed. The total cost of matching contributions to the savings plan was US Dollars 20.7 million for 2018 (US Dollars 18.9 million in 2017).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Other plans

The Group has a defined benefit pension plan for certain Talecris Biotherapeutics, GmbH employees in Germany as required by statutory law. The pension cost relating to this plan is not material for the periods presented.

(d) Purchase commitments

Details of the Group's commitments at 31 December 2018 are as follows:

Thousands of Euros
2019 179,766
2020 166,163
2021 149,318
2022 4,143
2023 1,067
More than 5 years 893

(e) Judicial procedures and arbitration

Details of legal proceedings in which the Company or Group companies are involved are as follows:

  • bioMérieux, S.A., et ano. v. Hologic, Inc. et al., Case No. 1:17-cv-102 (M.D.N.C); Case No. 18-21-LPS-CJB (D. Del.): On 3 February 2017, bioMérieux, S.A and bioMérieux, Inc. filed suit against Hologic, Inc. ("Hologic"), Grifols, S.A. ("GSA"), and GDS in the U.S. District Court for the Middle District of North Carolina, alleging infringement of U.S. Patent Nos. 8,697,352 and 9,074,262 by virtue of defendants' activities with respect to the Procleix HIV-1/HCV Assay®, Procleix Ultrio Assay®, and Procleix Ultrio Plus® products. Hologic and GDS filed a motion to dismiss for failure to state a claim on 3 April 2017. As a result of a claim of improper venue, the case was transferred to the U.S. District Court for the District of Delaware in early 2018. Hologic and GDS pursued defenses of failure to state a claim, non-infringement, invalidity, and that the infringement claims are contractually barred under a Non-Assertion Agreement. On 31 May 2018, Hologic, GDS and GSA filed a motion to sever and stay their contractual defense under the Non-Assertion Agreement pending resolution of the liability issues. Hologic and GDS filed a Motion to Dismiss for failure to state a claim and GSA filed a Motion to Dismiss for lack of personal jurisdiction. The Court denied Hologic's and GDS' Motions to Dismiss on 25 September 2018, and denied GSA's Motion to Dismiss on 26 September 2018. On September 28, 2018, bioMérieux filed an amended complaint. Requests for Institution of Inter Parties Review were filed by Hologic with the Patent and Trademark Appeals Board on 12 February 2018, and were also denied. Requests for rehearing of the Patent and Trademark Appeals Decisions were filed on 10 September 2018 and 24 September 2018. Discovery has been initiated and is scheduled to be completed by 15 February 2019. Based on the amounts as of today's date, the Group does not believe that the aforementioned litigation could result in a material impact on these financial statements.
  • Enzo Life Sciences, Inc. v. Hologic, Inc. et al., Case No. 1:16-cv-00894-LPS (D. Del.): On 4 October 2016, Enzo Life Sciences, Inc. ("Enzo") filed suit against Hologic in the U.S. District Court for the District of Delaware, alleging infringement of U.S. Patent No. 6,221,581 (the "'581 Patent") by virtue of Hologic's activities with respect to Progensa®, Procleix®, and Aptima®products. On 9 November 2017, the Court granted Enzo's motion to amend its complaint to add GSA and GDS as defendants with respect to the Procleix® products at issue. Hologic and GDS answered the complaint, alleging non-infringement and invalidity among their defenses. GSA filed a Motion to Dismiss for lack of personal jurisdiction, which was denied on 26 September 2018. A Request for Institution of Inter Parties Review was also filed by Hologic and denied by the Patent and Trademark Appeals Board on 18 April 2018. Trial was scheduled for September 2019. Fact discovery was nearly complete and depositions of key witnesses were scheduled. However, these activities were taken off calendar at the request of Enzo after issuance of the 15 October 2018 Court Order and

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Opinion on Claim Construction narrowing the scope of the '581 Patent claims such that the products at issue would not infringe the '581 Patent. On 5 November 2018, the Court entered final judgement in favor of Hologic, GSA and GDS following the filing of a Joint Stipulation of Noninfringement. Enzo intends to appeal the Court's claim construction ruling. Based on the amounts as of today's date, the Group does not believe that the aforementioned litigation could result in a material impact on these financial statements.

• Concerning the acquisition in 2014 of the transfusional Diagnostic unit and after an internal investigation by the Company, no abnormal commercial or contractual practices have been found.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(30) Financial Instruments

Classification

Disclosure of financial instruments by nature, category and fair value is as follows:

Thousand of Euros
31/12/2017
Carrying amount Fair Value
Loans and
receivables
Financial
instruments
held for trading
Available for
sale financial
assets
Debts and
payables
Total Level 1 Level 2 Level 3 Total
Non-current financial assets -- -- 38,708 -- 38,708 38,708 -- -- 38,708
Financial derivatives -- 8,338 -- -- 8,338 -- -- 8,338 8,338
Financial assets measured at fair value -- 8,338 38,708 -- 47,046
Non-current financial assets 22,843 -- -- -- 22,843
Other current financial assets 10,738 -- -- -- 10,738
Trade and other receivables 304,864 -- -- -- 304,864
Cash and cash equivalents 886,521 -- -- -- 886,521
Financial assets not measured at fair value 1,224,966 -- -- -- 1,224,966
Senior Unsecured Notes -- -- -- (858,911) (858,911) (1,018,130) -- -- (1,018,130)
Promissory Notes -- -- -- (90,294) (90,294)
Senior secured debt -- -- -- (4,853,939) (4,853,939) -- (5,063,769) -- (5,063,769)
Other bank loans -- -- -- (198,741) (198,741)
Finance lease payables -- -- -- (9,360) (9,360)
Other financial liabilities -- -- -- (45,640) (45,640)
Trade and other payables -- -- -- (423,096) (423,096)
Other current liabilities -- -- -- (14,879) (14,879)
Financial liabilities not measured at fair value -- -- -- (6,494,860) (6,494,860)
1,224,966 8,338 38,708 (6,494,860) (5,222,848)

The Group does not provide details of the fair value of certain financial instruments as their carrying amount is very similar to their fair value because of its short term.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Thousand of Euros
Carrying amount 31/12/2018 Fair Value
Financial assets
at amortised
costs
Financial
assets at
FVTPL
Financial
liabilities at
amortised costs
Other
financial
liabilities
Total Level 1 Level 2 Level 3 Total
Non-current financial assets -- 7 -- -- 7 7 -- -- 7
Current Financial derivatives -- 19,934 -- -- 19,934 -- -- 19,934 19,934
Financial assets measured at fair value -- 19,941 -- -- 19,941
Non-current financial assets 107,594 -- -- -- 107,594
Other current financial assets 34,031 -- -- -- 34,031
Trade and other receivables 361,585 -- -- -- 361,585
Cash and cash equivalents 1,033,792 -- -- -- 1,033,792
Financial assets not measured at fair value 1,537,002 -- -- -- 1,537,002
Senior Unsecured Notes -- -- (1,005,333) -- (1,005,333) (985,480) -- -- (985,480)
Promissory Notes -- -- (97,645) -- (97,645)
Senior secured debt -- -- (4,901,240) -- (4,901,240) -- (5,055,323) -- (5,055,323)
Other bank loans -- -- (264,525) -- (264,525)
Finance lease payables -- -- (12,885) -- (12,885)
Other financial liabilities -- -- (95,217) -- (95,217)
Debts with associates -- -- (7,079) -- (7,079)
Other non-current debts -- -- -- (1,301) (1,301)
Trade and other payables -- -- -- (721,699) (721,699)
Other current liabilities -- -- -- (169,189) (169,189)
Financial liabilities not measured at fair valu -- -- (6,383,924) (892,189) (7,276,113)
1,537,002 19,941 (6,383,924) (892,189) (5,719,170)

The Group does not provide details of the fair value of certain financial instruments as their carrying amount is very similar to their fair value because of its short term.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Financial derivatives

At 31 December 2018 and 2017 the Group has recognized the following derivatives:

Thousands of Euros
Financial derivatives Currency Notional
amount at
31/12/2018
Notional
amount at
31/12/2017
Value at
31/12/18
Value at
31/12/17
Maturity
Call Option (Interstate Blood Bank,
Inc., Bio-Blood Components, Inc and
Plasma Biological Services, LLC)
US Dollar N/A N/A 8,733 8,338 30/04/2019
Call Option (ADMA Centers) US Dollar N/A N/A 11,201 -- 01/01/2019
Total Assets 19,934 8,338

On 11 May 2016 the Group paid an aggregate amount equal to US Dollars 10,000 thousand (Euros 8,960 thousand at the exchange rate at the date of acquisition) in respect of the call option for the Interstate Blood Bank, Inc. shares, Bio-Blood Components, Inc. shares and Plasma Biological Services, LLC. shares that are not owned by the Group. The call option can be exercised by the Group by delivering written notice of its intention at any time on or after 1 February 2019 and on or before 30 April 2019 (see note 11).

On 6 June 2017, Biotest Pharmaceuticals Corporation agreed to purchase from ADMA Biologics all of its rights, titles and interests in two donation centers located in Georgia, USA. On 1 August 2018, Grifols acquired Biotest and its net assets (including the purchase option). The execution of the purchase option was carried out on 1 January 2019.

Financial derivatives are valued based on generally accepted valuation techniques (level 3 in the fair value hierarchy), using to the greatest extent data from the market and to a lesser extent specific data of the Group.

Derivative financial instruments that do not meet the hedge accounting requirements are classified and measured as financial assets or financial liabilities at fair value through profit and loss.

Credit risk

(a) Exposure to credit risk

The carrying amount of financial assets represents the maximum exposure to credit risk. At 31 December 2018 and 2017 the maximum level of exposure to credit risk is as follows:

Thousands of Euros
Carrying amount Note 31/12/2018 31/12/2017
Non-current financial assets 11 107,601 69,889
Other current financial assets 11 53,965 10,738
Trade receivables 13 269,167 286,198
Other receivables 13 45,327 18,666
Cash and cash equivalents 14 1,033,792 886,521
1,509,852 1,272,012

The maximum level of exposure to risk associated with receivables at 31 December 2018 and 2017, by geographical area, is as follows.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Thousands of Euros
Carrying amount 31/12/2018 31/12/2017
Spain 46,025 63,505
EU countries 48,354 53,403
United States of America 79,829 65,068
Other European countries 14,289 5,761
Other regions 125,997 117,127
314,494 304,864

(b) Impairment losses

A breakdown of the trade receivables net of the bad debt provision by ageing as of 31 December 2017 is as follows:

Thousands of Euros
ECL Rate Total gross carrying
amount
Provision Total net trade
receivable third
party
Not matured 0.19% 224,476 (35) 224,441
Past due 0-30 days 0.19% 41,145 (7,476) 33,669
Past due 31-60 days 0.62% 12,904 (3) 12,901
Past due 61-90 days 2.03% 715 (8) 707
Past due 91-180 days 3.01% 4,293 (35) 4,258
Past due 181-365 days 8.52% 7,468 (2,110) 5,358
More than one year 100.00% 7,260 (2,971) 4,289
Customers with objective evidence of
impairment 7,643 (7,068) 575
305,904 (19,706) 286,198

A breakdown of the trade receivables net of the bad debt provision by seniority as of December 31, 2018 is as follows:

Thousands
of Euros
ECL Rate Total gross carrying
amount
Provision Total net trade
receivable third
party
Not matured 0.19% 180,448 (335) 180,113
Past due 0-30 days 0.19% 52,310 (92) 52,218
Past due 31-60 days 0.62% 11,125 (67) 11,058
Past due 61-90 days 2.03% 10,729 (208) 10,521
Past due 91-180 days 3.01% 12,158 (353) 11,805
Past due 181-365 days 8.52% 4,158 (1,222) 2,936
More than one year 100.00% 7,549 (7,033) 516
Customers with objective evidence of impairment 11,221 (11,221) --
289,698 (20,531) 269,167

Unimpaired receivables that are past due mainly relate to public entities.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Movement in the bad debt provision was as follows:

Thousands of Euros
31/12/2018 31/12/2017 31/12/2016
Opening balance 19,706 17,987 13,210
Net charges for the year 6,443 8,003 6,411
Net cancellations for the year (5,650) (4,732) (2,217)
Translation differences 32 (1,552) 583
Closing balance 20,531 19,706 17,987

An analysis of the concentration of credit risk is provided in note 5 (a).

Liquidity risk

The management of the liquidity risk is explained in note 5.

Details of the contractual maturity dates of financial liabilities including committed interest calculated using interest rate forward curves are as follows:

Thousands of Euros
Carrying amount Note Carrying
amount at
31/12/17
Contractual
flows
6 months
or less
6 - 12
months
1-2
years
2- 5
years
More than
5 years
Financial liabilities
Bank loans 20 5,052,680 6,138,673 105,584 106,492 322,421 3,115,887 2,488,289
Other financial liabilities 20 45,640 45,642 19,393 2,610 10,758 10,497 2,384
Bonds and other marketable
securities
20 949,205 1,331,203 107,203 16,000 32,000 128,000 1,048,000
Finance lease payables 20 9,360 10,136 2,192 2,113 2,602 2,790 439
Payable to suppliers 21 423,096 423,096 423,020 76 -- -- --
Other current liabilities 22 14,878 14,878 14,462 416 -- -- --
Total 6,494,859 7,963,628 671,854 127,707 367,781 3,257,174 3,539,112
Thousands of Euros
Carrying amount Note Carrying
amount at
31/12/18
Contractual
flows
6 months
or less
6 - 12
months
1-2
years
2- 5 years More than
5 years
Financial liabilities
Bank loans 20 5,165,765 6,522,083 195,568 202,437 522,040 3,086,734 2,515,304
Other financial liabilities 20 95,217 95,218 14,167 2,095 21,324 55,863 1,769
Bonds and other
marketable securities 20 1,102,978 1,305,645 113,645 16,000 32,000 128,000 1,016,000
Finance lease payables 20 12,885 13,423 1,946 1,630 3,367 5,655 825
Debts with associates 31 7,079 7,079 -- 7,079 -- -- --
Payable to suppliers 21 561,883 561,884 561,559 325 -- -- --
Other current liabilities 22 16,029 16,028 15,861 167 -- -- --
Total 6,961,836 8,521,360 902,746 229,733 578,731 3,276,252 3,533,898

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Currency risk

The Group's exposure to currency risk is as follows:

Thousands of Euros
31/12/2017
Euros (*) Dollars (**)
Trade receivables 3,596 22,936
Receivables from Group companies 103,338 7,619
Loans to Group companies 34,140 91,566
Cash and cash equivalents 63,981 2,172
Trade payables (14,213) (3,582)
Payables to Group companies (42,296) (11,241)
Loans from Group companies (22,913) (3,953)
Bank loans (85,000) --
Balance sheet exposure 40,633 105,517

(*) Balances in Euros in subsidiaries with US Dollars functional currency

(**) Balances in US Dollars in subsidiaries with Euros functional currency

Thousands of Euros
31/12/2018
Euros (*) Dollars (**)
Trade receivables 2,691 45,801
Receivables from Group companies 54,903 6,291
Loans to Group companies 40,387 4,343
Cash and cash equivalents 120,281 1,296
Trade payables (13,354) (6,113)
Payables to Group companies (60,363) (63,932)
Loans from Group companies (94,771) (4,336)
Bank loans (74,375) --
Balance sheet exposure (24,601) (16,650)

(*) Balances in Euros in subsidiaries with US Dollars functional currency

(**) Balances in US Dollars in subsidiaries with Euros functional currency

The most significant exchange rates applied at 2018 and 2017 year ends are as follows:

Closing exchange rate
Euros 31/12/2018 31/12/2017
US Dollars 1.1450 1.1993

A sensitivity analysis for foreign exchange fluctuations is as follows:

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Had the US Dollar strengthened by 10% against the Euro at 31 December 2018, equity would have increased by Euros 506,131 thousand (Euros 416,116 thousand at 31 December 2017) and profit due to foreign exchange differences would have increased by Euros 4,125 thousand (Euros 14,615 thousand at 31 December 2017). This analysis assumes that all other variables are held constant, especially that interest rates remain constant.

A 10% weakening of the US Dollar against the Euro at 31 December 2018 and 2017 would have had the opposite effect for the amounts shown above, all other variables being held constant.

Interest rate risk

(a) Interest-rate profile

To date, the profile of interest on interest-bearing financial instruments is as follows:

Thousands of Euros
31/12/2018 31/12/2017
Fixed-interest financial instruments
Financial liabilities (1,244,375) (1,170,000)
(1,244,375) (1,170,000)
Variable-interest financial instruments
Financial liabilities (5,233,638) (5,049,382)
(5,233,638) (5,049,382)
(6,478,013) (6,219,382)

(b) Sensitivity analysis

If the interest rate had been 100 basis points higher during 2018, the interest expense would have increased by Euros 53,082 thousand.

If the interest rate had been 100 basis points higher during 2017, the interest expense would have increased by Euros 52,999 thousand. As the Group does not have any derivatives in place, the net effect on cash interest payments would have increased by the same amount.

(31) Balances and Transactions with Related Parties

Details of balances with related parties are as follows:

Thousands of Euros
31/12/2018 31/12/2017
Receivables from associates (note 13) 382 3,219
Trade payables associates (15,796) (4,583)
Loans to associates (note 11) 50,304 26,654
Loans to other related parties (note 11) 82,969 --
Debts with associates (7,079) --
Debts with key management personnel (4,425) (6,164)
Payables to members of the board of directors -- (463)
Payables to other related parties (7,706) (9,187)
98,649 9,476

Payables are included in trade and other payables (see note 21).

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(a) Group transactions with related parties

Group transactions with related parties during 2016 were as follows:

Thousands of Euros
Associates Key management
personnel
Other related
parties
Board of directors
of the Company
Net sales 193 -- -- --
Purchases (35,569) -- -- --
Other service expenses (7,591) -- (5,325) (905)
Operating lease expense -- -- (5,281) --
Remuneration -- (10,287) -- (3,668)
R&D agreements (10,188) -- -- --
Finance result 1,946 -- -- --
(51,209) (10,287) (10,606) (4,573)

Group transactions with related parties during 2017 were as follows:

Thousands of Euros
Associates Key management
personnel
Other related
parties
Board of directors
of the Company
Net sales 3,009 -- -- --
Purchases (68,335) -- -- --
Other service expenses (11,798) -- (7,100) (939)
Operating lease expense -- -- (5,426) --
Remuneration -- (13,672) -- (5,755)
R&D agreements (164) -- -- --
Finance Result 152 -- -- --
(77,136) (13,672) (12,526) (6,694)

Group transactions with related parties during 2018 are as follows:

Thousands of Euros
Associates Key management
personnel
Other related
parties
Board of directors
of the Company
Net sales 5,846 -- -- --
Purchases (97,941) -- -- --
Other service expenses (21,065) -- (4,282) (844)
Operating lease expense -- -- (5,469) --
Remuneration -- (16,070) -- (5,848)
R&D agreements (50) -- -- --
Sale of investments (note 3) -- -- 469,881 --
Finance result 3,372 -- -- --
(109,838) (16,070) 460,130 (6,692)

Every year the Group contributes 0.7% of its profits before tax to a non-profit organization.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

"Other service expenses" include contributions to non-profit organizations totaling Euros 4,282 thousand in 2018 (Euros 7,100 thousand in 2017 and Euros 5,325 thousand in 2016).

During 2011 one of the Company's directors signed a three-year consulting services contract. The director received annual fees of US Dollars 1 million for these services and an additional bonus of US Dollars 2 million for complying with certain conditions. In the years 2014, 2015, 2017 and 2018 the contract has been renewed, the amount of the fees corresponds to US Dollars 1 million per year. The contract has an expiration date of 31 March 2019.

On 28 December 2018, the Group sold Biotest and Haema to Scranton Enterprises B.V (shareholder of Grifols) for US Dollars 538,014 thousand (see note 3). For the payment of the mentioned amount of the sale, Scranton signed a loan contract dated 28 December 2018 for an amount of US Dollars 95,000 thousand (Euros 82,969 thousand) with Grifols Worldwide Operations Limited. The compensation is 2%+EURIBOR and due on 28 December 2025.

Directors representing shareholders´ interests have received remuneration of Euros 1,640 thousand in 2018 (Euros 1,881 thousand in 2017).

The Group has not extended any advances or loans to the members of the board of directors or key management personnel nor has it assumed any guarantee commitments on their behalf. It has also not assumed any pension or life insurance obligations on behalf of former or current members of the board of directors or key management personnel. In addition, certain Company directors and key management personnel have termination benefit commitments (see note 29 (c)).

(b) Conflicts of interest concerning the directors

The Company's directors and their related parties have not entered into any conflict of interest that should have been reported in accordance with article 229 of the revised Spanish Companies Act.

(32) Environmental Issues

The most significant systems, equipment and fixtures for the protection and improvement of the environment at 31 December 2017 are as follows:

Thousands of Euros
Project Cost Accumulated
depreciation
Net value
Waste water treatment 7,990 (1,976) 6,014
Waste management 5,060 (1,573) 3,487
Reduction of electricity consumption 13,606 (3,169) 10,437
Reduction of water consumption 12,948 (2,936) 10,012
Energy 6,051 (317) 5,734
Other 1,164 (135) 1,029
46,819 (10,106) 36,713

The most significant systems, equipment and fixtures for the protection and improvement of the environment at 31 December 2018 are as follows:

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Thousands of Euros
Project Cost Accumulated
depreciation
Net value
Waste water treatment 13,467 (2,599) 10,868
Waste management 6,399 (1,920) 4,479
Reduction of electricity consumption 13,210 (4,002) 9,208
Reduction of water consumption 18,815 (3,404) 15,411
Energy 13,819 (564) 13,255
Other 2,320 (262) 2,058
68,030 (12,751) 55,279

Expenses incurred by the Group for protection and improvement of the environment during 2018 totalled approximately Euros 15,474 thousand (Euros 13,554 thousand during 2017 and Euros 12,718 thousand during 2016).

The Group considers that the environmental risks are adequately controlled by the procedures currently in place.

The Group has not received environmental grants during 2018, 2017 and 2016.

(33) Other Information

Audit fees:

KPMG Auditores, S.L. has invoiced the following fees for professional services during 2018 and 2017:

Thousands of Euros
31/12/2018 31/12/2017
Audit services 1,534 1,844
Audit-related services 601 712
2,135 2,556

Amounts included in table above, includes the total amount of fees related to services incurred during 2018 and 2017 without considering the invoice date.

Audit-related services in 2018 include limited reviews of the semi-annual financial statements, the audit of the consolidated financial statements under PCAOB, the audit of GDS and reports of agreed-upon procedures.

Audit-related services in 2018 include limited reviews of the semi-annual financial statements, the audit of the consolidated financial statements under PCAOB, comfort letters in relation to debt issues and reports of agreed-upon procedures.

Notes to the Consolidated Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Other entities affiliated to KPMG International have invoiced the Group for the following fees for professional services during 2018 and 2017:

Thousands of Euros
31/12/2018 31/12/2017
Audit services 2,559 2,783
Audit-related 679 270
Tax advisory fees 232 51
Other services 228 7
3,698 3,111

Other audit firms have invoiced the Group for the following fees for professional services during 2018 and 2017:

Thousands of Euros
31/12/2018 31/12/2017
Audit services 83 52
83 52

APPENDIX I GRIFOLS, S.A. AND SUBSIDIARIES Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Acquisition / 31/12/2018 31/12/2017 31/12/2016
Registered Incorporation % shares % shares % shares
Name Offices date Activity Statutory Activity Direct Indirect Direct Indirect Direct Indirect
Fully Consolidated Companies
Diagnostic Grifols, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1987 Industrial Development and manufacture of diagnostic equipment, instruments and reagents. --- 100.000% --- 100.000% --- 100.000%
Instituto Grifols, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1987 Industrial Plasma fractioning and the manufacture of haemoderivative pharmaceutical products. 99.998% 0.002% 99.998% 0.002% 99.998% 0.002%
Grifols Worldwide Operations Spain, S.A
(formerly Logister, S.A.) Merged with Grifols International in
2018
Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1987 Services Manufacture, sale and purchase, commercialisation and distribution of all types of computer products
and materials.
--- --- --- 100.000% --- 100.000%
Laboratorios Grifols, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1989 Industrial Production of glass- and plastic-packaged parenteral solutions, parenteral and enteral nutrition products
and blood extraction equipment and bags.
99.999% 0.001% 99.999% 0.001% 99.999% 0.001%
Biomat, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1991 Industrial Analysis and certification of the quality of plasma used by Instituto Grifols, S.A. It also provides
transfusion centres with plasma virus inactivation services (I.P.T.H).
99.900% 0.100% 99.900% 0.100% 99.900% 0.100%
Grifols Engineering, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
2000 Industrial Design and development of the Group's manufacturing installations and part of the equipment and
machinery used at these premises. The company also renders engineering services to external
companies.
99.950% 0.050% 99.950% 0.050% 99.950% 0.050%
Biomat USA, Inc. 2410 Lillyvale Avenue
Los Angeles (California)
United States
2002 Industrial Procuring human plasma. --- 100.000% --- 100.000% --- 100.000%
Grifols Biologicals LLC. 5555 Valley Boulevard
Los Angeles (California)
United States
2003 Industrial Plasma fractioning and the production of haemoderivatives. --- 100.000% --- 100.000% --- 100.000%
Grifols Australia Pty Ltd. Unit 5/80 Fairbank
Clayton South
Victoria 3149
Australia
2009 Industrial Distribution of pharmaceutical products and the development and manufacture of reagents for
diagnostics.
100.000% --- 100.000% --- 100.000% ---
Medion Grifols Diagnostic AG Bonnstrasse,9
3186 Dügingen
Switzerland
2009 Industrial Development and manufacturing activities in the area of biotechnology and diagnostics. --- 100.000% --- 100.000% --- 100.000%
Grifols Therapeutics LLC. 4101 Research Commons
(Principal Address),
79 T.W. Alexander Drive,
Research Triangle Park,
North Carolina 277709,
United States
2011 Industrial Plasma fractioning and the production of haemoderivatives. --- 100.000% --- 100.000% --- 100.000%
Talecris Plasma Resources, Inc. 4101 Research Commons
(Principal Address),
79 T.W. Alexander Drive,
Research Triangle Park,
North Carolina 277709,
United States
2011 Industrial Procuring human plasma. --- 100.000% --- 100.000% --- 100.000%
Grifols Worldwide Operations Limited Grange Castle Business Park,
Grange Castle , Clondalkin,
Dublin 22,
Ireland
2012 Industrial Packaging, labelling, storage, distribution, manufacture and development of pharmaceutical products
and rendering of financial services to Group companies.
100.000% --- 100.000% --- 100.000% ---
Progenika Biopharma, S.A. Parque Tecnológico de Vizcaya,
Edificio 504
48160 Derio (Vizcaya)
Spain
2013 Industrial Development, production and commercialisation of biotechnological solutions. 99.998% --- --- 90.230% --- 89.250%
Progenika Latina, S.A. de CV Periferico Sur Nº 4118 Int 8 Col.
Jardines del Pedregal
CP 01900 Alvaro Obregon
DF Mexico
2013 Industrial Development, production and commercialisation of biotechnological solutions. --- --- --- --- --- 89.250%

Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016 (Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Acquisition / 31/12/2018 31/12/2017 31/12/2016
Name Registered
Offices
Incorporation
date
Activity Statutory Activity Direct % shares
Indirect
% shares
Direct
Indirect % shares
Direct
Indirect
Fully Consolidated Companies
Progenika Inc.
(Merged with Grifols Diagnostic Solutions Inc. in 2017)
Corporation Service Company,
2711
Centerville Road, Suite 400,
Wilmington, DE 19808
United States
2013 Industrial Development, production and commercialisation of genetic tools, diagnostic equipment and therapeutic
systems and products for personalised medicine and the highest quality healthcare in general.
--- --- --- --- --- 89.250%
Abyntek Biopharma, S.L. Parque Tecnológico de Vizcaya,
Edificio 504
48160 Derio (Vizcaya)
Spain
2013 Industrial Research, development and transfer of biotechnological products and processes, as well as the
commercialiation of products and services related to the biosciences.
--- --- --- --- --- 80.370%
Asociación I+D Progenika Parque Tecnológico de Vizcaya,
Edificio 504
48160 Derio (Vizcaya)
Spain
2013 Industrial Coordination, representation, management and promotion of the common interests of associated
companies, in addition to contributing to the development, growth and internationalisation of its
associates and of the biosciences sector in the Basque Country.
--- 99.998% --- 90.230% --- 89.250%
Grifols Diagnostics Solutions Inc
(formerly
G-C Diagnostics Corp.)
4560 Horton Street
94608 Emeryville, California
United States
2013 Industrial Manufacture and sale of blood testing products 100.000% --- 100.000% --- 100.000% ---
Grifols Worldwide Operations USA Inc. 13111 Temple Avenue, City of
Industry, California 91746-1510
Estados Unidos
2014 Industrial The manufacture, warehousing, and logistical support for biological products. --- 100.000% --- 100.000% --- 100.000%
Grifols Asia Pacific Pte, Ltd 501 Orchard Road nº20-01
238880 Wheelock Place,
Singapore
2003 Commercial Distribution and sale of medical and pharmaceutical products. 100.000% --- 100.000% --- 100.000% ---
Grifols Movaco, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1987 Commercial Distribution and sale of reagents, chemical products and other pharmaceutical specialities, and of
medical and surgical materials, equipment and instruments for use by laboratories and health centres.
99.999% 0.001% 99.999% 0.001% 99.999% 0.001%
Grifols Portugal Productos Farmacéuticos e Hospitalares, Lda. Rua de Sao Sebastiao,2
Zona Industrial Cabra Figa
2635-448 Rio de Mouro
Portugal
1988 Commercial Import, export and commercialisation of pharmaceutical and hospital equipment and products,
particularly Grifols products.
0.010% 99.990% 0.010% 99.990% 0.010% 99.990%
Grifols Chile, S.A. Avda. Americo Vespucio, 2242
Comuna de Conchali
Santiago de Chile
Chile
1990 Commercial Development of pharmaceutical businesses, which can involve the import, production,
commercialisation and export of related products.
99.000% --- 99.000% --- 99.000% ---
Grifols USA, LLC. 2410 Lillyvale Avenue
Los Angeles (California)
Estados Unidos
1990 Commercial Distribution and marketing of company products. --- 100.000% --- 100.000% --- 100.000%
Grifols Argentina, S.A. Bartolomé Mitre 3690/3790,
CPB1605BUT Munro
Partido de Vicente Lopez
Argentina
1991 Commercial Clinical and biological research. Preparation of reagents and therapeutic and diet products. Manufacture
and commercialisation of other pharmaceutical specialities.
95.010% 4.990% 95.010% 4.990% 95.010% 4.990%
Grifols s.r.o. Calle Zitna,2
Prague
Czech Republic
1992 Commercial Purchase, sale and distribution of chemical-pharmaceutical products, including human plasma. 100.000% --- 100.000% --- 100.000% ---
Grifols (Thailand) Ltd 191 Silom Complex Building,
21st Follor, Silom Road, Silom,
Bangrak
10500 Bangkok
Thailand
2003 Commercial Import, export and distribution of pharmaceutical products. --- 48.000% --- 48.000% --- 48.000%
Grifols Malaysia Sdn Bhd Level 18, The Gardens North
Tower, Mid Valley City,
Lingkaran Syed Putra
59200 Kuala Lumpur
Malaysia
2003 Commercial Distribution and sale of pharmaceutical products. --- 30.000% --- 30.000% --- 30.000%
Grifols International, S.A. Polígono Levante
Calle Can Guasch, s/n
08150 Parets del Vallès
(Barcelona) Spain
1997 Commercial Coordination of the marketing, sales and logistics for all the Group's subsidiaries operating in other
countries.
99.998% 0.002% 99.998% 0.002% 99.998% 0.002%
Grifols Italia S.p.A Via Carducci, 62d
56010 Ghezzano
Pisa, Italy
1997 Commercial Purchase, sale and distribution of chemical-pharmaceutical products. 100.000% --- 100.000% --- 100.000% ---
Grifols UK Ltd. Gregory Rowcliffe & Milners, 1
Bedford Row, London WC1R
4BZ
United Kingdom
1997 Commercial Distribution and sale of therapeutic and other pharmaceutical products, especially haemoderivatives. 100.000% --- 100.000% --- 100.000% ---

Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016 (Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Acquisition / 31/12/2018
% shares
31/12/2017
% shares
31/12/2016
% shares
Name Registered
Offices
Incorporation
date
Activity Statutory Activity Direct Indirect Direct Indirect Direct Indirect
Fully Consolidated Companies
Grifols Brasil, Lda. Rua Umuarama, 263
Condominio Portal da Serra
Vila Perneta
CEP 83.325-000 Pinhais
Paraná, Brazil
1998 Commercial Import and export, preparation, distribution and sale of pharmaceutical and chemical products for
laboratory and hospital use, and medical-surgical equipment and instruments.
100.000% --- 100.000% --- 100.000% ---
Grifols France, S.A.R.L. Arteparc, Rue de la Belle du
Canet, Bât. D, Route de la Côte
d'Azur, 13590 Meyreuil
France
1999 Commercial Commercialisation of chemical and healthcare products. 99.990% 0.010% 99.990% 0.010% 99.990% 0.010%
Grifols Polska Sp.z.o.o. Grzybowska 87 street00-844
Warsaw, Poland
2003 Commercial Distribution and sale of pharmaceutical, cosmetic and other products. 100.000% --- 100.000% --- 100.000% ---
Logística Grifols, S.A. de C.V. Calle Eugenio Cuzin, nº 909-913
Parque Industrial Belenes Norte
45150 Zapopán
Jalisco, Mexico
2008 Commercial Manufacture and commercialisation of pharmaceutical products for human and veterinary use. 99.990% 0.010% 99.990% 0.010% 99.990% 0.010%
Grifols México, S.A. de C.V. Calle Eugenio Cuzin, nº 909-913
Parque Industrial Belenes Norte
45150 Zapopán
Jalisco, Mexico
1993 Commercial Production, manufacture, adaptation, conditioning, sale and purchase, commissioning, representation
and consignment of all kinds of pharmaceutical products and the acquisition of machinery, equipment,
raw materials, tools, movable goods and property for the aforementioned purposes.
99.980% 0.020% 99.980% 0.020% 99.980% 0.020%
Medion Diagnostics GmbH Lochamer Schlag, 12D
82166 Gräfelfing
Germany
2009 Commercial Distribution and sale of biotechnological and diagnostic products. --- 100.000% --- 100.000% --- 100.000%
Grifols Nordic, AB Sveavägen 166
11346 Stockholm
Sweden
2010 Commercial Research and development, production and marketing of pharmaceutical products, medical devices and
any other asset deriving from the aforementioned activities.
100.000% --- 100.000% --- 100.000% ---
Grifols Colombia, Ltda Carrera 7 No. 71 52 Torre B piso
9
Bogotá. D.C.
Colombia
2010 Commercial Sale, commercialisation and distribution of medicines, pharmaceutical (including but not limited to
haemoderivatives) and hospital products, medical devices, biomedical equipment, laboratory instruments
and reagents for diagnosis and/or healthcare software.
99.990% 0.010% 99.990% 0.010% 99.990% 0.010%
Grifols Deutschland GmbH Lyoner Strasse 15, D
60528 Frankfurt am Main
Germany
2011 Commercial Procurement of the official permits and necessary approval for the production, commercialisation and
distribution of products deriving from blood plasma, as well as the import, export, distribution and sale
of reagents and chemical and pharmaceutical products, especially for laboratories and health centres and
surgical and medical equipment and instruments.
100.000% --- 100.000% --- 100.000% ---
Grifols Canada, Ltd. 5060 Spectrum Way, Suite 405
(Principal Address)
Mississauga,
Ontario L4W 5N5
Canada
2011 Commercial Distribution and sale of biotechnological products. --- 100.000% --- 100.000% --- 100.000%
Grifols Pharmaceutical Technology (Shanghai) Co., Ltd.
(formerly Grifols Pharmaceutical Consulting
(Shanghai) Co., Ltd.)
Unit 901-902, Tower 2, No. 1539,
West Nanjing Rd.,
Jing'an District, Shanghai 200040
China
2013 Commercial Pharmaceutical consultancy services (except for diagnosis), technical and logistical consultancy services,
business management and marketing consultancy services.
100.000% --- 100.000% --- 100.000% ---
Grifols Switzerland AG Steinengraben, 5
40003 Basel
Switzerland
2013 Commercial Research, development, import and export and commercialisation of pharmaceutical products, devices
and diagnostic instruments.
100.000% --- 100.000% --- 100.000% ---
Grifols (H.K.), Limited Units 1505-7 Bershire House, 25
Westlands Road
Hong Kong
2014 Commercial Distribution and sale of diagnostic products. --- 100.000% --- 100.000% --- 100.000%
Grifols Japan K.K. Hilton Plaza West Office Tower,
19th floor. 2-2, Umeda 2-chome,
Kita-ku Osaka-shi
Japan
2014 Commercial Research, development, import and export and commercialisation of pharmaceutical products, devices
and diagnostic instruments.
100.000% --- 100.000% --- 100.000% ---
Grifols India Healthcare Private Ltd Regus Business Centre
Pvt.Ltd.,Level15,Dev Corpora,
Plot No.463,Nr. Khajana
East.Exp.Highway,Thane (W),
Mumbai - 400604,
Maharashtra
India
2014 Commercial Distribution and sale of pharmaceutical products. 99.990% 0.010% 99.990% 0.010% 99.990% 0.010%

Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016 (Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Acquisition / 31/12/2018 31/12/2017 31/12/2016
Registered Incorporation % shares % shares % shares
Name Offices date Activity Statutory Activity Direct Indirect Direct Indirect Direct Indirect
Fully Consolidated Companies
Grifols Diagnostics Equipment Taiwan Limited 8F., No.367, Fuxing N. RD.,
Songshang Dist., Taipei City
10543, Taiwan
2016 Commercial Distribution and sale of diagnostic products. 100.000% --- 100.000% --- 100.000% ---
Grifols Viajes, S.A. Can Guasch, 2
08150 Parets del Vallès
Barcelona, Spain
1995 Services Travel agency exclusively serving Group companies. 99.900% 0.100% 99.900% 0.100% 99.900% 0.100%
Squadron Reinsurance Designated Activity Company
(formerly Squadron Reinsurance Ltd.)
The Metropolitan Building, 3rd Fl.
James Joyce Street, Dublin
Ireland
2003 Services Reinsurance of Group companies' insurance policies. --- 100.000% --- 100.000% --- 100.000%
Grifols Shared Services North America, Inc.
(formerly Grifols Inc.)
2410 Lillivale Avenue
90032 Los Angeles, California
United States
2011 Services Support services for the collection, manufacture, sale and distribution of plasma derivatives and related
products.
100.000% --- 100.000% --- 100.000% ---
Gripdan Invest, S.L Avenida Diagonal 477 Barcelona,
Spain
2015 Services Manufacturing buildings for rent 100.000% --- 100.000% --- 100.000% ---
Gri-Cel, S.A. Avenida de la Generalitat 152
Sant Cugat del Valles (Barcelona)
Spain
2009 Research Research and development in the field of regenerative medicine, awarding of research grants,
subscription to collaboration agreements with entities and participation in projects in the area of
regenerative medicine.
0.001% 99.999% 0.001% 99.999% 0.001% 99.999%
Araclon Biotech, S.L. Paseo de Sagasta, 17 2º izqda.
Zaragoza, Spain
2012 Research Creation and commercialisation of a blood diagnosis kit for the detection of Alzheimer's and
development of effective immunotherapy (vaccine) against this disease.
--- 73.220% --- 73.220% --- 73.220%
VCN Bioscience, S.L. Avenida de la Generalitat 152
Sant Cugat del Valles (Barcelona)
Spain
2012 Research Research and development of therapeutic approaches for tumours for which there is currently no
effective treatment.
--- 81.340% --- 81.340% --- 81.340%
Grifols Innovation and New Technologies Limited Grange Castle Business Park,
Grange Castle , Clondalkin,
Dublin 22,
Ireland
2016 Research Research and experimental development on biotechnology --- 100.000% --- 100.000% --- 100.000%
PBS Acquisition Corp. 2711 Centerville Road Suite 400,
Wilmington,
Delaware, New Castle County
United States
2016 Services Engage in any lawful act or activity for which corporations may be organized under the DGCL
(Delaware Code)
--- 100.000% --- 100.000% --- 100.000%
Kiro Grifols S.L
(formerly Kiro Robotics S.L)
Polígono Bainuetxe, 5, 2º planta,
Aretxabaleta, Guipúzcoa
Spain
2014 Research Development of machines and equipment to automate and control key points of hospital processes, and
hospital pharmacy processes.
90.000% --- 90.000% --- --- ---
Chiquito Acquisition Corp. 2711 Centerville Road Suite 400,
Wilmington, Delaware, County of
New Castle, United States
2017 Corporate Engage in any lawful act or activity for which a corporation may be organized under the General
Corporation Law of the State of Delaware, as amended from time to time (the "DGCL").
--- 100.000% --- 100.000% --- ---
Aigües Minerals de Vilajuiga, S.A. Carrer Sant Sebastià, 2, 17493
Vilajuïga, Girona
2017 Industrial Collection and use of mineral-medicinal waters and achievement of all necessary administrative
concessions in order to facilitate their industrial extraction and find the best way to take advantage of
them.
100.000% --- --- --- --- ---
Goetech LLC (D/B/A Medkeeper) 7600 Grandview Avenue, Suite 21
0, Arvada, CO 80002
2018 Industrial Development and distribution of web and mobile-based platforms for hospital pharmacies --- 54.760% --- --- --- ---
Haema, AG LandsteinerstraBe 1, 04103
Leipzig - Germany
2018 Industrial Procuring human plasma. --- --- --- --- ---
Biotest Pharmaceutical Corporation 901 Yamato Rd., Suite 101, Boca
Raton FL 33431 - USA
2018 Industrial Obtención de plasma humano. --- --- --- --- --- ---
Biotest US Corporation 901 Yamato Rd., Suite 101, Boca
Raton FL 33431 - USA
2018 Corporativo Corporate services to Biotest Pharmaceutical Corporation --- --- --- --- --- ---

Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/2018 31/12/2017 31/12/2016
% shares % shares % shares
Name Registered Offices Acquisition /
Incorporation
date
Activity Statutory Activity Direct Indirect Direct Indirect Direct Indirect
Equity Method consolidated companies and others
Aradigm Corporation 3929 Point Eden Way
Hayward, California
United States
2013 Research Development and commercialisation of drugs delivered by inhalation for the prevention and treatment of
severe respiratory diseases.
--- 35.130% --- 35.130% --- 35.130%
TiGenix N.V. Romeinse straat 12 bus 2,
3001 Leuven, Belgium
2013 Research Research and development of therapies based on stem cells taken from adipose tissue. --- --- --- 14.180% --- 16.130%
Mecwins, S.L. Avenida Fernandos Casas
Novoa, 37
Santiago de Compostela
Spain
2013 Research Research and production of nanotechnological, biotechnological and chemical solutions. --- 24.990% --- 8.420% --- 8.420%
Kiro Grifols S.L
(formerly Kiro Robotics S.L)
Polígono Bainuetxe, 5, 2º
planta, Aretxabaleta,
Guipúzcoa
Spain
2014 Research Development of machines and equipment to automate and control key points of hospital processes, and
hospital pharmacy processes.
--- --- --- --- 50.000% ---
Alkahest, Inc. 3500 South DuPont Hwy,
Dover, County of Kent
United States
2015 Research Development novel plasma-based products for the treatment of cognitive decline in aging and disorders
of the central nervous system (CNS).
--- 47.580% --- 47.580% --- 47.580%
Albajuna Therapeutics, S.L Hospital Germans Trias i
Pujol, carretera de Canyet,
s/n, Badalona
Spain
2016 Research Development and manufacture of therapeutic antibodies against HIV. --- 30.000% --- 30.000% --- 30.000%
Interstate Blood Bank, Inc. 5700 Pleasantville Road
Memphis, Tennessee
United States
2016 Industrial Procuring human plasma. --- 49.190% --- 49.190% --- 49.190%
Bio Blood Components Inc. 5700 Pleasantville Road
Memphis, Tennessee
United States
2016 Industrial Procuring human plasma. --- 48.972% --- 48.972% --- 48.972%
Plasma Biological Services, LLC 5700 Pleasantville Road
Memphis, Tennessee
United States
2016 Industrial Procuring human plasma. --- 48.900% --- 48.900% --- 48.900%
Singulex, Inc. 4041 Forest Park Avenue
St. Louis, Missouri
United States
2016 Research Development of the Single Molecule Counting (SMC™) technology for clinical diagnostic and scientific
discovery.
--- 19.330% --- 19.330% --- 20.000%

Information on Group Companies, Associates and others for the years ended 31 December 2018, 2017 and 2016

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

31/12/2018
% shares
31/12/2017
% shares
31/12/2016
% shares
Name Registered Offices Acquisition /
Incorporation
date
Activity Statutory Activity Direct Indirect Direct Indirect Direct Indirect
Equity Method consolidated companies and others
Aigües Minerals de Vilajuiga, S.A. Carrer Sant Sebastià, 2,
17493 Vilajuïga, Girona
2017 Industrial Collection and use of mineral-medicinal waters and achievement of all necessary administrative
concessions in order to facilitate their industrial extraction and find the best way to take advantage of
them.
--- --- 50.000% --- --- ---
Access Biologicals, LLC. 995 Park Center Dr,
Vista, CA 92081, USA
2017 Industrial Manufacture of biological products, including specific sera and plasma-derived reagents, which are used
by biotechnology and biopharmaceutical companies for in-vitro diagnostics, cell culture, and research and
development in the diagnostic field.
--- 49.000% --- 49.000% --- ---
Access Biologicals IC-DISC, Inc. 995 Park Center Dr,
Vista, CA 92081, USA
2017 Industrial Manufacture of biological products, including specific sera and plasma-derived reagents, which are used
by biotechnology and biopharmaceutical companies for in-vitro diagnostics, cell culture, and research and
development in the diagnostic field.
--- 49.000% --- 49.000% --- ---
Access Cell Culture, LLC. 995 Park Center Dr,
Vista, CA 92081, USA
2017 Industrial Manufacture of biological products, including specific sera and plasma-derived reagents, which are used
by biotechnology and biopharmaceutical companies for in-vitro diagnostics, cell culture, and research and
development in the diagnostic field.
--- 49.000% --- 49.000% --- ---
Access Manufacturing, LLC. 995 Park Center Dr,
Vista, CA 92081, USA
2017 Industrial Manufacture of biological products, including specific sera and plasma-derived reagents, which are used
by biotechnology and biopharmaceutical companies for in-vitro diagnostics, cell culture, and research and
development in the diagnostic field.
--- 49.000% --- 49.000% --- ---
Access Plasma, LLC. 995 Park Center Dr,
Vista, CA 92081, USA
2017 Industrial Manufacture of biological products, including specific sera and plasma-derived reagents, which are used
by biotechnology and biopharmaceutical companies for in-vitro diagnostics, cell culture, and research and
development in the diagnostic field.
--- 49.000% --- 49.000% --- ---
GigaGen Inc. 407 Cabot Road
South San Francisco, CA
94080, USA
2017 Industrial Engage in any lawful act or activity for which corporations may be organized under General Corporation
Law.
--- 43.960% --- 43.960% --- ---
Colmarer Strasse 22,
60528 Frankfurt am Main
- Germany
2018 Industrial Procuring human plasma. --- 50.000% --- --- --- ---

Plasmavita Healthcare GmbH

Operating Segments for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Bioscience Hospital Diagnostic Bio Supplies Others Intersegments Consolidated
2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016
Revenues from external customers 3,516,704 3,429,785 3,195,424 119,454 105,649 102,251 702,265 732,369 691,701 167,004 66,791 57,239 22,451 18,263 34,601 (41,154) (34,784) (31,386) 4,486,724 4,318,073 4,049,830
Total operating income 3,516,704 3,429,785 3,195,424 119,454 105,649 102,251 702,265 732,369 691,701 167,004 66,791 57,239 22,451 18,263 34,601 (41,154) (34,784) (31,386) 4,486,724 4,318,073 4,049,830
Profit/(Loss) for the segment 902,402 985,495 913,840 (12,587) (9,766) (8,765) 215,990 248,080 97,320 36,824 35,598 33,794 19,788 (9,632) 44,324 (5,764) (12,305) (1,316) 1,156,653 1,237,470 1,079,197
Unallocated expenses (162,529) (234,127) (139,789)
Operating profit 994,124 1,003,343 939,408
Finance result (257,244) (287,734) (233,589)
Share of profit/(loss) of equity
accounted investee 2,839 (10,434) (9,396) -- 2,112 (5,611) (10,975) (9,335) -- 3,039 1,830 -- (5,941) (4,060) 21,940 -- -- -- (11,038) (19,887) 6,933
Income tax expense
Profit for the year after tax
(131,436)
594,406
(34,408)
661,314
(168,209)
544,543
Segment assets 6,928,220 6,007,153 6,524,922 250,543 145,477 86,590 3,526,136 3,356,185 1,909,447 117,673 7,409 8,378 54,363 60,449 40,160 (29,281) (22,196) (11,964) 10,847,654 9,554,477 8,557,533
Equity accounted investments 99,547 83,905 104,996 -- -- 13,888 19,256 29,322 43,330 47,742 44,220 -- 60,360 61,562 39,131 -- -- -- 226,905 219,009 201,345
Unallocated assets -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1,402,487 1,146,778 1,370,894
Total assets 12,477,046 10,920,264 10,129,772
Segment liabilities 764,377 423,415 411,604 32,767 13,560 8,415 230,517 192,720 186,389 6,427 -- -- 34,698 26,903 1,843 -- -- -- 1,068,786 656,598 608,251
Unallocated liabilities -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 6,711,656 6,629,701 5,793,543
Total liabilities 7,780,442 7,286,299 6,401,794
Other information:
Amortisation and depreciation allocated 156,893 157,478 152,821 10,819 6,436 5,915 44,030 40,815 32,180 5,656 -- -- 1,941 2,237 3,445 -- -- -- 219,339 206,966 194,361
Amortisation and depreciation unallocated -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 9,270 8,524 7,508
Expenses that do not require cash payments
allocated
172,648 7,049 16,219 297 (514) 306 (27,651) (4,423) (2,001) 28 -- -- -- -- (32,534) -- -- -- 145,322 2,112 (18,010)
Expenses that do not require cash payments
unallocated
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1,339 (58,752) 4,608
Additions for the year of property, plant &
equipment and intangible assets allocated
220,531 227,635 197,741 15,354 10,429 9,193 58,064 70,032 89,760 2,050 198 84 883 20,911 13,313 -- -- -- 296,882 329,205 310,091
Additions for the year of property, plant &
equipment and intangible assets unallocated
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 19,795 11,268 12,011

* As a result of the creation of Bio Supplies segment and intersegments, the Group has reviewed the allocation of balances and transactions by segments. The comparative figure for year 2016 have been restated accordingly.

This appendix forms an integral part of note 6 to the consolidated annual accounts.

Reporting by geographical area

for the years ended 31 December 2018, 2017 and 2016

(Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Spain Rest of European Union USA + Canada Rest of World Consolidated
2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016 2018 2017 2016
Net Revenue 264,913 242,894 225,273 535,361 444,089 426,223 2,974,429 2,896,505 2,707,579 712,021 734,585 690,755 4,486,724 4,318,073 4,049,830
Assets by geographical area 898,599 899,223 847,467 3,177,781 2,397,200 2,467,295 8,133,108 7,341,174 6,535,420 267,558 282,667 279,590 12,477,046 10,920,264 10,129,772
Other information:
Additions for the year of property, plant &
equipment and intangible assets
70,639 62,271 73,365 69,534 80,910 39,603 166,353 188,557 190,358 10,151 8,735 18,776 316,677 340,473 322,102

This appendix forms an integral part of note 6 to the consolidated annual accounts.

Changes in Other Intangible Assets for the year ended 31 December 2018 (Expressed in thousands of Euros)

'(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Balances at
31/12/2017
Additions Business
combinations
Transfers Disposals Translation
differences
Balances at
31/12/2018
Development costs 311,694 55,439 -- -- (36) 10,215 377,312
Concessions, patents, licenses
brands & similar
182,885 -- 6,225 -- (757) 8,057 196,410
Computer software 174,945 20,252 34,319 (762) (1,116) 6,785 234,423
Currently marketed products 1,024,376 -- -- -- -- 47,451 1,071,827
Other intangible assets 147,307 48 19,749 -- -- 7,664 174,768
Total cost of intangible assets 1,841,207 75,739 60,293 (762) (1,909) 80,172 2,054,740
Accum. amort. of development costs (79,349) (10,660) -- -- -- (98) (90,107)
Accum. amort of concessions, patents,
licenses, brands & similar
(29,783) (6,132) -- -- -- (845) (36,760)
Accum. amort. of computer software (106,319) (12,918) (5,872) -- 1,116 (2,660) (126,653)
Accum. amort. of currently marketed products (231,068) (36,154) -- -- -- (11,573) (278,795)
Accum. amort. of other intangible assets (61,966) (5,536) -- 246 -- (3,297) (70,553)
Total accum. amort intangible assets (508,485) (71,400) (5,872) 246 1,116 (18,473) (602,868)
Impairment of other intangible assets (63,380) -- -- -- -- (2,955) (66,335)
Carrying amount of intangible assets 1,269,342 4,339 54,421 (516) (793) 58,744 1,385,537

(See note 3)

This appendix forms an integral part of note 8 to the consolidated annual accounts.

Changes in Other Intangible Assets for the year ended 31 December 2017 (Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Balances at
31/12/2016
Additions Business
combinations *
Transfers Disposals Translation
differences
Balances at
31/12/2017
Development costs 142,693 43,152 142,529 -- (81) (16,599) 311,694
Concessions, patents, licenses
brands & similar 60,471 -- 142,174 -- -- (19,760) 182,885
Computer software 168,623 19,626 26 529 (126) (13,733) 174,945
Currently marketed products 1,162,204 -- -- -- -- (137,828) 1,024,376
Other intangible assets 148,682 17,348 -- -- -- (18,723) 147,307
Total cost of intangible assets 1,682,673 80,126 284,729 529 (207) (206,643) 1,841,207
Accum. amort. of development costs (72,073) (5,834) -- -- -- (1,442) (79,349)
Accum. amort of concessions, patents,
licenses, brands & similar
(24,994) (6,004) -- -- -- 1,215 (29,783)
Accum. amort. of computer software (99,927) (13,549) -- -- 111 7,046 (106,319)
Accum. amort. of currently marketed products (220,988) (38,216) -- -- -- 28,136 (231,068)
Accum. amort. of other intangible assets (69,389) (865) -- -- -- 8,288 (61,966)
Total accum. amort intangible assets (487,371) (64,468) -- -- 111 43,243 (508,485)
Impairment of other intangible assets -- (64,734) -- -- -- 1,354 (63,380)
Carrying amount of intangible assets 1,195,302 (49,076) 284,729 529 (96) (162,046) 1,269,342

(See note 3)

This appendix forms an integral part of note 8 to the consolidated annual accounts.

APPENDIX IV

GRIFOLS, S.A. AND SUBSIDIARIES

31 December 2018 Movement in Property, Plant and Equipment for the year ended (Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of any discrepancy, the Spanish-language version prevails)

Balances at Translation Balances at
31/12/2017 Additions Business
combination
Transfers Disposals differences 31/12/2018
Cost:
Land and buildings 673,534 1,223 19,344 6,051 (280) 26,540 726,412
Plant and machinery 1,704,679 57,699 79,003 100,961 (15,855) 58,366 1,984,853
Fixed Assets under construction 262,119 182,016 1,746 (106,473) -- 5,983 345,391
2,640,332 240,938 100,093 539 (16,135) 90,889 3,056,656
Accumulated depreciation:
Buildings (66,765) (15,224) (4,682) -- 222 (2,929) (89,378)
Plant and machinery (810,782) (141,985) (46,995) (23) 13,025 (25,975) (1,012,735)
(877,547) (157,209) (51,677) (23) 13,247 (28,904) (1,102,113)
Impairment of other property, plant
and equipment
(2,732) 81 -- -- -- 91 (2,560)
Carrying amount 1,760,053 83,810 48,416 516 (2,888) 62,076 1,951,983

(See note 3)

This appendix forms an integral part of note 9 to the consolidated annual accounts.

APPENDIX IV

GRIFOLS, S.A. AND SUBSIDIARIES

31 December 2017 Movement in Property, Plant and Equipment for the year ended (Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of any discrepancy, the Spanish-language version prevails)

Balances at Translation Balances at
Business
31/12/2016 Additions combination Transfers Disposals differences 31/12/2017
Cost:
Land and buildings 687,856 28,503 19,628 12,694 (823) (74,324) 673,534
Plant and machinery 1,655,837 82,234 9,068 123,816 (10,098) (156,178) 1,704,679
Fixed Assets under construction 275,003 149,610 555 (137,073) -- (25,976) 262,119
2,618,696 260,347 29,251 (563) (10,921) (256,478) 2,640,332
Accumulated depreciation:
Buildings (59,376) (14,708) -- -- 710 6,609 (66,765)
Plant and machinery (746,268) (136,314) -- 34 7,993 63,773 (810,782)
(805,644) (151,022) -- 34 8,703 70,382 (877,547)
Impairment of other property, plant
and equipment
(3,200) 258 -- -- -- 210 (2,732)
Carrying amount 1,809,852 109,583 29,251 (529) (2,218) (185,886) 1,760,053

(See note 3)

This appendix forms an integral part of note 9 to the consolidated annual accounts.

APPENDIX V GRIFOLS, S.A. AND SUBSIDIARIES Statement of Liquidity for Distribution of Interim Dividend 2018 (Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of any discrepancy, the Spanish-language version prevails)

Thousands of Euros
Forecast profits distributable for 2018:
Projected profits net of taxes until 31/12/2018 258,091
Less, charge required to legal reserve --
Estimated profits distributable for 2018 258,091
Interim dividend distributed 136,747
Forecast cash for the period 26 October 2018 to 26 October 2019:
Cash balances at 26 October 2018 --
Projected amounts collected 572,263
Projected payments, including interim dividend 544,112
Projected cash balances at 26 October 2019 28,151

This appendix forms an integral part of note 15 to the consolidated annual accounts.

APPENDIX V GRIFOLS, S.A. AND SUBSIDIARIES Statement of Liquidity for Distribution of Interim Dividend 2017 (Expressed in thousands of Euros)

(Free translation from the original in Spanish. In the event of any discrepancy, the Spanish-language version prevails)

Thousands of Euros
Forecast profits distributable for 2017:
Projected profits net of taxes until 31/12/2017 273,472
Less, charge required to legal reserve --
Estimated profits distributable for 2017 273,472
Interim dividend distributed 122,986
Forecast cash for the period 15 December 2017 to 15 December 2018:
Cash balances at 15 December 2017 --
Projected amounts collected 475,209
Projected payments, including interim dividend 468,117
Projected cash balances at 15 December 2018 7,092

This appendix forms an integral part of note 15 to the consolidated annual accounts.

Consolidated Directors' Report

1.- THE GRIFOLS GROUP TODAY

Grifols is a global healthcare leader dedicated to enhancing the health and well-being of patients worldwide. Founded in 1940, the company develops plasma protein therapies (Bioscience Division), leading-edge diagnostic solutions (Diagnostic Division), specialty pharmaceuticals for hospital use (Hospital Division), and biological products for research purposes (Bio Supplies Division).

Grifols has roughly 21,000 employees in more than 30 subsidiaries, operations in over 100 countries and manufacturing plants in six.

For more information on "Grifols today" see "Non-Financial Information Statement".

GRIFOLS' CORE INITIATIVES IN 2018

Grifols' 2018-2022 strategic plan is grounded on six main pillars: development of "One Grifols", business optimization, innovation, digitalization, enhanced customer focus and talent development. In 2018, Grifols concentrated its efforts in the following areas in order to advance these corporate priorities:

- Sustainable growth and global expansion: A higher sales volume in the Bioscience Division was the primary driver of corporate growth. The Diagnostic Division consolidated its performance, while the Hospital Division laid important groundwork for future expansion.

The United States (U.S.) and main European countries remain key markets for the group. The company aims to reinforce its strategic presence in China. In this regard, Grifols initiated talks with Shanghai RAAS Blood Products to explore a possible corporate transaction and also reached an agreement with Boya-Pharmaceutical to open plasma centers in China. In addition, the Bioscience Division recently established operations in India.

- Leadership, expansion and diversification of plasma centers: As outlined in its strategic plan, Grifols made efforts to expand its network of plasma centers via both organic and corporate transactions to meet the growing demand of its plasma products. Grifols leads the market in plasma centers, managing 256 sites worldwide, including 35 in Europe.

In 2018, the company collected 12 million liters of plasma, approximately a 30% increase over the previous year.

- Innovation: Grifols remains firmly committed to fostering innovation. In 2018, the company allocated EUR 291.4 million toward R+D+i, a 9.4% increase compared to 2017. The company made further inroads to enhance integration among its diverse manufacturing, sales and R+D operations through the Grifols Innovation Office.

In October 2018, the company presented the top-line results of the AMBAR (Alzheimer Management by Albumin Replacement) clinical trial, which indicated a significant improvement in slowing down the disease's progression in patients with moderate AD. These findings mark an important step forward in the treatment of Alzheimer's, as well as a major breakthrough in Grifols' 15 years of AD research.

  • Teamwork and talent development: Notable progress was made on the training and management development plan for future corporate leaders. The plan has gradually broadened since 2017, following the generational succession.

Grifols' leadership focuses on collaboration, intrapreneurship, performance and accountability. The company promotes the concept of "One Grifols" to encourage transversal projects and knowledge sharing that contribute to greater innovation and business opportunities.

The company is firmly committed to the environment and contributing to social progress. Detailed information on its key areas of focus is available in "Non-Financial Information Statement".

Consolidated Directors' Report

Grifols' main achievements in 2018 are as follows (in EUR million except for workforce):

Value generated 4,501.2
Growth Net profit 596.6
Headcount increase 2,808
Diversity & Talent Talent pool 21,230
R+D+i investment 291.4
Innovation Investment in manufacturing installations 252.2
Resources allocated to environmental issues 18.2
Sustainability Community investments 33.3
Fiscal contributions 624.3
Contributions Employee salaries 849.5
Dividends 242.6

2.- GRIFOLS' PROGRESS AND PERFORMANCE

Estimates for the global hemoderivatives indicate it is worth more than EUR 20,600 million1 for 2017. Grifols remains an industry forerunner, with an estimated market share of more than 18%2 . The group's main products lead global sales in the hemoderivatives market:

Global market Global market
share position
Imnmunoglobulin 23% 1
Alfa-1 antitrypsin 67% 1
Albumin 18% 2
Factor VIII 20% 1

Grifols continues to expand its in-vitro diagnostics sector through the Diagnostics Division. The company is an international player in blood and plasma analysis systems (transfusional diagnostics), a market estimated at USD 4,000 million2 . The company leads the segment in nucleic acid technology (NAT) processing systems, with a 55%2 global market share. Grifols is also a global reference in the manufacture of antigens for immunoassays and in the blood typing and immunohematology segment.

The Hospital Division leads the Spanish market as an IV solutions provider. The division recently continues to offer a broad portfolio of hospital pharmacy solutions in Spain and Latin America, while expanding its business in the U.S.

1 Source: Marketing Research Bureau (MRB) and internal information, 2017.

2 Source: Internal information.

Consolidated Directors' Report

REVENUE PERFORMANCE

Grifols reported EUR 4,486.7 million in revenues at the close of 2018, growing by 9.2%3 cc (3.9% taking into account exchange rate variations). The company reported growth in all of its divisions and geographic regions where it operates.

Bioscience drives corporate growth: EUR 3,517 million in revenues and 8.0% cc growth

The division grew by 8.0% cc in 2018 (2.5% taking exchange rate fluctuations into account), to EUR 3,516.7 million. Robust sales of the main plasma proteins – immunoglobulin, albumin and alpha-1 antitrypsin – were the main drivers of revenue growth throughout the year. Of note are higher sales and price points of immunoglobulin in some markets. Sales growth of these plasma proteins, together with certain specialty immunoglobulins, offset the decline in sales of factor VIII. The renewal processes of certain licenses in China suffered delays in the last quarter of 2018, impacting sales.

The demand for immunoglobulin remains strong in Grifols' core markets, especially in the U.S. and main EU countries led by Spain, Germany and the United Kingdom. Sales also grew in Turkey, Brazil and Australia, where, in addition to primary immunodeficiencies, immunoglobulins are also used to treat secondary immunodeficiencies and neurological diseases like chronic inflammatory demyelinating polyneuropathy (CIPD), a market segment that Grifols leads.

Grifols achieved double-digit growth in immunoglobulin sales in 2018 and plans on launching a 20% subcutaneous immunoglobulin in the second half of 2019 that will expand its immunoglobulin franchise.

Albumin sales grew markedly in the U.S. and in several European countries including Italy, the United Kingdom and Turkey. China is a market with significant underlying demand and remains a core focus in Grifols' global sales strategy.

Grifols continues to lead in alpha-1 antitrypsin sales. Market penetration of this plasma protein grew in the U.S. and main EU markets thanks to effective sales strategies and an increase in the number of diagnosed patients.

Also of note is Grifols' FDA-approved genetic test for alpha-1 deficiency and Prolastin®-C Liquid, recently introduced in the U.S. This liquid formulation enhances Grifols' respiratory franchise and offers a new treatment alternative for patients.

Sales of factor VIII dropped notably in 2018 due to their declining use to treat patients with inhibitors. The company positions factor VIII as the best treatment for Hemophilia A patients, concentrating its efforts in the U.S. and emerging markets.

Grifols continues to promote its specialty proteins to enhance its differential product portfolio. Two new formulations helped boost sales in the specialty hyperimmunoglobulins segment: an anti-rabies immunoglobulin (HyperRAB®), with a twice the potency (300 IU/mL) of currently available rabies immune globulin options; and GamaSTAN®, an intramuscular immunoglobulin for patients exposed to hepatitis A or measles. Both products earned FDA approval in the first half of 2018.

Diagnostic remains stable: 0.7% growth cc leads to EUR 702 million in revenues

The Diagnostic Division reported EUR 702.3 million in revenues, a 0.7% cc year-on-year increase and -4.1% considering exchange rate variations. Grifols is the worldwide leader in transfusional diagnostics, the division's main engine for growth in 2018. This business area includes NAT donor-screening diagnostics (Procleix® NAT Solutions), blood-typing solutions and the production of antigens for immunoassays.

Higher NAT solutions sales were driven mainly by a greater volume of plasma donations and increasing use of the Zika-virus screening test (Procleix® Zika Virus). The company also broadened its product portfolio with

3 Operative or constant currency (cc) excludes exchange rate variations of the year.

Consolidated Directors' Report

newly FDA-approved reagents to detect HIV, hepatitis B and C virus (Procleix® Ultrio Elite), and the West Nile virus (Procleix® WNV), among others.

In addition to the U.S., sales of this leading-edge technology were also strong in Latin America, Poland and Indonesia. The company continues its efforts to raise its presence in the Middle East.

The blood-typing line notably contributed to the division's overall performance, particularly in the U.S., core markets in Latin America, Europe and Saudi Arabia.

European sales of Erytra Eflexis® gained traction, with more than 200 units sold since its launch in June 2017. Grifols already introduced the product in the U.S. in 2019 after earning FDA approval. Also of note in 2018 was the release of a new line of conventional antiserums, which broadened the product portfolio after earning FDA approval.

The company further consolidated its line of antigens to produce immunoassays in 2018.

Revenues in specialty diagnostics remained stable and are expected to rise as Grifols widens its clinical diagnostics offerings. In 2018, the FDA approved two diagnostic products designed to detect autoimmune diseases. Both were developed by AESKU and distributed by Grifols on the Helios platform.

The company is committed to developing new diagnostic tests for personalized medicine through Progenika Biopharma. Its molecular diagnostic ID CORE XT for genotyping blood groups recently earned FDA approval.

Hospital grows 16% cc to EUR 120 million in revenues, fueled by strong U.S. sales

The Hospital Division earned EUR 119.5 million in revenues in 2018, growing 16% cc and 13.1% taking into account exchange rate variations.

Sales of all business lines grew, especially its Pharmatech line in the U.S. market. A key strategic area for future growth, this business line offers integral services to hospital pharmacies for IV compounding, including MedKeeper and Kiro Oncology products.

The division also reported stronger IV solutions sales, especially the physiological saline solution manufactured in the Murcia (Spain) plant. The product was introduced in the U.S. market after obtaining FDA approval and is also used in Grifols' own network of plasma centers. These milestones allowed the division to bolster its presence in the United States and support the group's global expansion strategy.

Sales of the Nutrition and Medical Devices lines also increased, accompanied by an increase in third-party manufacturing services.

Bio Supplies Division: Kedrion manufacturing agreement and third-party plasma sales drive growth

This division oversees three main areas: sales of biological products for non-therapeutic uses, Kedrion production agreements, and third-party plasma sales channeled through Haema and Biotest, which represent EUR 80.3 million. Bio Supplies earned EUR 167.0 million in revenues in 2018, a substantial increase from the EUR 66.8 million reported in 2017.

Consolidated Directors' Report

Revenues by division:

In thousands of euros 12M 2018 % of Net
Revenues
12M 2017 % of Net
Revenues
% Var % Var cc*
BIOSCIENCE 3,516,704 78.4% 3,429,785 79.4% 2.5% 8.0%
DIAGNOSTIC 702,265 15.6% 732,369 17.0% (4.1%) 0.7%
HOSPITAL 119,454 2.7% 105,649 2.4% 13.1% 16.0%
BIO SUPPLIES 167,004 3.7% 66,791 1.6% 150.0% 154.9%
OTHERS 22,451 0.5% 18,263 0.4% 22.9% 29.6%
INTERSEGMENTS (41,154) (0.9%) (34,784) (0.8%) 18.3% 24.8%
TOTAL 4,486,724 100.0% 4,318,073 100.0% 3.9% 9.2%

* Constant currency (cc) excludes the impact of exchange rate movements

Revenues by region:

In thousands of euros 12M 2018 % of Net
Revenues
12M 2017 % of Net
Revenues
% Var % Var cc*
US + CANADA 2,974,429 66.3% 2,896,505 67.1% 2.7% 8.7%
EU 800,274 17.8% 686,983 15.9% 16.5% 16.7%
ROW 712,021 15.9% 734,585 17.0% (3.1%) 4.0%
TOTAL 4,486,724 100.0% 4,318,073 100.0% 3.9% 9.2%

* Constant currency (cc) excludes the impact of exchange rate movements

Underlying EBITDA4 ascends to EUR 1,218 million

Underlying EBITDA4 rose to EUR 1,218.4 million, representing a 27.7% margin. Gross margin continues impacted by higher plasma procurement costs related to the company's efforts, both organic and inorganic, to increase its plasma supply and meet the solid demand of its plasma-derived therapies.

Grifols operates the largest plasma collection network in the world, with 256 centers. This network includes the acquisition of six Kedplasma centers; 24 Biotest US centers in the U.S.; 35 Haema centers in Germany; and a newly inaugurated center, also in Germany, as part of its joint venture with Plasmavita Healthcare.

The last quarter of the year saw a significantly higher demand for immunoglobulin, especially in the United States, where Grifols works on the launch of 20% subcutaneous immunoglobulin. This upturn has affected the utilization of liters of plasma. Gross margin was also affected by temporary albumin sales restriction in China; by the geographic mix of factor VIII sales, tender volatility; and the product mix of the Diagnostic Division, which reported stronger demand for antigens used to produce immunoassays and transfusion-medicine diagnostic instruments.

In terms of operating expenses, Grifols decided to increase its R+D+i investment in certain projects, specifically those related to albumin, in light of the positive results of the AMBAR trial and trials on liver diseases (PRECIOSA and APACHE studies). Corporate operations, including Haema and Biotest acquisitions, as well as the negotiations with Shanghai RAAS, caused related operating expenses to rise.

Net profits reach EUR 597 million

Grifols' annual financial results totaled EUR 257.2 million. This figure includes an influx of EUR 32.0 million following the expected divestment in Tigenix executed in the second quarter of 2018. The effective tax rate was 18.1%. The decline from previous years owes mainly to the U.S. tax reform approved in December 2017.

4 Underlying EBITDA excludes the impact derived from Haema and Biotest third-party sales.

Consolidated Directors' Report

Excluding non-recurrent expenses5 recognized at the end of 2017, Grifols' net profit increased by 1.5% to EUR 596.6 million, compared to EUR 587.9 million in 2017. Net profits represent 13.3% of revenues.

BALANCE SHEET

Grifols' solid performance and positive cash flow trend helped reinforce the balance sheet. Consolidated assets as of December 2018 totaled EUR 12,477.0 million (EUR 10,920.3 million in 2017). This upturn was fueled primarily by the Bioscience Division, which grew both organically and via corporate transactions, and capital investments carried out.

Optimized management of working capital

Optimizing working capital remained a priority to strengthen the company's financial position.

Inventory levels increased to EUR 1,949.4 million, with a turnover of 292 days compared to 275 days in December 2017 after the implementation of several initiatives to better anticipate and meet the solid demand for plasma-derived products.

The average collection period improved to 22 days (24 days in 2017), reflecting the success of these measures. The average payment period is 65 days, a slight increase from the 53-day period in 2017.

With regard to the group's Spanish subsidiaries, the average payment period to suppliers was 72.6 days, reflecting a similar trend as last year's average of 72.9 days.

Strong cash flow position

Grifols' cash position was EUR 1,033.8 million (EUR 886.5 million in 2017) on December 31, 2018. The company maintained a high and sustainable operational cash-flow generation in view of the current context of growth and investment increases. The EUR 737.4 million cash flow from operating activities allows the firm to effectively assume its planned investments.

In 2018, Grifols allocated EUR 252.2 million (EUR 271.1 in 2017) toward CAPEX and EUR 291.4 million (EUR 266.3 million in 2017) of net investments toward R+D+i. The company remains firmly committed to future growth and its long-term strategic vision.

At the close of 2018, Grifols agreed to sell Haema AG and Biotest US Corporation to Scranton Enterprises, B.V. for USD 538 million to monetize earlier these investments and reinforce its financial structure. Grifols maintains operational control of the plasma centers and holds an exclusive and irrevocable call option for both companies.

Equity

The company's equity was EUR 4,696.6 million as of December 31, 2018.

The share capital includes 426,129,798 common shares (Class A), with a nominal value of EUR 0.25 per share, and 261,425,110 non-voting shares (Class B), with a nominal value of EUR 0.05 per share

Grifols' ordinary shares (Class A) are listed on the Spanish Stock Market and form part of the Ibex-35, while its non-voting shares (Class B) are traded on both the Spanish Stock Exchange (GRF.P) and the U.S. NASDAQ exchange (GRFS) via ADRs (American Depositary Receipts).

Two dividend payments totaling EUR 278.8 million were distributed in 2018. A second dividend, charged against 2017 earnings, was paid out as a final dividend in the second quarter and an interim dividend was paid in December 2018. Grifols remains committed to compensating its shareholders with dividend payouts.

5 It relates to the Hologic acquisition; the Aradigm assets reassessment; and the U.S. tax reform.

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LIQUIDITY AND CAPITAL RESOURCES

The group's main liquidity and capital resources requirements aim to cover operating costs, capital expenditures, including the maintenance and construction of manufacturing facilities; direct and indirect R+D+i investments; and debt service.

Historically, the company has met its liquidity and capital requirements using resources generated from its operating activities and long-term external financing. As of December 2018, Grifols' cash position was EUR 1,033.8 million and its liquidity position was roughly EUR 1,400 million.

Cash flows from operating activities

Cash flows from operating activities remained robust in 2018, reaching EUR 737.4 million as a result of the following initiatives:

  • Positive impact of EUR 33.3 million thanks to improvements in accounts receivable. The average collection period dropped to 22 days, compared to 24 days in 2017.
  • Improved payment management led to a positive impact of EUR 117.1 million.
  • Increased inventory levels had a positive impact of EUR 231.7 million due to higher volumes of plasma collected to meet the rising demand of the main plasma proteins. Grifols' inventory management aims to anticipate the growing demand reflected in growth forecasts.

Cash flows from investment activities

Cash flows from investment activities reached EUR 781.9 million derived mainly from actions to optimize and monetize earlier specific investments made during the fiscal year:

  • Acquisition of 100% share capital of Haema, the largest independent network of plasma centers, for EUR 220 million. The transaction included the Haema business; 35 centers and three under construction; a 24,000-square-meter building that houses Haema's corporate headquarters in Leipzig (Germany); and a central laboratory in Berlin (Germany).
  • Acquisition of 24 plasma centers in the U.S. from Biotest for USD 286 million, in addition to two centers under construction and other assets.
  • Capital expenditures totaling EUR 252.2 million, allocated largely to opening new plasma centers; expanding, renovating and relocating existing centers; expanding manufacturing facilities; and opening new corporate headquarters.

Cash flow for financing activities

Cash flows for financing activities totaled EUR 152.5 million in 2018. This comprises dividend payouts of EUR 278.8 million and the subsequent sale of Haema and Biotest on the same terms and conditions as their acquisition. Grifols maintains operating control of the plasma centers and holds an exclusive and irrevocable call option for both companies.

Capital resources and credit ratings

Grifols' net financial debt was EUR 5,343.1 million, including EUR 1,033.8 million (EUR 886.5 million in 2017) in cash. The company has nearly EUR 400 million in undrawn lines of credit, which increase its liquidity position to nearly EUR 1,400 million.

The group's net financial debt over EBITDA ratio was 4.32x as of December 2018. This figure drops to 4.19x excluding the impact of exchange rate variations.

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Leverage management remains among the company's top priorities. To this end, Grifols maintains high, sustainable levels of operational activities and strong cash flow generation. The EUR 737.4 million cash flow from operating activities allows the firm to effectively assume its planned investments in view of the current context of growth and investment increases.

In 2018, Grifols signed a new loan for EUR 85 million with the European Investment Bank (EIB) to support its R+D+i investments. The financial terms included a fixed interest rate, maturity in 2028 and a two-year grace period. This is Grifols' third agreement with BEI within the framework of the Investment Plan for Europe.

The credit ratings issued by Standard and Poor's and Moody's remained unchanged in 2018.

3.- INVESTMENT ACTIVITIES: R+D+i, CAPEX AND ACQUISITIONS

RESEARCH, DEVELOPMENT AND INNOVATION

Strategic focus

Grifols advocates an integrated R+D+i strategy that comprises both in-house initiatives and external projects in investee companies whose research complements its core business. This dual approach and long-term vision earned Grifols the distinction as one of the top 1,000 global firms that dedicate the most resources to R+D in "2018 Global Innovation 1000" by Strategy&, the consulting arm of PwC.

The company's integrated R+D+i strategy is managed through the Grifols Innovation Office, which evaluates and expedites research projects, and promotes the on-going development and marketing of innovative treatments, products and services. It also aims to promote the continuous improvement of existing products and activities, and foster collaboration in the company's innovation ecosystem, including academic and research institutions.

Grifols intensified its net R+D+i investments in 2018 by 9.4% to EUR 291.4 million, taking into account net investments for both internal and external research initiatives. This investment represents 6.5% of 2018 revenues.

Preliminary results on the effectiveness of AMBAR

Grifols presented the top-line results of the phase IIb/IIII of its AMBAR (Alzheimer Management By Albumin Replacement) clinical trial in October 2018 at the Clinical Trials on Alzheimer's Disease Congress.

AMBAR is an international, multicenter and double-blind clinical trial designed to evaluate the efficacy and safety of plasma exchange – a procedure combining periodic extractions of plasma through plasmapheresis and its replacement with albumin – to slow down the progression of Alzheimer's disease (AD) in patients in mild to moderate stages.

The trial results demonstrated a statistically significant 61% slowdown in the disease's progression among patients with moderate AD and fulfillment of its primary endpoints: improvement in cognitive function (measured on the ADAS Cog scale) and ability to carry out daily activities (measured on the ADCS-ADL scale).

These results mark an important milestone in Alzheimer's research and inspire the company to continue its research on the benefits of plasma exchange with Grifols albumin toward slowing down the progression of AD.

Ebola Project: a non-profit initiative to produce anti-Ebola immunoglobins

In 2014, Grifols launched a non-profit initiative to produce anti-Ebola immunoglobulin to treat afflicted populations in West African countries. The project's research forms part of a long-term clinical trial to evaluate

Consolidated Directors' Report

whether plasma from healthy Ebola survivors can boost the immune response in afflicted patients and help them overcome the disease.

Grifols fully financed the project, which included the collaboration of the Liberian government, the FDA, World Health Organization (WHO) and various NGOs. The initiative centered on three main efforts: the construction of a modular convalescent-plasma center in Liberia similar to other Grifols plasma centers; the construction of an isolated plant to fractionate and purify anti-Ebola immunoglobulin at the Clayton complex, authorized by the FDA under its "import for export" provision; and specific training in Grifols Academies to equip staff with the necessary tools to help in the plasma-collection process and offer support to local communities.

Grifols began processing the first batch of plasma from Ebola survivors at the end of 2018 and anticipates delivering the first anti-Ebola immunoglobulins to the Republic of Liberia in the first quarter of 2019.

Main research lines

Immunoglobulins

Grifols successfully completed the clinical research phase of a new 20% subcutaneous immunoglobulin to treat patients with primary immunodeficiencies. The product has been submitted to the FDA for marketing authorization.

The company also developed a new predictive model for population pharmacokinetics (PopPK) to administer subcutaneous immunoglobulin in patients with primary immunodeficiencies, which would inform the proper dosing of this plasma-derived product and guide its treatment usage.

Grifols continues its research on Gamunex® as maintenance therapy for myasthenia gravis (MG), a chronic autoimmune neuromuscular disease. The company plans to submit the application for EMA marketing authorization in 2019.

Albumin

Research continues on the phase III PRECIOSA study on the potential benefits of albumin to treat liver cirrhosis, as well as the phase III APACHE trial on its use to treat acute-on-chronic liver failure (ACLF). Additionally, the product's new flexible packaging format is presently in the registration stage.

Diagnostic

Grifols' blood test to detect the babesiosis parasite (Procleix® Babesia) was submitted for FDA approval, expected in the first quarter of 2019. The product is currently available as an IND (Investigational New Drug). Clinical trials also continue in China on the Procleix® Ultrio Elite line.

The FDA approved Erytra Eflexis®, a new medium-sized and totally automated analyzer. The company continues to expand its portfolio of recombinant proteins.

Intravenous solutions

Grifols presented two new products for FDA approval: a physiological saline solution in a needle-free Fleboflex® container, which, in addition to enhancing the product portfolio, can be utilized in Kiro-Grifols robotics; and an anti-coagulant in a bag format that will be used in Grifols' plasma centers and expand the third-party product portfolio.

Patents and trademarks

Grifols protects the intellectual property of its main products through ownership, co-proprietorship and patent licenses. An international department manages the company's patents and trademarks, supervises their maintenance and monitors any possible breaches.

Consolidated Directors' Report

The following tables summarize the total number of patents, applications, and patents in the final approval process, as well as a geographic overview of patents and trademarks completed in 2018.

2018
Total number of patents and applications 2,965
Patents in the final authorization phase 600
Patents Trademarks
USA 258 162
Europe 1,615 1,029
RoW 1,092 1,997
Total 2,965 3,188

CAPEX AND MANUFACTURING OPERATIONS

Grifols invested EUR 252.2 million in 2018 as part of its continuous efforts to expand and enhance its manufacturing facilities. This figure is stipulated in the 2016-2020 Capital Investment Plan, endowed with EUR 1,200 million to ensure the company's long-term sustainable growth. The main investments include:

Investment to increase access to plasma

As of December 2018, Grifols operated the largest plasma network in the world, with 256 centers. Thanks to its capital investments, the company increased its average number of daily donations to 39,000 and total volume of plasma obtained for fractionation to nearly 12 million liters. This volume is a 30% increase compared to 2017.

Bioscience Division: greater capacity to fractionate and purify plasma proteins

Construction on a new plasma fractionation plant at Grifols' North Carolina (USA) complex continues according to plan. The facility will have a fractionation capacity of 6 million liters per year, double its current volume. Construction is also underway on a new purification, dosing and sterile filling plant of immunoglobulin in flexible containers. The facility will have an annual capacity of 6 million equivalent liters of plasma per year.

The industrial complex in Los Angeles (California, USA) obtained FDA approval for a second immunoglobulin (Gamunex®) purification, dosing and sterile filling line. This addition will enable the facility to double its annual production capacity to 5.1 million equivalent liters of plasma per year. Also worth noting is the sterile filling plant of albumin in flexible containers, whose validation process finalized in 2018. The plant has an annual production capacity of 1.5 million equivalent liters of plasma per year.

The construction of a new albumin purification, dosing and sterile filling plant in Dublin (Ireland) continues as planned. The plant will have an annual production capacity of 6 million equivalent liters of plasma per year and incorporate state-of-the-art filling technology to boost productivity.

The Barcelona industrial complex completed the validation process of the alpha-1 antitrypsin purification, dosing and sterile filling plant. The site is equipped with Grifols' next-generation filling technology and has an annual production capacity of 4.3 million equivalent liters of plasma per year.

This complex is also moving forward on the construction of a manufacturing plant to produce fibrin sealant and topical thrombin. The facility will have a production capacity of 1.7 million units per year.

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Diagnostic Division: Emeryville plant earns FDA approval

The Emeryville (California, USA) plant received FDA approval for its new installations to manufacture recombinant proteins and a recombinant antigen for hepatitis C. The company plans to submit additional FDA applications in 2019 to relocate the production of 21 antigens to its new facilities.

The validation process of the San Diego (California, USA) installation is underway, following renovations to consolidate production of the NAT product line.

The Brazil plant, dedicated to the manufacture of collection, separation, storage and transfusion bags for blood components, is nearing the end of the validation stage. The installation currently has a production capacity of 2 million units per year, scalable to 4 million units.

Hospital Division: production increase of IV solutions

The division's capital investments were dedicated to expanding the capacity and productivity of its intravenous lines at its Barcelona and Murcia (Spain) complexes in order to meet the expected growth of this segment.

ACQUISITIONS AND CORPORATE TRANSACTIONS

Haema and Biotest

Grifols strengthened its leadership position in global plasma supply following the 100% acquisitions of Haema AG, headquartered in Germany, and Biotest US Corporation.

The Haema acquisition has enabled Grifols to operate its first plasma centers outside the U.S. The transaction included 35 centers and three under construction; a 24,000-square-meter building in Leipzig which houses Haema's corporate headquarters; and a central laboratory located in Berlin.

For its part, the Biotest US Corporation acquisition included 24 U.S.-based plasma centers and two under construction, as well as diverse assets.

Subsequent to these acquisitions, Grifols sold both companies under the same terms and conditions to strengthen its financial structure. The company holds an exclusive and irrevocable call option to be executed at any time for both Haema and Biotest, and maintains operating control of their plasma centers.

Boya Bio-Pharmaceutical

In 2018, Grifols signed an agreement with Boya Bio-Pharmaceutical, a producer of plasma-derived medicines in China, to build and manage plasma centers in the country. The plasma obtained from these centers will be used for Boya Bio-Pharmaceutical, although Grifols will be able to access up to 50% of the total collected when the applicable Chinese legislation allows.

Kedrion plasma centers

Grifols acquired six plasma centers from Kedplasma in 2018.

MedKeeper

In line with the Hospital Division's strategic growth plan, Grifols acquired a 51% stake in MedKeeper, a U.S. technology firm that develops and markets mobile and web-based software applications to optimize the efficiency and safety of hospital pharmacies. The agreement includes a call option to acquire the remaining 49% interest within a three-year timeframe.

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6.- NON-FINANCIAL INFORMATION STATEMENT

Grifols' mission is to ethically and responsibly provide life-saving treatments and essential, leading-edge diagnostic and hospital solutions for patients and healthcare professionals around the world. It aspires to continually advance its current commitments while staying true to its corporate values:

Corporate values Commitments
Safety Safety and quality throughout the value chain
Effort Economic performance
Commitment Social outreach
Teamwork Employment
Innovation and improvement R+D+i
Pride Ethical approach, transparency and legal compliance
Excellence Environemntal management

Grifols' Corporate Responsibility Policy is guided by its corporate values, which underpin its identity, operational principles and commitment to stakeholders.

The objectives and norms in the Corporate Responsibility Policy are inspired by an ethos of integrity and transparency; legal compliance and prevention of unlawful actions; staunch commitment to the environment; safety and health; and a commitment to society as a whole.

Grifols has carried out a materiality analysis to identify the most significant economic, environmental and social impacts of Grifols' value chain as defined by its business model. This analysis is updated on an annual basis.

As a result of this report, Grifols has identified 18 of the most noteworthy material issues that stem from its corporate commitments. Detailed information is available in "Basis for the preparation of the Non-Financial Information Statement".

GEOGRAPHIC SCOPE

  • Grifols' global reach includes operations in more than 100 countries.
  • The company has 30 subsidiaries and 6 production plants.
  • Global headquarters in Barcelona (Spain).

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GRIFOLS' BUSINESS MODEL

Grifols promotes a vertically integrated business model in its divisions to maximize involvement and control of the various phases of its value chain.

Bioscience Division

Grifols exercises complete control of the division's value chain, controlling all strategic activities and processes, from plasma collection to the finished product. Plasma proteins are specialty medicines that require long, complex and extensive production processes to guarantee their quality and safety. Complete control of the value chain ensures product quality and safety, as well as complete traceability.

The demand for plasma proteins has increased as a result of improved healthcare coverage, longer life expectancies, new indications, and enhanced diagnostics for certain rare diseases treated with plasma proteins.

Within this context, Grifols' lines of action in 2018 aimed to generate growth opportunities and bolster the projection of this division, centering its efforts in the following areas:

  • Increasing and diversifying its plasma supply. Grifols is the worldwide leader in plasma centers. As of December 31, 2018, Grifols operated a global network of 256 centers that allow the company to guarantee and diversify its access to its main raw material in order to increase production of its plasmaderived medicines.
  • Expansion of its manufacturing facilities. Capital investments to boost production of the main plasma proteins continue according to the 2016-2020 Capital Investments Plan.
  • Development of new formulations and indications to better address the needs of patients and healthcare professionals. The division earned several approvals in 2018:
  • FDA approval for a new alpha-1 antitrypsin liquid formulation (Prolastin®-C Liquid)
  • FDA approval for a new intramuscular immunoglobulin formulation (GamaSTAN®) for immediate protection against hepatitis A and measles
  • FDA approval for a new anti-rabies immunoglobulin formulation (HyperRAB®) to treat patients exposed to the rabies virus
  • Development of clinical trials associated with new plasma protein indications. Among them, the topline efficacy results from the AMBAR clinical trial to treat Alzheimer's disease (AD) through plasma exchange and its replacement with Grifols' albumin. Results demonstrated a significant slowdown in patients with moderate AD and encourage the company to conduct further AD research.
  • Improve the diagnosis of diseases associated with diverse plasma proteins:
  • Alpha-1 antitrypsin deficiency. A rare genetic disorder caused by low levels of alpha-1 antitrypsin protein. Grifols strives to improve its diagnosis rate by developing clinical diagnostics and spearheading patient-outreach initiatives.
  • Chronic inflammatory demyelinating polyneuropathy (CIPD). A neurological disorder characterized by progressive weakness and impaired sensory function. The company promotes the use of immunoglobulin in this field of neurology.
  • Immunodeficiencies. Grifols promotes diagnostic programs around the world to identify patients with immunodeficiencies.
  • Market inroads in several countries in the Middle East, Asia Pacific and Latin America. In 2018, Grifols began operations India and explored further market opportunities in China. To this end, the company entered talks with Shanghai RAAS Blood Product for a potential corporate transaction. It also reached an agreement with Boya Bio-Pharmaceutical to open plasma centers in China.

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Diagnostic Division

Grifols controls all of the strategic operations and processes that make up the Diagnostic Division's value chain, including the development, production and marketing of its products. The division's business model reinforces its value chain through a diversification strategy based on distributing and marketing third-party products complementary to its product portfolio.

In 2018, the company focused its efforts on the following areas to bolster the division's growth opportunities and market expansion:

  • Ongoing innovation to expand the product portfolio resulted in 6 FDA approvals, including a test used to detect RNA specific for the Zika virus (Procleix® Zika Virus); a test to detect HIV and hepatitis B and C (Procleix® Ultrio Elite); and a West Nile virus detection test (Procleix® WNV). In the blood-typing line, of note is the FDA approval for the conventional antiserums line and the diagnostic ID CORE XT, used to genotype blood groups.
  • Internationalization and expansion in strategic markets: the U.S. remains the division's most important market for its line blood-typing solutions and NAT donor-screening systems. Grifols has also become an important supplier of NAT technology in the Middle East. Other strategic growth regions include China and the Asia Pacific.
  • Potential to lead transfusional diagnostics in the future: Given its strength in the three technologies, Grifols is the only company with the potential to lead the transfusional diagnostics sector, a position that would offer differential value and enhance its image as an industry beacon. The genomic amplification possible with NAT technology is a global reference. The company promotes the on-going development of the ultrasensitive technology SMC™ (Simple Molecular Counting) through its investee company Singulex.

Hospital Division

The company also controls the strategic operations of the Hospital Division's value chain, including the development, production and marketing of its product and services.

International expansion, particularly its marketing positioning in the U.S. market, forms the basis of the division's growth strategy. The most noteworthy initiatives to growth-generation opportunities include:

  • Agreement with Henry Schein for the U.S. distribution of the physiological saline solution produced in Grifols' Murcia (Spain) plant. This product is also used in Grifols' network of plasma centers in the U.S. This milestone reinforces the company's vertical integration and ensures the product's quality and supply.
  • Acquisition of MedKeeper to enhance the Pharmatech line (which includes systems to automate hospital pharmacy services), expanding Grifols' portfolio.
  • Leverage of legislative changes that affect U.S. hospital pharmacy operations and control of compounding preparations. These changes could represent a unique market opportunity for Grifols as a supplier of a broad range of innovative hospital pharmacy operations.

CORPORATE GOVERNANCE

For a global company like Grifols, a reliable and robust corporate governance structure is vital to creating long-term value. Integrity, honesty, transparency and compliance with the highest ethical standards are the core values that guide Grifols' corporate culture and governance.

Grifols S.A., as incorporated in Spain and listed on the Spanish stock market, complies with the Spanish Companies Act and other relevant Spanish regulations. Furthermore, as a foreign private issuer of securities listed in the United States, Grifols complies with the requirements established by the U.S. Securities and

Consolidated Directors' Report

Exchange Commission, the NASDAQ Corporate Governance Rules, and the U.S. Sarbanes-Oxley law of 2002.

For Grifols, mere legal compliance is not enough. The company has built a corporate governance based on integrity, honesty and transparency, which, in practical terms, translate into the following corporate policies:

Corporate Responsability Corporate Responsibility guidelines: integrity and transparency,
compliance with regulations and
prevention of unlawful conducts, commitment with the environment,
security and health, social commitment
Communication with Financial Markets General principles: transparency, veracity, equality, symmetry in
information disclosure, compliance with applicable legislation
Internal code of conduct for matters
relating to stock markets
Determines conduct and action criteria, must be followed by the affected
person, covers the handling, use and disclosure of confidential insider
and Relevant Information
Tax compliance and best practices Corporate tax policy principles: responsible taxation, prudence,
collaboration with competent tax authorities, no presence in tax havens,
compliance with the strictest legal framework applicable in each
legislation, aligned with OECD and EU principles
Risk control and Management Policy Established on: a zero-tolerance risk framework, leadership of senior
management to allocate the necessary resources, integration of
strategic and planning management processes, segregation of duties,
holistic and harmonized management approach, continuous
improvements through periodic reviews
Director's remuneration policy The Directors' Remuneration Report was approved by the Ordinary
General Shareholders Meeting held on May 26, 2017 and will be valid for
the next three years unless amended by the Grifols General
Shareholders Meeting.

General Shareholders' Meeting6

The General Shareholders' Meeting serves as Grifols' governing body and represents all shareholders on matters within its competence. Grifols welcomes all shareholders, with no minimum number of shares required to attend.

Board of Directors7

The Board of Directors is Grifols' highest decision-making body, with the exception of matters that fall under the competence of the General Shareholders' Meeting. Grifols Board of Directors is responsible for approving the company's corporate strategy and execution. To this end, it guides and controls the actions of Grifols management to ensure it achieves established objectives and satisfies stakeholder expectations.

The company has an Audit Committee and Appointments and Remuneration Committee that both include a secretary and three members appointed based on their knowledge, skills and experience in committee matters. All committee members are non-executive directors and at least two must be independent directors. Committee presidents are independent directors.

6 Information on the powers granted to the Grifols General Shareholders' Meeting and other issues regarding the last meeting and published on www.grifols.com

7 Detailed information on the responsibilities of Grifols Board of Directors and Board Committees are available on www.grifols.com

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Beyond legal requirements, and in alignment with best practices in corporate governance, Grifols' Board of Directors has a lead independent director who coordinates the independent directors and safeguards ensures independence between the company's governance and management functions.

Board of Directors' profile:

  • A well-balanced and diverse board in terms of gender, age and experience
  • More than 50% of board members are independent
  • 31% of board members are women, exceeding Spain's Comisión Nacional del Mercado de Valores recommendation, which aims to increase female participation on executive boards by 2020
Name Board of Directors
Víctor Grífols Roura Non-executive Chairman / Proprietary
Raimon Grífols Roura Co-CEO / Executive
Víctor Grífols Deu Co-CEO / Executive
Ramón Riera Roca Director/ Other external
Tomás Dagá Gelabert Director and Vice Secretary/ Other external
Thomas Glanzmann Non-Executive Vice Chairman/ Other external
Anna Veiga Lluch Director/ Independent
Steven F. Mayer Director/ Independent
Luis Isasi Fernández de Bobadilla Director/ Independent
Belén Villalonga Morenés Director/ Independent
Marla E. Salmon Director/ Independent
Iñigo Sánchez- Asiaín Mardones Lead Independent Director / Independent
Carina Szpilka Lázaro Director/ Independent
Nuria Martín Barnés Secretary/Non member

RISKS AND UNCERTAINTIES

Grifols' risk management system applies to all companies that make up the group, including investees.

The company's risk control and management policy aims to provide greater security to patients, donors, employees, shareholders, clients, suppliers and other stakeholders by anticipating, controlling and managing risks that could prevent Grifols from achieving its objectives. It comprises specific risk policies that are formulated within a risk control and assurance framework.

Grifols' Board of Directors is responsible for approving the company's risk control and management policy.

For its part, the Audit Committee supervises the efficiency of the risk control and management system, including periodic evaluations. The Internal Audit Department supports the committee in these functions. At the same time, the senior management team oversees the risk management process by identifying and evaluating relevant risks and determining appropriate responses, taking into account the potential business impact, costs and benefits.

The primary risk factors that Grifols is subject to are outlined, in general terms, in its risk control and assurance policy8 . These include:

  • Regulatory risks: arising from regulatory changes or from changes in social, environmental or tax regulations.

8 http://www.grifols.com/documents/10180/14422120/risk-control-and-management-policy-2017-es/362de5d6-8f36-4c3caedd-10811f8dd3ec

Consolidated Directors' Report

  • Market risks: relating to the exposure of the results and Grifols' equity to changes in market prices and variables, such as exchange rates, interest rates, prices of raw materials, prices of financial assets and others.
  • Credit risks: the possibility that counterparty fails to perform its contractual obligations and produces an economic or financial loss for the company.
  • Business risks: uncertainty regarding the performance of key variables inherent in the Grifols' business: demand, supply of raw materials and new competitive products.
  • Operational risks: resulting from inadequate internal procedures, technical failures, human error or as a consequence of certain external events, including legal risks, fraud, and those related to information technologies, cybersecurity.
  • Reputational risks: potential negative impact resulting from changes in the perception of Grifols among various stakeholders.

- Penal risks

At the date of formal preparation of these consolidated financial statements, Grifols adopted measures to mitigate any possible effects arising from the aforementioned events.

Grifols' risk control and management system is grounded on the following principles:

  • A tolerance framework, which reflects the levels of risk that the company deems acceptable and consistent with its corporate objectives.
  • Leadership of senior management to allocate the necessary resources.
  • Integration in management processes, especially strategic and planning processes.
  • Separation of functions among business areas and supervision and quality assurance mechanisms.
  • Integrated approach and corporate alignment to ensure all risks adhere to the same identification, assessment and treatment process.
  • Ongoing improvements through periodic reviews of the system's strength and effectiveness, as well as risk-related best practices and recommendations.

By establishing and enforcing these norms and control procedures, the group aspires to cultivate an atmosphere of strict and constructive control throughout the organization in which all employees fully understand their roles and obligations.

More information on Grifols' risk control and management policy may be found in the annex, in Note 5 of its annual consolidated financial statements.

Consolidated Directors' Report

ENVIRONMENTAL GRIFOLS' GENERAL FRAMEWORK FOR ENVIRONMENTAL ACTION

Environmental management

Grifols minimizes the potential impact of its operations on the environment. In alignment with its commitment to sustainable development, the company has diverse policies and standard guidelines in place to ensure efficient resources management. Communicated across the organization at the behest of Grifols' top management, they define and articulate the company's environmental management efforts:

Environmental Policy Defines organization-wide guidelines, principles and commitments to control and improve
Grifols' environmental impact
Energy Policy Defines organization-wide guidelines and operational principles to optimize the use of energy
resources
Corporate Environmental Manual Manual applicable for most manufacturing centers and others certified with the international
ISO 14001 standard. It serves as an organization-wide reference for environmental behavior.
Environmental Programs Includes specific lines of action for each business area to reach overall objectives. The 2017-
2019 ENVIRONMENTAL PLAN is currently in force.
- Participation of senior management of each ISO 14001-certified company (or in the
certification process) and of Grifols Committee, S.A., which encompasses the environmental
management of all companies.
- Control and follow-up of the environmental management system
Environmental Committees - Proposal, follow-up and supervision of environmental programs.
- Review of follow-up indicators, application of corrective measures and compliance of the
current legal framework
- Identification of areas for improvement.

Efficient environmental management: key considerations

Grifols' environmental management includes a range of initiatives to optimize its resource management and mitigate any potential environmental impact caused by its operations. These include:

Ecoefficiency Integration of environmental criteria in the design systems of projects, products and services in
order to incorporate adequate prevention and eco-efficiency measures that minimize the
environmental impact. The R+D, Engineering and Grifols Engineering Departments study and
apply the most eco-efficient alternatives from a life cycle perspective.
Prevention - Periodic review of preventive measures to minimize the potential impact of environmental risks
identified by the company.
- Perform periodic simulations in manufacturing plants to evaluate the reaction capacity in case
of emergencies or incidents with environmental impact.
- Specific training for employees.
Development of specific self
protection plans for each installation
Define action plans in case of emergencies with environmental implications and appoint teams
responsible for their implementation.
Legal compliance Legislative monitoring systems allow identifying the legal requirements that each facility must
comply with and periodic compliance assessments.
Communication Internal and external communication procedures to guarantee an adequate response for each
type communication received within a stipulated timeframe.

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Environmental certifications

Grifols' environmental management system is certified by the international ISO 14001 standard, which ensures the company has procedures in place to prevent environmental risk and minimize the environmental impact of its operations.

The company aspires to obtain ISO 14001 certification in all of its manufacturing facilities. Grifols' plants in Spain have been ISO-14001-certified since 2004 and 2005, while the Clayton (North Carolina, USA) hemoderivatives plant was certified in 2016. In 2018, the company worked to earn certification for the Diagnostic Division's Emeryville plant (obtained in June) and initiated the certification process for the Bioscience Division plant in Los Angeles. All certified plants have adopted the new ISO 14001:2015 standard. To date, 75% of Grifols' total production is manufactured in ISO-14001-certified installations.

In 2018, the Clayton plant was also distinguished with the Leadership in Energy and Environmental (LEED) for its sustainable design. The Grifols facility became the first to receive this distinction in Johnston County.

Provisions and safeguards for environmental risks

Grifols has civil responsibility insurance to cover accidental contamination of the environment, understood as the disturbance of the natural state of air, groundwater, flora or fauna (or any other situation legally deemed as environmentally harmful), caused by emissions from Grifols installations due to accidental, sudden and unforeseen consequences. Grifols' responsibility extends to all of its companies, manufacturing facilities and sales offices in all of the countries where it operates.

In 2018, Grifols received no fines or economic sanctions related to its environmental management.

EVOLUTION AND ACTION LINES IN 2018

Resource allocation to prevent environmental impacts

Grifols carried out notable investments in 2018 to improve its environmental performance and meet its 2017- 2019 Environmental Program Policy objectives.

In 2018, investments focused primarily on reducing water consumption and emissions from refrigerant gases. Corporate investment in environmental assets reached EUR 2.7 million (EUR 8.5 million in 2017). Costs rose to EUR 15.5 million, compared to the EUR 13.6 million reported in 2017.

The difference in comparison with previous years derives from a change in accounting criteria for this type of investments. In previous years, only the portion of the project carried out during the year was listed for accounting purposes; starting in 2018, the entire investment is recorded in the year the project is finalized. The main environmental costs related to waste management and the treatment of wastewater.

On the whole, including costs and investments, 63% of resources were allocated toward waste management; 32% were related to managing the water cycle; and the remaining 5% were allocated to reducing atmospheric emissions, energy and others.

Expenses

In thousands of euros 2016 2017 2018
Waste management 9,073.5 9,621.9 11,419.2
Water cycle 3,195.8 3,636.6 3,718.2
Reducing atmospheric emissions, energy 186.1 54.7 74.2
Others 262.5 241.1 290.3
Total 12,717.9 13,554.3 15,501.9

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Investments

In thousands of euros 2016 2017 2018
Waste management 389.2 420.8 52.6
Water cycle 2,064.4 4,002.2 2,084.6
Reducing atmospheric emissions, energy 2,600.3 3,723.6 121.5
Others 96.8 347.9 474.0
Total 5,150.7 8,494.5 2,732.7

2017-2019 Environmental Program: progress in 2018

Grifols' 2017-2019 Environmental Program outlines its environmental goals and targets for this two-year period. Specific action items are attached to all objectives, which are carried out in Grifols' various manufacturing facilities.

The following table details the overall objectives of the 2017-2019 Environmental Program. The degree of fulfillment refers to the extent to which the objectives have been implemented.

2017 - 2019 OBJECTIVES DEGREE OF FULFILLMENT
OF OBJECTIVES ( 2018
OVERVIEW)
ENERGY
Reduction of electrical consumption by 2.06 million kWh per year in
specific installation
15.1%
Reduction in electrical demand in new installations by 6.2 million kWh
per year
44.9%
Decrease in the consumption of heat energy by 19.7 million kWh per
year in specific buildings
99.4%
Reduction in natural gas consumption in the construction of new
installations by 0.92 million kWh per year
25.3%
WATER
Reduction in water consumption by 265,000 m3 per year in specific
installations
36.0%
WASTE
Reduction in the volume of waste by 450 T per year in specific
installations
79.5%
Increase in waste recycling by 270 T per year in specific installations 100% - COMPLETED
CONSUMPTION
Reduction in the consumption of raw materials in specific installations 16.7%
OTHERS
Standardization of the environmental management system in specific
installations
78.0%
Reduction of atmospheric gas emissions in specific installations 38.0%
Environmental awareness in specific installations 100% - COMPLETED

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New objectives and targets for 2018:

ENERGY
Continuity on projects aimed to decrease
electrical consumption by more than 800,000
kWh in current installations
Increase in number of energy audits in manufacturing centers (Ireland) and subsidiaries
(Germany and France)
Decrease electrical consumption in cooling capacity systems in Bioscience Division
installations (Barcelona)
Modelling for electrical consumption of air conditioning in headquarters (Barcelona)
Projects to decrease natural gas consumption
by 4.1million kWh per year in existing
installations
Enhance efficiency of heaters and condensation recovery systems in the Bioscience Division
installations (Barcelona and Clayton)
Optimization of natural gas consumption Installation of a high-efficiency heater in the Bioscience Division's installations in Ireland.
Estimated savings of 1.12 million kWh per year compared to a conventional heater
WATER
Reducción del consumo anual de agua en
6.500 m3
Installation of water and condensation recovery systems in Bioscience Division installations
(Clayton)
ATMOSPHERIC EMISSIONS
Incorporation of new cold gas refrigerant installations with lower GWP or GWP=0 (Global Warming Potential)
Study on installation of solar-energy plants in Hospital Division (Murcia) and Bioscience Division (Clayton) installations

Like all Program objectives, these targets are supported by concrete metrics, execution deadlines, human and financial resources, as well as deadlines for implementation.

KEY METRICS IN 2018

Emissions

Grifols calculated its carbon footprint to identify greenhouse gas emissions generated by its operations and their impact on the environment. Calculations follow the Greenhouse Gas Protocol (GHG Protocol) methodology, the international standard used to measure and report greenhouse gas emissions.

Total emissions in 2018 were 296,000 tons of CO2 equivalent, 0.4% higher than the previous year. Broken down by scopes according to the GHG, as follows:

Emissions by source 2018 (t CO2e)

Scope 1 Scope 2 Scope 3
Direct emissions generated by the
activity itself, mainly through
consumption of natural gas and
other fuels, and fugitive emissions
such as refrigerant leaks.
Indirect emissions from electricity
consumption.
Other indirect emissions: business
travel, employee commuting and
transportation, as well as emissions
resulting from waste treatment and
recovery.
Fuel (Gasoline and Diesel) Electricity Transportation (Imports and exports
managed from Grifols International)
2,512 120,493 8,665
Fugitive emissions
19,975
Waste management
16,112
Natural Gas
75,556
Business travel
12,535
Employee commuting
40,076
TOTAL Emissions
295,924

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Refrigerant gas leaks (absolute value, T)

2016 2017 2018
HCFC (T) 1.68 0.28 0.34
HFC (T) 6.18 7.93 5.75
Otros (T) 0.01 0.01 0.01

Other significant air emissions

2016 2017 2018
NOx (T) 68.0 68.3 66.5
CO (T) 11.5 58.5 58.5
SO2 (T) 1.0 1.2 1.4

Waste

Grifols' waste management strategy prioritizes preventing and minimizing waste and encouraging recovery whenever possible, as opposed to landfill or incineration. Grifols' commitment to optimize waste management includes recycling, anaerobic digestion and energy recovery.

Waste generated by type and disposal method

2016 2017 2018
Total weight of hazardous waste (T) Energy recovery and by-products 1,476 1,707 2,093
Reused and recycled 2,440 2,706 2,963
Disposed of 3,935 4,275 5,007
Total weight of non-hazardous waste (T) Energy recovery and by-products 3,971 5,138 4,762
Composted 394 29 50
Reused and recycled 4,407 5,494 7,402
Other 869 *0 *0
Disposed of 14,258 15,974 18,947
Other (non-hazardous/hazardous waste) (T) Disposed of 2,135 2,648 *0
Total 33,885 37,971 41,224

*Waste classified as "Other" in previous years has been reclassified with greater detail into other categories.

Sustainable use of resources

Water consumption

In 2018, water consumption totaled 3,320,383 m3, a 1.8% increase compared to 2017.

By source % of consumption on
Third-party water-stressed
Total Groundwater water regions*
Bioscience 3,059,184 175,817 2,883,367 17.9%
Diagnostic 177,106 177,106 84.7%
Water consumed (m3) Hospital 84,093 79,612 4,481 0.1%
Total 3,320,383 255,429 3,064,954 21.0%

*High and high-hazard risk areas according to World Resource Institute.

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Grifols operates in geographic regions where controlling water consumption is a necessity. To this end, the company applies preventive measures when it designs new facilities and modifies existing facilities to reduce water consumption. Among the measures implemented are recovering clean water used in production processes for auxiliary uses and using automated CIP cleaning systems to reduce the amount of water used to clean reactors.

Wastes

Grifols complies with all relevant regulations and authorizations applicable to the elimination of wastewater in its facilities. Wastewater is managed in proprietary or municipal treatment systems. In 2018, 2,647,969 m3 of wastewater was discharged into the public sewer system. Of the water consumed, 79.7% is transformed into wastewater, while the remaining 20.3% is used in auxiliary processes that do not involve discharge, such as the cooling towers, or incorporated into the product during the manufacturing process. The Bioscience Division's facilities in Barcelona and Clayton treat wastewater with biological systems prior to discharge.

By destination By treatment By region
Total (Public
sewer system)
No treatment Biological
systems
prior to
discharge
% of consumption on
water-stressed
regions*
Bioscience 2,408,593 1,415,348 993,245 11.7%
Diagnostic 182,955 182,955 75.3%
Water discharged (m3) Hospital 56,421 56,421 0.1%
Total 2,647,969 1,654,724 993,245 15.9%

*High and high-hazard risk areas according to World Resource Institute.

Raw materials consumption (by divisions)

Main materials consumed Bioscience -
Absolute value (T)
2016 2017 2018 Variation
Sorbitol 1,672 1,420 1,994 40.4%
Ethanol 3,024 2,953 2,781 -5.8%
Polyethylene glycol 1,635 1,914 2,245 17.3%
Glass packaging 253 262 325 24.0%
Total 6,584 6,549 7,345 12.2%
Main materials consumed Diagnostic -
Absolute value (T)
2016 (*) 2017 (*) 2018 Variation
Circuit boards (units) 31,680 30,115 31,991 6.2%
PP Plastic Cards 192 177 248 40.1%
Glass packaging 1
9
1
7
2
0
17.6%
Plastic reagent packaging 2
5
2
2
2
3
4.5%
Red cell reagents (liters) 254,836 249,205 274,034 10.0%
PVC pellets, flat tubes and sheets 623 429 573 33.5%
Total 859 645 864 34.0%

(*) Figures updated according to new consolidation criteria. Starting in 2018, all types are consolidated into a single PCV category.

Main materials consumed Hospital -
Absolute value (T)
2016 2017 2018 Variation
PP, pellets and flat tubes 219 522 618 18.4%
Glucose 79 254 206 -18.9%
Sodium chloride 165 176 212 20.5%
Glass packaging 1,355 1,117 800 -28.4%
Total 1,818 2,069 1,836 -11.3%

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Energy consumption

In 2018, Grifols consumed a total of 384.0 million kWh, compared to 353.6 million kWh in 2017. The Bioscience Division represents 87% of Grifols' total energy consumption. Higher consumption in absolute values stems from production increases and expansion of the plasma donation network. The Diagnostic Division's electricity usage was 34.3 million kWh, a 5% increase compared to 2017. The Hospital Division accounts for the remaining 4.2% of electricity consumed. Its energy consumption in absolute values was 16.3 million kWh, a 7% increase compared to 2017 despite a 16% increase in productive output. The Division improved its energy efficiency by relocating most of its manufacturing operations from the oldest plant in Murcia to a newer, more modern and efficient plant.

In terms of renewable energy, 4,905,592 kWh were consumed in Spain, Ireland and Italy.

Electricity consumption by division (kWh)

2016 2017 2018
Bioscience 303,698,495 305,509,272 333,293,034
Diagnostic 24,020,385 32,816,148 34,367,035
Hospital 14,371,821 15,296,445 16,380,793
Total 342,090,701 353,621,865 384,040,862
Aigües de Vilajuïga 6,716
TOTAL 384,047,578

Cogeneration

Cogeneration figures 2016 2017 2018
Natural gas consumed (kwh) 101,044,947 85,979,380 89,417,050
Total electricity generated (kwh) 37,802,940 35,024,990 32,984,680
Useful heat recovered (kwh) 27,335,440 23,134,790 25,266,980
Global output 71.5% 68.0% 71.6%
Primary energy saving (pes) 18.9% 17.0% 17.6%
Co2 emissions (t) 18,101 15,612 16,315
Co2 emissions savings (t) 3,416 3,277 3,492

Natural gas

The consumption of natural gas in 2018 totaled 415 million kWh, a 6% increase over the previous year. Most consumption derives from the Bioscience Division, which represented 87% of the total in 2018. The division increased its usage by 5% due to higher production output and expansion of the plasma center network. The Diagnostic Division also increased its consumption following validations for the Emeryville plant. The Hospital Division's consumption remained stable despite increasing its yearly manufacturing output. The division relocated most of its operations to a newer, more energy-efficient plant in Murcia, Spain.

In terms of geographic regions, 62% is consumed in the United States.

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Natural gas consumption by division (kWh)

2016 2017 2018
Bioscience 336,692,316 342,916,221 358,704,138
Diagnostic 13,347,316 28,247,569 35,149,360
Hospital 19,761,841 20,451,580 20,886,079
Total 369,801,473 391,615,370 414,739,577

Other combustibles

The Bioscience Division also consumes other fuels including diesel, gasoline and propane, which are used in its own generators, equipment and vehicles. In 2018, 8,306 MWh were consumed, a 6% increase compared to the previous year due mainly to greater diesel consumption.

Climate change

Grifols implements preventive pollution strategies to mitigate the environmental impact of its operations and the effects of climate change.

The company participates in the Carbon Disclosure Project (CDP), an annual program that evaluates the organization's strategy and performance with respect to climate change. The company received the CDP2018 participation questionnaire in June. Grifols obtained a "B Management" grade in 2018, the same score as last year. This rating indicates the company's strides to minimize atmospheric emissions by assessing its impacts, risks and opportunities, as well as the effectiveness of its policy and strategy framework toward reducing the negative impact of climate change.

SOCIAL AND PERSONNEL

PERSONNEL MANAGEMENT AT GRIFOLS

Grifols' success resides in the dedication and commitment of its workforce, which the company considers among its most important assets.

The company advocates an equal-opportunity policy in its selection processes, training initiatives, remuneration, promotions and professional development efforts, and fosters a culture of diversity, inclusion, equal opportunities and non-discrimination. To this end, Grifols has a range of standard, organization-wide of policies and guidelines:

  • Selection processes follow Grifols Recruiting Policy to guarantee systematic hiring procedures that comply with current legal frameworks and support corporate values. As part of this commitment, Grifols bases its talent search on criteria including professional profile, functional profile, motivation and growth potential.
  • In alignment with its remuneration policy, Grifols offers competitive pay packages and compensates employees who support the company's ongoing development and demonstrate solid individual and professional performance. As established in its corporate policies, each country offers remuneration and benefit systems adapted to their region.
  • The company utilizes a Grifols Performance System (GPS) to promote the professional development of its talent pool. All employees are invited to carry out an annual performance review using this systematic process, which assesses their attitudes, performance and behaviors within the framework of Grifols' corporate values. The GPS allows employees to examine their strengths and areas for growth and cocreate individual growth tracks and professional development plans.
  • Employee education is an essential component of Grifols' professional development. Grifols strives to continuously train its talent pool with the necessary skills and competencies to successfully perform their jobs and prepare them for roles of greater responsibility in the future. The company established the

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"Grifols Academy" in 2009 to enhance the skillset and leadership potential of its talent pool and cultivate dynamic forums for learning and knowledge-sharing.

Every role at Grifols requires specific skillsets, competencies and attitudes that align with the company's values. Grifols places a high value on teamwork, honesty, integrity, ethics and compliance at all levels of the organization. The Board of Directors and top-level executive team actively promote these values as mainstays of the corporate culture through:

  • The Code of Conduct9 establishes guidelines for all Grifols employees when performing their diverse functions, as well as in their professional relationships.
  • Grifols Anti-Corruption Policy10 defines the standards of conduct for all employees, including executives and top-decision bodies. It applies to all subsidiaries and investees worldwide. Available for all employees, the policy advocates a "zero-tolerance approach" regarding any acts of corruption or bribery.
  • Diversity, inclusion, equal opportunity and non-discrimination: core aspects

The diversity in Grifols' workforce is grounded on a respect for individual differences including ethnicity, race, color, gender, age, physical appearance and ability/disability, and underlying characteristics like attitudes, religion and beliefs, education, nationality and personal trajectories. Diversity also encompasses sexual orientation, marriage and civil partnerships, gender identity and/or expression and other personal aspects.

Grifols is proud of the diverse talents and abilities in its global talent pool. The sum of employees' individual differences, life experiences, knowledge, singular abilities and talents undoubtedly enhance Grifols' corporate culture and organizational outcomes.

As a result of the company's efforts to maintain a discrimination-free workplace, only 33 incidents of discrimination were reported in 2018 out of a total of 21,230 employees, compared to 48 incidents out of 18,296 employees in 2017 and 25 incidents out of 14.877 employees in 2016. Grifols thoroughly reviewed these claims, and although none was considered discriminatory in legal terms, there were actions taken including admonition, counseling and training to guarantee a discrimination-free environment.

Diversity includes labor integration of persons with disabilities

The company is committed to hiring individuals with disabilities. Grifols adopts alternative measures when accommodating a disabled individual is not possible for technical or organizational reasons, as established in the General Law on Persons With Disabilities, applicable to private and public-sector firms in Spain. As of 2018, 461 people with some type of disability form part of Grifols' talent pool (61 in Spain and 400 in the U.S.11).

Grifols promotes universal access to people with disabilities. Its accessibility principles include the removal of architectural barriers and pledge of equal opportunities for persons with disabilities. The company's new buildings and installations comply with current legislation and necessary structural reforms are carried out when necessary.

9 See https://www.grifols.com/documents/51507592/51526483/internal-code-of-conduct-2016-en.pdf/d03bff73-e6cc-481abdfa-32eb6efb6ac9

10 Available at https://www.grifols.com/en/corporate-policies

11 This indicator scope excludes Biotest USA and Goetech companies.

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Equal opportunities

Grifols makes no distinction between men and women in its hiring practices, compensation or benefits packages. In accordance with the Grifols Equal Opportunities philosophy, salaries for new incorporations are the same regardless of gender.

The company has equal-opportunity programs in place in alignment with its policy of non-discrimination and equal opportunity, and in compliance with the Equality Act 3/2007 of 22 March.

As outlined in Grifols' Equality Program, the Equality Committee is responsible for monitoring the system, including periodical and objective evaluations. Among the actions included since it was set in 2014 are:

  • Distribution of Equal Treatment and Opportunities Program.
  • Incorporation of training activities on equality issues, as part of Grifols' Professional Development Plans
  • Consolidation of the positive action measures outlined in Art. 11 and 18 of the XVII Chemical Industry General Agreement regarding recruitment and hiring practices, by which candidates of the underrepresented sex in the professional area or segment in question are given preference, all other issues being equal, i.e. competencies, skill and suitability.
  • Increase awareness to prevent sexual and gender-based harassment throughout the organization and rollout of a harassment prevention protocol.
  • Flexible working arrangements and work-life balance initiatives.
  • Training initiatives to raise awareness and encourage the use of inclusive language.

These actions align with the core principles established in Grifols Code of Conduct and Code of Ethics for Executives.

The company continues to focus on a range of areas of intervention. These include actions to advance equalitarian organizational management; increase female representation in management bodies; contribute to eliminating pay gaps in positions of equal value; promote flexible work and work-life balance policies; and ensure internal and external communications use inclusive language and convey a gender-neutral approach, as established in the company's official information channels on equal opportunities and the importance of language.

Work organization and work-life balance

Effective equality is promoted through work-life balance measures that allow employees to reconcile their professional and personal commitments. Grifols continues to integrate work-life balance policies in the organization. In 2018, the company rolled out two important measures: A Friday workday of 8 a.m.-3 p.m. in Grifols' centers in Spain for employees with standard business hours; and the option of dividing up one vacation day per year. In the U.S., all vacation days may be divided into half-day allotments. Grifols does not have "right to disconnect" policies.

Anti-discrimination policy in the U.S.

The company complies with the Office of Federal Contract Compliance Programs (OFCCP) of the U.S. Department of Labor, which requires employers like Grifols to take active steps to ensure equal-opportunity employment and prevent discrimination based on race, gender and disability, among others. These Affirmative Action Plans (AAPs) to promote the employment of women and legally protected minority groups apply to companies with more than 50 employees.

In 2018, Grifols' AAPs led to 96 concrete action plans, a 40% increase compared to 2017 (57 action plans).

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Grifols' workforce

In 2018, Grifols' workforce included 21,230 employees, growing more than 16% compared to the previous year (18,296 employees in 2017). The number of women increased in all professional categories, especially in occupational positions (+37%), to 1,379 women; management (+25%) to 590 women; and top management (+24%) to 172 women.

The evolution of Grifols' workforce in 2018 and the positive impact of its proactive talent management strategies are summarized in the following data:

  • 59% women and 41% men.
  • 98.3% permanent contracts overall and 98.7% in the case of women.
  • More than 51.7% of employees are between 30 and 50 years old.
  • 93.8% of employees work full time: 92.4% in the case of women.
  • Women comprise 32% of top management positions.

Distribution of employees by country

Employees %
Spain 3,858 18.2%
USA 15,299 72.1%
Rest of the World 2,073 9.8%
Total 21,230 100.0%

Distribution of employees by gender and type of contract

2016 2017 2018
Permanent Temporary Total Permanent Temporary Total Permanent Temporary Total
Women 7,889 176 8,065 10,329 186 10,515 12,402 164 12,566
Men 6,577 235 6,812 7,548 233 7,781 8,464 200 8,664
Total 14,466 411 14,877 17,877 419 18,296 20,866 364 21,230
% 97.2% 2.8% 100.0% 97.7% 2.3% 100.0% 98.3% 1.7% 100.0%

Distribution of employees by region and type of contract

2016 2017 2018
Permanent Temporary Total Permanent Temporary Total Permanent Temporary Total
North America 10,553 3 10,556 13,670 1 13,671 15,330 0 15,330
Europe 3,540 385 3,925 3,829 386 4,215 5,119 348 5,467
Rest of the world 373 23 396 378 32 410 417 16 433
Total 14,466 411 14,877 17,877 419 18,296 20,866 364 21,230

Distribution of employees by age

2016 2017 2018
<30 3,871 5,503 6,528
30-50 8,378 9,754 10,988
>50 2,628 3,039 3,714
Total 14,877 18,296 21,230

Distribution of employees by gender and workday

2016 2017 2018
Full-time Part-time Total Full-time Part-time Total Full-time Part-time Total
Women 7,477 588 8,065 9,861 654 10,515 11,610 956 12,566
Men 6,625 187 6,812 7,571 210 7,781 8,306 358 8,664
Total 14,102 775 14,877 17,432 864 18,296 19,916 1,314 21,230
% 94.8% 5.2% 100.0% 95.3% 4.7% 100.0% 93.8% 6.2% 100.0%

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Distribution (%) by professional category and gender

2017 2018
Women Men Total Women Men Total
Top management 29.0% 71.0% 472 32.0% 68.0% 542
Senior management 40.0% 60.0% 490 41.0% 59.0% 495
Management 44.0% 56.0% 1,074 48.0% 52.0% 1,224
Senior professional 45.0% 55.0% 1,631 47.0% 53.0% 1,816
Professional 51.0% 49.0% 1,978 56.0% 44.0% 2,474
Administratives/ Manufacturing
operators
63.0% 37.0% 12,651 64.0% 36.0% 14,679
Total 57.0% 43.0% 18,296 59.0% 41.0% 21,230

Distribution (%) by professional category and age

2017 2018
<30 30-50 >50 Total <30 30-50 >50 Total
Top management 0.0% 46.0% 54.0% 472 1.0% 40.0% 59.0% 542
Senior management 0.0% 63.0% 37.0% 490 0.0% 59.0% 41.0% 495
Management 2.0% 68.0% 30.0% 1,074 2.0% 63.0% 35.0% 1,224
Senior professional 6.0% 70.0% 24.0% 1,631 6.0% 69.0% 25.0% 1,816
Professional 15.0% 68.0% 17.0% 1,978 15.0% 67.0% 18.0% 2,474
Administratives/ Manufacturing
operators
40.0% 48.0% 12.0% 12,651 41.0% 46.0% 13.0% 14,679
Total 30.0% 53.0% 17.0% 18,296 31.0% 52.0% 17.0% 21,230

The U.S. and Spain represent 90.2% of Grifols' workforce. In these countries, there were 1,255 dismissals in 2018: 25 in Spain and 1,230 in the United States6

Breakdown by gender6

2018
Women Men Total
SPAIN 13 12 25
USA 840 390 1,230
Total 853 402 1,255
% 68.0% 32.0% 100.0%

Breakdown by age6

2018
<30 30-50 >50 TOTAL
SPAIN 3 16 6 25
USA 590 515 125 1,230
Total 593 531 131 1,255
% 47.3% 42.3% 10.4% 100.0%

Breakdown by professional category6

2018 SPAIN USA
Top management 1 8
Senior management 4 4
Management 3 10
Senior professional 5 16
Professional 4 31
Administratives/ Manufacturing
operators
8 1,161
Total 25 1,230

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Gender pay gap

The gender pay gap refers to the difference between men's and women's wages and salaries, calculated as the differential between the average salary of both divided by the average salary of men.

Grifols provides gender pay gap information per professional category of its workforce in Spain and the U.S., which together represent more than 90% of the group's workforce.

The last report of the World Economic Forum (WEF) places the gender pay gap at 68%. This means that, on average, there is still a gap of 32% to close. To date, no country has reached parity and only seven countries have closed at least 80% of the gap. In Spain, the latest available data from Eurostat12 places the gender pay gap adjusted per hour at 14.2%.

In the United States, the U.S. Census Bureau reported that full-time female employees receive, on average, 80% of salaries paid to male employees. The OECD13, on the other hand, data places the gender pay gap at 18.2%.

Grifols is committed to effective equality, which includes equal pay for work of equal value. The data reported in 2018 highlight the company's efforts to gradually reduce the gap across all professional categories:

Gender pay gap by job category in Spain

Job Category Gender gap 2018 Gender gap 2017
Top management 13.8% 27.1%
Senior management 5.4% 9.3%
Management 9.7% 12.3%
Senior professional 9.0% 9.7%
Professional 6.3% 8.5%
Admin./Manuf. Operators 2.8% 3.3%

Gender pay gap by job category in the U.S. – plasma centers

Job Category Gender gap 2018 Gender gap 2017
Top management 3.0% 11.6%
Senior management 1.2% 3.9%
Management 9.5% 1.1%
Senior professional 3.3% 1.5%
Professional 6.8% 6.0%
Admin./Manuf. Operators 0.0% -1.5%

Gender pay gap by job category in the U.S. – rest of activities

Job Category Gender gap 2018 Gender gap 2017
Top management 11.3% 15.8%
Senior management 1.6% 2.9%
Management 4.5% 4.7%
Senior professional 2.6% 2.2%
Professional 5.2% 3.1%
Admin./Manuf. Operators 4.7% 4.2%

Salary differences between men and women are often indicative of the company's organizational structure. Grifols has proportionally more women than men in its plasma collection centers and, proportionally, with

12 Source: Eurostat 2016. https://ec.europa.eu/eurostat/web/equality/overview

13 Source: Organisation for Economic Co-operation and Development. Gender Wage Gap OECD, 2017

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more men in its senior leadership team. Most of the gender pay gap is attributable to this organizational profile.

The company is committed to gradually improving this situation and plans to deepen its understanding of its root causes in 2019. Based on this analysis, the action plan will be updated to implement solutions that are practical and beneficial for Grifols' talent pool.

Average wage14 by category and gender

Spain

Job Category Fixed Wage
average 2018
Fixed Wage
average 2017
Women 134,008.0 € 107,557.8 €
Top management Men 155,492.2 € 150,585.0 €
Women 76,002.9 € 72,133.4 €
Senior management Men 80,315.1 € 77,055.0 €
Women 51,989.7 € 49,121.8 €
Management Men 57,588.3 € 55,165.6 €
Women 39,644.6 € 37,733.9 €
Senior professional Men 43,565.1 € 41,302.0 €
Women 34,304.5 € 32,889.7 €
Professional Men 36,628.8 € 35,895.2 €
Women 25,558.4 € 24,834.2 €
Admin./Manuf. Operators Men 26,290.0 € 25,621.2 €

USA – plasma center

UNITED STATES DONOR CENTERS
Fixed Wage Fixed Wage
Job Category average 2018 average 2017
Women \$221,983.7 \$200,139.7
Top management Men \$228,951.5 \$226,335.0
Senior management Women \$122,292.4 \$165,157.7
Men \$123,810.3 \$171,934.4
Women \$97,009.0 \$102,137.6
Management Men \$107,175.5 \$103,319.9
Women \$85,205.8 \$88,640.2
Senior professional Men \$88,145.0 \$90,029.1
Women \$63,334.0 \$62,199.8
Professional Men \$67,937.4 \$66,202.0
Women \$34,075.4 \$33,722.4
Admin./Manuf. Operators Men \$34,060.5 \$33,228.4

14 To avoid distorting the results, the average fixed salary excludes salaries based on seniority or individual/personal events.

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USA – rest of activities

UNITED STATES OTHER ACTIVITIES
Fixed Wage Fixed Wage
Job Category average 2018 average 2017
Women \$208,103.9 \$208,363.0
Top management Men \$234,554.7 \$247,426.3
Senior management Women \$159,042.8 \$155,342.7
Men \$161,570.1 \$159,904.8
Women \$121,734.5 \$118,288.1
Management Men \$127,429.6 \$124,162.7
Women \$100,294.3 \$97,407.7
Senior professional Men \$102,983.8 \$99,616.8
Women \$71,395.5 \$70,395.3
Professional Men \$75,281.2 \$72,612.4
Admin./Manuf. Operators Women \$53,490.9 \$53,461.9
Men \$56,142.5 \$55,777.4

Average wage by age6

Spain

Age Fixed Wage
average 2018
Fixed Wage
average 2017
<30 27,513.1 € 28,310.4 €
30-50 36,491.9 € 37,174.0 €
>50 53,363.3 € 53,587.2 €

USA

Age Fixed Wage
average 2018
Fixed Wage
average 2017
<30 \$32,877.5 \$31,022.7
30-50 \$57,849.5 \$56,864.3
>50 \$84,747.4 \$86,057.3

Average retribution of board members and executives by gender

In Euros Women Men Total
Average total wage 222,289.4 279,777.4 261,371.2
Directive employees and BoD
members 146 310 456
Gender Gap 20,5%

Contributions to long-term savings systems

In Spain, retirement savings form part of a public social protection system. The U.S. model offers a very limited range of basic services, transferring pension coverage to the private sector and individuals' own initiative.

Considering the characteristics of each country's model and current legislation, Grifols' contributions toward pension plans in 2018 may be summarized as follows6 :

In thousands of euros Men Women Total
SPAIN 437.2 339.9 777.1
USA 9,301.2 8,135.4 17,436.6
Total 9,738.4 8,475.3 18,213.7
% 53.5% 46.5% 100.0%
32

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HEALTH AND SAFETY

Health and safety management

Grifols' Health and Safety Policy advocates a rigorous system of occupational health, safety and riskprevention in the workplace. The policy guarantees that all of the group's companies, as well as collaborating companies, act in accordance with country-specific regulations, rules, provisions and legislation, as well as with Grifols' own health and safety standards.

The Occupational Health and Safety Department establishes corporate objectives and each center determines its annual safety and health initiatives. The department also monitors the Occupational Health and Safety Systems of Grifols subsidiaries through corporate audits. International subsidiaries employ their own individual systems in line with their specific markets and corporate policies.

Grifols employees actively participate in the company's occupational health and safety teams and committees to help identify and control risks, and promote new ideas surrounding the issue.

Grifols' centers in Spain are OHSAS 18.001:2007-certified. International subsidiaries employ their own systems in accordance with their corporate policies and specific countries.

Grifols' risk-prevention department offers guidance to the entire group, monitoring the occupational safety and health program on three distinct levels:

  • Monthly monitoring of key performance indicators
  • Advisory visits in all companies and follow-up of preventive plans
  • Corporate audits
Identification of risks Integrated during the design phase of new installations, modification of production processes
and acquisition of new equipment.
Training and awareness programs
on occupational health and safety
Guarantees that all employees receive information and training on risk prevention. Offered to
new hires, employees with new job responsibilities and in the case of operational changes.
Training is adapted to function and workplace.
Employee health and well-being
initiatives
Grifols has various programs to promote the wellbeing of its employees in the main countries
where it operates. In this U.S., this includes a personal health advisor, biometrics, etc.
In Spain, health programs are reinforced with medical teams and physiotherapists in the field.
In addition, during a week is foccus on health and safety where sports activities are
supported.

Progress in 2018

Grifols' employees in Spain and the U.S. represent 90,2% of its workforce. The accident rate15 in 2018 is as follows:

USA 2018 Spain 2018
Women Men Women Men Formula
No. of work accidents with sick
leave* (LTI) without sick leave
(NLTI) and first aids (FA)
532 232 96 143 Total no. of work-related accidents with sick leave (non
itinere); without sick leave and first aids
Total number of work-related
accidents resulting in sick leave*
(LTI)
39 27 28 51 No. of work accidents with sick leave (non itinere)
Accident frequency rate 2.8 2.5 10.7 15.1 No. of work accidents with sick leave (non itinere)/no. total
hours of real hours worked *10^6
Degree of severity 0.08
0.4
0.4 No. of days not worked for work accidents with sick leave
(non itinere)/no. Total real hours worked *10^3
No. of lost days is calculated as the difference between
calendar days (not including weekends and holidays)
between the leaving date and the entry date
* Within the accidents calculation, occupational diseases occurring in Spain are included: 1 for men and 1 for women

15 The severity index breakdown by gender is not available in this reporting period in the US.

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Grifols investigates all accidents, both with and without sick leave, minor incidents and accidents on work commutes in countries where it is regulated as part of its on-going efforts to improve its prevention systems.

In 2018, Grifols launch a corporate program Behavioral Based Safety (BBS) to encourage managers to support safety behaviors amongst its teams. This program has been implemented in productive companies and is scheduled to be implemented in Ireland and Spain in 2019.

In Grifols' manufacturing plants, plasma-related processes follow strict protocols. Technical, organizational and personal prevention measures are adhered to at all times, resulting in a low frequency of occupational disease. Plasma centers pose a potential risk of contagion from contact with blood at the time of extraction. For this reason, Grifols has implemented an exposure control program to foresee and efficiently act in case of an incident.

Absenteeism

The occupational health, safety and wellbeing of Grifols' employees have a direct impact on absentee rates. The company works with an absenteeism management model with established benchmarks to quantify its cost impact. Grifols implemented several measures to foster the integrated health management of its workforce in order to address the root causes of absenteeism. These measures include complementing accident insurance and corporate medical services with physiotherapy sessions to prevent musculoskeletal injuries. The company also carries out awareness sessions, return-to-work interviews after extended sick leaves, and communication protocols for employee absences.

Breakdown of absenteeism hours in Spain16:

Illness Illness. Hospit. Work accident Maternity/Paternity Paid Leave Unpaid Leave TOTAL
Women 114,632 12,153 11,041 54,978 27,582 1,334 221,720
Men 87,196 24,282 9,764 14,719 26,001 3,636 165,598
Total 201,828 36,435 20,805 69,697 53,583 4,970 387,318

PROFESSIONAL DEVELOPMENT AND TRAINING

Grifols recognizes the importance of professional development to remain competitive in today's dynamic international environment.

In 201817, Grifols employees collectively received 2.5 million training hours. Women received 65.9% of total training hours and men received the remaining 34.1%.

In terms of areas of focus in 2018, the company concentrated its efforts on promoting Grifols' corporate culture, developing leadership competencies, and maintaining its trademark high standards of quality, safety and technical excellence.

Grifols Academy offers ongoing educational opportunities in Spain and the United States focused along three main lines: professional development, plasmapheresis and immunohematology.

In 2018, roughly half of Grifols managers took part in at least one leadership development offering. The company also runs an executive development program in collaboration with ESADE (Barcelona) and Georgetown University's McDonough School of Business, now in its second year. The program enables Grifols employees to enhance their strategic thinking, better anticipate change and elevate their leadership potential. The company offers other leadership-competency programs that explore emotional intelligence, problem resolution and decision-making.

16 Due to regulatory differences between countries, only the absenteeism rate is reported in Spain, where it set a material issue.

17 In 2018 there was a change in the reporting criteria, including as of this year the total number of hours of on-job training in the USA plasma centers. This figure is therefore not comparable to that reported in 2017.

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2018
Women Men Total
Top management 5,574 11,901 17,475
Senior management 7,853 12,157 20,010
Management 17,151 24,455 41,606
Senior professional 41,691 60,673 102,364
Professional 46,262 53,488 99,750
Administratives/
Manufacturing operators
1,556,125 705,134 2,261,259
Total 1,674,656 867,808 2,542,464

Breakdown in training hours by professional category

EMPLOYEE VALUE PROPOSITION (EVP)

In 2018, Grifols' Human Resources and Corporate Communications finalized the design of the Employee Value Proposition (EVP). This initiative reinforces Grifols' branding and market position as a top employer.

The EVP communication campaign targeting employees and job candidates will launch in 2019 using a multichannel approach to bolster Grifols' position as an outstanding employer.

COLLECTIVE LABOR RELATIONS

The Spanish labor system establishes two classifications of employee representatives: union representatives and unit representatives, who serve as members of employee committees and personnel delegates.

Grifols has corporate committees in several of the group's companies and union delegates that oversee specific duties in accordance with current legislation. The company advocates an open and transparent flow of communication with employee representatives. To the extent possible, Grifols strives to centralize crosscutting issues that require collective bargaining. For this reason, Grifols created a forum in 2018 aimed at encouraging dialogue among committee members.

Collective labor agreements

Employees in some of Grifols' subsidiaries in Spain, Germany, Italy, France, Argentina and Brazil are covered under collective agreements. In 2018, 4,246 employees were covered under this type of agreement, representing 20% of Grifols' workforce.

In 2018, in the framework of the collective labor agreement in Spain, the "variable remuneration agreement" was signed, in which it was included three specific points related to health.

Employee representation in formal joint management-worker health and safety committees

In Spain, Chile and Germany, where labor committees are required by law, Grifols has employees designated on occupational health and safety risk prevention committees. OHS meetings ensure regular communication in these countries.

In 2018, 66% of employees in Spain have been represented by a joint occupational health and safety committee. In Chile and Germany, 100% of employees have been represented in these meetings. In

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subsidiaries with no formal representation, Grifols regularly communicates and consults with its workers, who establish committees that encourage employees participation and input. Each subsidiary decides on the frequency of these meetings and establishes follow-up plans, action items and concrete measures that stem from them.

HUMAN RIGHTS

Protecting and respecting human rights forms an intrinsic part of Grifols, guided by its mission to enhance the health and wellbeing of people worldwide and it staunch commitment to promote the wellbeing of residents in the communities where it operates.

Using international frameworks as reference points (United Nations Global Compact, UN Guiding Principles on Business and Human Rights, OECD guidelines for multinational companies, ILO declaration on multinational enterprises), the company does its utmost to support and promote human rights in everything it does. The company takes concrete actions to avoid infringing on the rights of third parties and prevent any potential adverse impacts.

Grifols' Code of Ethics applies to all activities and operations carried out by employees and collaborators on the company's behalf to ensure strict compliance with current legislation. This commitment also includes protecting human rights. To this end, the company offers a Grifols Ethics Helpline open to employees and third parties to report any concerns regarding human rights violations or cases of ethical misconduct. All allegations follow a standard operating procedure to ensure that all claims are properly investigated and resolved, and that corrective actions are taken, if necessary.

The Grifols Ethics Helpline received 230 calls in 2018 (170 calls in 2017). The company actively encourages people to use the helpline in all of its countries of operation.

Breakdown of helpline calls in 2018:

COMBATTING CORRUPTION AND BRIBERY

Grifols is a global company committed to strict compliance with all applicable laws and norms in the countries where it operates. Supervised by the International Compliance Review Board, the compliance program includes policies and procedures to foster ethical conduct and fulfillment of anti-corruption norms throughout the organization (Ethics & Compliance). Promoting integrity and transparency regarding data processing, money laundering, conflicts of interest and third-party interactions are among its main priorities.

The Grifols Code of Ethics for Directors and Senior Executives, the Grifols Code of Conduct, and the Grifols Anti-Corruption Policy form the foundation of the company's compliance program. Other policies and

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procedures related to explicit legal domains, compliance risks and country-specific requirements complement this program. Among this area's achievements in 2018 was the approval of the crime-prevention policy.

Crime prevention policy

In 2018, Grifols' Board of Directors approved the crime prevention policy, aimed at reinforcing the company's unequivocal rejection of the commission of crimes, criminal acts or any other type of unethical behavior, and its steadfast determination to prevent and combat these actions.

The Crime Prevention Policy is available to all employees and third parties on the Grifols corporate website. This policy was developed through the roll-out of the Crime Risk Management System, or CRSM.

The objective of the CRMS is to assure public administrations, judicial and administrative ,and third parties that Grifols effectively exercises the requisite supervision, monitoring and control over board members, executives, employees, subsidiaries and other individuals by establishing measures to prevent crime or reduce their risk of commission.

In accordance with current legislation, an independent expert annually reviews the CRMS to ensure an effective crime-prevention system is in place, with appropriate crime-detection and prevention control measures, both in terms of design and operative efficiency.

Anti-corruption policy

Approved by the Board of Directors' Audit Committee, Grifols' Anti-Corruption Policy establishes appropriate standards of behavior for executives, employees and third parties that collaborate in the company's day-to-day operations. Grifols reinforces compliance through various review processes. The leadership teams in Grifols' subsidiaries and other members of the executive team ensure that the policy is implemented in their areas of responsibility.

Grifols Anti-Corruption Policy is available to all employees on the corporate website. Specific training is offered to Grifols employees and members of its corporate governance board whose roles make them more likely to witness ethical breaches.

Grifols enforces a "zero-tolerance" approach to acts of bribery and corruption by any and all members of the company and third parties. Violations of Grifols Anti-Corruption Policy may lead to disciplinary actions including termination of employment. In 2018, Grifols had no confirmed incidents of corruption in where it operates.

To guarantee compliance with anti-corruption policies and procedures, Grifols' business associates are subject to a thorough process of due diligence prior to any authorization or completion of commercial transactions.

Similarly, contracts include an annex on Grifols' current anti-corruption policy and international distributors carry out mandatory annual online training on the Foreign Corrupt Practices Act (FCPA). Distributors are also required to provide annual certifications of compliance with Grifols' anti-corruption policy, signed by the general manager or similar. Distributor contracts include clauses that grant Grifols the right to perform audits on an as-needed basis. These clauses stipulate the termination of business relationships if Grifols determines any breach of its anti-corruption rules.

Money laundering

Grifols has established mechanisms, procedures and policies to prevent money laundering and respond to any possible breaches detected in the course of their business dealings.

Prevention: The Code of Ethics, Code of Conduct and Anti-Corruption Policy include measures for the prevention of money laundering applicable all Grifols' employees and activities.

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Detection: Some of the aforementioned policies and procedures also permit taking concrete actions to detect the risk of money laundering. The company has a communication channel open to employees and third parties to anonymously report any concerns of possible ethical misconduct (Grifols Ethics Helpline).

Reaction and response: Grifols has a reaction and response protocol, as well as a sanctions system, to amend any claims of unethical behavior or irregularities using all means possible, and if necessary, take corrective actions to prevent them from happening in the future. Grifols also collaborates with the competent authorities in each country to combat money laundering and the financing of terrorist activities. To this end, it is committed to providing all information requested in accordance with current legislation and reporting any suspicious transactions.

SOCIAL COMMITMENT

As a global healthcare company, patients and medical professionals are at the very heart of Grifols' activities. For this reason, the company ensures that all of its processes integrate the highest standards of quality and safety. Each division adheres to rigorous policies and procedures to guarantee the safety and quality of Grifols' products throughout the value chain. The firm's vertically integrated business model permits even greater control over its production processes.

SUPPLIER RELATIONS

Supply management

Each Grifols division has qualified suppliers whose technical, management and control capabilities have been previously evaluated and approved by the corresponding control overseers. The company subjects all suppliers of materials or services that could impact the quality of Grifols' products to a prior authorization process. Qualifications are granted for a specific material or service.

Grifols carries out on-going evaluation procedures for suppliers that vary depending on the level of risk their material or service and its impact on the value chain. The company conducts routine audits to evaluate and monitor new suppliers. The following audits were conducted in 2018:

DIVISION / AREA TYPE OF SUPPLIER NO. OF QUALITY
AUDITS IN 2018
RESULTS
174 Favorable
1 NoT Favorable
Raw material suppliers 179 Rest pending evaluation
and final report
Bioscience Division Service suppliers (cleaning services, 57 Favorable
analysis, warehouse, transport, CROs for 63 1 No Favorable
clinical trials) Rest pending evaluation
and final report
Raw material suppliers 15 15 Favorable
Diagnostic Division Service suppliers (manufacturers of semi
finished or finished goods, warehouses,
etc.)
4 4 Favorable
Raw material suppliers 8 8 Favorable
Hospital Division Service suppliers 2 2 Favorable
73 56 Favorable
Distributors Rest pending evaluation
and final report
18 12 Favorable
Transport companies 2 No Favorable
Grifols global subsidiaries Rest pending evaluation
and final report
21 Favorable
Service suppliers (warehouse, courier 25 1 No Favorable
services, analytical labs, etc.) Rest pending evaluation
and final report
Others (Grifols Engineering, Service suppliers (engineering firms, 35 35 Favorable
GWWO,Kiro) transport companies, etc.)
384 Favorable
TOTAL 422 5 Not Favorable
38 33 pending evaluation
and final report

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The audits conducted on raw material and service providers focus on the quality and safety of the products and services supplied. Some Grifols companies require their suppliers to have environmental certifications such as ISO 14000 (for environmental management systems) ad OSHAS (for occupational health and safety management).

Plasma as a raw material

Plasma is the main raw material used by the Bioscience Division. The generosity of donors allows the company to produce life-saving medications for patients.

Grifols only uses plasma from qualified donors collected in centers that have been approved by the competent health authorities. Donors undergo annual medical exams and routine health screenings before every donation. Eighteen (18) analyses certify the safety and quality of the plasma collected.

Grifols does not discriminate on the basis of race, gender or socioeconomic status. The company only accepts healthy donors who are committed to the donation process, have proof of a permanent local residence and meet rigorous health and safety criteria.

CONSUMER RELATIONS: PATIENTS AND HEALTHCARE PROFESSIONALS

The manufacture of medicines and medical devices is regulated. Rigorous legislation, both in Europe and globally, ensures proper patient protection. Furthermore, the company is exceptionally transparent with regard to its interactions with healthcare professionals and healthcare organizations.

Safety and health measures

Grifols has a pharmacovigilance system to monitor adverse reactions from the administration of its plasmaderived medicines and a surveillance system to control adverse reactions arising from the use of its medical devices.

All activities and requirements of the Pharmacovigilance System and Medical Device Surveillance System are described in Grifols Standardized Operating Procedures, which are periodically updated to adapt to current legislation.

Grifols also conducts periodic internal audits on both systems as part of its quality-control compliance framework. These systems are subject to external inspections by the competent health authorities.

Breakdown of its application by division:

DIVISION / AREA TYPE OF PRODUCT PHARMACOVIGILANCE
SYSTEM
MEDICAL DEVICE
SURVEILLANCE SYSTEM
Bioscience Medicines Applicable Not applicable
Diagnostic Medical devices Not applicable Applicable
Hospital Medicines and medical devices Applicable Applicable

Pharmacovigilance system for medications

Pharmacovigilance encompasses all activities related to the detection, evaluation, understanding and prevention of adverse effects or other problems arising from the use of medicinal products. Grifols has a robust and consolidated pharmacovigilance system. Each division has a manager responsible for establishing and maintaining the system. In this role, they also guarantee 24/7 availability to attend health inspections requested by the competent authorities and respond to issues regarding the safety of Grifols' medicines or pharmacovigilance. Grifols complies with all applicable legislation

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Surveillance System for Medical Devices

Manufacturers of medical devices are required to establish and maintain procedures to identify and monitor any adverse effects resulting from the use of these products. The divisions subject to this system each have a trained professional or technical director in charge of its maintenance. Grifols Medical Device Surveillance Systems complies with all legislation in force.

Grifols does not outsource its core Pharmacovigilance or Medical Device Surveillance activities to third parties.

Labels and package leaflets

The information contained in product leaflets and labels complies with the standards and regulations applicable in each country where Grifols' products are marketed, including EU Medicines Directive 2001/83/EC and the U.S. 21 CFR Chapter 1, Subchapters C, D, F.

The possible adverse effects and contraindications described in the leaflets are based on data obtained from clinical studies conducted prior to the product's commercialization. These studies are approved and evaluated by the competent health authorities.

For medical devices, the information contained in the leaflets and labels is established in accordance with the standards and regulations applicable in each country.

The labeling and prospectus also include any mitigating effects identified by risk analyses, carried out in accordance with the application of risk management to medical devices (EN ISO 14971: 2012 Medical Devices), or those requirements communicated by health authorities following the review of the product licensing process.

Claims system

Grifols' three divisions have claims systems established to register and review all notifications received from healthcare centers, patients and users with consumer appraisals regarding possible defects in product quality.

In each division, a trained professional or technical director is appointed to evaluate all claims received, including carrying out the appropriate inquiries and implementing corrective and preventative measures, if necessary.

DIVISION / AREA CLAIMS RECEIVED / NO. OF UNITS PRODUCTS
DISTRIBUTED
Bioscience Division 1 claim for every 34,592 units distributed
(Medicines)
Hospital Division 1 claim for every 1,831,402 units distributed
(Medicines)
Hospital Division
(Medical Devices) 1 claim for every 84,087 units distributed
Diagnostic Division
(Medical Devices) N/A*

*Ratio not applicable for the type of product manufactured by the Diagnostic Division.

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Product Recall System

Each division has a Product Recall System to address confirmed critical defects in the quality or safety of products. The trained individual or technical director is responsible for managing the product withdrawal, including relevant communication with healthcare authorities.

The claims and product withdrawal systems are outlined in the Standard Operating Procedures. The company internally audits them to verify their effectiveness and adaptation to current legislation. In addition, they are inspected by the competent health authorities.

Transparency in interactions with healthcare professionals

Interactions between the healthcare sector and healthcare professionals have an undeniably positive impact to advance patient care and research, creating tangible value and furthering the efforts of everyone involved.

Grifols voluntarily adopted the European Federation of Pharmaceutical Industries and Associations (EFPIA) Disclosure Code in 2015. In 2018, for the third consecutive year, the company disclosed all payments and other transfers of value made in 2017 to healthcare professionals and organizations in 33 European countries, including Spain.

Grifols publishes a Methodology Note, as well as the country-specific reports on transfers of value made by Grifols to healthcare professionals and organizations during 201718. Transfers of value made in 2018 will be published on Grifols' website on July 1, 2019: www.grifols.com.

Although the EFPIA Code applies to medicines, Grifols voluntarily decided to extend this transparency initiative to transfers unrelated to medicines and to its three divisions: Bioscience, Diagnostic and Hospital.

In the U.S., the PPS Act or Open Payment Program Law obliges manufacturers of biological products and medical devices to disclose all the information related to payments and transfers of value made to certain professionals and organizations, including doctors and health professionals and university hospitals.

Grifols applies this transparency policy in the U.S.19 as stipulated by the competent authority (Centers for Medicaid and Medicare Services, or CMS). In addition to the U.S. and Europe, the company plans to implement transparency initiatives in other countries, including Australia and Japan.

COMMUNITY CONTRIBUTIONS AND SPONSORSHIP

"Educate, advocate, engage and support" are the four values that underline Grifols' social engagement, which extends to its diverse stakeholders, including patients, donor communities, medical and scientific communities, clients, employees and local communities.

In 2018, the company allocated EUR 33.3 million toward community outreach initiatives including EUR 2.1 million to the Ebola Project.

In line with Grifols' commitment to patients and patient organizations, the company develops and actively promotes educational, awareness and patient-protection programs and services. It also supports patient advocacy groups through product-donation programs and facilitating access to its treatments. These collaborations adhere to the principles of transparency and country-specific regulations, which define the types of information that must be publicly disclosed.

In 2018, Grifols donated 25 million international units (IU) of factor VIII to the WFH Humanitarian Aid Program as part of its commitment to donate 140 million IU over a five-year timeframe. The donation will

18 Information available at https://www.grifols.com/documents/51507592/51526521/methodology-note-en-2017.pdf/17101a4c-0cf8-4567-be5c-638d5a8ac852

19 Information on transfer of value to healthcare professional in the U.S. in conformity with the Open Payments Program is available at www.cms.gov/OpenPayments/index.html according to local regulations

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provide an average of 10,300 doses to treat 6,000 patients every year until 2021 in emerging markets, where access to adequate treatment is frequently lacking or non-existent.

Grifols' commitment to plasma donors extends to the communities where its centers are located. Plasma centers create added value for communities by generating employment, contributing taxes and stimulating the local economy. Grifols organizes community engagement events and gives back through charitable donations and volunteer programs.

The active involvement of Grifols' workforces in supporting local communities has been extremely significant. Collectively, Grifols' employees have participated in hundreds of initiatives, including collecting supplies for U.S. schools, organizing Open Days and supporting communities affected by Hurricane Florence in North Caroline.

The company also channels its social commitment through its two foundations: Víctor Grífols i Lucas Foundation and the Probitas Foundation.

Detailed information on the scope of Grifols' social engagement initiatives is available on the corporate website in the Corporate Responsibility Report: www.grifols.com

Grifols is member in the following industry associations20:

• FENIN: Federación Española de Empresas de Tecnología Sanitaria

• MedTech Europe: European Trade Association representing the medical technology industries, Diagnosis and Medical Devices manufacturers.

• EURORDIS: non-profit alliance of 826 rare disease patient organisations from 70 countries that work together to improve the lives of the 30 million people living with a rare disease in Europe.

• The United States-Spain Council: an organization in which the US and Spanish leaders promote stronger ties between two countries

• EUCOPE: Trade Association representing Small to Medium-Sized Companies Active in Pharmaceuticals & Medical Technologies in Europe

• PPTA: Plasma Protein Therapeutics Association

• ASEBIO: Asociación Española de Bioempresas

• American Chamber of Commerce in Spain

• AEF: Asociación Española de Farmacología

• AES: Asociación de la Economía de la Salud

• SESPAS: Sociedad Española de Salud Pública y Administración Sanitaria

• SEFH: Sociedad Española de Farmacia Hospitalaria

• SIGRE: Sistema Integrado de Gestión de Residuos de la Industria Farmacéutica

• ISPE: International Society for Pharmaceutical Engineering

• WHC: Wildlife Habitat Council

• ESI: Environmental Stewardship Initiative of the North Carolina Department of Environmental and Natural Resources

• ACS: American Chemical Society

• Farmafluid: Asociación Española de Laboratorios Farmacéuticos de Fluidoterapia y Nutrición Parenteral

• National Health Council (EEUU)

• Biotechnology Innovation Organization (BIO)

• AENE: Asociación Española de Fabricantes y Distribuidores de Productos de Nutrición Enteral

• SENPE: Sociedad Española de Nutrición Parenteral y Enteral

20 It includes the most relevant organizations in which Grifols is a member.

Consolidated Directors' Report

VALUE GENERATION: CREATION AND DISTRIBUTION

Grifols focuses its strategy on long-term profit and value creation. Toward this end, the company strives to create wealth for its various stakeholder groups by generating stable employment opportunities, promoting research, fostering the economic development in regions where it operates, and gaining the trust of stakeholders and investors to guarantee sustainable growth in line with its overriding mission to improve the health of patients.

Grifols' value creation in 2018 reached EUR 4,501.2 million, a 4% increase over the previous year. Nineteen percent (21%) of the value generated was allocated to its global talent pool, which grew by 15% in 2018 to 21,230 employees. Resources channeled to innovation totaled EUR 197.5 million and represent 5% to total generated value, while community investments totaled more than EUR 33,3 million. This figure includes research awards, educational programs and scholarships to promote global research; donations to foundations and NGOs; and a range of social outreach activities aimed at patients and local communities. The company contributed EUR 624.3 million in taxes, which represents 16% of total value generated.

The following tables offer an overview of Grifols' creation and distribution of economic value. As a whole, they highlight the company's efforts to ethically and responsibly manage its resources in strict compliance with the legislation in the countries where it operates:

Thousands of euros 2018
Value generated 4,501.2
Value distributed 4,023.8
Value retained 477.4

Ninety percent (90%) of Grifols' generated value in 2018 was distributed by the company:

Thousands of euros Amount % over total
Remunerations 849.4 21.1%
Tax contributions* 624.3 15.5%
Financial creditors*** 360.2 9.0%
Dividends**** 242.6 6.0%
Community investments 33.3 0.8%
Innovation** 197.5 4.9%
Purchase of raw materials and others 1,716.5 42.7%
TOTAL 4,023.8

* Direct taxes, indirect taxes and taxes collected on behalf of third parties in Spain and the U.S. These include employee income taxes and taxes on shareholder dividends, among others.

** Innovation investments exclude personnel costs recorded in the "Worker retributions" section.

*** Payments to financial creditors include interest and capital.

**** Net dividend paid.

Consolidated Directors' Report

2018 FISCAL OVERVIEW: CONTRIBUTIONS, PRINCIPLES AND BEST PRACTICES

Tax contributions

Grifols upholds its commitment to contributing toward economic, social and industrial development through rigorous compliance with the tax laws in force in each jurisdiction and in line with OECD Guidelines for Multinational Enterprises.

Its diverse operations generate direct and collected taxes that are paid to tax authorities.

The company's direct tax contributions for the 2018 fiscal year totaled approximately EUR 372 million. This amount includes direct taxes such as corporate income tax, social security payments and taxes on products and services, as well as environmental taxes, which are paid in the countries where Grifols operates.

Grifols also contributes by collecting taxes derived from its operations on behalf of governmental authorities. In 2018, the company withhold EUR 252.2 million in third-party taxes, which were paid to the corresponding governmental authorities in the U.S. and Spain. These amounts primarily include income taxes and dividend taxes. Value added tax (VAT) and other taxes are not included in the tax contribution for 2018.

The principles that underpin the group's tax strategy are manifest in its contributions.

Tax contribution by region

Grifols is taxed on the profits generated in the territories where it operates. Spain and the United States account for approximately 70% of the group's global revenues and the main industrial and R+D+i complexes are mainly located in these countries.

Thousands of euros Profit* Taxes paid**
Spain 9.7 1.8
United States 462.3 102.7
Ireland 40.3 14.7
Rest of the world 25.0 8.7

* After-tax profits in 2018 excluding dividends.

** Net tax payable related to fiscal year 2018.

In Spain, during fiscal year 2018, EUR 24 million were refunded as a result of anticipated tax payments above the net tax payable corresponding to previous years.

Grifols Fiscal Policy

  • Business decisions are tied to the payment of required taxes in all jurisdictions where the Group operates. For Grifols, tax compliance is a core element of its Corporate Social Responsibility policy, as well as a pillar of its economic contribution and social commitment.
  • Grifols has no operations in territories qualified as tax havens. Its commercial operations with third parties based in such territories, or any others, are carried out as part of its ordinary industrial or commercial activity.
  • In line with international taxation principles and recommendations by the OECD Committee on Tax Matters, Grifols rejects artificially shifting results to such territories or taking advantage of the information opacity that these territories may offer. Transparency in tax-related matters is a cornerstone of Grifols' tax policy.
  • Grifols' system of internal information and control procedures significantly mitigates fiscal risk.

Consolidated Directors' Report

  • Grifols' tax policy is guided by a reasonable and prudent interpretation of the tax regulations in force in each jurisdiction.
  • The company consults with reputable independent tax advisors before making business decisions that could have a tax impact.
  • Grifols follows a transfer pricing policy for all operations with related parties that aligns with the principles of the main competent international organizations. This policy is reviewed on an annual basis.
  • Grifols understands and supports tax contributions that adequately correlate with the structure and location of its activities, resources, human resources, and materials and business risks assumed.
  • Grifols does not use artificial structures unrelated to its activity to reduce the tax burden or for profit shifting.
  • Grifols fosters a cooperative and fluid relationship with tax authorities based on respect for the law, trust, good faith, reciprocity and cooperation.
  • Grifols collaborates with the competent tax authorities to detect fraud and seek solutions to address fraudulent fiscal practices that may arise in markets where the company operates.
  • In alignment with its commitment to transparency, Grifols does its utmost to provide complete information and documentation requested by tax administrations in the shortest timeframe possible.

On October 26, 2018, the Board of Directors of Grifols adhered to the Code of Good Tax Practices.

PUBLIC GRANTS

Thousands of euros Subsidies
Spain 448.0
United States 1,624.0
Rest of the world 603.0

The grants received in Spain correspond mainly to initiatives related to the training of workers.

BASES FOR THE PREPARATION OF THE NON-FINANCIAL INFORMATION STATEMENT

In compliance with Law 11/2018, of December 28, regarding non-financial information and diversity, Grifols includes its Non-Financial Information Statement (EINF, for its initials in Spanish) in the Consolidated Management Report for the period January 1 to December 31, 2018. This EINF has been prepared taking into account the standards of the Global Reporting Initiative (GRI). For this, Grifols has defined its content taking into account the inclusion of stakeholders, the context of sustainability and the principles of materiality and completeness.

In order to examine Grifols' most significant non-financial aspects, the company performs an annual materiality analysis to identify the most relevant non-financial risks and issues which could impact its stakeholders. The detail on the followed methodology and the results of the materiality analysis are included annually in Grifols' Corporate Responsibility Report. The topics cited by Law 11/2018 of December 28 regarding non-financial information and diversity which the company has identified as material are outlined in the following table.

For the purposes of this consolidated EINF, Grifols S.A. and all its subsidiaries are considered as "Grifols". The reporting scope coincides with that of the financial statement and the consolidated management report taking into account the following considerations:

Consolidated Directors' Report

  • Due to the complexity and global distribution of Grifols' business operations, the scope of some of the non-financial indicators may differ from the established standard. In cases in which reported indicators have exceptions to the scope, these have been adequately identified and reasoned in each case. The selected and reported indicators cover, at least, 90% of the scope.
  • In the section related to environmental issues, all the quantitative data reported by Grifols represents both its production and commercial activity, except for the commercial subsidiaries with less than 10 employees and the acquisitions done after August 2018.

The non-financial indicators selected by Grifols comply with the principles of comparability, materiality, relevance and reliability and the information is accurate, comparable and verified by an independent provider of verification services. The independent assurance report, which includes the objectives and scope of the process, as well as the review procedures used and their conclusions, is attached as an annex to this report.

Consolidated Directors' Report

Law 11/2018 contents Materiality Placement in this report Assurance on law 11/2018 Reporting framework*
Brief description of the contents
group's business model
(business environment and
organization)
Material Grifols' Business Model GRI 102-2
GRI 102-6
General information Geographic presence Material Geographic presence GRI 102-3
GRI 102-4
GRI 102-6
Objectives and strategies of
the organization
Material Grifols' Business Model GRI 103
Main factors and trends that
may affect its future
evolution
Material Risks and uncertainties GRI 102-15
GRI 103
Management approach Material Grifols' General framew
ork for
environmental action
GRI 103
Grifols' General framew
ork for
environmental action
Environmental management Material Evolution and action lines in
2018
GRI 103
Pollution Material Emissions GRI 305-6
GRI 305-7
Circular economy and
w
aste prevention and
Material Waste
Sustainable use of resources
GRI 306-1
GRI 306-2
Environmental issues management
Sustainable use of
resources
Material Sustainable use of resources GRI 301-1
GRI 302-1
GRI 302-4
GRI 303-1 (2016)
GRI 201-2
Climate change Material Emissions GRI 305-1
GRI 305-2
Climate change GRI 305-3
GRI 305-5
Protection of biodiversity No material Not reported because it is a non
material topic for the company.
Not applicable (non-material topic)
Management approach Material Personnel management at
Grifols
GRI 103
Personnel management at
Grifols
Grifols' w
orkforce
Gender Pay Gap
Average w
age by category
and gender
GRI 102-8
GRI 103
Employment Material Average w
age by age
GRI 201-3
Average retribution of board GRI 405-1
members and executives by
gender
GRI 405-2
Contributions to long-term
savings systems
Absenteeism
Social and employee related issues Work organization and w
ork-life
GRI 103
Work organization Material balance
Collective labor relations
GRI 403-2 (2016)
Health & safety Material Health and safety GRI 103
GRI 403-2 (2016)
GRI 403-3 (2016)
Social relations Material Work organization and w
ork-life
GRI 103
GRI 102-41
balance GRI 102-43
Training Material Professional development and
training
GRI 103
GRI 404-1
Diversity includes labor
Universal accessibility for
people w
ith disabilities
Material integration of persons w
ith
disabilities
GRI 103
Diversity, inclusion, equal GRI 103
Equality Material opportunity and non
discrimination: core aspects
GRI 405-1
GRI 406-1
Management approach No material Human Rights GRI 103
Respect for human rights Human Rights No material Human Rights GRI 102-16
GRI 102-17
GRI 103
Management approach Material Combatting corruption and
bribery
GRI 103
Fight against corruption and bribery Combatting corruption and GRI 102-16
Corruption and bribery Material bribery
Community contributions and
GRI 102-17
GRI 103
Management approach Material sponsorship
Social commitment
GRI 205-1
GRI 103
Company's commitment w
ith
Community contributions and GRI 102-43
sustainable development Material sponsorship GRI 103
GRI 413-1
Subcontracting and Material Supplier relations GRI 102-9
suppliers GRI 103
GRI 103
Information related to society Consumers Material Consumer relations: patients
and healthcare professionals
GRI 416-1
GRI 416-2
Fiscal overview
: contributions,
principles and best practices
Fiscal information Material 2018 GRI 103
GRI 201-4
Public grants

Index of contents required by Law 11/2018, of December 28, regarding non-financial information and diversity.

* In the case in which the GRI standard or GRI specific content does not cover the entire Law 11/2018 requirement, the reporting criteria selected by Grifols has been followed in order to comply with the provisions of the aforementioned Law.

Consolidated Directors' Report

7.- TREASURY STOCK

The operations carried out in 2018 with treasury stock are described in the annual accounts included as an annex to this report.

8.- SUBSEQUENT EVENTS

No relevant subsequent events took place after the year-end 2018.

9.- FORESEEABLE DEVELOPMENTS OF THE GROUP

Raimon Grífols Roura and Víctor Grífols Deu concluded their second year as co-CEOs, building on the track record of solid growth and consolidation as a diversified and profitable firm.

True to its mission, Grifols aspires to grow and evolve as a global company capable of leveraging its wealth of collective knowledge and innovative spirit to improve patient care and support healthcare professionals. To reach this overriding objective, the company centers its efforts on business optimization, globalization, innovation, digitalization, talent development, and outstanding customer service.

The company is committed to a path of sustainable growth. The cornerstones of its five-year strategic plan are innovation, to continue developing a differential product portfolio; enhanced customer centricity, to successfully address the evolving needs of global healthcare professionals and patients; global expansion, especially in the U.S. as a key market and emerging markets like China; corporate growth, via organic growth and corporate transactions amid in an increasingly competitive market; a robust human resources strategy focused on employee retention, talent development and on-going training; and promotion of the "One Grifols" philosophy to cultivate the continuous quest for knowledge and innovation through value-creating activities and transversal teams.

More details on the trends and opportunities of the company's diverse business areas and divisions may be found in "Non-Financial Information Statement" as part of the 2018 Consolidated Directors' Report.

10.- ANNUAL CORPORATE GOVERNANCE REPORT

The Grifols 2018 Annual Corporate Governance Report forms part of this Consolidated Directors' Report. From the date of publication of Grifols' consolidated financial statements, it is available on Grifols' corporate website and the Comisión Nacional del Mercado de Valores (Spanish Stock Exchange Commission) website.

Section E of the aforementioned report includes an analysis of the company's risk controls and management systems, and section F includes details of the internal control and risk management systems in relation to the financial information issuing process ("SCIIF").

Consolidated Directors' Report

ANNEX - NON-GAAP MEASURES RECONCILIATION

Reconciliation between recurring and reported Income Statement

In thousands of euros 2018 2017(1) % Var
NET REVENUES 4,486,724 4,318,073 3.9%
COST OF SALES (2,437,164) (2,164,762) 12.6%
GROSS MARGIN 2,049,560 2,153,311 (4.8%)
% Net revenues 45.7% 49.9%
R&D (240,661) (223,742) 7.6%
SG&A (814,775) (839,480) (2.9%)
OPERATING EXPENSES (1,055,436) (1,063,222) (0.7%)
OPERATING RESULT (EBIT) 994,124 1,090,089 (8.8%)
% Net revenues 22.2% 25.2%
FINANCIAL RESULT (257,244) (269,251) (4.5%)
SHARE OF RESULTS OF EQUITY ACCOUNTED INVESTEES (11,038) (14,051) (21.4%)
PROFIT BEFORE TAX 725,842 806,787 (10.0%)
% Net revenues 16.2% 18.7%
INCOME TAX EXPENSE (131,436) (220,236) (40.3%)
% of pre-tax income 18.1% 27.3%
CONSOLIDATED PROFIT 594,406 586,551 1.3%
RESULT ATTRIBUTABLE TO NON-CONTROLLING INTERESTS (2,236) (1,386) 61.3%
GROUP PROFIT 596,642 587,937 1.5%
% Net revenues 13.3% 13.6%
NON-RECURRING ITEMS
Non-recurring items related to the Hologic acquisition - (22,168)
Non-recurring items related to the Aradigm assets reassessment - (88,897)
Non-recurring items related to the U.S. tax reform and tax related to other
non-recurring items - 185,828
REPORTED GROUP PROFIT 596,642 662,700 (10.0%)

(1) Relates to the "2017 Recurrent P&L". The details of the non-recurrent items are disclosed below.

Consolidated Directors' Report

Net revenues reported by division at constant currency

In thousands of euros 12M 2018 12M 2017 % Var
REPORTED NET REVENUES 4,486,724 4,318,073 3.9%
VARIATION DUE TO EXCHANGE RATE EFFECTS 226,534
NET REVENUES AT CONSTANT CURRENCY 4,713,258 4,318,073 9.2%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED BIOSCIENCE NET REVENUES 3,516,704 3,429,785 2.5%
VARIATION DUE TO EXCHANGE RATE EFFECTS 186,084
REPORTED BIOSCIENCE NET REVENUES AT CONSTANT CURRENCY 3,702,788 3,429,785 8.0%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED DIAGNOSTIC NET REVENUES 702,265 732,369 (4.1%)
VARIATION DUE TO EXCHANGE RATE EFFECTS 35,079
REPORTED DIAGNOSTIC NET REVENUES AT CONSTANT CURRENCY 737,344 732,369 0.7%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED HOSPITAL NET REVENUES 119,454 105,649 13.1%
VARIATION DUE TO EXCHANGE RATE EFFECTS 3,137
REPORTED HOSPITAL NET REVENUES AT CONSTANT CURRENCY 122,591 105,649 16.0%
In thousands of euros
12M 2018 12M 2017 % Var
REPORTED BIO SUPPLIES NET REVENUES 167,004 66,791 150.0%
VARIATION DUE TO EXCHANGE RATE EFFECTS 3,272
REPORTED BIO SUPPLIES NET REVENUES AT CONSTANT CURRENCY 170,276 66,791 154.9%
In thousands of euros
12M 2018 12M 2017 % Var
REPORTED OTHERS NET REVENUES 22,451 18,263 22.9%
VARIATION DUE TO EXCHANGE RATE EFFECTS
REPORTED OTHERS NET REVENUES AT CONSTANT CURRENCY
1,226
23,677
18,263 29.6%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED INTERSEGMENTS NET REVENUES (41,154) (34,784) 18.3%
VARIATION DUE TO EXCHANGE RATE EFFECTS (2,264)

Consolidated Directors' Report

Net revenues reported by region at constant currency

In thousands of euros 12M 2018 12M 2017 % Var
REPORTED U.S. + CANADA NET REVENUES 2,974,429 2,896,505 2.7%
VARIATION DUE TO EXCHANGE RATE EFFECTS 173,578
U.S. + CANADA NET REVENUES AT CONSTANT CURRENCY 3,148,007 2,896,505 8.7%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED EU NET REVENUES 800,274 686,983 16.5%
VARIATION DUE TO EXCHANGE RATE EFFECTS 1,119
EU NET REVENUES AT CONSTANT CURRENCY 801,393 686,983 16.7%
In thousands of euros 12M 2018 12M 2017 % Var
REPORTED ROW NET REVENUES 712,021 734,585 (3.1%)
VARIATION DUE TO EXCHANGE RATE EFFECTS 51,837
ROW NET REVENUES AT CONSTANT CURRENCY 763,858 734,585 4.0%

Reconciliation of other figures

In millions of euros 12M 2018 12M 2017 % Var
R&D RECURRENT EXPENSES IN P&L 240.6 223.2
R&D CAPITALIZED 55.4 43.3
R&D DEPRECIATION & AMORTIZATION & WRITE OFFS (19.8) (14.7)
R&D CAPEX FIXED ASSETS 4.9 3.4
R&D EXTERNAL 10.3 11.0
R&D NET INVESTMENT 291.4 266.2 9.5%
In thousands of euros 12M 2018 12M 2017 % Var
PP&E ADDITIONS 240,938 260,347
SOFTWARE ADDITIONS 20,252 19,626
INTEREST CAPITALIZED (8,955) (8,839)
CAPEX 252,235 271,134 (7.0%)
In millions of euros except ratio 12M 2018 12M 2017
NET FINANCIAL DEBT 5,343.1 5,170.4
EBITDA EXCL. NON-RECURRING ITEMS 1,236.0 1,305.6
NET LEVERAGE RATIO 4.32 x 3.96 x

Consolidated Directors' Report

In thousands of euros 12M 2018 12M 2017 % Var
EBIT REPORTED 994,124 1,003,343
D&A 228,609 215,490
NON-RECURRING ITEMS(1) 13,243 86,746
EBITDA EXCL. NON-RECURRING ITEMS 1,235,976 1,305,579 (5.3%)

(1) Non-recurring items related to acquisitions; the Aradigm assets reassessment and the U.S. tax reform and tax related to other nonrecurring items in 2017

In thousands of euros 12M 2018 12M 2017 % Var
EBIT REPORTED 994,124 1,003,343 (0.9%)
D&A 228,609 215,490
IMPACT OF PLASMA SOLD TO THIRD PARTIES (4,323) -
EBITDA UNDERLYING 1,218,410 1,218,833 (0.0%)
% Net revenues 27.7% 28.2%

52

KPMG Asesores, S.L. Torre Realia Plaça d'Europa, 41-43 08908 L'Hospitalet de Llobregat Barcelona

Independent Assurance Report on the Consolidated Non-Financial Information Statement of Grifols, S.A. and its Subsidiaries for the year 2018

(Free translation from the original in Spanish. In case of discrepancy, the Spanish language version prevails.)

To the shareholders of Grifols, S.A.:

Pursuant to article 49 of the Spanish Code of Commerce, we have provided limited assurance on the consolidated Non-Financial Information Statement (hereinafter NFIS) for the year ended 31 December 2018, of Grifols S.A. (hereinafter the Parent Company) and its subsidiaries (hereinafter the Group) which forms part of the Group's 2018 consolidated Directors' Report.

The contents of the consolidated Directors' Report includes additional information to that required by prevailing mercantile legislation on non-financial information which it is not possible to provide assurance. In this regard, our assurance work was limited only to providing assurance on the information contained in table "Index of contents required by Law 11/2018, of December 28, regarding non-financial information and diversity".

Directors' responsibilities _________________________________________________

The Parent Company's Board of Directors is responsible for the preparation and presentation of the NFIS included in the Group's Consolidated Directors' Report. The NFIS has been prepared in accordance with prevailing mercantile legislation and selected Sustainability Reporting Standards of the Global Reporting Initiative (GRI Standards), in accordance with that mentioned for each subject area in table "Index of contents required by Law 11/2018, of December 28, regarding non-financial information and diversity" of said Consolidated Directors' Report.

This responsibility also encompasses the design, implementation and maintenance of internal control deemed necessary to ensure that the NFIS is free from material misstatement, whether due to fraud or error.

The Parent Company's Directors are also responsible for defining, implementing, adapting and maintaining the management systems from which the information necessary for preparing the NFIS was obtained.

Our independence and quality control _____________________________________

We have complied with the independence and other ethical requirements of the Code of Ethics for Professional Accountants issued by the International Ethics Standards Board for Accountants (IESBA), which is founded on fundamental principles of integrity, objectivity, professional competence and due care, confidentiality and professional behaviour.

Our firm applies International Standard on Quality Control 1 (ISQC1) and accordingly maintains a comprehensive system of quality control including documented policies and procedures regarding compliance with ethical requirements, professional standards and applicable legal and regulatory requirements.

The engagement team was comprised of professionals specialised in reviews of non-financial information and, specifically, in information on economic, social and environmental performance.

Our responsibility ________________________________________________________

Our responsibility is to express our conclusions in an independent limited assurance report based on the work performed that refers exclusively to the year 2018. The data for previous years were not subject to the assurance foreseen in the mercantile legislation in force.

We conducted our review engagement in accordance with International Standard on Assurance Engagements, "Assurance Engagements other than Audits or Reviews of Historical Financial Information" (ISAE 3000), issued by the International Auditing and Assurance Standards Board (IAASB) of the International Federation of Accountants (IFAC) and with the Performance Guide on assurance engagements on the Non-Financial Information Statement issued by the Spanish Institute of Registered Auditors (ICJCE).

The procedures performed in a limited assurance engagement vary in nature and timing from, and are less in extent than for, a reasonable assurance engagement, and consequently, the level of assurance provided is also lower.

Our work consisted of making inquiries of management, as well as of the different units and responsible areas of the Group that participated in the preparation of the NFIS, in the review of the processes for compiling and validating the information presented in the NFIS and in the application of certain analytical procedures and sample review testing described below:

  • Meetings with the Group's personnel to gain an understanding of the business model, policies and management approaches applied, the principal risks related to these questions and to obtain the information necessary for the external review.
  • Analysis of the scope, relevance and completeness of the content of the NFIS based on the materiality analysis performed by the Group and described in the section "Bases for the preparation of the non-financial information statement", and considering the content required in prevailing mercantile legislation.
  • Analysis of the processes for compiling and validating the data presented in the Non-Financial Information Statement for 2018.
  • Review of the information relative to the risks, policies and management approaches applied in relation to the material aspects presented in the NFIS.

  • Corroboration, through sample testing, of the information relative to the content of the NFIS for 2018 and whether it has been adequately compiled based on data provided by internal and external information sources or third party reports.

  • Procurement of a representation letter from the Directors and management.

Conclusion _______________________________________________________________

Based on the assurance procedures performed and the evidence obtained, nothing has come to our attention that causes us to believe that the NFIS of Grifols, S.A. and its subsidiaries for the year ended 31 December 2018 has not been prepared, in all material respects, in accordance with prevailing mercantile legislation and the content of the selected GRI Standards, in accordance with that mentioned for each subject area in the table "Index of contents required by Law 11/2018, of December 28, regarding non-financial information and diversity" included in the Consolidated Directors' Report.

Use and distribution ______________________________________________________

This report has been prepared in response to the requirement established in prevailing mercantile legislation in Spain, and thus may not be suitable for other purposes and jurisdictions.

KPMG Asesores, S.L.

(Signed)

Patricia Reverter Guillot 27 February 2019

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

At their meeting held on 22 February 2019, pursuant to legal requirements, the Directors of Grifols, S.A. authorised for issue the consolidated annual accounts and consolidated directors' report for the period from 1 January 2018 to 31 December 2018. The consolidated annual accounts comprise the documents that precede this certification.

Victor Grifols Roura
(signed)
Raimon Grifols Roura
(signed)
Víctor Grifols Deu
(signed)
President –
Board
member
Chief Executive Officer Chief Executive Officer
Carina Szpilka Lázaro Tomás Dagà Gelabert Thomas Glanzmann
(signed) (signed) (signed)
Board member Board member Vice-Chairman
Iñigo Sánchez-Asiaín Anna Veiga Lluch Luis Isasi Fernández de
Mardone
(*)
(signed) Bobadilla
(signed)
Board member Board member Board member
Steven F. Mayer Belen Villalonga
Morenés
Marla E. Salmon
(signed) (signed) (signed)
Board member Board member Board member
Ramón Riera
Roca
Nuria Martín Barnés
(signed) (signed)
Board Member Secretary to the Board

(*) Absent on a business trip, attended the meeting by conference call and did not express any disconformity with the documentation.

Recoverable Amount of Investments in Group Companies
See notes 4 and 12 to the annual accounts
Key Audit Matters How the Matter was Addressed in Our Audit
As described in the notes to the annual
accounts, at 31 December 2018 the
Company has recognised non-current
investments in Group companies and
associates totalling Euros 3,270,828
thousand. The Company performs an
annual assessment of the existence of
objective evidence of impairment of
investments in Group companies and
estimates the recoverable amount at
reporting date of those entities for which
objective evidence of impairment exist.
The recoverable amount of these
investments is determined by applying
valuation techniques that require the
Directors' judgement and the use of
assumptions and estimates. Due to the
uncertainty and judgement associated
with these assumptions and estimates,
as well as the significance of the carrying
amount of the investments in Group
companies, we have considered this
valuation as a key audit matter.
Our audit procedures comprised the following:
assessing the design and implementation of
$\bullet$
key controls established by the Company with
respect to the process of estimating the
recoverable amount of investments in Group
companies,
the evaluation of criteria used by the Company
$\bullet$
to assess the existence of objective evidence
of impairment of the value of investments in
Group companies identified by the Company.
assessing the reasonableness of the
$\bullet$
methodology and assumptions used by the
Company in estimating the recoverable amount
of investments in Group companies, in
collaboration with our valuation specialists. We
have compared the cash flow forecasts
estimated in prior years with actual flows
obtained by the investees. We have also
performed an analysis of the sensitivity of the
estimates of recoverable amount to relevant
assumptions and judgements, such as the
discount rate, expected future growth rate and
future cash flows.
We have also assessed whether the disclosures
in the annual accounts meet requirements of the
financial reporting framework applicable to the
Company.

Annual Accounts and Directors' Report for the year

31 December 2018

(With Independent Auditor's Report Thereon)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Balance Sheets

31 December 2018 and 2017

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Assets Note 2018 2017
Intangible assets Note 5 14,534,419 12,911,968
Computer softw are 14,534,419 12,911,968
Property, plant and equipment Note 6 22,894,137 19,194,743
Technical installations, machinery,
equipment, furniture and other items 16,526,040 11,656,861
Under construction and advances 6,368,097 7,537,882
Investment property Note 7 54,820,824 56,602,713
Land 7,465,344 7,465,344
Buildings 40,723,584 36,184,109
Investments in adaptation and advances 6,631,896 12,953,260
Non-current investments in Group
companies and associates 4,864,254,923 4,872,893,986
Equity instruments Note 12 3,270,828,231 3,124,452,858
Loans to companies Note 14 1,593,426,692 1,748,441,128
Non-current investments Note 14 1,622,650 1,608,091
Other financial assets 1,622,650 1,608,091
Deferred tax assets Note 21 13,996,465 10,936,470
Total non-current assets 4,972,123,418 4,974,147,971
Inventories 6,223,503 5,216,392
Raw materials and other supplies 6,223,503 5,216,392
Trade and other receivables Note 14 58,285,542 75,412,980
Trade receivables – current 874,963 1,005,160
Trade receivables from Group companies Note 23 19,526,804 19,485,499
and associates – current
Other receivables 378,527 352,704
Personnel 173,455 117,449
Current tax assets Note 21 25,911,844 48,155,917
Public entities, other Note 21 11,419,949 6,296,251
Current investments in Group
companies and associates
Note 14 91,209,026 97,473,673
Loans to companies 91,209,026 22,474,552
Other financial assets -- 74,999,121
Current investments Note 14 4,306 16,033
Other financial assets 4,306 16,033
Prepayments for current assets Note 15 6,360,153 6,048,768
Cash and cash equivalents 2,432,907 8,948,352
Cash 2,432,907 8,948,352
Total current assets 164,515,437 193,116,198
Total assets 5,136,638,855 5,167,264,169

Balance Sheets

31 December 2018 and 2017

(Expressed in Euros)

Equity and Liabilities Note 2018 2017
Capital and reserves Note 16 1,719,323,992 1,582,702,913
Capital
Registered capital 119,603,705 119,603,705
Share premium 910,727,619 910,727,619
Reserves
Legal and statutory reserves 23,920,741 23,920,741
Other reserves 514,890,169 358,660,877
(Treasury stock and equity holdings) (55,441,210) (62,422,309)
Profit for the year 329,718,263 341,327,404
(Interim dividend) (136,747,291) (122,986,278)
Other equity instruments 12,651,996 13,871,154
Grants, donations and bequests
received 112,549 123,265
Total equity 1,719,436,541 1,582,826,178
Non-current payables Note 19 1,739,694,842 1,679,299,634
Promissory notes 987,249,676 985,248,207
Loans and borrow ings 747,069,488 690,441,900
Finance lease payables Note 8 2,496,750 1,861,931
Other financial liabilities 2,878,928 1,747,596
Group companies and associates, Note 19 1,512,716,087 1,790,682,269
non-current
Deferred tax liabilities
Note 21 1,691,193 1,859,414
Total non-current liabilities 3,254,102,122 3,471,841,317
Current payables Note 19 39,800,087 17,569,839
Promissory notes 5,333,333 5,244,444
Loans and borrow ings 31,296,281 4,653,935
Finance lease payables Note 8 1,119,117 1,071,228
Other financial liabilities 2,051,356 6,600,232
Group companies and associates,
current
Note 19 39,766,089 19,907,750
Trade and other payables Note 19 83,534,016 75,119,085
Current payables to suppliers 42,530,365 39,404,813
Suppliers, Group companies and
associates, current Note 23 8,032,244 5,290,662
Personnel (salaries payable) 10,100,816 9,872,640
Public entities, other Note 21 22,870,591 20,550,970
Total current liabilities 163,100,192 112,596,674
Total equity and liabilities 5,136,638,855 5,167,264,169

Statements of Changes in Equity for the years ended 31 December 2018 and 2017

A) Statements of Recognised Income and Expense for the years ended 31 December 2018 and 2017

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Note 2018 2017
Revenues 647,280,993 590,907,263
Services rendered Note 24 116,197,231 111,327,946
Finance income Note 13 and
23
52,115,757 39,070,699
Dividends 478,968,005 440,508,618
Self-constructed assets 2,198,881 4,719,071
Supplies (2,614,325) (2,357,003)
Raw materials and consumables used Note 24 (2,577,734) (2,469,572)
Subcontracted w ork (766) --
Impairment of merchandise, raw materials and
other supplies
(35,825) 112,569
Other operating income 6,623,910 6,629,640
Non-trading and other operating income 6,466,963 6,464,412
Operating grants taken to income 156,947 165,228
Personnel expenses (61,889,453) (56,966,231)
Salaries and w ages (50,556,677) (46,867,614)
Employee benefits expense Note 24 (11,105,836) (9,931,996)
Provisions (226,940) (166,621)
Other operating expenses (127,386,959) (122,344,136)
External services (126,486,261) (120,778,366)
Taxes (228,873) (267,109)
Other operating expenses (671,825) (1,298,661)
Amortisation and depreciation Notes 5, 6
and 7
(13,065,662) (12,793,942)
Non-financial and other capital grants 14,289 14,289
Impairment and gains/(losses) on disposal
of fixed assets
(26,248,587) (674,446)
Impairment and losses Note 12 (26,039,347) (674,446)
Gains/(losses) on disposal and other Note 7 (209,240) --
Results from operating activities 424,913,087 407,134,505
Finance income 360,023 412,522
Other third parties Note 13 3,122 2,913
Capitalised borrow ing costs Note 6 356,901 409,609
Finance costs Note 18 (137,809,892) (103,637,249)
Group companies and associates
Other third parties
Note 23 (86,972,977)
(50,836,915)
(77,098,571)
(26,538,678)
Notes 14 and
Exchange losses 19 (712,374) 1,402,235
Net finance cost (138,162,243) (101,822,492)
Profit before income tax 286,750,844 305,312,013
Income tax Note 21 42,967,419 36,015,391
Profit for the year 329,718,263 341,327,404

Statements of Changes in Equity for the years ended 31 December 2018 and 2017

A) Statements of Recognised Income and Expense for the years ended 31 December 2018 and 2017

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Note 2018 2017
Profit for the year 329,718,263 341,327,404
Income and expense recognised directly in
equity
Grants, donations and bequests
Tax effect
--
--
--
--
Total income and expense recognised directly in
equity
-- --
Amounts transferred to the income
statement
Grants, donations and bequests
Tax effect
(14,289)
3,573
(14,289)
3,573
Total amounts transferred to the income
statement
(10,716) (10,716)
Total recognised income and expense 329,707,547 341,316,688

Statements of Changes in Equity for the years ended 31 December 2018 and 2017

B) Statement of Total Changes in Equity for the year ended 31 December 2018

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Registered
capital
Share
premium
Reserves Treasury
stock
Profit for the
year
Interim
dividend
Other equity
instruments
Grants,
donations
and
bequests
received
Total
Balance at 31 December 2017 119,603,705 910,727,619 382,581,618 (62,422,309) 341,327,404 (122,986,278) 13,871,154 123,265 1,582,826,178
Recognised income and expense -- -- -- -- 329,718,263 -- -- (10,716) 329,707,547
Transactions w ith shareholders or
ow ners
Net movement in treasury stock -- -- -- 6,981,099 -- -- -- -- 6,981,099
Interim dividend -- -- -- -- -- (136,747,291) -- -- (136,747,291)
Restricted share plan -- -- (318,879) -- -- -- (1,219,158) -- (1,538,037)
Other movements -- -- 80,301,167 -- -- -- -- -- 80,301,167
Distribution of profit/(Application of
loss) for the period 2017
Reserves -- -- 76,247,004 -- (76,247,004) -- -- -- --
Dividends -- -- -- -- (265,080,400) 122,986,278 -- -- (142,094,122)
--
Balance at 31 December 2018 119,603,705 910,727,619 538,810,910 (55,441,210) 329,718,263 (136,747,291) 12,651,996 112,549 1,719,436,541

Statements of Changes in Equity for the years ended 31 December 2018 and 2017

B) Statement of Total Changes in Equity for the year ended 31 December 2017

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Registered
capital
Share
premium
Reserves Treasury
stock
Profit for the
year
Interim
dividend
Other equity
instruments
Grants,
donations
and
bequests
received
Total
Balance at 31 December 2016 119,603,705 910,727,619 278,879,344 (68,710,268) 321,792,932 (122,908,351) 7,945,464 133,981 1,447,464,426
Recognised income and expense -- -- -- -- 341,327,404 -- -- (10,716) 341,316,688
Transactions w ith shareholders or
ow ners
Net movement in treasury stock -- -- -- 6,287,959 -- -- -- -- 6,287,959
Interim dividend -- -- -- -- -- (122,986,278) -- -- (122,986,278)
Restricted share plan -- -- -- -- -- -- 5,925,690 -- 5,925,690
Other movements -- -- 91,742 -- -- -- -- -- 91,742
Distribution of profit/(Application of
loss) for the period 2016
Reserves -- -- 103,610,532 -- (103,610,532) -- -- -- --
Dividends -- -- -- -- (218,182,400) 122,908,351 -- -- (95,274,049)
Balance at 31 December 2017 119,603,705 910,727,619 382,581,618 (62,422,309) 341,327,404 (122,986,278) 13,871,154 123,265 --
1,582,826,178

Statements of Cash Flows for the years ended 31 December 2018 and 2017

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

2018 2017
Cash flows from operating activities
Profit for the year before tax 286,750,844 305,312,013
Adjustments for:
Dividend income (478,968,005) (440,508,618)
Impairment 26,039,347 674,446
Amortisation and depreciation 13,065,662 12,793,942
Finance income (52,472,658) (39,483,221)
Finance costs 110,257,698 102,908,118
Change in fair value of financial instruments 209,240 --
Other income and expenses 1,245,155 1,535,603
Changes in operating assets and liabilities
Inventories (1,007,111) (663,201)
Trade and other receivables 7,063 (5,194,213)
Other current assets (311,385) 295,942
Trade and other payables 6,523,628 14,834,285
Other current assets and liabilities 1,239,165 37,077
Other cash flows from operating activities
Interest paid (98,145,695) (93,812,559)
Dividends received 401,693,670 365,509,497
Interest received 52,060,671 38,947,344
Income tax paid (received) 57,737,477 56,129,584
Cash flows from operating activities 325,924,766 319,316,039
Cash flows from investing activities
Payments for investments
Group companies and associates (28,195,954) (1,349,494,019)
Intangible assets (6,941,270) (7,815,892)
Property, plant and equipment (9,694,395) (8,122,575)
Investment property -- (5,618,263)
Other financial assets (14,561) (16,850)
Proceeds from sale of investments
Group companies and associates 177,704 --
Other financial assets 11,727 8,715
Cash flows used in investing activities (44,656,749) (1,371,058,884)
Cash flows from financing activities
Proceeds from and payments for financial liability instruments
Disposal
Promissory notes -- 1,000,000,000
Loans and borrow ings 83,004,887 686,761,564
Group companies and associates (91,946,935) (392,437,491)
Financing costs included on the amortised costs of the debt -- (28,075,862)
Dividends and interest on other equity instruments paid
Dividends (278,841,414) (218,260,327)
Cash flows from/(used in) financing activities (287,783,462) 1,047,987,884
Net decrease in cash and cash equivalents (6,515,445) (3,754,961)
Cash and cash equivalents at beginning of year 8,948,352 12,703,313
Cash and cash equivalents at year end 2,432,907 8,948,352

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(1) Nature and Activities of the Company and Composition of the Group

Grifols, S.A. (hereinafter the Company) was incorporated with limited liability under Spanish law on 22 June 1987. Its registered office is in Barcelona. The Company's statutory activity consists of providing corporate and business administrative, management and control services, as well as investing in assets and property. Its principal activity involves rendering administrative, management and control services to its subsidiaries.

Its main facilities are located in Sant Cugat del Vallés (Barcelona) and Parets del Vallés (Barcelona).

Grifols, S.A.'s shares are listed on the Barcelona, Madrid, Valencia and Bilbao stock exchanges and on the electronic stock market. As of 2 June 2011 the class B non-voting shares were listed on the NASDAQ (USA) and the Automated Quotation System (SIBE/Continuous Market).

In accordance with prevailing legislation, the Company is the Parent of a Group comprising the Company and the subsidiaries listed in note 12. In accordance with generally accepted accounting principles in Spain, consolidated annual accounts must be prepared to give a true and fair view of the financial position of the Group, the results of operations and changes in its equity and cash flows. Details of investments in Group companies are provided in Appendix XV.

On 22 February 2019 the Company's board of directors authorised for issue the consolidated annual accounts of Grifols, S.A. and subsidiaries for 2018 prepared in accordance with International Financial Reporting Standards as adopted by the European Union (IFRS-EU), which show consolidated profit attributable to the Parent of Euros 596,642 thousand, total assets 12,477,046 thousand and consolidated equity of Euros 4,696,604 thousand (Euros 662,700 thousand, Euros 10,920,264 thousand and Euros 3,633,965 thousand, respectively, in 2017).

(2) Basis of Presentation

(a) True and fair view

The accompanying annual accounts have been prepared on the basis of the accounting records of Grifols, S.A. The annual accounts for 2018 have been prepared in accordance with prevailing legislation and the Spanish General Chart of Accounts to give a true and fair view of the equity and financial position of the Company at 31 December 2018 and results of operations, changes in equity, and cash flows for the year then ended.

The directors consider that the annual accounts for 2018, authorised for issue on 22 February 2019, will be approved with no changes by the shareholders at their annual general meeting.

(b) Comparative information

The balance sheet, income statement, statement of changes in equity, statement of cash flows and the notes thereto for 2018 include comparative figures for 2017, which formed part of the annual accounts approved by shareholders at the annual general meeting held on 25 May 2018.

(c) Functional and presentation currency

The figures disclosed in the annual accounts are presented in Euros, the Company's functional and presentation currency, rounded off to the nearest Euro.

(d) Critical issues regarding the valuation and estimation of relevant uncertainties and judgements used when applying accounting principles.

Relevant accounting estimates and judgements and other estimates and assumptions have to be made when applying the Company's accounting principles to prepare the annual accounts. A summary of the items requiring a greater degree of judgement or which are more complex, or where the assumptions and estimates made are significant to the preparation of the annual accounts, is as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(i) Relevant accounting estimates and assumptions

The Company tests investments in Group companies for impairment on an annual basis when the net value of the investment exceeds the carrying amount of the subsidiary and where indications of impairment exist. Fair value of the investment used as recoverable value is measured based on estimates made by management. The Company generally uses cash flow discounting methods to calculate this value. Cash flow discounting calculations are based on the 5-year projections of the budgets approved by management. The cash flows take into consideration past experience and represent management's best estimate of future market performance. From the fifth year cash flows are extrapolated using individual growth rates. The key assumptions employed to calculate the fair value include growth rates and the discount rate. The estimates, including the methodology used, could have a significant impact on values and impairment.

(ii) Changes in accounting estimates

Although estimates are calculated by the Company's directors based on the best information available at 31 December 2018, future events may require changes to these estimates in subsequent years. Any effect on the annual accounts of adjustments to be made in subsequent years would be recognised prospectively. Grifols, S.A. management does not consider that there are any assumptions or sources of uncertainty that would have a significant risk of resulting in a material adjustment within the next financial year.

(3) Distribution of Profit

The distribution of profit and reserves of the Company for the year ended 31 December 2017, approved by the shareholders at their annual general meeting held on 25 May 2018, is as follows:

2017

Euros
Basis of allocation
Profit for the year 341,327,404
Distribution
Voluntary reserve 76,247,004
Mandatory preferred dividend on Class B shares 2,614,251
Dividends 262,466,149
341,327,404

At the general meeting held on 25 May 2018, the shareholders of Grifols, S.A. approved the distribution of a mandatory preferred dividend of Euros 0.01 for every Class B share, for a total amount of Euros 2,614,251.

On 26 October 2018 the Company's board of directors approved the distribution of an interim dividend of Euros 0.20 for every class A and B share with a charge to the 2018 income statement, totalling Euros 136,747 thousand, payable on 4 December 2018. The amount distributed did not exceed the profits reported by the Company since the end of the previous reporting period, after deducting the estimated income tax payable on these profits, as required by article 277 of the revised Spanish Companies Act. The provisional accounting statement prepared in accordance with statutory requirements demonstrating that sufficient cash was available for distribution of the aforementioned dividend is provided in Appendix XlV.

The proposed distribution of profit for the year ended 31 December 2018 to be submitted to the shareholders for approval at their annual general meeting is as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

2018

Euros
Basis of allocation
Profit for the year 329,718,263
Distribution
Voluntary reserve 91,059,463
Mandatory preferred dividend on Class B shares 2,614,251
Dividends 236,044,549
329,718,263

At 31 December 2018 and 2017 non-distributable reserves are as follows:

2018 2017
Non-distributable reserves
Legal reserve 23,920,741 23,920,741
Other 3,020 3,020
23,923,761 23,923,761

Profit recognised directly in equity cannot be distributed, either directly or indirectly.

(4) Significant Accounting Policies

(a) Business combinations

As the Company applied the third transitional provision of Royal Decree 1514/2007, only those business combinations that occurred on or after 1 January 2008, the date of transition to the Spanish General Chart of Accounts, have been recognised using the acquisition method. Business combinations that occurred prior to that date were recognised in accordance with accounting principles prevailing at that time, taking into account the necessary corrections and adjustments at the transition date.

Business combinations carried out since 1 January 2010 are recognised by applying the acquisition method established in Recognition and Measurement Standard 19 of the Spanish General Chart of Accounts amended by article 4 of Royal Decree 1159/2010, which approves the standards for the preparation of consolidated annual accounts and amends the Spanish General Chart of Accounts.

The Company applies the acquisition method for business combinations, except for mergers, spin-offs and nonmonetary contributions of a business between group entities.

The acquisition date is the date on which the Company obtains control of the acquiree.

The cost of the business combination is calculated as the sum of the acquisition-date fair values of the assets transferred, the liabilities incurred or assumed, the equity instruments issued and any consideration contingent on future events or compliance with certain conditions in exchange for control of the acquiree.

The cost of a business combination excludes any payments that do not form part of the consideration given in exchange for the acquiree. Acquisition costs are recognised as an expense when incurred.

The costs of issuing equity and liability instruments are recognised using the measurement criteria applicable to these transactions.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Company recognises the assets acquired and liabilities assumed at their acquisition-date fair value. Liabilities assumed include any contingent liabilities that represent present obligations arising from past events for which the fair value can be reliably measured. The Company also recognises indemnification assets transferred by the seller at the same time and following the same measurement criteria as the item that is subject to indemnification from the acquiree, taking into consideration, where applicable, the insolvency risk and any contractual limitations on the indemnified amount.

(b) Foreign currency transactions, balances and cash flows

(i) Foreign currency transactions, balances and cash flows

Foreign currency transactions have been translated into Euros using average exchange rates for the prior month for all foreign currency transactions during the current month. This method does not differ significantly from applying the exchange rate at the date of the transaction.

Monetary assets and liabilities denominated in foreign currencies have been translated into Euros at the closing rate, while non-monetary assets and liabilities measured at historical cost have been translated at the exchange rate prevailing at the transaction date.

In the statement of cash flows, cash flows from foreign currency transactions have been translated into Euros using the average exchange rates for the prior month for all flows that occur during the following month. This method does not differ significantly from applying the exchange rate at the date of the transaction.

Exchange gains and losses arising on the settlement of foreign currency transactions and the translation into Euros of monetary assets and liabilities denominated in foreign currencies are recognised in profit or loss.

(c) Capitalised borrowing costs

In accordance with the second transitional provision of Royal Decree 1514/2007 enacting the Spanish General Chart of Accounts, the Company has opted to apply this accounting policy to work in progress at 1 January 2008 which will not be available for use, capable of operating or available for sale for more than one year. Until that date, the Company opted to recognise borrowing costs as an expense as they were incurred.

Borrowing costs related to specific and general financing that are directly attributable to the acquisition, construction or production of intangible assets, property, plant and equipment and investment property that will not be available for use, capable of operating or available for sale for more than one year are included in the cost of the asset.

To the extent that funds are borrowed specifically for the purpose of obtaining a qualifying asset, the amount of borrowing costs eligible for capitalisation is determined as the actual borrowing costs incurred. Non-commercial general borrowing costs eligible for capitalisation are calculated as the weighted average of the borrowing costs applicable to the Company's outstanding borrowings during the period, other than those specifically for the purpose of obtaining a qualifying asset and the portion financed using equity. The borrowing costs capitalised cannot exceed the borrowing costs incurred during that period.

The Company begins capitalising borrowing costs as part of the cost of a qualifying asset when it incurs expenditures for the asset, interest is accrued, and it undertakes activities that are necessary to prepare the asset for its intended use, operation or sale, and ceases capitalising borrowing costs when all or substantially all the activities necessary to prepare the qualifying asset for its intended use, operation or sale are complete, even though the necessary administrative permits may not have been obtained. Interruptions in the active development of a qualifying asset are not considered. Nonetheless, restated advances on account are not qualifying assets for the purpose of capitalising borrowing costs.

Capitalised borrowing costs are recognised in the income statement under capitalised borrowing costs.

(d) Intangible assets

Intangible assets are measured at cost or cost of production. Capitalised production costs are recognised under selfconstructed assets in the income statement. Intangible assets are carried at cost, less any accumulated amortisation and impairment.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Advances on account of fixed assets are initially measured at cost. In subsequent years, advances accrue interest at the supplier's incremental borrowing rate when the period between payment and the receipt of the asset exceeds one year.

Cost of production of intangible assets comprises the purchase price and any costs directly related to production.

Expenditure on activities that contribute to increasing the value of the Company's business as a whole, such as goodwill, trademarks and other similar items generated internally, as well as establishment costs, are recognised as expenses when incurred.

(i) Computer software

Computer software acquired and developed by the Company is recognised to the extent that costs can be clearly allocated, expensed and distributed over time to each project, and when there is evidence of technical success and economic viability. Computer software maintenance costs are charged as expenses when incurred.

(ii) Subsequent costs

Subsequent costs incurred on intangible assets are recognised in profit and loss, unless they increase the expected future economic benefits attributable to the intangible asset.

(iii) Useful life and amortisation rates

Intangible assets with finite useful lives are amortised by allocating the depreciable amount of an asset on a systematic basis over its useful life, by applying the following criteria:

Amortisation
method
Rates %
Computer softw are Straight-line 16‑33

The depreciable amount is the acquisition or production cost of an asset.

The Company considers that the residual value of the assets is zero unless:

  • There is a commitment by a third party to purchase the asset at the end of its useful life.
  • There is an active market for the intangible asset and:
  • Residual value can be determined by reference to that market; and
  • It is probable that such a market will exist at the end of the asset's useful life.

The Company reviews the useful life and amortisation method for intangible assets at each financial year end. Changes to initially established criteria are accounted for as a change in accounting estimates.

(iv) Impairment losses

The Company measures and determines impairment to be recognised or reversed based on the criteria in section (g) Impairment of non-financial assets subject to amortisation or depreciation.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • (e) Property, plant and equipment
  • (i) Initial recognition

Property, plant and equipment are measured at cost of acquisition or production, using the same criteria as for determining the cost of production of intangible assets. Capitalised production costs are recognised under "Selfconstructed assets" in the income statement. Property, plant and equipment are carried at cost less any accumulated depreciation and impairment.

The cost of an item of property, plant and equipment includes the estimated costs of its dismantling or removal and restoration of the site on which it is located, provided that the obligation is incurred as a consequence of having used the item.

(ii) Depreciation

Property, plant and equipment are depreciated by allocating the depreciable amount of the asset on a systematic basis over its useful life. The depreciable amount is the cost of an asset. The Company determines the depreciation charge separately for each component of an item of property, plant and equipment with a cost that is significant in relation to the total cost of the asset and with a useful life that differs from the remainder of the asset.

Property, plant and equipment are depreciated using the following criteria:

Amortisation
method
Rates %
Technical installations and machinery Straight-line 10
Other installations, equipment and furniture Straight-line 4‑10
Other property, plant and equipment Straight-line 7‑33

The Company reviews useful lives and depreciation methods at each financial year end. Changes to initially established criteria are accounted for as a change in accounting estimates.

(iii) Subsequent costs

Subsequent to initial recognition of the asset, only the costs incurred which increase capacity or productivity or which lengthen the useful life of the asset are capitalised. The carrying amount of parts that are replaced is derecognised. Costs of day-to-day servicing are recognised in profit and loss as incurred.

Replacements of property, plant and equipment that qualify for capitalisation are recognised as a reduction in the carrying amount of the items replaced. Where the cost of the replaced items has not been depreciated independently and it is not possible to determine the respective carrying amount, the replacement cost is used as indicative of the cost of items at the time of acquisition or construction.

(iv) Impairment

The Company measures and determines impairment to be recognised or reversed based on the criteria in section (g) Impairment of non-financial assets subject to amortisation or depreciation.

(f) Investment property

The Company classifies property leased to its subsidiaries under this caption. All property is earmarked exclusively for own use or the use of Group companies.

Property that is being constructed or developed for future use as investment property is classified as property, plant and equipment under development until construction or development is complete. Nevertheless, redevelopment work to extend or improve property is classified as investment property.

The Company measures and recognises investment property following the policy for property, plant and equipment.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The Company reclassifies property, plant and equipment to investment property when it ceases to use the building in the production or supply of goods or services, for administrative purposes or when it is held to earn rentals or for capital appreciation or both.

Investment property is depreciated applying the following policies:

Amortisation
method
Rates %
Buildings and other installations Straight-line 1‑10

(g) Impairment of non-financial assets subject to amortisation or depreciation

The Company evaluates whether there are indications of possible impairment losses on non-financial assets subject to amortisation or depreciation to verify whether the carrying amount of these assets exceeds the recoverable amount. The recoverable amount is the higher of the fair value less costs to sell and the value in use.

Impairment losses are recognised in the income statement.

At the end of each reporting period the Company assesses whether there is any indication that an impairment loss recognised in prior periods may no longer exist or may have decreased. Impairment losses on goodwill are not reversible. Impairment losses on other assets are only reversed if there has been a change in the estimates used to calculate the recoverable amount of the asset.

A reversal of an impairment loss is recognised in the income statement. The increased carrying amount of an asset attributable to a reversal of an impairment loss may not exceed the carrying amount that would have been determined, net of depreciation or amortisation, had no impairment loss been recognised.

After an impairment loss or reversal of an impairment loss is recognised, the depreciation (amortisation) charge for the asset is adjusted in future periods based on its new carrying amount.

However, if the specific circumstances of the assets indicate an irreversible loss, this is recognised directly in losses on the disposal of fixed assets in the income statement.

(h) Leases

(i) Lessor accounting

Leases which, on inception, transfer to third parties substantially all the risks and rewards incidental to ownership of the assets are classified as finance leases, otherwise they are classified as operating leases.

(ii) Lessee accounting

Leases in which, upon inception, the Company assumes substantially all the risks and rewards incidental to ownership are classified as finance leases, otherwise they are classified as operating leases.

  • Finance leases

At the commencement of the lease term, the Company recognises finance leases as assets and liabilities at the lower of the fair value of the leased asset and the present value of the minimum lease payments. Initial direct costs are added to the asset's carrying amount. Minimum lease payments are apportioned between the finance charge and the reduction of the outstanding liability. Interest is expensed using the effective interest method.

Contingent rents are recognised as an expense when it is probable that they will be incurred.

The accounting policies applied to the assets used by the Company by virtue of finance lease contracts are the same as those set out in sections (e) and (f) (Property, plant and equipment or Investment Property).

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • Operating leases

Lease payments under an operating lease, net of incentives received, are recognised as an expense on a straight-line basis over the lease term.

Contingent rents are recognised as an expense when it is probable that they will be incurred.

  • (i) Financial instruments
  • (i) Classification and separation of financial instruments

Financial instruments are classified on initial recognition as a financial asset, a financial liability or an equity instrument in accordance with the economic substance of the contractual arrangement and the definitions of a financial asset, a financial liability and an equity instrument.

The Company classifies financial instruments into different categories based on the nature of the instruments and the Company's intentions on initial recognition.

(ii) Offsetting principles

A financial asset and a financial liability are offset only when the Company currently has the legally enforceable right to offset the recognised amounts and intends either to settle on a net basis or to realise the asset and settle the liability simultaneously.

(iii) Financial assets and financial liabilities held for trading

Financial assets or financial liabilities held for trading are those which are classified as held for trading from initial recognition.

A financial asset or financial liability is classified as held for trading if it:

  • Originates or is acquired or incurred principally for the purpose of selling or repurchasing it in the near term;
  • Forms part of a portfolio of identified financial instruments that are managed together and for which there is evidence of a recent actual pattern of short-term profit-taking or;
  • Is a derivative, except for a derivative that is a financial guarantee contract or a designated and effective hedging instrument.

Financial assets and financial liabilities held for trading are initially recognised at fair value. Transaction costs directly attributable to the acquisition or issue are recognised as an expense when incurred.

After initial recognition, they are recognised at fair value through profit or loss. Fair value is not reduced by transaction costs incurred on sale or disposal. Accrual interest and dividends are recognised separately.

The Company does not reclassify any financial asset or financial liability into or out of this category while it is recognised in the balance sheet, except when there is a change in the classification of hedging financial instruments.

(iv) Financial assets and financial liabilities at fair value through profit or loss

Financial assets and financial liabilities at fair value through profit or loss, which comprise derivatives, are initially recognised at fair value and after initial recognition are recognised at fair value through profit or loss.

(v) Loans and receivables

Loans and receivables comprise trade and non-trade receivables with fixed or determinable payments that are not quoted in an active market other than those classified in other financial asset categories. These assets are initially recognised at fair value, including transaction costs, and are subsequently measured at amortised cost using the effective interest method.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Nevertheless, financial assets which have no established interest rate, which mature or are expected to be received in the short term, and for which the effect of discounting is immaterial, are measured at their nominal amount.

(vi) Available-for-sale financial assets

The Company classifies in this category debt securities and equity instruments which do not qualify for inclusion in the aforementioned categories.

Available-for-sale financial assets are initially recognised at fair value plus transaction costs directly attributable to the acquisition.

After initial recognition, financial assets classified in this category are measured at fair value and any gain or loss is accounted for in income and expenses recognised in equity. On disposal of the financial assets, amounts recognised in equity or the impairment loss are reclassified to profit or loss.

(vii) Investments in Group companies and associates

Group companies are those over which the Company, either directly, or indirectly through subsidiaries, exercises control as defined in article 42 of the Spanish Code of Commerce, or when the companies are controlled by one or more individuals or entities acting jointly or under the same management through agreements or statutory clauses.

Control is the power to govern the financial and operating policies of an entity or business so as to obtain benefits from its activities. In assessing control, potential voting rights held by the Company or other entities that are exercisable or convertible at the end of each reporting period are considered.

Associates are entities over which the Company, either directly, or indirectly through subsidiaries, exercises significant influence. Significant influence is the power to participate in the financial and operating policy decisions of the investee but is not control or joint control over those policies. The existence of potential voting rights that are exercisable or convertible at the end of each reporting period, including potential voting rights held by the Company or other entities, are considered when assessing whether an entity has significant influence.

Investments in Group companies and associates are initially recognised at cost, which is equivalent to the fair value of the consideration given, including transaction costs in the case of investments in associates, and are subsequently measured at cost net of any accumulated impairment. The cost of investments in Group companies acquired before 1 January 2010 includes any transaction costs incurred.

If an investment no longer qualifies for classification under this category, it is reclassified as available-for-sale and is measured as such from the reclassification date.

(viii) Non-monetary contributions in exchange for investments in the equity of other companies

However, in non-monetary contributions of businesses (including investments in Group companies) to other Group companies, equity investments received are measured at the transaction date at the higher of the carrying amount of the assets and liabilities transferred in the individual annual accounts of the contributing company and the amount representative of the percentage of interest in the equity of the business contributed. Gains or losses deferred in recognised income and expense associated with the assets and liabilities conveyed continue to be recognised in equity but are linked to the investment received.

(ix) Interest and dividends

Interest is recognised using the effective interest method.

Dividends from investments in equity instruments are recognised when the Company is entitled to receive them. If the dividends are clearly derived from profits generated prior to the acquisition date because amounts higher than the profits generated by the investment since acquisition have been distributed, the carrying amount of the investment is reduced.

Interest and dividend income are classified as revenue when they form part of the Company's ordinary activity.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(x) Impairment of financial assets

A financial asset or a group of financial assets is impaired and impairment losses are incurred if there is objective evidence of impairment as a result of one or more events that occurred after the initial recognition of the asset and the event or events have an impact on the estimated future cash flows of the financial asset or group of financial assets that can be reliably estimated.

The Company recognises impairment of loans and receivables and debt instruments when estimated future cash flows are reduced or delayed due to debtor insolvency.

For equity instruments, objective evidence of impairment exists when the carrying amount of an asset is uncollectible due to a significant or prolonged decline in its fair value.

Investments in Group companies

Impairment is calculated by comparing the carrying amount of the net investment in the associate with its recoverable amount. The recoverable amount is the higher of value in use and fair value less costs to sell.

Value in use is calculated based on the Company's share of the present value of future cash flows expected to be derived from ordinary activities and from the disposal of the asset. Unless better evidence is available, the investee's equity is taken into consideration, corrected for any unrealised gains existing at the measurement date.

In subsequent years, reversals of impairment losses in the form of increases in the recoverable amount are recognised, up to the limit of the carrying amount that would have been determined for the investment if no impairment loss had been recognised.

The recognition or reversal of an impairment loss is disclosed in the income statement unless it should be recognised in equity.

Impairment of an investment is limited to the amount of the investment, except when contractual, legal or constructive obligations have been assumed by the Company or payments have been made on behalf of the companies. In the latter case, provision is made.

(xi) Financial liabilities

Financial liabilities, including trade and other payables, that are not classified as held for trading or as financial liabilities at fair value through profit or loss are initially recognised at fair value less any transaction costs directly attributable to the issue of the financial liability. After initial recognition, liabilities classified under this category are measured at amortised cost using the effective interest method.

Nevertheless, financial liabilities which have no established interest rate, which mature or are expected to be settled in the short term, and for which the effect of discounting is immaterial, are measured at their nominal amount.

The Company measures financial liabilities at amortised cost provided that reliable estimates of cash flows can be made based on the contractual terms.

(xii) Derecognition and modifications of financial liabilities

The Company derecognises all or part of a financial liability when it either discharges the liability by paying the creditor, or is legally released from primary responsibility for the liability either by process of law or by the creditor. The exchange of debt instruments between the Company and the counterparty or substantial modifications of initially recognised liabilities are accounted for as an extinguishment of the original financial liability and the recognition of a new financial liability, provided that the instruments have substantially different terms.

The Company considers the terms to be substantially different if the discounted present value of the cash flows under the new terms, including any fees paid net of any fees received and discounted using the original effective interest rate, is at least 10 per cent different from the discounted present value of the remaining cash flows of the original financial liability.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

If the exchange is accounted for as an extinguishment of the financial liability, any costs or fees incurred are recognised as part of the gain or loss on the extinguishment. If the exchange is not accounted for as an extinguishment, any costs or fees incurred adjust the carrying amount of the liability and are amortised over the remaining term of the modified liability.

The difference between the carrying amount of a financial liability, or part of a financial liability, extinguished or transferred to another party and the consideration paid, including any non-cash assets transferred or liabilities assumed, is recognised in profit or loss.

(xiii) Reverse factoring

The Company has contracted reverse factoring facilities with various financial institutions to manage payments to suppliers. Trade payables settled under the management of financial institutions are recognised under trade and other payables in the balance sheet until they are settled, repaid or have expired.

(j) Own equity instruments held by the Company.

Equity instruments acquired by the Company are shown separately at cost of acquisition as a reduction in capital and reserves in the balance sheet. Any gains or losses on transactions with own equity instruments are not recognised in profit or loss.

Transaction costs related to own equity instruments, including issue costs related to a business combination, are accounted for as a deduction from reserves, net of any tax effect.

(k) Inventories

Inventories are measured using the FIFO (first in, first out) method. When the cost of inventories exceeds replacement value, materials are written down to net realisable value.

Inventories are mainly spare parts used to maintain the Company's buildings and facilities.

(i) Emission allowances

Emission allowances acquired are recognised and measured using the inventories accounting policies.

(l) Cash and cash equivalents

Cash and cash equivalents include cash on hand and demand deposits in financial institutions. They also include other short-term, highly liquid investments that are readily convertible to known amounts of cash and which are subject to an insignificant risk of changes in value. An investment normally qualifies as a cash equivalent when it has a maturity of less than three months from the date of acquisition.

(m) Grants

Grants are recorded in recognised income and expense when, where applicable, they have been officially awarded and the conditions attached to them have been met or there is reasonable assurance that they will be received.

(n) Defined contribution plans

The Company recognises the contributions payable to a defined contribution plan in exchange for a service when an employee has rendered service to the Company. The contributions payable are recognised as an expense for employee remuneration and as a liability after deducting any contribution already paid. If the contribution already paid exceeds the contribution due for service before the end of the period, the Company only recognises that excess as an asset (prepaid expense) to the extent that the prepayments will lead to, for example, a reduction in future payments or cash refund.

13

GRIFOLS, S.A.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • (o) Provisions
  • (i) General criteria

Provisions are recognised when the Company has a present obligation (legal, contractual, constructive or tacit) as a result of a past event; it is probable that an outflow of resources embodying economic benefits will be required to settle the obligation; and a reliable estimate can be made of the amount of the obligation.

The amount recognised as a provision is the best estimate of the expenditure required to settle the present obligation at the end of the reporting period, taking into account all risks and uncertainties surrounding the amount to be recognised as a provision and, where the time value of money is material, the financial effect of discounting provided that the expenditure to be made each period can be reliably estimated. The discount rate is a pre-tax rate that reflects the time value of money and the specific risks for which future cash flows associated with the provision have not been adjusted at each reporting date.

If it is not probable that an outflow of resources will be required to settle an obligation, the provision is reversed.

(ii) Provisions for taxes

Provisions for taxes are measured at the estimated amount of tax debt calculated in accordance with the aforementioned criteria. Provision is made with a charge to income tax for the tax expense for the year, to finance costs for the late payment interest, and to other income for the penalty. The effects of changes in estimates of prior years' provisions are recognised according to their nature, unless they involve the correction of an error.

(p) Revenue from the rendering of services

Revenue from the rendering of services is measured at the fair value of the consideration received or receivable.

Practically all services are rendered to Group companies.

(q) Income tax

The income tax expense or tax income for the year comprises current tax and deferred tax.

Current tax assets or liabilities are measured at the amount expected to be paid to or recovered from the taxation authorities, using the tax rates and tax laws that have been enacted or substantially enacted at the reporting date.

Current and deferred tax are recognised as income or an expense and included in profit or loss for the year, except to the extent that the tax arises from a transaction or event which is recognised, in the same or a different year, directly in equity, or from a business combination.

Government assistance provided in the form of deductions and other tax relief applicable to income tax payable is recognised as a reduction in the income tax expense in the year in which it is accrued.

The Company files consolidated tax returns with its Spanish subsidiaries: Laboratorios Grifols, S.A., Instituto Grifols, S.A., Diagnostic Grifols, S.A., Grifols Movaco, S.A., Biomat, S.A., Grifols International, S.A., Grifols Engineering, S.A., Grifols Viajes S.A., Gri-Cel, S.A., Gripdan Invest, S.L. and VCN Biosciencies, S.L..

In addition to the factors to be considered for individual taxation, set out previously, the following factors are taken into account when determining the accrued income tax expense for the companies forming the consolidated tax group:

  • Temporary and permanent differences arising from the elimination of profits and losses on transactions between Group companies, derived from the process of determining consolidated taxable income.
  • Deductions and credits corresponding to each company forming the consolidated tax group. For these purposes, deductions and credits are allocated to the company that carried out the activity or obtained the profit necessary to obtain the right to the deduction or tax credit.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Temporary differences arising from the elimination of profits and losses on transactions between tax group companies are allocated to the company which recognised the profit/loss and are valued using the tax rate of that company.

A reciprocal credit and debit arises between the companies that contribute tax losses to the consolidated Group and the rest of the companies that offset those losses. Where a tax loss cannot be offset by the other consolidated Group companies, these tax credits for loss carryforwards are recognised as deferred tax assets using the applicable recognition criteria, considering the tax group as a taxable entity.

The Parent of the Group records the total consolidated income tax payable with a debit to receivables from Group companies.

The amount of the debt relating to the subsidiaries is recognised with a credit to payables to Group companies.

(i) Deferred Tax liabilities

Deferred tax liabilities derived from taxable temporary differences are recognised in all cases except where they arise from the initial recognition of goodwill or an asset or liability in a transaction that is not a business combination and, at the time of the transaction, affects neither accounting profit nor taxable income.

(ii) Deferred Tax assets

Deferred tax assets derived from deductible temporary differences are recognised provided that it is probable that sufficient taxable income will be available against which they can be utilised. Nonetheless, assets arising from the initial recognition of an asset or liability in a transaction that is not a business combination and, at the time of the transaction, affects neither accounting profit nor taxable income, are not recognised.

(iii) Measurement

Deferred tax assets and liabilities are measured at the tax rates that are expected to apply to the years when the asset is realised or the liability is settled, based on tax rates and tax laws that have been enacted or substantially enacted. The tax consequences that would follow from the manner in which the Company expects to recover or settle the carrying amount of its assets or liabilities are also reflected in the measurement of deferred tax assets and liabilities.

(iv) Offset and classification

The Company only offsets tax assets and liabilities if it has a legally enforceable right to offset the recognised amounts and intends either to settle on a net basis or to realise the assets and settle the liabilities simultaneously.

Deferred tax assets and liabilities are recognised in the balance sheet under non-current assets or liabilities, irrespective of the expected date of recovery or settlement.

(r) Share-based payment transactions

The Group headed by the Company extends share-based payments to certain employees currently rendering services. The fair value of the services received is calculated by estimating the fair value of the shares extended at the grant date. As the equity instruments granted do not vest until the employees complete a specified period of service, those services are accounted for in the income statement as an expense for the year during the vesting period, with a corresponding increase in other equity instruments. The amount recognised reflects the amount that will be settled once the agreed conditions are met, and will not be revised or remeasured during the vesting period, as the commitment was settled through shares.

The total amount recognised is calculated based on the incentive payable in shares plus a percentage defined by the Company. If an employee leaves his job before the vesting period is completed, only the agreed share-based incentive is received, and the Company can decide whether to pay the incentive in cash or in shares.

The Company has a share option plan over its own equity instruments for employees of several Group companies, the cost of which is assumed by the Company. The Company recognises the transaction as a contribution to the subsidiary in the form of remuneration for services received settled through equity instruments. In accordance with the aforementioned criteria, the Company therefore recognises the accrued cost of the plan as an increase in the

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

value of the investment in the subsidiary with a credit to other equity instruments.

The Company is paid by the subsidiary for the intrinsic value of the cost assumed. The payment arrangement is recognised separately from the option plan as a return of the investment and with a charge to a loan to Group companies, when the subsidiary's commitment effectively arises.

(s) Classification of assets and liabilities as current and non-current

The Company classifies assets and liabilities in the balance sheet as current and non-current. Current assets and liabilities are determined as follows:

  • Assets are classified as current when they are expected to be realised or are intended for sale or consumption in the Company's normal operating cycle, they are held primarily for the purpose of trading, they are expected to be realised within twelve months after the reporting date or are cash or a cash equivalent.
  • Liabilities are classified as current when they are expected to be settled in the Company's normal operating cycle, they are held primarily for the purpose of trading, or they are due to be settled within twelve months after the reporting date.
  • (t) Environmental issues

The Company takes measures to prevent, reduce or repair the damage caused to the environment by its activities.

Expenses derived from environmental activities are recognised as other operating expenses in the period in which they are incurred.

Property, plant and equipment acquired by the Company to minimise the environmental impact of its activity and protect and improve the environment, including the reduction and elimination of future pollution from the Company's activities, are recognised as assets applying the measurement, presentation and disclosure criteria described in section (e) Property, plant and equipment.

(u) Transactions between Group companies

Transactions between Group companies, other than mergers, spin-offs and non-cash contributions, are recognised at the fair value of the consideration given or received. The difference between this value and the amount agreed is recognised in line with the underlying economic substance of the transaction.

In non-cash contributions to Group companies, the contributor will value its interests at the carrying amount of the equity investments, in the consolidated annual accounts at the date the transaction occurred.

Any difference between thevalue assigned to the interest received by the contributor and the carrying amount of the investments contributed will be recognised in reserves.

(5) Intangible Assets

  • a) Details of intangible assets and movement are shown in Appendix I.
  • b) Fully amortised assets

The cost of fully amortised intangible assets in use at 31 December is as follows:

Euros
2018 2017
Computer softw are 36,335,118 25,376,107

Fully amortised computer software in use at 31 December 2018 and 2017 mainly reflects computer licences.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(6) Property, Plant and Equipment

(a) General

Details of property, plant and equipment and movement are shown in Appendix II.

(b) Capitalised borrowing costs

During 2018 the Company has capitalised borrowing costs in investments in progress amounting to Euros 357 thousand (Euros 410 thousand in 2017) (see note 4 (c)).

(c) Fully depreciated assets

Details of the cost of fully depreciated property, plant and equipment in use at 31 December are as follows:

Euros
2018 2017
Technical installations and machinery 5,821,895 3,067,451
Other installations, equipment and furniture 7,758,067 4,589,425
Other property, plant and equipment 11,512,576 8,584,218
25,092,538 16,241,094

(d) Insurance

The Company has taken out insurance policies to cover the risk of damage to its property, plant and equipment. These policies amply cover the net carrying amount of the Company's assets.

(7) Investment Property

(a) General

Details of and movement in investment property are shown in Appendix III.

At 31 December 2018 and 2017 additions comprise the investments incurred to expand the Company's facilities.

(b) Fully depreciated assets

The cost of fully depreciated investment property in use at 31 December is as follows:

Euros
2018 2017
Buildings
Other installations
1,031,791
15,256,715
1,031,791
13,712,960
16,288,506 14,744,751

(c) Income and expenses from investment property

Details of income and expenses from investment property are as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018 2017
Assignemet for use income (note 23)
Operating expenses
16,626,213 15,437,827
From income-generating investments (17,205,701) (15,548,575)
Net (579,488) (110,748)

The Company assigns the use of the premises and installations that it owns and leases from third parties to its Spanish subsidiaries (see notes 9, 10 and 23).

(d) Insurance

The Company has taken out insurance policies to cover the risk of damage to its investment property. The coverage of these policies is considered sufficient.

(8) Finance Leases - Lessee

The Company has leased the following types of property, plant and equipment and investment property under finance leases:

Euros
Land Other property,
plant and
equipment
Total
Initially recognised at:
Fair value 435,000 6,276,244 6,711,244
Accumulated depreciation (53,876) (3,402,262) (3,456,138)
Carrying
amount
at
31
December 2018
381,124 2,873,982 3,255,106
Initially recognised at:
Fair value 435,000 6,057,063 6,492,063
Accumulated depreciation (45,020) (3,782,563) (3,827,583)
Carrying
amount
at
31
December 2017
389,980 2,274,500 2,664,480

Future minimum lease payments are reconciled with their present value as follows:

Euros
2018 2017
Future minimum payments
Unaccrued finance costs
3,794,242
(178,375)
3,211,053
(277,894)
Present value 3,615,867 2,933,159

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details of minimum payments and the present value of finance lease liabilities, by maturity date, are as follows:

Euros
2018 2017
Minimum
payments
Present value Minimum
payments
Present value
Less than one year 1,225,427 1,119,117 1,242,409 1,071,228
One to five years 2,568,815 2,496,750 1,968,644 1,861,931
3,794,242 3,615,867 3,211,053 2,933,159
Less current portion (1,225,427) (1,119,117) (1,242,409) (1,071,228)
Total non-current 2,568,815 2,496,750 1,968,644 1,861,931

(9) Operating Leases - Lessee

At 31 December 2018 and 2017, the Company has contracted various office premises and a plot of land under operating leases from third parties, and one related party.

The most significant lease contracts are as follows:

Offices located in Sant Cugat del Vallès (Barcelona) and Barcelona, leased from a related party

This contract is valid for a mandatory period of 10 years from 2015 and is automatically renewable for five-year periods from year 10 onwards until 2035.

Offices located in Barcelona, Jesus y Maria, 6 (Barcelona), leased from a third party.

This contract is valid for 5 years from 2011 and is automatically renewable for five-year periods, unless one of the parties, cancels the contract giving notice of 6 months in advance.

Operating lease payments have been recognised as an expense for the year as follows:

Euros
2018 2017
Lease payments (recognised as an expense) 9,975,445 9,791,091

Future minimum payments under non-cancellable operating leases are as follows:

Euros
2018 2017
Less than one year 6,132,837 6,073,802
One to five years 21,164,966 20,975,109
Over five years 32,100,877 11,304,386
59,398,680 38,353,297

The Company uses part of these premises for its own use and the rest are assigned for use to its Spanish subsidiaries (see note 7 (c)).

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(10) Assignment for Use of premises and installations

As described in note 7 (c), note 9 and note 23, the Company assigns the use of the premises and installations that it owns and leases from third parties to its Spanish subsidiaries.

Services included in the assignment for use agreements are: surveillance, cleaning of common areas, greeting and messaging, maintenance and water, energy and gas supply. In order to take advantage of these services, the Spanish subsidiaries will use the premises in accordance with the statutory activity.

Contracts signed with its subsidiaries are renewed automatically on an annual basis and can be cancelled at any time with three months' prior notice. The minimum non-cancellable amount receivable totals Euros 4,157 thousand at 31 December 2018 (Euros 3,859 thousand in 2017).

(11) Risk Management Policy

(a) Financial risk factors

The Company's activities are exposed to various financial risks: market risk (including currency risk, fair value interest rate risk and price risk), credit risk, liquidity risk, and cash flow interest rate risk. The Company's global risk management programme focuses on uncertainty in the financial markets and aims to minimise potential adverse effects on the Company's profits. The Company's risk management policies are established in order to identify and analyse the risks to which the Company is exposed, establish suitable risk limits and controls, and control risks and compliance with limits. Risk management procedures and policies are regularly reviewed to ensure they take into account changes in market conditions and in the Company's activities. The Company's management procedures and rules are designed to create a strict and constructive control environment in which all employees understand their duties and obligations.

The Group's Audit Committee supervises how management controls compliance with the Group's risk management procedures and policies and reviews whether the risk management policy is suitable considering the risks to which the Group is exposed. This committee is assisted by Internal Audit which acts as supervisor. Internal Audit performs regular and ad hoc reviews of the risk management controls and procedures and reports its findings to the Audit Committee.

(i) Market risk

The Company is not exposed to market risks associated with non-financial assets.

(ii) Currency risk

The Company operates internationally and is therefore exposed to currency risk when operating with foreign currencies, especially with regard to the US Dollar. Currency risk is associated with recognised assets and liabilities, and net investments in foreign operations.

The Company holds several investments in foreign operations, the net assets of which are exposed to currency risk. Currency risk affecting net assets of the Company's foreign operations in US Dollars is mitigated primarily through borrowings in the corresponding foreign currency.

Details of financial monetary assets and liabilities in foreign currencies and transactions in foreign currencies are provided in notes 14 (d) and 19 (f).

At 31 December 2018 had the US Dollar weakened by 10% against the Euro, with the other variables remaining constant, post-tax profit would have been Euros 283 thousand lower, mainly as a result of converting payables to Group companies (Euros 96 thousand at 31 December 2017).

(iii) Credit risk

The Company's financial assets mainly comprise the trade receivables from and loans to Group companies.

The Company considers that its financial assets are not significantly exposed to credit risk.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(iv) Liquidity risk

The Company applies a prudent policy to cover its liquidity risks based on having sufficient cash, as well as sufficient financing through credit facilities, to settle market positions.

Details of financial liabilities by contractual maturity date are provided in notes 14 and 19 (e).

(v) Cash flow and fair value interest rate risks

Interest rate risk arises on loans extended to Group companies and current and non-current borrowings. Borrowings and loans extended at variable interest rates expose the Company to cash flow interest rate risks. The Company's policy involves contracting borrowings and extending loans to Group companies at variable interest rates.

At 31 December 2018, had interest rates been 10% higher/lower, with the other variables remaining constant, post-tax profit would have been Euros 1,245 thousand lower/higher, mainly because of higher borrowing costs on variable interest debt (Euros 1,098 thousand at 31 December 2017).

(12) Investments in Equity Instruments of Group Companies and Associates

Details of investments in equity instruments of Group companies are as follows:

Euros
2018 2017
Non-current Non-current
Group companies
Equity investments
3,287,312,325 3,136,440,705
Impairment (16,484,094) (11,987,847)
3,270,828,231 3,124,452,858
Associates
Equity investments -- 550,000
Impairment -- (550,000)
-- --
Total 3,270,828,231 3,124,452,858

During 2018 the following changes to Company investments in equity instruments took place:

• In 2015, for the annual bonus of certain eligible employees, the Group set up a Restricted Share Unit Retention Plan (hereinafter RSU plan) (see note 16). In 2018 the bonuses accrued in the RSU plan during the period were recognised as an investment by the Company in those subsidiaries with employees adhering to this plan, as it is considered as a non-cash contribution from the shareholder totalling Euros 3,755 thousand.

• In 2018 there was a transfer of Progenika Biopharma, S.A.'s shares through a distribution in kind effective 31 December 2018 with a net book value of US Dollars 76,982,493 (Euros 67,724,547). Additionally, Grifols Diagnostics Solutions has transferred two participative loans agreements granted to Progenika Biopharma, S.A. for a total of US Dollars 11,900,332 (Euros 10,487,221) as principal and US Dollars 1,511,917 (Euros 1,321,266) as interests. An amount of Euros 79,523,834 has been recognized in the Company reserves related to the investment in Progenika Biopharma,S.A..

• The Company has subscribed to an increase in the capital of Laboratorios Grifols, S.A. contributing an amount of Euros 18,000 thousands.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

• In January 2018 the Company acquired a 50% interest in Aigües de Vilajuïga S.A. for a purchase of shares of 37,500. From the total amount of shares, 37,499 are acquired by Grifols, S.A. and 1 share is acquired by Grifols International, S.A.. The total price amounts Euros 549,985 for Grifols,S.A. and Euros 15 for Grifols International, S.A.. With this new shares acquisition, Aigües de Vilajuïga, S.A. is now part of the Group. During 2018 the Company has recognised impairment of Euros (549,985) on the investment based on an analysis of its recoverability.

• In December 2018 the Company Grifols Diagnostic Solutions transferred Singulex shares to Grifols, S.A. through a distribution in kind. The fair value at 31 December 2018 is US Dollars 50 Million (Euros 43,987 thousands). Transfer of three loan agreements with GDS as a lender and Singulex as the borrower for a total amount of US Dollars 35,849,289 (Euros 31,538,039) as principal and US Dollars 1,988,448 (Euros 1,749,316) as interests. The second transaction done was between Grifols, S.A. and Grifols Shared Services North America Inc., with a transfer of shares through a capital contribution. The fair value of Singulex shares and loans has been recognized in the Company as a dividend amounting Euros 77,274,335.

During 2017 the following changes to Company investments in equity instruments took place:

• In 2015, for the annual bonus of certain eligible employees, the Group set up a Restricted Share Unit Retention Plan (hereinafter RSU plan) (see note 16). In 2017 the bonuses accrued in the RSU plan during the period were recognised as an investment by the Company in those subsidiaries with employees adhering to this plan, as it is considered as a non-cash contribution from the shareholder totalling Euros 6,327 thousand.

• On 24 July 2017, Grifols acquired an additional 40% interest in Kiro Grifols, S.L. for a purchase price of Euros 12,800 thousand. In September 2014 Grifols subscribed to a capital increase by virtue of which it acquired 50% of Kiro Grifols, S.L.'s economic and voting rights. With this new acquisition, Grifols reached a 90% interest in Kiro Grifols, S.L. The remaining 10% will continue to be held by Socios Fundadores Kiro, S.L. a company wholly owned by cooperatives of the Mondragon Corporation. Associate investment before the acquisition amounting Euros 17,153 thousand, was recognized as group company equity investment.

• The Company subscribed to an increase in the capital of Grifols Colombia Ltda contributing an amount of Euros 433,729.

• The Company subscribed two increases in the capital of Grifols Worldwide Operations Limited (hereinafter GWWO) contributing an amount of Euros 700,000 thousand and 150,000 thousand respectively.

• The Company subscribed to an increase in the capital of Grifols Diagnostic Solutions, Inc (hereinafter GDS) contributing an amount of Euros 469,395 thousand.

• The Company subscribed to an increase in the capital of Grifols India Healthcare Private Ltd. contributing an amount of Euros 597,786.

• In June 2017 the Company acquired a 50% interest in Aigües de Vilajüiga S.A. for a purchase price of Euros 475,000. In October 2017 the Company made an additional capital contribution of Euros 75,000. During 2017 the Company recognised impairment of Euros (550,000) on the investment based on an analysis of its recoverability.

• The Company subscribed to an increase in the capital of Grifols Brasil Ltda contributing an amount of Euros 15,717,504.

• During 2017 the Company recognised impairment of Euros 95.5 thousand on the investment in Grifols Nordic, A.B based on an analysis of its recoverability.

• During 2017 the Company recognised impairment of Euros 28.8 thousand on the investment in Grifols Switzerland, A.G based on an analysis of its recoverability.

(a) Investments in Group companies

Details of investments in Group companies are provided in Appendix XV.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Subsidiaries' activities comprise the following:

  • Industrial activity: consisting of the manufacture, preparation and sale of therapeutic products and other pharmaceutical specialities, particularly haemoderivatives and parenteral solutions, reagents, chemical products for use in laboratories and healthcare centres, and medical-surgical materials, equipment and instruments; the collection and analysis of products of biological origin, and the procurement of human plasma.

  • Commercial activity: consisting primarily of the marketing of products manufactured by the industrial Group companies.

  • Service activity: comprising the management of business trips for Group companies, the preparation and implementation of engineering projects for both the Group and third parties, and the rendering of centralised services such as accounting, human resources, marketing, etc. This activity also includes the reinsurance of the Group's insurance policies.

The percentage ownerships included in Appendix XV reconcile with the voting rights the Company has in its subsidiaries, except for: Grifols Thailand, Ltd. (48% ownership) and Grifols Malaysia Sdn Bhd (30% ownership), in which the Company has majority voting rights through the type of shares it holds in Grifols Thailand, Ltd and a contract entered into with the other shareholder and the pledging of this shareholder's shares in Grifols Malaysia.

(i) Foreign currency

The functional currencies of foreign operations are the currencies of the countries in which they are domiciled, except for Grifols Worldwide Operations Limited, the functional currency of which is the US Dollar.

(b) Other Information

The subsidiaries have been audited/reviewed by the associates of KPMG International in the countries in which they are domiciled, with the exception of Grifols Argentina, S.A. (audited by Alexia Consulting group, S.R.L.).

Grifols Viajes, S.A., Gri-Cel, S.A., VCN Biosciencies, S.L., Kiro Grifols, S.L., Medion Diagnostics GmbH, Grifols Japan K.K., Grifols Switzerland A.G,Grifols Diagnostic Equip Taiwan, Ltd and Aigües de Vilajuïga, S.A. have not been audited.

(13) Financial Assets by Category

(a) Classification of financial assets by category

The classification of financial assets by category and class and a comparison of the fair value and the carrying amount are provided in Appendix IV.

(i) Net losses and gains by category of financial asset

Net losses and gains by category of financial asset are as follows:

Euros
2018 Loans and
receivables
Total
Finance income at amortised cost, Group companies
Finance income at amortised cost
52,115,757
3,122
52,115,757
3,122
Net gains in profit and loss 52,118,879 52,118,879
Total 52,118,879 52,118,879

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2017 Loans and
receivables
Total
Finance income at amortised cost, Group companies
Finance income at amortised cost
39,070,699
2,913
39,070,699
2,913
Net gains in profit and loss 39,073,612 39,073,612
Total 39,073,612 39,073,612

(14) Investments and Trade Receivables

(a) Investments in Group companies

Details of investments in Group companies and related parties are as follows:

Euros
2018 2017
Non-current Current Non-current Current
Group
Loans 1,593,426,692 57,813,083 1,748,441,128 3,798,908
Dividends pending to recover -- -- 74,999,121
Receivables, tax effect (note 21) 31,253,153 -- 18,380,110
Interest 2,142,790 -- 144,929
Associates
Loans -- -- 150,000
Interest -- -- 605
Total 1,593,426,692 91,209,026 1,748,441,128 97,473,673

At 31 December 2018 the Company has three loans with group companies. The two most significant loans amounts Euros 1,607,000 thousand, falling due in 2023 and 2025 with an accrue interest at arm's length basis. The third loan amounts Euros 10,487 thousand and falls due in 2019.

At 31 December 2018 the Company has a balance of Euros 21,847 thousand (Euros 141,441 thousand in 2017) corresponding to cash pooling accounts with Group companies (see note 19 (b)). These receivables accrue interest at a rate of 5.37% (interest rate on the group senior loan plus a spread of 0.75%) and they fall due in 2025 (4.69% interest rate on the group senior loan plus a spread of 0.75% and falling due in 2024 at 31 December 2017).

(b) Investments

Details of investments are as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018
2017
Non-current Current Non-current Current
Deposits and guarantees 1,622,650 4,306 1,608,091 16,033
Total 1,622,650 4,306 1,608,091 16,033

At 31 December 2018 and 2017, Euros 832 thousand of guarantees and deposits are associated with leases with Centurion Real State S.A (formerly Scranton Enterprise B.V.), a related party of Grifols S.A. (see note 23) and Euros 559 thousand correspond to leases arranged with a Group company.

(c) Trade and other receivables

Details of trade and other receivables are as follows:

Euros
2018 2017
Current Current
Group
Trade receivables (note 23) 19,526,804 19,485,499
Unrelated parties
Trade receivables 874,963 1,005,160
Other receivables 378,527 352,704
Personnel 173,455 117,449
Taxation authorities, income tax (note 21) 25,911,844 48,155,917
Public entities, other (note 21) 11,419,949 6,296,251
Total 58,285,542 75,412,980

At 31 December 2018 and 2017 public entities, other predominantly comprise recoverable value added tax. The Company files consolidated VAT and income tax returns.

(d) Amounts denominated in foreign currencies

Details of monetary financial assets denominated in foreign currencies are as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018 US Dollar Other Total
Trade and other receivables
Trade receivables – current 147,664 -- 147,664
Trade receivables from Group companies
and associates – current
860,756 112 860,868
Other receivables 8,246 1,631 9,877
Total current financial assets 1,016,666 1,743 1,018,409
Total financial assets 1,016,666 1,743 1,018,409
Euros
2017 US Dollar Other Total
Trade and other receivables
Trade receivables – current 140,978 -- 140,978
Trade receivables from Group companies
and associates – current
919,956 564 920,520
Other receivables 6,329 914 7,243
Total current financial assets 1,067,263 1,478 1,068,741
Total financial assets 1,067,263 1,478 1,068,741

Details of exchange differences recognised in profit or loss on financial instruments, distinguishing between settled and outstanding transactions, are as follows:

Euros
2018 2017
Settled Outstanding Settled Outstanding
Investments in Group companies
Loans to Group companies (1,413) (31,658) 449,354 (197,159)
Total non-current financial assets (1,413) (31,658) 449,354 (197,159)
Trade and other receivables
Trade receivables – current (19,174) 19,464 61,990 12,833
Trade
receivables
from Group
companies

current
-- (6,247) -- (19,935)
Current investments
Loans to Group companies 39,092 -- (87,231) --
Total current financial assets 19,918 13,217 (25,241) (7,102)
Total financial assets 18,505 (18,441) 424,113 (204,261)

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(15) Prepayments

At 31 December 2018 and 2017 prepayments include advanced payments for insurance premiums and maintenance fees.

(16) Equity

Details of equity and movement during the year are shown in the statement of changes in equity.

(a) Capital

At 31 December 2018 and 2017 the share capital of Grifols S.A. amounts to Euros 119,603,705 and is represented by:

  • Class A shares: 426,129,798 ordinary shares of Euros 0.25 par value each, subscribed and fully paid and of the same class and series.

  • Class B shares: 261,425,110 non-voting preference shares of Euros 0.05 par value each, of the same class and series, and with the preferential rights set forth in the Company's by-laws.

The main characteristics of the Class B shares are as follows:

  • Each Class B share entitles its holder to receive a minimum annual preferred dividend out of the distributable profits at the end of each year equal to Euros 0.01 per Class B share provided that the aggregate preferred dividend does not exceed the distributable profits for that year and a distribution of dividends has been approved by the Company's shareholders. This preferred dividend is not cumulative if sufficient distributable profits are not obtained in the period.
  • Each Class B share holder is entitled to receive, in addition to the above-mentioned preferred dividend, the same dividends and other distributions as for one Grifols ordinary share.
  • Each Class B share entitles the holder to its redemption under certain circumstances, if a takeover bid for all or part of the shares in the Company has been made, except if holders of Class B shares have been entitled to participate in the bid on the same terms as holders of Class A shares. The redemption terms and conditions reflected in the Company's by-laws limit the amount that may be redeemed, requiring that sufficient distributable reserves be available, and limit the percentage of shares to be redeemed in line with the ordinary shares to which the bid is addressed.
  • In the event the Company were to be wound up and liquidated, each Class B share entitles the holder to receive, before any amounts are paid to holders of ordinary shares, an amount equal to the sum of (i) the par value of the Class B share, and (ii) the share premium paid for the Class B share when it was subscribed. In addition to the Class B liquidation preference amount, each holder is entitled to receive the same liquidation amount that is paid for each ordinary share. These shares are freely transferable.

The Company's knowledge of its shareholders is based on information provided voluntarily or in compliance with applicable legislation. According to the information available to the Company, there are no interests higher than 10% with voting rights at 31 December 2018 and 2017.

(b) Share premium

This reserve is freely distributable.

(c) Reserves

Details of reserves and movement during the year are shown in Appendix V.

During 2017 the Company settled the RSUS of 2014 giving rise to an increase of Euros 91,742 in reserves. In 2018

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

the Company has settled the RSUS of 2015 giving rise to an increase of Euros 318,879 in reserves.

(i) Legal reserve

The legal reserve has been appropriated in compliance with article 274 of the Spanish Companies Act, which requires that companies transfer 10% of profits for the year to a legal reserve until this reserve reaches an amount equal to 20% of share capital. At 31 December 2018 and 2017, legal reserve is 20% of share capital.

The legal reserve is not distributable to shareholders and if it is used to offset losses, in the event that no other reserves are available, the reserve must be replenished with future profits.

(ii) Treasury stock and reserve for Company shares

At the ordinary general meeting held on 29 May 2015 the shareholders of the Company agreed to authorise the acquisition of a maximum of treasury stock equivalent to 10% of the Company's share capital at a minimum price equal to the par value of shares and a maximum equal to the price quoted on the stock exchange on the date of acquisition or, where applicable, the price authorised by the Spanish National Securities Market Commission.

This acquisition has been authorised for a period of five years from the date this decision was taken. Shares acquired may be handed over to the Group's employees or directors either directly or as a result of them exercising share options they may hold.

At 31 December 2018 and 2017 the Company does not have any Class A treasury stock.

Movement in Class B treasury stock during 2017 was as follows:

Number of
Class B shares Euros
Balance at 1 January 2017 4,730,735 68,710,268
Disposals of Class B shares (432,929) (6,287,959)
Balance at 31 December 2017 4,297,806 62,422,309

In March 2017 the Group delivered 432,929 treasury stocks (Class B shares) to eligible employees as compensation for the Restricted Share Unit Retention Plan, of which 198,863 treasury stocks were given to Company employees (see note 16 (d)).

The Parent held Class B treasury stock equivalent 0.6% of its capital at 31 December 2017 (0.7% at 31 December 2016).

Movement in Class B treasury stock during 2018 is as follows:

Number of
Class B shares Euros
Balance at 1 January 2018 4,297,806 62,422,309
Disposals of Class B shares (479,355) (6,981,099)
Balance at 31 December 2018 3,818,451 55,441,210

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

In March 2018 the Group delivered 480,661treasury stocks (Class B shares) to eligible employees as compensation for the Restricted Share Unit Retention Plan, of which 193,606 treasury stocks were given to Company employees (see note 16 (d)).

The Parent held Class B treasury stock equivalent to 0.6% of its capital at 31 December 2018 (0.6% at 31 December 2017).

(iii) Differences on redenomination of capital to Euros

This reserve is not distributable.

(iv) Voluntary reserves

These reserves are freely distributable.

(d) Other own equity instruments

For the annual bonus, the Group has set up a Restricted Share Unit Retention Plan (RSU Plan), for certain employees. Under this plan, employees can choose to receive up to 50% of their yearly bonus as non-voting Class B ordinary shares (Grifols Class B Shares) or Grifols American Depositary Shares (Grifols ADS), and the Company will match this with an additional 50% in RSU.

Grifols Class B Shares and Grifols ADS are valued at bonus grant date.

These RSU will have a vesting period of two years and one day and, subsequently, they will be exchanged for Grifols Class B Shares or Grifols ADS (American Depositary Share representing 1 Class B Share).

If an eligible employee leaves the Company or is terminated with cause before the vesting period, he/she will not be entitled to the additional RSU.

At 31 December 2017, the Company settled the 2014 RSU plan for an amount of Euros 7,303 thousand, of which 3,148 thousand were from the Company.

At 31 December 2018, the Company has settled the 2015 RSU plan for an amount of Euros 6,662 thousand, of which 2,681 thousand are from the Company.

Because this commitment is settled in shares, it is recognised in equity and it totals Euros 12,652 thousand at 31 December 2018 (Euros 13,871 thousand in 2017).

(17) Other Provisions, Other Guarantees with Third Parties and Other Contingent Liabilities

Contingencies

Contingent liabilities for bank and other guarantees are disclosed in note 19. The Company does not expect any significant liabilities to arise from these guarantees.

In the event of a takeover, the Company has agreements with 26 employees/directors whereby they can unilaterally rescind their employment contracts with the Company and are entitled to termination benefits ranging from two to five years' salary.

The Company has three contracts with three members of senior management who will receive a termination benefit ranging from one to two years' salary, depending on the circumstances.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(18) Financial Liabilities by Category

(a) Classification of financial liabilities by category

The classification of financial liabilities by category and class and a comparison of the fair value with the carrying amount are provided in Appendix VI.

(i) Net losses and gains by financial liability category

Net losses and gains by financial liability category are as follows:

Euros
2018 Debts and payables Total
Finance costs at amortised cost, third parties
Finance costs at amortised cost, Group companies
(50,836,915)
(86,972,977)
(50,836,915)
(86,972,977)
Net losses in profit and loss (137,809,892) (137,809,892)
Total (137,809,892) (137,809,892)
Euros
2017 Debts and payables Total
Finance costs at amortised cost, third parties
Finance costs at amortised cost, Group companies
(26,538,678)
(77,098,571)
(26,538,678)
(77,098,571)
Net losses in profit and loss (103,637,249) (103,637,249)

Total (103,637,249) (103,637,249)

(19) Payables and Trade Payables

(a) Group companies and associates

Details of Group companies and associates are as follows:

Euros
2018 2017
Non-current
Current
Non-current Current
Group
Payables 1,512,716,087 -- 1,790,682,269 --
Loans received -- -- --
Payables, tax effect (note 21) -- 32,574,660 -- 19,907,750
Interest -- 7,191,429 -- --
Associates
Loans received -- -- -- --
Total 1,512,716,087 39,766,089 1,790,682,269 19,907,750

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Details of payables to Group companies do not include trade payables to Group companies, details of which are provided in section d) of this note.

(b) Payables

Details of payables are as follows:

Euros
2018 2017
Non-current
Current
Non-current Current
Unrelated parties
Promissory notes 987,249,676 5,333,333 985,248,207 5,244,444
Loans and borrow ings 747,069,488 30,681,772 690,441,900 4,509,164
Interest 614,509 -- 144,771
Finance lease payables (note 8) 2,496,750 1,119,117 1,861,931 1,071,228
Payables 2,878,928 2,044,257 1,747,596 6,593,133
Guarantees and deposits received -- 7,099 -- 7,099
Total 1,739,694,842 39,800,087 1,679,299,634 17,569,839

On 6 February 2017 the Group refinanced its senior secured debt with the existing lenders and obtained the additional debt required for the acquisition of Hologic for an amount of US Dollars 1,816 million. The new senior debt consists of a Term Loan A ("TLA"), which amounts to US Dollars 2,350 million and Euros 607 million with a 1.75% margin over Libor and Euribor respectively, falling due in 2023 and a quasi-bullet repayment structure, and a Term Loan B ("TLB") totalling US Dollars 3,000 million with a 2.25% margin over Libor, falling due in 2025 and a quasi-bullet repayment structure.

The Company is the borrower of the Term Loan A in Euros, the principal of which amounts to Euros 607 million.

Grifols Worldwide Operations Limited is the borrower of the Term Loan A in US Dollars and for the Term Loan B the borrower is Grifols Worldwide Operations USA, Inc. Both these companies are wholly-owned by the Company.

On 18 April 2017, the Company issued Euros 1,000 million of senior unsecured notes, falling due in 2025 and bearing an annual coupon of 3.20%.

On 5 December 2017 the Company received a fixed-interest rate loan from the European Investment Bank for total of Euros 85 million, falling due in 10 years and with an interest-free period of two years. The loan will be used to support some of the Grifols Group's R&D investments which are mainly focused on searching for new applications for plasmatic proteins.

On September 7, 2018, Grifols obtained a new long-term loan from the European Investment Bank totaling Euros 85,000 thousand that will be used by Grifols to support its investments in R&D, mainly focused on the search for new therapeutic indications for plasma-derived protein therapies. The financial conditions include a fixed interest rate for a tenor of 10 years and a two-year grace period.

At 31 December 2017, "other current financial liabilities" included an amount of Euros 5,000 thousand related to the remaining call option extended by the Group and the shareholders of Progenika with maturity on 2018. This option was executed in June 2018.

(i) Senior Unsecured Notes

On 18 April 2017, Grifols, S.A. issued Euros 1,000 million of senior unsecured notes, falling due in 2025 and bearing an annual coupon of 3.20%. These notes have been exchanged with 97.1% of the senior unsecured notes issued in 2014 by Grifols Worldwide Operations Limited, a wholly-owned subsidiary of the Company. On 2 May 2017 the notes have been listed on the Irish Stock Exchange.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

The transaction costs of the senior unsecured notes have amounted to Euros 16.1 million. These finance costs, together with other costs deriving from the debt issue will be taken to profit or loss in accordance with the new effective interest rate. Unamortised financing costs from the senior unsecured notes amount to Euros 12.8 million at 31 December 2018 (Euros 14.8 million at 31 December 2017).

The notes have been issued by Grifols, S.A. and are guaranteed on a senior unsecured basis by subsidiaries of Grifols, S.A. that are guarantors and co-borrowers under the New Credit Facilities agreement. The guarantors are Grifols Worldwide Operations Limited, Biomat USA, Inc., Grifols Biologicals Inc., Grifols Shared Services North America, Inc., Grifols Diagnostic Solutions Inc., Grifols Therapeutics, Inc., Instituto Grifols, S.A. Grifols Worldwide Operations USA, Inc. and Grifols USA, Llc

(ii) Senior Secured Debt. Euros Term Loan A

On 6 February 2017 the Group refinanced its senior secured debt, with the Company being the borrower of the Term Loan A in Euros, the principal of which amounts to Euros 607 million.

The terms and conditions of the Euros Tranche A senior secured debt are as follows:

  • Original principal of Euros 607 million.
  • Applicable margin of 175 basis points (bp) pegged to Euribor.
  • Quasi-bullet repayment structure.
  • Maturity in 2023

Detail of the maturity of the principal of Term Loan A in Euros at 31 December 2018 is as follows:

Thousand of Euros
Principal
Maturity
2019 30,350
2020 60,700
2021 60,700
2022 341,437
2023 113,813
Total 607,000

The transaction costs of Tranche A of the senior unsecured debt in Euros amount to Euros 11.9 million. These finance costs, together with other costs deriving from the debt issue will be taken to profit or loss in accordance with the new effective interest rate. Unamortised financing costs from the Tranche A in Euros amount to Euros 7.5 million at 31 December 2018 (Euros 9.8 million at 31 December 2017).

Both the senior term loans and the revolving loans of the Grifols Group are secured by the Company and other significant Group companies which, in conjunction with Grifols, S.A. represent, in the aggregate, at least 80% of the consolidated assets and consolidated EBITDA of the Group.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

  • (c) Other information on payables
  • (i) Main characteristics of payables

The terms and conditions of loans and payables are provided in Appendix VIII.

Non-current and current loans and borrowings are presented net of loan arrangement costs, which at 31 December 2018 amount to Euros 7,524 thousand (Euros 9,856 thousand at 31 December 2017).

The Company has extended guarantees to banks on behalf of Group companies for Euros 2,438 thousand at 31 December 2018 (Euros 4,014 thousand at 31 December 2017).

(d) Trade and other payables

Details of trade and other payables are as follows:

Euros
2018 2017
Current Current
Group
Suppliers (note 23) 8,032,244 5,290,662
Related parties
Suppliers (note 23) 7,531,508 9,186,754
Unrelated parties
Suppliers 34,998,857 30,218,059
Personnel 10,100,816 9,872,640
Taxation authorities, income tax (note
21) -- --
Public entities, other (note 21) 22,870,591 20,550,970
Total 83,534,016 75,119,085

(e) Classification by maturity

The classification of financial liabilities by maturity is included in Appendix VII.

(f) Amounts denominated in foreign currencies

The Euro value of monetary financial liabilities denominated in foreign currencies is as follows:

Euros
2018 US Dollar Argentine
Peso
Brazilian
Real
Other
currencies
Total
Trade and other payables
Suppliers 1,977,100 131 -- 33,618 2,010,849
Suppliers, Group companies 263,364 2 170 582 264,118
Other financial liabilities 89 -- -- 195 284
Total current liabilities 2,240,553 133 170 34,395 2,275,251
Total financial liabilities 2,240,553 133 170 34,395 2,275,251

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2017 US Dollar Argentine
Peso
Brazilian
Real
Other
currencies
Total
Trade and other payables
Suppliers
1,455,143 -- -- 1,485 1,456,628
Suppliers, Group companies
Other financial liabilities
665,042
140
69,160
30
167,344
17
634
358
902,180
545
Total current liabilities 2,120,325 69,190 167,361 2,477 2,359,353
Total financial liabilities 2,120,325 69,190 167,361 2,477 2,359,353

Details of exchange differences recognised in profit or loss on financial instruments, distinguishing between settled and outstanding transactions, are as follows:

Euros
2018 2017
Settled Outstanding Settled Outstanding
Current payables
Loans and borrow ings (519,706) (13,638) 189,772 --
Suppliers (80,885) (34,153) 413,180 50,299
Group companies
Suppliers, Group companies (65,007) 951 445,428 83,704
Total current liabilities (665,598) (46,840) 1,048,380 134,003
Total financial liabilities (665,598) (46,840) 1,048,380 134,003

(20) Late Payments to Suppliers. "Reporting Requirement". Second Additional Provision of Law 31/2014 of 4 December 2014

The average payment period to suppliers for fiscal year 2018 is 64 days (61 days for fiscal year 2017). The total average is obtained by dividing the resulting amount of weighting the number of days between the payment date and the issuance date of each invoice with the total amount of each of the invoices, among total amount of invoices.

During 2018 the Company has made payments of Euros 154,305 thousand (Euros 166,802 thousand at 2017). Outstanding payments at 31 December 2018 total Euros 17,273 thousand (Euros 13,320 thousand for fiscal year 2017). In 2018 the ratio of paid operations stands at 64 days and the ratio of operations payable stands at 60 days (61 days and 60 days respectively at 2017).

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(21) Taxation

Details of balances with public entities are as follows:

Euros
2018 2017
Non
Current
current
Non-current Current
Assets
Deferred tax assets
Current tax assets
13,996,465
--
--
25,911,844
10,936,470
--
--
48,155,918
Value added tax and similar taxes -- 11,419,949 -- 6,296,250
Total 13,996,465 37,331,793 10,936,470 54,452,168
Liabilities
Current tax liabilities -- -- -- --
Deferred tax liabilities 1,691,193 -- 1,859,414 --
Social Security -- 825,007 -- 773,591
Withholdings -- 22,045,584 -- 19,777,379
Total 1,691,193 22,870,591 1,859,414 20,550,970

Details by company of intercompany receivables and payables resulting from the tax effect of filing consolidated tax returns are as follows:

Euros
2018 2017
Current Current
Receivables (note 14)
Instituto Grifols,S.A. 21,748,510 11,568,411
Grifols Worldw ide Operations Spain S.A. -- 438,372
Biomat,S.A. 298,154 178,902
Grifols International,S.A. 3,923,729 1,748,464
Grifols Movaco,S.A. 4,273,654 3,904,790
Grifols Viajes,S.A. 85,103 61,391
Grifols Engineering,S.A. 614,549 230,386
Diagnostic Grifols S.A. -- --
Gripdan Invest, S.L 309,454 249,394
31,253,153 18,380,110

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018 2017
Current Current
Payables (note 19)
VCN Biosciencies S.L 891,302 314,995
Biomat, S.A. 241,494 290,009
Grifols Viajes, S.A 14,924 6,631
Instituto Grifols,S.A. 8,821,679 5,123,484
Diagnostic Grifols,S.A. 5,524,621 5,699,196
Laboratorios Grifols,S.A. 5,013,503 4,560,609
Grifols Movaco, S.A 1,035,879 1,061,597
Grifols Worldw ide Operations Spain S.A. -- 171,204
Grifols International,S.A. 245,815 --
Grifols Engineering,S.A. 148,360 17,557
Gri‑Cel, S.A 10,435,174 2,574,683
Gripdan Invest, S.L 201,909 87,785
32,574,660 19,907,750

Balances receivable and payable at 31 December 2018 and 2017 comprise accrued income tax and value added tax.

The Company has the following main applicable taxes open to inspection by the Spanish taxation authorities:

Tax Years open
to inspection
Income tax 2014-2018
Value added tax 2015-2018
Personal income tax 2015-2018
Capital gains tax 2015-2018
Tax on Economic Activities 2015-2018
Social Security 2015-2018
Non-residents 2015-2018
Customs duties 2015-2018

There are no tax inspections opened in 2018.

(a) Income tax

The Company files consolidated tax returns with Instituto Grifols, S.A., Laboratorios Grifols, S.A., Diagnostic Grifols, S.A., Grifols Movaco, S.A., Biomat, S.A., Grifols International, S.A., Grifols Engineering, S.A., Grifols Viajes, S.A., Gripdant Invest, S.L., Gri-Cel, S.A. and VCN Biosciencies, S.L.

A reconciliation of net income and expenses for the year with the taxable income is provided in Appendix IX.

The relationship between the tax income and accounting profit for the year is shown in Appendix X.

Details of the tax income recognised in the income statement are as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018 2017
Current tax
Present year
(39,754,655) (32,066,557)
(39,754,655) (32,066,557)
Deferred tax
Source and reversal of temporary differences
Property, plant and equipment (185,097) (229,015)
Investments 89,262 (7,221)
Cost of reducing deferred tax assets recognised in
prior years
170,561 (67,141)
Deductions generated (4,187,460) (3,232,988)
Deductions applied 621,300 1,044,945
Adjustment of deductions in prior years 278,670 (1,457,414)
Adjustment of deferred tax assets and liabilities -- --
Tax provisions -- --
(42,967,419) (36,015,391)

Details of deferred tax assets and liabilities by type of asset and liability are as follows:

Euros
Assets Liabilities Net
2018 2017 2018 2017 2018 2017
Property, plant and equipment 105,692 247,735 (1,653,677) (1,818,326) (1,547,985) (1,570,591)
Grants -- (37,516) (41,088) (37,516) (41,088)
Restricted
share
unit retention
plan 1,671,951 1,340,913 -- -- 1,671,951 1,340,913
Group Financial Investments 961,527 961,526 -- -- 961,527 961,526
Rights
to
tax
deductions
and
credits
11,257,295 8,386,296 -- -- 11,257,295 8,386,296
Total assets/liabilities 13,996,465 10,936,470 (1,691,193) (1,859,414) 12,305,272 9,077,056

In accordance with prevailing tax legislation in Spain, share-based payments to employees are income tax deductible for the intrinsic amount of the share options when they are exercised, thus giving rise to a deductible temporary difference for the difference between the amount the taxation authorities will admit as a future deduction and the zero carrying amounts of the share-based payments. At the close of the reporting period, the Company estimates the future tax deduction based on the price of the shares at that time. The amount of the tax deduction is recognised as current or deferred income tax with a balancing entry in the income statement.

Details of deferred tax assets and liabilities that are expected to be realised or reversed in periods exceeding 12 months are as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Euros
2018 2017
Deferred tax assets relating to temporary differences 2,739,170 727,111
Total assets 2,739,170 727,111
Deferred tax liabilities 1,691,193 1,684,327
Net 1,047,977 (957,216)

The commitments from the reversal of deferred tax related to provisions of investments in subsidiaries are not significant.

(b) Value added tax

Since 1 January 2008, the Company has filed consolidated tax returns with Instituto Grifols, S.A., Laboratorios Grifols, S.A., Diagnostic Grifols, S.A., Grifols Movaco, S.A., Biomat, S.A., Grifols International, S.A., Grifols Engineering, S.A., Grifols Viajes, S.A., Gri-Cel, S.A. (since 2009), Gripdan Invest, S.L. (since 2016) and VCN Biosciencies, S.L. (since 2017).

(22) Environmental Information

Details at 31 December of property, plant and equipment used to minimise the Company's impact on the environment are as follows:

Euros
2018
Description Cost Accumulated
depreciation
Net
Sew age treatment 141,724 (91,625) 50,099
Water saving 311,021 (275,181) 35,840
Electricity saving
Waste management
3,375,890
352,524
(1,000,843)
(251,644)
2,375,047
100,880
Others 164,551 (17,743) 146,808
4,345,710 (1,637,036) 2,708,674
Euros
2017
Description Cost Accumulated
depreciation
Net
Sew age treatment 494,248 (316,805) 177,443
Water saving 311,022 (248,301) 62,721
Electricity saving 2,836,222 (799,457) 2,036,765
Waste management 125,726 (2,096) 123,630
3,767,218 (1,366,659) 2,400,559

Environmental expenses amounts to Euros 163,155 in 2018 (Euros 151,120 in 2017).

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(23) Related Party Balances and Transactions

(a) Related party balances

Details of balances receivable from and payable to Group companies and related parties and the main characteristics are disclosed in notes 14 and 19.

Details of balances by category are provided in Appendix XI.

(b) Related party transactions

Details of the Company's transactions with related parties are provided in Appendix XII.

Services are normally negotiated with Group companies to include a mark-up of between 5% and 10%.

The Company contributes 0.7% of pre-tax consolidated profits for each year to a non-profit organisation.

Transactions with other related parties are conducted at arm's length.

(c) Information on the Company's directors and senior management personnel

In 2018 the independent members of the Company's board of director's accrued Euros 925 thousand in their capacity as such (Euros 925 thousand in 2017). In 2018, Directors representing shareholders' interests received remuneration of Euros 1,610 thousand (Euros 1,881 thousand in 2017). The members of the Company's board of directors who have a labour relationship with the Company and senior management personnel received total remuneration of Euros 3,240 thousand and Euros 6,566 thousand, respectively (Euros 2,951 thousand and Euros 5,739 thousand in 2017). Members of the board of directors have not received any loans or advances nor has the Company extended any guarantees on their behalf. The Company has no pension or life insurance obligations with its former or current directors or senior management personnel. In addition, termination benefit commitments are in place for certain Company directors and senior management personnel (see note 17).

During fiscal year 2018, the Company has paid insurance premiums for civil liability of directors amounting to Euros 175 thousand (Euros 190 thousand in 2017).

(d) Conflicts of interest concerning the directors

The directors of the Company and their related parties have had no conflicts of interest requiring disclosure in accordance with article 229 of the Revised Spanish Companies Act.

(24) Income and Expenses

(a) Revenues

Details of revenues by category of activity and geographical market are shown in Appendix XIII.

(b) Supplies

Details of other supplies used are as follows:

Euros
2018 2017
Other supplies used
Purchases of spare parts
Change in inventories
3,620,670
(1,042,936)
3,020,202
(550,630)
2,577,734 2,469,572

39

GRIFOLS, S.A.

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

(c) Employee benefits expense and provisions

Details of employee benefits expense are as follows:

Euros
2018 2017
Employee benefits expense
Social Security payable by the Company 8,457,327 7,804,286
Defined contribution plan contributions 134,284 125,026
Other employee benefits expenses 2,514,225 2,002,684
Annual contributions 226,940 166,621
11,332,776 10,098,617

(25) Employee Information

The average headcount of the Company, distributed by department, is as follows:

Number
2018 2017
Technical area 98 84
Administration and other 462 440
General management 59 55
619 579

The average number of Company employees with disability rating of more than 33% distributed by department, is as follows:

Number
2018 2017
Technical area 3 1
Administration and other 7 5
General management -- 1
10 7

At 31 December 2018 and 2017 the distribution by gender of Company personnel and the members of the board of directors is as follows:

Notes to the Annual Accounts

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

Number
2018 2017
Female Male Female Male
Technical area 90 16 84 14
Administration and other 155 328 149 310
General management 33 28 26 29
Directors 4 9 4 9
282 381 263 362

(26) Audit Fees

KPMG Auditores, S.L. and Grant Thornton S.L as co-auditors of the Company's annual accounts for 2018 have invoiced the Company expenses for professional services amounting to a total of Euros 75,635 during the year ended 31 December 2018 (a total of Euros 79,600 in 2017), to be split in half every year.

Additionally, KPMG Auditores, S.L. has invoiced the Company the following fees for professional service regarding the Company's annual accounts during the year ended 31 December 2018 and 2017:

Euros
2018 2017
Audit services 968,700 1,300,790
Other assurance services 493,018 683,110
1,461,718 1,983,900

The amounts in the above table include the total fees for services rendered in 2018 and 2017, irrespectively of the date of invoice.

During the year ended 31 December 2018 "Other assurance services" includes audit services for the PCAOB, semianual limited review services of the financial statements, and two reports of agreed-upon procedures by KPMG Auditores, S.L. to Grifols, S.A. During the year end 31 December 2017, included the audit services for the PCAOB, semianual limited review services of the financial statements, comfort letters related to Debt issuances and a report of agreed procedures provided by KPMG Auditores, S.L to the Company. Grifols, S.A.

Other entities affiliated to KPMG International have invoiced the Company expenses for other assurance professional services amounting to Euros 25,000 during the year ended 31 December 2018 (Euros 73,000 during 2017).

GRIFOLS, S.A. Details of intangible assets and movement for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Computer
software Total
Cost at 1 January 2018 48,728,356 48,728,356
Additions 6,941,270 6,941,270
Disposals -- --
Transfers 80,519 80,519
Irreversible impairment losses -- --
Cost at 31 December 2018 55,750,145 55,750,145
Accumulated amortisation at 1 January 2018 (35,816,388) (35,816,388)
Additions (5,399,338) (5,399,338)
Disposals -- --
Accumulated amortisation at 31 December 2018 (41,215,726) (41,215,726)
Carrying amount at 31 December 2018 14,534,419 14,534,419

GRIFOLS, S.A. Details of intangible assets and movement for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Computer
software Total
Cost at 1 January 2017 40,837,731 40,837,731
Additions 7,815,892 7,815,892
Disposals -- --
Transfers 74,733 74,733
Irreversible impairment losses -- --
Cost at 31 December 2017 48,728,356 48,728,356
Accumulated amortisation at 1 January 2017 (30,480,912) (30,480,912)
Additions (5,335,476) (5,335,476)
Disposals -- --
Accumulated amortisation at 31 December 2017 (35,816,388) (35,816,388)
Carrying amount at 31 December 2017 12,911,968 12,911,968

Details of Property, Plant and Equipment and Movement for the year ended 31 December 2018

(Expressed in euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Technical
installations
and machinery
Other
installations,
equipment and
furniture
Under construction
and
advances
Other items Total
Cost at 1 January 2018 8,244,329 17,630,336 7,537,882 17,924,168 51,336,715
Additions 295,200 465,364 847,752 3,830,830 5,439,146
Disposals (875,425) (1,953) -- (27,046) (904,424)
Transfers 882,301 3,444,475 (2,017,537) 400,105 2,709,344
Cost at 31 December 2018 8,546,405 21,538,222 6,368,097 22,128,057 58,580,781
Accumulated depreciation at 1 January 2018 (6,841,933) (12,156,064) -- (13,143,975) (32,141,972)
Additions (432,678) (1,359,945) -- (2,477,828) (4,270,451)
Disposals 697,821 1,953 -- 27,046 726,820
Transfers -- (1,041) -- -- (1,041)
Accumulated depreciation at 31 December 2018 (6,576,790) (13,515,097) -- (15,594,757) (35,686,644)
Carrying amount at 31 December 2018 1,969,615 8,023,125 6,368,097 6,533,300 22,894,137

Details of Property, Plant and Equipment and Movement for the year ended 31 December 2017

(Expressed in euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Technical
installations
and machinery
Other
installations,
equipment and
furniture
Under construction
and
advances
Other items Total
Cost at 1 January 2017 8,023,698 16,464,708 1,855,271 15,744,731 42,088,408
Additions 116,618 247,360 6,116,195 2,052,011 8,532,184
Disposals -- (1,400) -- (2,982) (4,382)
Transfers 104,013 919,668 (433,584) 130,408 720,505
Cost at 31 December 2017 8,244,329 17,630,336 7,537,882 17,924,168 51,336,715
Accumulated depreciation at 1 January 2017 (6,325,987) (10,880,573) -- (10,668,815) (27,875,375)
Additions (515,946) (1,276,894) -- (2,478,141) (4,270,981)
Disposals -- 1,403 -- 2,981 4,384
Transfers -- -- -- -- --
Accumulated depreciation at 31 December 2017 (6,841,933) (12,156,064) -- (13,143,975) (32,141,972)
Carrying amount at 31 December 2017 1,402,396 5,474,272 7,537,882 4,780,193 19,194,743

Details of Investment Property and Movement for the year ended 31 December 2018

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Land Buildings and
other
installations
Investments in
adaptation and
advances
Total
Cost at 1 January 2018 7,465,344 71,594,983 12,953,260 92,013,587
Additions -- 749,476 3,862,674 4,612,150
Disposals -- (223,347) -- (223,347)
Transfers -- 7,394,174 (10,184,038) (2,789,864)
Cost at 31 December 2018 7,465,344 79,515,286 6,631,896 93,612,526
Accumulated depreciation at 1 January 2018 -- (35,410,874) -- (35,410,874)
Additions -- (3,395,877) -- (3,395,877)
Disposals -- 14,008 -- 14,008
Transfers -- 1,041 -- 1,041
Accumulated depreciation at 31 December 2018 0 (38,791,702) 0 (38,791,702)
Carrying amount at 31 December 2018 7,465,344 40,723,584 6,631,896 54,820,824

Details of Investment Property and Movement for the year ended 31 December 2017

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Land Buildings and
other
installations
Investments in
adaptation and
advances
Total
Cost at 1 January 2017 5,296,480 68,413,415 13,480,667 87,190,562
Additions 2,168,864 248,724 3,200,675 5,618,263
Disposals -- -- -- --
Transfers -- 2,932,844 (3,728,082) (795,238)
Cost at 31 December 2017 7,465,344 71,594,983 12,953,260 92,013,587
Accumulated depreciation at 1 January 2017 -- (32,223,389) -- (32,223,389)
Additions -- (3,187,485) -- (3,187,485)
Disposals -- -- -- --
Transfers -- -- -- --
Accumulated depreciation at 31 December 2017 0 (35,410,874) 0 (35,410,874)
Carrying amount at 31 December 2017 7,465,344 36,184,109 12,953,260 56,602,713

Appendix IV 1 of 2

GRIFOLS, S.A.

Classification of Financial Assets by Category for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

At amortised cost or cost Non-current At amortised cost or cost Current
Fair value Total Carrying amount Fair value Total
59,955,873
--
--
31,253,153
4,306
378,527
20,401,767
-- -- -- 173,455 173,455 173,455
1,595,049,342 1,595,049,342 1,595,049,342 112,167,081 112,167,081 112,167,081
1,595,049,342 1,595,049,342 1,595,049,342 112,167,081 112,167,081 112,167,081
Carrying amount
1,000,000,000
593,426,692
--
--
1,622,650
--
--
1,000,000,000
593,426,692
--
--
1,622,650
--
--
1,000,000,000
593,426,692
--
--
1,622,650
--
--
59,955,873
--
--
31,253,153
4,306
378,527
20,401,767
59,955,873
--
--
31,253,153
4,306
378,527
20,401,767

Appendix IV 2 of 2

GRIFOLS, S.A.

Classification of Financial Assets by Category for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Fair value
Total
4,094,442
4,094,442
--
--
74,999,121
74,999,121
18,380,110
18,380,110
16,033
16,033
352,704
352,704
20,490,659
20,490,659
117,449
117,449
118,450,518
118,450,518
118,450,518
118,450,518

APPENDIX V GRIFOLS, S.A.

Details of Reserves and Profit and movement for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Legal and
statutory
reserves
Differences on
translation of
capital to Euros
Voluntary
reserves
Profit for the
year
Total
Balance at 1 January 2018 23,920,741 3,020 358,657,857 341,327,404 723,909,022
Recognised income and expense -- -- -- 329,718,263 329,718,263
Net movement in treasury stock
Other movements
--
--
--
--
--
79,982,288
--
--
--
79,982,288
Distribution of profit for 2017
Reserves
Preferred dividend
Interim dividend
Dividend
--
--
--
--
--
--
--
--
76,247,004
--
--
--
(76,247,004)
(2,614,251)
(122,986,278)
(139,479,871)
--
(2,614,251)
(122,986,278)
(139,479,871)
Balance at 31 December 2018 23,920,741 3,020 514,887,149 329,718,263 868,529,173

APPENDIX V GRIFOLS, S.A.

Details of Reserves and Profit and movement for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Legal and
statutory
reserves
Differences on
translation of
capital to Euros
Voluntary
reserves
Profit for the
year
Total
Balance at 1 January 2017 23,920,741 3,020 254,955,583 321,792,932 600,672,276
Recognised income and expense -- -- -- 341,327,404 341,327,404
Net movement in treasury stock
Other movements
--
--
--
--
--
91,742
--
--
--
91,742
Distribution of profit for 2016
Reserves
Preferred dividend
Interim dividend
Dividend
--
--
--
--
--
--
--
--
103,610,532
--
--
--
(103,610,532)
(2,614,251)
(122,908,351)
(92,659,798)
--
(2,614,251)
(122,908,351)
(92,659,798)
Balance at 31 December 2017 23,920,741 3,020 358,657,857 341,327,404 723,909,022

(Expressed in Euros) Details of Financial Liabilities by Category for the year ended 31 December 2018

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Non-current Current
At amortised cost or cost At amortised cost or cost
Carrying amount Fair value Total Carrying amount Fair value Total
Debts and payables
Fixed rate Bonds and other marketable securities 987,249,676 985,480,000 987,249,676 5,333,333 5,333,333 5,333,333
Variable rate Loans from group companies 1,512,716,087 1,512,716,087 1,512,716,087 -- -- --
Variable rate loans and borrowings 577,069,488 577,069,488 577,069,488 31,296,281 31,296,281 31,296,281
Fixed rate loans and borrowings 170,000,000 170,000,000 170,000,000
Finance lease payables 2,496,750 2,496,750 2,496,750 1,119,117 1,119,117 1,119,117
Other financial liabilities 2,878,928 2,878,928 2,878,928 2,051,356 2,051,356 2,051,356
Group companies and associates, current -- -- -- 39,766,089 39,766,089 39,766,089
Trade and other payables
Suppliers -- -- -- 42,530,365 42,530,365 42,530,365
Suppliers, Group companies -- -- -- 8,032,244 8,032,244 8,032,244
Other payables -- -- -- 10,100,816 10,100,816 10,100,816
Total 3,252,410,929 3,250,641,253 3,252,410,929 140,229,601 140,229,601 140,229,601
Total financial liabilities 3,252,410,929 3,250,641,253 3,252,410,929 140,229,601 140,229,601 140,229,601

(Expressed in Euros) Details of Financial Liabilities by Category for the year ended 31 December 2017

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Non-current Current
At amortised cost or cost At amortised cost or cost
Carrying amount Fair value Total Carrying amount Fair value Total
Debts and payables
Fix rate Bonds and other marketable securities 985,248,207 1,018,730,000 985,248,207 5,244,444 5,244,444 5,244,444
Variable rate Loans from group companies 1,790,682,269 1,790,682,269 1,790,682,269 -- -- --
Variable rate loans and borrowings 690,441,900 690,441,900 690,441,900 4,653,935 4,653,935 4,653,935
Finance lease payables 1,861,931 1,861,931 1,861,931 1,071,228 1,071,228 1,071,228
Other financial liabilities 1,747,596 1,747,596 1,747,596 6,600,232 6,600,232 6,600,232
Group companies and associates, current -- -- -- 19,907,750 19,907,750 19,907,750
Trade and other payables
Suppliers -- -- -- 39,404,813 39,404,813 39,404,813
Suppliers, Group companies -- -- -- 5,290,662 5,290,662 5,290,662
Other payables -- -- -- 9,872,640 9,872,640 9,872,640
Total 3,469,981,903 3,503,463,696 3,469,981,903 92,045,704 92,045,704 92,045,704
Total financial liabilities 3,469,981,903 3,503,463,696 3,469,981,903 92,045,704 92,045,704 92,045,704

Classification of Financial Liabilities by Maturity for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

140,229,600 73,110,320 82,772,181 363,565,376 2,732,963,052 (140,229,600) 3,252,410,929
10,100,817 -- -- -- -- (10,100,817) --
7,606,181 -- -- -- -- (7,606,181) --
8,032,244 -- -- -- -- (8,032,244) --
34,924,182 -- -- -- -- (34,924,182) --
2,051,356 1,610,520 838,664 429,744 -- (2,051,356) 2,878,928
1,119,117 890,374 862,194 493,799 250,383 (1,119,117) 2,496,750
31,296,281 70,609,426 81,071,323 362,641,833 232,746,906 (31,296,281) 747,069,488
5,333,333 (5,333,333) 987,249,676
1,512,716,087
Total
2018
2019
39,766,089
2020
--
--
Euros
2021
--
--
2022
--
--
Subsequent years
1,512,716,087
987,249,676
Less current portion
(39,766,089)

This appendix forms an integral part of note 19 to the annual accounts, in conjunction with which it should be read.

Classification of Financial Liabilities by Maturity for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Total financial liabilities 92,045,704 32,409,623 71,728,172 70,691,686 3,295,152,422 (92,045,704) 3,469,981,903
Personnel 9,872,640 -- -- -- -- (9,872,640) --
Suppliers, related parties 9,186,754 -- -- -- -- (9,186,754) --
Suppliers, Group companies 5,290,662 -- -- -- -- (5,290,662) --
Suppliers 30,218,059 -- -- -- -- (30,218,059) --
Trade and other payables
Other financial liabilities 6,600,232 993,926 753,670 -- -- (6,600,232) 1,747,596
Finance lease payables 1,071,228 752,965 517,791 483,170 108,005 (1,071,228) 1,861,931
Loans and borrowings 4,653,935 30,662,732 70,456,711 70,208,516 519,113,941 (4,653,935) 690,441,900
Bonds and other marketable securities 5,244,444 -- -- -- 985,248,207 (5,244,444) 985,248,207
Payables
Group companies and associates
19,907,750 -- -- -- 1,790,682,269 (19,907,750) 1,790,682,269
2018 2019 2020 2021 Subsequent years Less current portion Total
Euros
2017

This appendix forms an integral part of note 19 to the annual accounts, in conjunction with which it should be read.

Main characteristics of payables for the year ended 31 December 2018

(Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Loan Currency Interest rate Grant date Maturity Amount received Carrying amount
Total value Current Non-current
Group
Cash pooling (note 19) EUR 5,3685% (Group senior debt
interest rate + 0,75%)
2025 -- 1,512,716,087 -- 1,512,716,087
Unrelated parties
Senior Unsecured Notes EUR 3.20% 26/04/2017 26/04/2025 1,000,000,000 987,249,676 -- 987,249,676
Senior Debt. Tranche A EUR Euribor + 1,75% 31/01/2017 31/01/2023 607,000,000 599,564,465 28,118,722 571,445,743
European Investment Bank EUR 2.02% 22/12/2017 22/12/2027 85,000,000 85,000,000 38,137 85,000,000
European Investment Bank EUR 2.15% 25/09/2018 25/09/2028 85,000,000 85,000,000 481,136 85,000,000
Bankinter EUR 2,25% (until 2018) 21/11/2014 30/09/2024 10,000,000 6,199,987 996,185 5,203,802
Banco Popular EUR Euribor + 2,3% 03/03/2015 04/03/2020 8,000,000 2,078,926 1,662,101 419,943
795,000,000 777,843,378 31,296,281 747,069,488
1,795,000,000 3,277,809,141 31,296,281 3,247,035,251

Main characteristics of payables for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Loan Currency Interest rate Grant date Maturity Amount received Total value Carrying amount
Current
Non-current
Group
Cash pooling (note 19) EUR 4,6877% (Group senior debt
interest rate + 0,75%)
2024 -- 1,790,682,269 -- 1,790,682,269
Unrelated parties
Senior Unsecured Notes EUR 3.20% 26/04/2017 26/04/2025 1,000,000,000 985,248,207 -- 985,248,207
Senior Debt. Tranche A EUR Euribor + 1,75% 31/01/2017 31/01/2023 607,000,000 597,165,716 -- 597,165,716
European Investment Bank EUR 2.02% 22/12/2017 22/12/2027 85,000,000 85,000,000 -- 85,000,000
Banca March EUR Euribor + 4% 10/07/2013 01/08/2018 6,500,000 1,298,962 1,298,962 --
Bankinter EUR 2,25% (until 2018) 21/11/2014 30/09/2024 10,000,000 7,161,588 964,330 6,197,258
Banco Popular EUR Euribor + 2,3% 03/03/2015 04/03/2020 8,000,000 3,705,140 1,626,214 2,078,926
Credit facilities EUR 1,25% - 2,8% 2018 43,050,000 619,711 619,711 --
759,550,000 694,951,117 4,509,217 690,441,900
1,759,550,000 3,470,881,593 4,509,217 3,466,372,376

APPENDIX IX

GRIFOLS, S.A.

Reconciliation between net income and expense for the year and the tax loss for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Income statement
Increases Decreases Net Increases Decreases Net Total
Income and expenses for the period 329,718,263 14,289 -- 14,289 329,732,552
Income tax
Income tax, prior years
(43,254,163)
286,744
(3,572) -- (3,572) (43,257,735)
286,744
Profit before income tax
Permanent differences
286,750,844 10,716 -- 10,716 286,761,560
Individual company 13,207,303 165,788,929 (152,581,626) -- -- -- (152,581,626)
Tax consolidation adjustments 22,093,101 313,179,076 (291,085,975) -- -- -- (291,085,975)
Temporary differences
Individual company
Unrecognised temporary differences (assets)
originating in current year 2,541,435 42,390 2,499,045 -- -- 0 2,499,045
originating in prior years 1,534,566 3,650,273 (2,115,707) -- -- -- (2,115,707)
Tax loss (156,533,419) 10,716 (156,522,703)

Reconciliation between net income and expense for the year and the tax loss for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Income statement Income and expense recognised in equity
Increases Decreases Net Increases Decreases Net Total
Income and expenses for the period 341,327,404 14,289 -- 14,289 341,341,693
Income tax
Income tax, prior years
(34,728,489)
(1,286,902)
(3,573) -- (3,573) (34,732,062)
(1,286,902)
Profit before income tax
Permanent differences
305,312,013 10,716 -- 10,716 305,322,729
Individual company 9,896,846 129,304,162 (119,407,316) -- -- -- (119,407,316)
Tax consolidation adjustments -- 311,204,456 (311,204,456) -- -- -- (311,204,456)
Temporary differences
Individual company
Unrecognised temporary differences (assets)
originating in current year 297,448 23,265 274,183 (10,716) -- (10,716) 263,467
originating in prior years 1,069,986 301,221 768,765 -- -- -- 768,765
Tax loss (124,256,811) -- (124,256,811)

Details of income tax expense/(tax income) related to profit/(loss) for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Profit and loss Equity Total
Income and expenses for the period before tax 286,750,844 14,289 286,765,133
Tax at 25% 71,687,711 3,572 71,691,283
Non-taxable income
Dividends from group companies (97,613,353) -- (97,613,353)
Dividends, double taxation (exemption) (22,128,648) -- (22,128,648)
Non-deductible expenses
Donations 2,172,848 -- 2,172,848
Provision for investments in group companies 6,652,092 -- 6,652,092
Sanctions and fines 161 -- 161
Tax-deductible expenses
Deductions and credits for the current year (4,187,460) -- (4,187,460)
Prior years' adjustments 449,230 -- 449,230
Taxable income/(tax loss) (42,967,419) 3,572 (42,963,847)

Details of income tax expense/(tax income) related to profit/(loss) for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Profit and loss Equity Total
Income and expenses for the period before tax 305,312,013 10,716 305,322,729
Tax at 25% 76,328,003 2,679 76,330,682
Non-taxable income
Dividends from group companies
Dividends, double taxation (exemption)
(77,801,114)
(32,326,041)
--
--
(77,801,114)
(32,326,041)
Non-deductible expenses
Donations
Provision for investments in group companies
Sanctions and fines
2,298,647
170,388
5,177
--
--
--
2,298,647
170,388
5,177
Tax-deductible expenses
Deductions and credits for the current year (3,232,988) -- (3,232,988)
Prior years' adjustments (1,457,463) -- (1,457,463)
Taxable income/(tax loss) (36,015,391) 2,679 (36,012,712)

GRIFOLS, S.A. Related Party Balances for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish, In the event of discrepancy, the Spanish-language version prevails,)

Euros
Group
companies
Associates Directors Other related
parties
Total
Non-current investments in Group companies
Loans to companies 1,593,426,692 -- -- -- 1,593,426,692
Deposits and guarantees 614,313 -- -- 831,996 1,446,309
Total non-current assets 1,594,041,005 -- -- 831,996 1,594,873,001
Trade and other receivables
Trade receivables – current 19,526,804 -- -- -- 19,526,804
Current investments in Group companies and
associates
Loans to companies 91,209,026 -- -- 91,209,026
Total current assets 110,735,830 -- -- -- 110,735,830
Total assets 1,704,776,835 -- -- 831,996 1,705,608,831
Non-current payables to Group companies 1,512,716,087 -- -- -- 1,512,716,087
Total non-current liabilities 1,512,716,087 -- -- -- 1,512,716,087
Current payables to Group companies and
associates
Trade and other payables (note 20)
39,766,089 -- -- -- 39,766,089
Suppliers -- -- -- 7,531,508 7,531,508
Suppliers, Group companies and associates 8,032,244 -- -- -- 8,032,244
Total current liabilities 47,798,333 -- 0 7,531,508 55,329,841
Total liabilities 1,560,514,420 -- 0 7,531,508 1,568,045,928

GRIFOLS, S.A. Related Party Balances for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish, In the event of discrepancy, the Spanish-language version prevails,)

Euros
Group
companies
Associates Directors Other related
parties
Total
Non-current investments in Group companies
Loans to companies 1,748,441,128 -- -- -- 1,748,441,128
Deposits and guarantees 614,313 -- -- 831,996 1,446,309
Total non-current assets 1,749,055,441 -- -- 831,996 1,749,887,437
Trade and other receivables
Trade receivables – current 19,485,499 -- -- -- 19,485,499
Current investments in Group companies and
associates
Loans to companies 97,323,068 150,605 -- -- 97,473,673
Total current assets 116,808,567 150,605 -- -- 116,959,172
Total assets 1,865,864,008 150,605 -- 831,996 1,866,846,609
Non-current payables to Group companies 1,790,682,269 -- -- -- 1,790,682,269
Total non-current liabilities 1,790,682,269 -- -- -- 1,790,682,269
Current payables to Group companies and
associates
19,907,750 -- -- -- 19,907,750
Trade and other payables (note 20)
Suppliers
-- -- 462,500 8,997,018 9,459,518
Suppliers, Group companies and associates 5,290,662 -- -- -- 5,290,662
Total current liabilities 25,198,412 -- 462,500 8,997,018 34,657,930
Total liabilities 1,815,880,681 -- 462,500 8,997,018 1,825,340,199

Related Party Transactions for the year ended 31 December 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Group
companies
Key management
personnel
Directors Other related
parties
Total
Income
Licencing income
Other services rendered
Finance income
Dividends
16,626,213
99,571,018
52,115,757
478,968,005
--
--
--
--
--
--
--
--
--
--
--
--
16,626,213
99,571,018
52,115,757
478,968,005
Total income 647,280,993 -- -- -- 647,280,993
Expenses
Operating lease expenses
Contributions to foundations
Other services received
Personnel expenses
Finance costs
3,707,540
--
11,604,755
--
86,972,977
--
--
--
6,565,512
--
--
--
2,535,000
3,240,246
--
5,468,710
4,282,050
844,364
--
--
9,176,250
4,282,050
14,984,119
9,805,758
86,972,977
Total expenses 102,285,272 6,565,512 5,775,246 10,595,124 125,221,154
Investments
Cost of assets acquired
Buildings and other installations
Income of assets acquired
Buildings and other installations
348,621
(177,604)
--
--
--
--
--
--
348,621
(177,604)
Total investments 171,017 -- -- -- 171,017

Related Party Transactions for the year ended 31 December 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Group
companies
Key management
personnel
Directors Other related
parties
Total
Income
Licencing income 15,437,827 -- -- -- 15,437,827
Other services rendered 95,880,343 -- -- -- 95,880,343
Finance income 39,070,699 -- -- -- 39,070,699
Dividends 440,508,618 -- -- -- 440,508,618
Total income 590,897,487 -- -- -- 590,897,487
Expenses
Operating lease expenses 3,581,195 -- -- 5,425,609 9,006,804
Contributions to foundations -- -- -- 7,100,268 7,100,268
Other services received 11,612,938 -- 2,806,000 939,585 15,358,523
Personnel expenses -- 5,738,519 2,845,872 -- 8,584,391
Finance costs 77,098,571 -- -- -- 77,098,571
Total expenses 92,292,704 5,738,519 5,651,872 13,465,462 117,148,557
Investments
Cost of assets acquired
Buildings and other installations 531,672 -- -- -- 531,672
Total investments 531,672 -- -- -- 531,672

(Expressed in Euros) Details of Revenues by Category of Activity and Geographical Market for the years ended 31 December 2018 and 2017

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Domestic Rest of European Union United States Rest of the world Total
2018 2017 2018 2017 2018 2017 2018 2017 2018 2017
Revenue from the rendering of services 57,700,659 41,230,851 17,829,911 22,366,688 22,132,062 30,050,248 1,908,386 2,242,332 99,571,018 95,890,119
Licencing income 16,626,213 15,437,827 -- -- -- -- -- -- 16,626,213 15,437,827
Finance income 4,940,904 3,978,074 47,177,975 35,092,625 -- -- -- 52,118,879 39,070,699
Dividends 390,453,411 311,204,455 88,514,594 116,937,641 -- -- -- 12,366,522 478,968,005 440,508,618
469,721,187 371,851,207 153,522,480 174,396,954 22,132,062 30,050,248 1,908,386 14,608,854 647,284,115 590,907,263

31 December 2017 and 2016 Details of Revenues by Category of Activity and Geographical Market for the years ended (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Euros
Domestic Rest of European Union
United States
Rest of the world Total
2017 2016 2017 2016 2017 2016 2017 2016 2017 2016
Revenue from the rendering of services 41,230,851 43,495,642 22,366,688 22,096,415 30,050,248 25,997,309 2,242,332 2,611,407 95,890,119 94,200,773
Licencing income 15,437,827 15,067,748 -- -- -- -- -- -- 15,437,827 15,067,748
Finance income 3,978,074 20,707,923 35,092,625 -- -- -- -- 29,399 39,070,699 20,737,322
Dividends 311,204,455 127,795,046 116,937,641 256,493,977 -- -- 12,366,522 4,417,352 440,508,618 388,706,375
371,851,207 207,066,359 174,396,954 278,590,392 30,050,248 25,997,309 14,608,854 7,058,158 590,907,263 518,712,218

APPENDIX XIV GRIFOLS, S.A. Statement of Interim Dividend Liquidity for 2018 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Thousands of Euros
Forecast distributable profit for 2018:
Projected profit after income tax to 31/12/2018
Less, provision required for legal reserve
258.091.000
--
Estimated distributable profit for 2018 258.091.000
Interim dividend distributed 136.747.291
Forecast cash for the period from 26 October 2018 to 26 October 2019:
Cash balances at 26 October 2018 --
Projected collections 572.263.000
Projected payments, including interim dividend (544.112.000)
Projected cash balances at 26 October 2019 28.151.000

APPENDIX XIV GRIFOLS, S.A. Statement of Interim Dividend Liquidity for 2017 (Expressed in Euros)

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.)

Thousands of Euros
Forecast distributable profit for 2017:
Projected profit after income tax to 31/12/2017 273.472.000
Less, provision required for legal reserve --
Estimated distributable profit for 2017 273.472.000
Interim dividend distributed 122.986.278
Forecast cash for the period from 15 December 2017 to 15 December 2018:
Cash balances at 15 December 2018 --
Projected collections 475.209.000
Projected payments, including interim dividend (468.117.000)
Projected cash balances at 15 December 2018 7.092.000

GRIFOLS, S.A. Information on Group Companies, Associates and others 31 December 2018

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.) (Expressed in Euros)

% ownership
Name Registered office Activity Dir Ind Total Share capital Reserves Other equity items Interim dividend Profit/(loss) for the year Total equity Carrying amount of
investment
Dividends received in 2018
0016 Alkahest, Inc. United States Research -- 47.580 47.580 5,930 14,909,323 (3,404,707) 11,510,547 -- --
0017 Kiro Grifols S.L
(formerly Kiro Robotics S.L.) Spain Research 90.000 -- 90.000 4,000,000 (2,890,375) -- -- (4,629,751) (3,520,127) 29,953,050 --
0019 Aradigm Corporation United States Research -- 35.130 35.130 386,599,127 (382,898,690) -- -- (14,425,328) (10,724,891) -- --
0021 VCN Biosciences, S.L. Spain Research -- 81.340 81.340 152,421 2,104,642 -- -- (1,505,640) 751,423 -- --
0029 Progenika Biopharma, S.A. Spain Industrial 99.998 0 99.998 615,374 15,373,147 -- -- 691,283 16,679,803 67,724,547 --
0030 Asociación I+D Progenika Spain Industrial -- 99.998 99.998 196,000 25,636 -- -- 6,724 228,361 -- --
0032 Instituto Grifols, S.A. Spain Industrial 99.998 0.002 100.000 1,537,989 16,497,121 717,803 (156,000,000) 169,165,043 31,917,956 2,255,793 296,024,581
0033 Diagnostic Grifols,s.A. Spain Industrial -- 100.000 100.000 336,560 42,417,027 106,659 -- 4,959,830 47,820,075 -- --
0034 Grifols Movaco,S.A. Spain Commercial 99.999 0.001 100.000 2,404,601 2,242,284 180,711 -- 1,395,502 6,223,098 4,085,334 --
0037 Laboratorios Grifols,S.A. Spain Industrial 99.999 0.001 100.000 21,798,360 5,769,578 267,750 -- (9,169,101) 18,666,588 83,066,117 --
0039 Gripdan Invest, S.L Spain Services 100.000 -- 100.000 3,006,000 1,347,668 -- -- 1,590,454 5,944,122 24,583,993 2,292,790
0040 Biomat,S.A. Spain Industrial 99.900 0.100 100.000 60,110 1,640,405 95,909 -- 761,396 2,557,820 155,950 570,607
0041 Grifols International,S.A. Spain Commercial 99.998 0.002 100.000 2,860,154 7,090,864 1,882,833 -- 12,850,540 24,684,390 4,555,179 11,292,595
0042 Grifols Engineering,S.A. Spain Industrial 99.950 0.050 100.000 60,120 745,340 51,805 -- 908,061 1,765,327 111,895 2,998,500
0045 Grifols Viajes,S.A. Spain Services 99.900 0.100 100.000 60,110 868,448 -- -- 23,038 951,596 60,041 --
0047 Gri-Cel, S.A. Spain Research 0.001 99.999 100.000 15,060,102 20,659,751 -- (37,000,000) 27,476,168 26,196,021 1 --
0048 Araclon Biotech, S.L. Spain Research -- 73.220 73.220 11,215 (5,526,789) -- -- (7,510,565) (13,026,140) -- --
0050 Grifols Worldwide Operations USA
Inc. United States Industrial -- 100.000 100.000 1 38,010,865 2,351,776 -- 206,395 40,569,037 -- --
385,453 23,268,736 (1,878,005) -- (481,209) 21,294,974 --
0051 Grifols Chile,S.A. Chile Commercial 99.000 -- 99.000 385,454
0052 Grifols Argentina,S.A. Argentina Commercial 95.010 4.990 100.000 955,675
92,279
21,347,057
3,510,951
(18,159,865)
(514,229)
--
--
166,676
203,179
4,309,544
3,292,181
4,502,857 --
--
0054 Logística Grifols,S.A. de CV Mexico Commercial 99.990 0.010 100.000 235,258
0055 Grifols Portugal Productos
Farmacéutiocs e Hospitalares,Lda.
Portugal Commercial 0.010 99.990 100.000 511,806 6,977,271 -- -- 603,392 8,092,470 -- --
0056 Grifols, s.r.o. Czech Republic Commercial 100.000 -- 100.000 51,597 12,754,775 513,215 -- 1,092,657 14,412,244 51,600 --
0057 Grifols USA, LLC United States Commercial -- 100.000 100.000 561,686 18,337,686 (11,642,569) -- 92,335,003 99,591,806 -- --
0058 Grifols UK,Ltd. United Kingdom Commercial 100.000 -- 100.000 4,285 5,028,843 (833,217) -- 331,875 4,531,786 21,167,620 --
0059 Grifols Italia,S.p.A. Italy Commercial 100.000 -- 100.000 2,496,000 11,177,307 -- -- 2,467,569 16,140,877 12,862,540 --
0062 Grifols Brasil,Lda. Brazil Commercial 100.000 -- 100.000 46,110,919 (1,634,032) (8,382,373) -- 197,826 36,292,339 41,045,148 --
0063 Grifols France,S.A.R.L. France Commercial 99.990 0.010 100.000 657,734 1,898,302 -- -- 745,793 3,301,829 657,657 --
0065 Biomat USA,Inc. United States Industrial -- 100.000 100.000 0 416,196,901 20,958,786 -- 74,030,619 511,186,307 -- --
Squadron Reinsurance Designated
0066 Activity Company Ireland Services -- 100.000 100.000 635,000 55,421,545 (3,906,423) -- 6,732,693 58,882,815 --
(formerly Squadron Reinsurance Ltd.)
--
0067 Grifols Biologicals, LLC. 1 128,114,113 26,236,952 -- 13,733,523 168,084,588 --
United States Industrial -- 100.000 100.000 --
Grifols Shared Services North
0068 America, Inc. United States Services 100.000 -- 100.000 (1) 314,256,737 318,279,023 -- 1,943,404,715 2,575,940,473 --
(formerly Grifols Inc.)
1,112,596,665
0071 Grifols Asia Pacific Pte. Ltd. Singapore Commercial 100.000 -- 100.000 362,387 5,898,305 859,613 -- 2,640,949 9,761,254 749,709 --
0072 Grifols (Thailand), Ltd. Thailand Commercial -- 48.000 48.000 61,198 6,298,780 837,005 -- 371,717 7,568,701 -- --
0074 Grifols Malaysia Sdn Bhd Malaysia Commercial -- 30.000 30.000 30,283 2,086,645 (104,084) -- 465,692 2,478,536 -- --
0075 Grifols Polska, Sp.z.o.o. Poland Commercial 100.000 -- 100.000 10,714 2,737,178 153,979 -- (230,082) 2,671,789 10,714 --
0078 Grifols México,S.A. de CV Mexico Commercial 99.980 0.020 100.000 461,397
1,695,072
14,057,296
9,248,429
(3,024,798)
(2,179,314)
--
--
1,170,279
399,946
12,664,174
9,164,134
461,224 --
--
0081 Grifols Australia Pty Ltd
0084 Medion Diagnostic Grifols AG
Australia
Switzerland
Industrial
Industrial
100.000
--
--
100.000
100.000
100.000
2,487,150 1,373,333 (534,290) -- 1,085,202 4,411,395 34,974,212
--
--
0085 Medion Diagnostic GmbH Germany Commercial -- 100.000 100.000 1,500,000 (1,005,873) -- -- -- 494,127 -- --
0086 Grifols Colombia, Ltda. Colombia Commercial 99.000 1.000 100.000 822,620 (174,762) (212,407) -- 403,361 838,813 575,032 --
0087 Grifols Nordic AB Sweden Commercial 100.000 -- 100.000 10,392 1,756,608 (191,156) -- 606,831 2,182,675 1,579,452 --
0089 Grifols Deutschland,GmbH Germany Commercial 100.000 -- 100.000 25,000 4,349,883 (481,969) (3,000,000) 6,006,637 6,899,551 12,736,312 7,000,000
0090 Grifols Therapeutic LLC. United States Industrial -- 100.000 100.000 (2,885,734) 1,021,551,915 277,750,750 -- 204,664,824 1,501,081,755 -- --
0091 Talecris Plasma Resources Inc. United States Industrial -- 100.000 100.000 7 41,369,463 13,575,445 -- 12,633,967 67,578,882 -- --
0094 Grifols Worldwide Operations Limited Ireland Industrial 100.000 -- 100.000 1 874,754,772 2,107,588 (45,018,530) 59,019,234 890,863,065 926,044,178 81,514,594
Grifols Pharmaceutical Technology
(Shanghai) Co., Ltd. (formerly Grifols
0095 Pharmaceutical Consulting China Commercial 100.000 -- 100.000 1,000,000 4,809,708 (326,421) -- 1,596,027 7,079,313 --
(Shanghai) Co., Ltd.) 1,000,000
81,189 (242,413) 342,637 -- (3,500) 177,912 --
0097 Grifols Switzerland, AG Switzerland Commercial 100.000 -- 100.000 169,208
0096 Grifols Diagnostics Solutions Inc 37 878,603,861 24,188,992 -- 96,268,649 999,061,539 --
(formerly G-C Diagnostics Corp.) United States Industrial 100.000 -- 100.000 880,982,529 --
0098 Grifols (H.K.), Limited 37,899,374 21,638,440 5,397,582 -- 4,488,632 69,424,028 --
Hong Kong Commercial -- 100.000 100.000 -- --
0099 Grifols Japan KK Japan Commercial 100.000 -- 100.000 354,409 572,822 100,707 -- 86,108 1,114,045 708,818
00A1 Grifols Pharmaceutical Technology China Commercial 100.000 -- 100.000 -- (3,269,486) 225,392 -- (1,120,512) (4,164,606) --
Co., Ltd. Beijing Branch --
00A2 Grifols India Healthcare Private Ltd India Commercial 99.990 0.010 100.000 1,688 706,450 (91,170) -- (74,450) 542,518 599,086 --
00A4 Grifols Canadá, Ltd. Canada Industrial -- 100.000 100.000 6 24,473,822 (1,389,826) -- 1,737,805 24,821,807 -- --
00A5 Grifols Diagnostics Equipment Taiwan Limit Taiwan Commercial 100.000 -- 100.000 181,343 425,574 39,379 -- 103,332 749,629 181,060 --
00A6 Grifols Innovation and New Technologies Li Ireland Research -- 100.000 100.000 1 76,558,775 (4,100,220) -- (24,078,187) 48,380,369 -- --
00A7 AlbaJuna Therapeutics, S.L Spain Research -- 30.000 30.000 7,143 6,107,818 (2,283,349) 3,831,612 -- --
00A8 Interstate Blood Bank, Inc. United States Industrial -- 49.190 49.190 83,886 7,029,481 1,356,371 -- 1,859,161 10,328,900 -- --
00A9 Bio Blood Components Inc. United States Industrial -- 48.972 48.972 12,052 9,468,016 686,643 -- 2,332,003 12,498,714 -- --
00B1 Singulex, Inc. United States Research -- 19.330 19.330 4,169 (275,653,786) 48,458 (275,601,159) -- 77,274,335
00B2 PBS Acquisition Corp. United States Industrial -- 100.000 100.000 (196,179) 26,435,246 (300,202) -- -- 25,938,865 -- --
00B3 Plasma Biological Services, LLC. United States Industrial -- 48.900 48.900 7,860
0
(7,912,108)
48,059,553
--
(3,386,032)
(3,066,334)
--
266,286
1,588,846
(10,704,296)
46,262,367
-- --
--
00B4 Chiquito Acquisition Corp.
00B5 Access Biologicals, LLC. and Subsidiaries.
United States
United States
Corporate
Industrial
-- 100.000 100.000 -- -- -- -- -- -- --
00B7 Aigües Minerals Vilajuïga Spain Industrial --
99.990
49.000
0.010
49.000
100.000
75,000 36,127 -- -- (1,002,168) (891,041) --
--
--
00B8 GigaGen Inc. United States Industrial -- 43.960 43.960 1,172 26,640,662 -- -- 789,573 27,431,406 -- --
00B9 Plasmavita Healthcare GmbH Germany Industrial -- 50.000 50.000 10,025 564,262 -- -- (564,887) 9,400
00C1 Goetech LLC (D/B/A Medkeeper) United States Industrial -- 54.760 54.760 -- 45,562,218 3,629,296 -- 1,778,263 50,969,777 -- --
00C2 Haema AG Germany Industrial -- -- -- 15,000,000 34,058,096 (989) -- (16,122) 49,040,985 -- --
00C3 Biotest Pharma Corp United States Industrial -- -- -- 183,148,729 (120,762,497) (175) -- 31,224,868 93,610,925 -- --
00C4 Biotest US Corporation United States Services -- -- -- 87,077,673 97,007,293 546,628 -- -- 184,631,594 -- --

00C5 Mecwins, S.A. Spain Industrial -- 24.990 24.990 126,000 5,361,642 85,581 -- (498,996) 5,074,227 -- --

GRIFOLS, S.A. Information on Group Companies, Associates and others 31 December 2017

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails.) (Expressed in Euros)

'% ownership Carrying amount of
Name Registered office Activity Dir Ind Total Share capital Reserves Other equity items Interim dividend Profit/(loss) for the year Total equity investment Dividends received in 2017
0016 Alkahest, Inc. United States Research -- 47.580 47.580 5,670 17,936,296 (2,834,153) 15,107,813 -- --
0017 Kiro Grifols S.L
(formerly Kiro Robotics S.L.)
Spain Research 90.000 -- 90.000 4,000,000 (1,455,607) -- -- (1,434,768) 1,109,625 29,953,050 --
0018 TiGenix N.V. Belgium Research 14.180 -- -- -- -- -- -- -- -- -- --
0019 Aradigm Corporation United States Research -- 35.130 35.130 369,095,306 (365,562,411) -- -- (13,772,200) (10,239,306) -- --
0021 VCN Biosciences, S.L. Spain Research -- 81.340 81.340 152,421 3,563,954 -- -- (1,459,312) 2,257,063 -- --
0022 Progenika Inc.
(Merged with Grifols Diagnostics
Solutions Inc. in 2017)
United States Industrial -- -- -- -- -- -- -- -- -- -- --
0023 Progenika Latina ,S.A. de CV Mexico Industrial -- -- -- -- -- -- -- -- -- -- --
0027 Abyntek Biopharma, S.L Spain Industrial -- -- -- -- -- -- -- 201,780 201,780 -- --
0029 Progenika Biopharma, S.A. Spain Industrial -- 90.230 90.230 615,374 16,165,942 -- -- (792,794) 15,988,521 -- --
0030 Asociación I+D Progenika Spain Industrial -- 90.230 90.230 196,000 50,330 -- -- (24,694) 221,636 -- --
0032 Instituto Grifols, S.A. Spain
Spain
Industrial
Industrial
99.998 0.002 100.000 1,537,989
336,560
18,799,129
34,099,418
527,119
98,766
--
--
137,728,421
8,317,625
158,592,658
42,852,369
2,065,109 267,472,955
--
0033 Diagnostic Grifols,s.A. -- 100.000 100.000 2,404,601 1,841,887 130,403 -- 400,397 4,777,289 -- --
0034 Grifols Movaco,S.A. Spain Commercial 99.999 0.001 100.000 4,035,023
0036 Grifols Worldwide Operations Spain,
S.A
(formerly Logister, S.A.)
Spain Services -- 100.000 100.000 105,325 1,903,675 411,641 -- 1,403,434 3,824,076 -- --
0037 Laboratorios Grifols,S.A. Spain Industrial 99.999 0.001 100.000 21,798,360 (2,110,117) 235,393 -- (10,120,304) 9,803,332 65,033,759 --
0039 Gripdan Invest, S.L Spain Services 100.000 -- 100.000 3,006,000 1,347,668 -- -- 2,292,790 6,646,458 46,677,094 30,000,000
0040 Biomat,S.A. Spain Industrial 99.900 0.100 100.000 60,110 1,640,405 94,513 -- 571,179 2,366,206 154,554 591,218
0041 Grifols International,S.A. Spain Commercial 99.998 0.002 100.000 2,860,154 6,362,434 1,086,522 -- 11,292,821 21,601,932 3,946,616 12,199,744
0042 Grifols Engineering,S.A. Spain Industrial 99.950 0.050 100.000 60,120 2,810,273 47,643 -- 935,067 3,853,103 107,733 940,539
0045 Grifols Viajes,S.A. Spain Services 99.900 0.100 100.000 60,110 782,370 -- -- 86,078 928,558 60,041 --
0047 Gri-Cel, S.A.
0048 Araclon Biotech, S.L.
Spain
Spain
Research
Research
0.001
--
99.999
73.220
100.000
73.220
15,060,102
11,215
(258,220)
513,023
19,601,938
--
--
--
1,316,033
(6,039,813)
35,719,853
(5,515,574)
1
--
--
--
0050 Grifols Worldwide Operations USA
Inc.
United States Industrial -- 100.000 -- 1 2,249,013 (383,062) -- (895,039) 970,913 -- --
385,453 20,978,052 (258,109) -- 2,290,682 23,396,078 --
0051 Grifols Chile,S.A.
0052 Grifols Argentina,S.A.
Chile
Argentina
Commercial
Commercial
99.000
95.010
--
4.990
99.000
100.000
955,675 21,568,605 (14,564,734) -- (221,547) 7,738,000 385,454
6,563,003
--
0054 Logística Grifols,S.A. de CV Mexico Commercial 99.990 0.010 100.000 92,279 3,136,542 (661,054) -- 374,408 2,942,175 235,258 --
0055 Grifols Portugal Productos
Farmacéutiocs e Hospitalares,Lda. Portugal Commercial 0.010 99.990 100.000 511,806 6,595,826 -- -- 381,445 7,489,077 -- --
0056 Grifols, s.r.o. Czech Republic Commercial 100.000 -- 100.000 51,597 12,183,846 615,360 -- 570,927 13,421,729 51,600 --
0057 Grifols USA, LLC United States Commercial -- 100.000 100.000 561,686 223,624,765 (7,603,820) -- 78,159,632 294,742,264 -- --
0058 Grifols UK,Ltd.
0059 Grifols Italia,S.p.A.
United Kingdom
Italy
Commercial
Commercial
100.000
100.000
--
--
100.000
100.000
4,285
2,496,000
4,654,663
9,196,071
(791,372)
--
--
--
374,182
1,981,236
4,241,759
13,673,307
21,167,620
12,862,540
2,269,761
--
0062 Grifols Brasil,Lda. Brazil Commercial 100.000 -- 100.000 46,110,919 (2,848,397) (4,169,658) -- 1,214,366 40,307,229 42,381,263 --
0063 Grifols France,S.A.R.L. France Commercial 99.990 0.010 100.000 657,734 2,191,330 -- -- (293,028) 2,556,036 657,657 --
0065 Biomat USA,Inc. United States Industrial -- 100.000 100.000 -- 308,665,932 (3,141,819) -- 41,933,278 347,457,390 -- --
0066 Squadron Reinsurance Designated
Activity Company
(formerly Squadron Reinsurance Ltd.)
Ireland Services -- 100.000 100.000 635,000 50,113,972 (6,492,257) -- 5,307,573 49,564,288 -- --
0067 Grifols Biologicals, LLC. United States Industrial -- 100.000 100.000 1 302,034,490 24,086,481 -- 20,443,082 346,564,054 -- --
Grifols Shared Services North
0068 America, Inc.
(formerly Grifols Inc.)
United States Services 100.000 -- 100.000 -- 330,634,515 153,448,812 -- (93,652,115) 390,431,213 1,032,704,254 --
0071 Grifols Asia Pacific Pte. Ltd. Singapore Commercial 100.000 -- 100.000 362,387 3,095,480 393,056 -- 2,802,824 6,653,747 714,769 10,096,761
0072 Grifols (Thailand), Ltd. Thailand Commercial -- 48.000 48.000 61,198 5,548,428 439,955 -- 832,378 6,881,958 -- --
0074 Grifols Malaysia Sdn Bhd Malaysia Commercial -- 30.000 30.000 30,283 1,758,941 (156,502) -- 327,780 1,960,501 -- --
0075 Grifols Polska, Sp.z.o.o. Poland Commercial 100.000 -- 100.000 10,714 2,475,493 231,889 -- 261,714 2,979,809 10,714 --
0078 Grifols México,S.A. de CV Mexico Commercial 99.980 0.020 100.000 461,397 15,807,075 (3,572,157) -- (1,749,778) 10,946,536 461,224 --
0081 Grifols Australia Pty Ltd
0084 Medion Diagnostic Grifols AG
Australia
Switzerland
Industrial
Industrial
100.000
--
--
100.000
100.000
100.000
1,695,072
2,487,150
6,604,848
959,998
(1,640,304)
(613,000)
--
--
2,643,604
(2,181,295)
9,303,220
652,853
34,974,212
--
--
--
0085 Medion Diagnostic GmbH Germany Commercial -- 100.000 100.000 1,500,000 (1,005,873) -- -- -- 494,127 -- --
0086 Grifols Colombia, Ltda. Colombia Commercial 99.000 1.000 100.000 822,620 (101,829) (166,734) -- (72,933) 481,124 575,032 --
0087 Grifols Nordic AB Sweden Commercial 100.000 -- 100.000 10,392 1,921,181 (126,793) -- (164,735) 1,640,045 1,579,452 --
0089 Grifols Deutschland,GmbH Germany Commercial 100.000 -- 100.000 25,000 4,279,587 (604,367) (3,000,000) 7,070,296 7,770,515 12,716,099 16,937,641
0090 Grifols Therapeutic LLC.
0091 Talecris Plasma Resources Inc.
United States
United States
Industrial
Industrial
--
--
100.000
100.000
100.000
100.000
(2,885,734)
7
2,228,654,149
(18,168,778)
248,881,319
9,182,229
--
--
323,727,951
14,186,774
2,798,377,685
5,200,232
--
--
--
--
0094 Grifols Worldwide Operations Limited Ireland Industrial 100.000 -- 100.000 1 874,407,707 (40,925,983) (100,000,000) 115,425,412 848,907,138 926,367,184 100,000,000
0095 Grifols Pharmaceutical Technology
(Shanghai) Co., Ltd. (formerly Grifols
Pharmaceutical Consulting
China Commercial 100.000 -- 100.000 1,000,000 2,994,696 (259,981) -- 1,815,013 5,549,727 1,000,000 --
(Shanghai) Co., Ltd.)
0097 Grifols Switzerland, AG
Switzerland Commercial 100.000 -- 100.000 81,189 (240,517) 336,241 -- (1,896) 175,017 169,208 --
0096 Grifols Diagnostics Solutions Inc
(formerly G-C Diagnostics Corp.)
United States Industrial 100.000 -- 100.000 37 923,571,607 (28,550,291) -- 107,496,400 1,002,517,752 875,354,371 -- --
0098 Grifols (H.K.), Limited Hong Kong Commercial -- 100.000 100.000 37,899,374 13,815,054 2,290,092 -- 7,823,384 61,827,904 -- --
0099 Grifols Japan KK Japan Commercial 100.000 -- 100.000 354,409 500,412 27,872 -- 72,410 955,102 708,818 --
00A1 Grifols Pharmaceutical Technology
Co., Ltd. Beijing Branch
China Commercial 100.000 -- 100.000 -- (2,084,931) 187,517 -- (1,184,554) (3,081,968) -- --
00A2 Grifols India Healthcare Private Ltd
00A4 Grifols Canadá, Ltd.
India
Canada
Commercial
Industrial
99.990
--
0.010
100.000
100.000
100.000
1,688
6
641,489
20,230,562
(62,414)
(2,879,681)
--
--
65,985
4,243,260
646,749
21,594,147
599,086
--
--
--
00A5 Grifols Diagnostics Equipment Taiwan Limited Taiwan Commercial 100.000 -- 100.000 181,343 170,253 (185) -- 255,321 606,732 181,061 --
00A6 Grifols Innovation and New Technologies Limite Ireland Research -- 100.000 100.000 1 169,407,849 (6,403,463) -- (92,849,074) 70,155,313 -- --
00A7 AlbaJuna Therapeutics, S.L Spain Research -- 30.000 30.000 7,143 3,824,469 (1,384,316) 2,447,295 -- --
00A8 Interstate Blood Bank, Inc. United States Industrial -- 49.190 49.190 80,088 7,607,601 1,294,960 -- 1,181,026 10,163,675 -- --
00A9 Bio Blood Components Inc. United States Industrial -- 48.972 48.972 11,507 7,101,024 655,554 -- (1,153,615) 6,614,470 -- --
00B1 Singulex, Inc. United States Research -- 19.330 19.330 3,335 (161,630,118) (27,718,669) (189,345,452) -- --
00B2 PBS Acquisition Corp.
00B3 Plasma Biological Services, LLC.
United States
United States
Industrial
Industrial
--
--
100.000
48.900
100.000
48.900
(196,179)
7,504
26,435,246
(6,313,242)
(1,474,621)
--
--
--
--
644,972
24,764,446
(5,660,765)
--
--
--
--
00B4 Chiquito Acquisition Corp. United States Corporate -- 100.000 100.000 -- 48,059,553 (5,526,067) -- -- 42,533,486 -- --
00B5 Access Biologicals, LLC. and Subsidiaries. United States Industrial -- 49.000 49.000 -- 7,839,027 -- 3,496,885 11,335,912 -- --
00B7 Aigües Minerals Vilajuïga Spain Industrial 50.000 -- 50.000 75,000 275,136 231,262 -- (467,009) 114,389 -- --

00B8 GigaGen Inc. United States Industrial -- 43.960 43.960 1,117 29,303,768 896 (3,002,866) 26,302,915 -- --

Directors Report

To the shareholders:

  1. Business performance and position of the Company

Grifols, S.A. is a Spanish holding company specialized in the pharmaceutical-clinical sector. It is the Parent of the Grifols Group and its principal activities are as follows:

  • Defining action plans and general procedures for the entire Group
  • Planning future investments by entering new markets or through product diversification

  • Providing support to the various functional areas in each Group company (products division, technical division, marketing/sales division, scientific division, financial division and planning and control division)

  • Leasing buildings to Group companies.

  • Rendering services to subsidiaries such as personnel recruitment and management, communications and corporate image, IT services and maintenance.

The Company obtains its income from leasing its buildings and rendering services, and through dividends from its subsidiaries.

  1. Forecast

The Company's profits could be affected by events related to the activities of its subsidiaries, such as a lack of raw materials for product manufacturing, the arrival of competitor products on the market or regulatory changes in the markets in which it operates.

At the date of authorization for issue of these annual accounts, the Company has taken the measures it considers appropriate to mitigate any possible effects arising from the aforementioned events.

  1. Treasury stock

At 31 December 2018, the Company has treasury stock of Euros 55,441,210, as described in note 16 to the accompanying annual accounts. Transactions involving treasury stock in 2018 are described in note 16 to the accompanying annual accounts.

  1. Research and development

The Company does not conduct any research and development activities.

  1. Management of financial risks

The Company's financial risk management policy is detailed in note 11 to the accompanying annual accounts.

  1. Deferred payments to suppliers

As indicated in note 20 to these annual accounts, and as the average payment period is greater than the maximum period established in late payment legislation, the Company is studying best practices to reduce the average number of days.

  1. Non-financial information statement

The non-financial information statement is presented in the consolidated directors' report of the Grifols, S.A and Subsidiaries Group of which the Company forms part, and has been prepared in line with the requirements set out in Law 11/2018 of 28 December 2018 on non-financial information and diversity, approved on 13 December 2018 by the Spanish Congress of Representatives, amending the Spanish Code of Commerce, the Revised Spanish Companies Act approved by Royal Legislative Decree 1/2010 of 2 July 2010 and Spanish Audit Law 22/2015 of 20 July 2015, as regards non-financial information and diversity (under Royal-Decree Law 18/2017 of 24 November 2017).

  1. Annual Corporate Governance report

The annual corporate governance report of Grifols, S.A. forms part of this directors' report and is available at www.grifols.es. It is also published Significant Events on the Spanish National Securities Market Commission (CNMV) website

(Free translation from the original in Spanish. In the event of discrepancy, the Spanish-language version prevails)

At their meeting held on 22 February 2019, pursuant to the requirements of article 253.2 pf the Revised Spanish Companies Act and article 37 of the Spanish Code of commerce, the Directors of Grifols, S.A. authorised for issue the annual accounts and directors' report for the period from 1 January 2018 to 31 December 2018. The annual accounts comprise the documents that precede this certification.

Victor Grifols Roura Raimon Grifols Roura Víctor Grifols Deu
(signed) (signed) (signed)
President –
Board
Chief Executive Officer Chief Executive Officer
Member
Carina Szpilka Lázaro Tomás Dagà Gelabert Thomas Glanzmann
(signed) (signed) (signed)
Board member Board member Vice-Chairman
Iñigo Sánchez-Asiaín Anna Veiga Lluch Luis Isasi Fernández de
Mardone Bobadilla
(*) (signed) (signed)
Board member Board member Board member
Steven F. Mayer Belen Villalonga Marla E. Salmon
Morenés
(signed) (signed) (signed)
Board member Board member Board member
Ramón Riera Roca Nuria Martín Barnés
(signed) (signed)
Board Member Secretary to the Board

(*) Absent on a business trip, attended the meeting by conference call and did not express any disconformity with the documentation.

DECLARACIÓN DE RESPONSABILIDAD DECLARATION OF RESPONSIBILITY

De conformidad con lo dispuesto en el artículo 8.1.b del Real Decreto 1362/2007, de 19 de octubre, los consejeros de Grifols, S.A. (la "Sociedad")

DECLARAN DECLARE

Bajo su responsabilidad que, hasta donde alcanza su conocimiento, las cuentas anuales del ejercicio cerrado a 31 de diciembre de 2018, elaboradas con arreglo a los principios de contabilidad aplicables, ofrecen la imagen fiel del patrimonio, de la situación financiera y de los resultados de la Sociedad y de las empresas comprendidas en la consolidación tomados en su conjunto, y que el informe de gestión incluye un análisis fiel de la evolución y los resultados empresariales y de la posición de la Sociedad y de las empresas comprendidas en la consolidación tomadas en su conjunto, junto con la descripción de los principales riesgos e incertidumbres a que se enfrentan.

En Barcelona, a 27 de febrero 2019 In Barcelona, on 27 February 2019

Pursuant to the provisions of article 8.1.b of Royal Decree 1362/2007, of 19 October, the directors of Grifols, S.A. (the "Company")

On their own responsibility that, to the Best of their knowledge, the annual accounts for the fiscal year ended on 31 December 2018, prepared in accordance with applicable accounting standards, give a fair view of the net worth, financial situation and results of the Company and of the companies included in its consolidation scope, considered as a whole, and that the director's report contains an accurate analysis of the evolution, business results and position of the Company and of the companies included in its consolidate scope, taken as a whole, together with a description of the main risks and uncertainties which they face.

Firmado By:

Victor Grifols Roura (signed)
Chairman
Raimon
Grifols
Roura
(signed)
Board Member
Víctor Grifols Deu (signed)
Board Member
Ramón Riera Roca (signed)
Board member
Thomas Glanzmann (signed)
Board Member
Tomás
Dagá
Gelabert
(signed)
Board member
Carina
Szpilka
Lázaro
(signed)
Board member
Íñigo
Sánchez-Asiaín
Mardones
(signed)
Board
member
Marla E. Salmon (signed)
Board member
Anna Veiga Lluch (signed)
Board member
Luis
Isasi
Fernández
de
Bobadilla (signed)
Board member
Steven F. Mayer (signed)
Board member
Belén
Villalonga
Morenés
(signed) Board member
Núria Martín Barnés (signed)
Secretary

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