Zealand Pharma

Earnings Release • Apr 30, 2015

Lyxumia® royalty revenue to Zealand amounted to DKK 6.3 / EUR 0.9 million in Q1
2015 based on Sanofi's ex-US sales of the product in the period

Copenhagen, 2015-04-30 07:39 CEST (GLOBE NEWSWIRE) -- 30 April 2015 – Zealand
Pharma A/S (“Zealand”) (Nasdaq Copenhagen: ZEAL) reports Lyxumia®
(lixisenatide) royalty revenue of DKK 6.3 / EUR 0.9 million for the 1st quarter
2015. The reported royalty revenue is based on Sanofi’s sales of Lyxumia® ex-US
in the reported period and represents a 66% increase over the same period in
2014.

Lyxumia® is a once-daily prandial GLP-1 receptor agonist for the treatment of
Type 2 diabetes, invented by Zealand and developed and commercialized by Sanofi
under a global license agreement. Lyxumia® is approved in over 50 countries
ex-US and so far, Sanofi has launched the product in more than 35 of these
countries with further launches planned later in 2015.

Following supportive top-line results from ELIXA, the cardiovascular safety
outcome trial on Lyxumia®, reported on 19 March 2015 (company announcement no.
07-15), Sanofi proceeds towards planned US regulatory submission in Q3 2015.

Commenting on this announcement, Britt Meelby Jensen, President and CEO of
Zealand, said: “Lyxumia® is the first Zealand invented medicine to be marketed,
representing the start of sustainable revenue for our company. With the
recently announced top-line results of the cardiovascular safety study, ELIXA,
another important milestone has been met for Lyxumia®, paving the way also for
Sanofi’s planned regulatory submission in the US in Q3 this year."

Terms of the license collaboration with Sanofi

Under the license agreement with Sanofi, covering lixisenatide (Lyxumia®) and
any combination products, which include lixisenatide, Zealand is eligible to
receive remaining milestone payments of up to USD 160 million. Further, Zealand
is entitled to tiered low double-digit percentage royalties on Sanofi's global
sales of Lyxumia® and to fixed low double-digit percentage royalties on global
full net sales of LixiLan. LixiLan is the single once-daily injection
combination of Lyxumia® with Lantus®, planned by Sanofi for regulatory
submissions in the US and Europe in Q4 2015, pending the results of two
clinical Phase III trials, expected in Q3 2015.

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For further information, please contact:

Britt Meelby Jensen, President and Chief Executive Officer

Tel: +45 51 67 61 28, email: bmj@zealandpharma.com

Hanne Leth Hillman, Senior Vice President for Communications and Investor
Relations

Tel: +45 50 60 36 89, email: hlh@zealandpharma.com

About Zealand Pharma

Zealand Pharma A/S (“Zealand”) (Nasdaq Copenhagen: ZEAL) is a biotechnology
company based in Copenhagen, Denmark. Zealand has leading expertise in the
discovery, design and development of novel peptide medicines and possesses
in-house competences in clinical trial design and management with a therapeutic
focus on metabolic diseases and acute care indications. The company is
advancing a pipeline of novel wholly-owned medicines alongside a partnered
product and development portfolio.

Zealand’s first invented medicine, lixisenatide, a once-daily prandial GLP-1
agonist for the treatment of Type 2 diabetes, is marketed globally (ex-US) as
Lyxumia® and in Phase III development as a single-injection combination with
Lantus® (LixiLan), both under a global license agreement with Sanofi. US
regulatory submission of Lyxumia® is planned for Q3 2015 and US/EU regulatory
submissions for LixiLan in Q4 2015.

Zealand’s wholly-owned products include danegaptide (prevention of Ischemic
Reperfusion Injury) in Phase II and the stable glucagon product, ZP4207
(treatment of severe hypoglycemia) in Phase I as well as several preclinical
peptide therapeutics. Partnering represents an important component of strategy
to leverage in-house expertise, share development risk in large clinical
trials, provide funding and commercialize the company’s products. Zealand
currently has global license agreements and partnerships with Sanofi, Helsinn
Healthcare, Boehringer Ingelheim and Eli Lilly.

For further information: www.zealandpharma.com Follow us on Twitter
@ZealandPharma