VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2012

May 9, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2012-05-07

Reporting Person: Kelly Lisa (SVP, Human Resources)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-07	Common Stock	M	28593	$32.16	Acquired	57168	Direct
2012-05-07	Common Stock	M	3813	$32.16	Acquired	60981	Direct
2012-05-07	Common Stock	S	16242	$55.00	Disposed	44739	Direct
2012-05-07	Common Stock	S	7187	$52.13	Disposed	37552	Direct
2012-05-07	Common Stock	S	14297	$57.50	Disposed	23255	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-05-07	Stock Option	$32.16	M	28593	Disposed	2018-07-23	Common Stock (28593)	Direct
2012-05-07	Stock Option	$18.93	M	3813	Disposed	2018-02-06	Common Stock (3813)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1667	Indirect

Footnotes

F1: Transaction made pursuant to Ms. Kelly-Croswell's company approved trading plan under Rule 10b5-1.

F2: Fully vested.