VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2012

May 16, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2012-05-09

Reporting Person: Silva Paul M (SVP & Corp Controller)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-09	Common Stock	M	7500	$36.27	Acquired	13625	Direct
2012-05-09	Common Stock	M	7032	$18.93	Acquired	20657	Direct
2012-05-09	Common Stock	M	5156	$33.28	Acquired	25813	Direct
2012-05-09	Common Stock	M	3515	$32.16	Acquired	29328	Direct
2012-05-09	Common Stock	M	1125	$37.86	Acquired	30453	Direct
2012-05-09	Common Stock	M	8437	$39.05	Acquired	38890	Direct
2012-05-09	Common Stock	M	4687	$38.80	Acquired	43577	Direct
2012-05-09	Common Stock	M	3281	$33.82	Acquired	46858	Direct
2012-05-09	Common Stock	M	12187	$33.55	Acquired	59045	Direct
2012-05-09	Common Stock	M	3375	$51.75	Acquired	62420	Direct
2012-05-09	Common Stock	S	55295	$60.85	Disposed	7125	Direct
2012-05-09	Common Stock	S	1000	$61.08	Disposed	6125	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-05-09	Stock Option	$36.27	M	7500	Disposed	2017-08-12	Common Stock (7500)	Direct
2012-05-09	Stock Option	$18.93	M	7032	Disposed	2018-02-06	Common Stock (7032)	Direct
2012-05-09	Stock Option	$33.28	M	5156	Disposed	2019-07-15	Common Stock (5156)	Direct
2012-05-09	Stock Option	$32.16	M	3515	Disposed	2018-07-23	Common Stock (3515)	Direct
2012-05-09	Stock Option	$37.86	M	1125	Disposed	2022-02-01	Common Stock (1125)	Direct
2012-05-09	Stock Option	$39.05	M	8437	Disposed	2020-02-03	Common Stock (8437)	Direct
2012-05-09	Stock Option	$38.80	M	4687	Disposed	2021-02-02	Common Stock (4687)	Direct
2012-05-09	Stock Option	$33.82	M	3281	Disposed	2020-07-13	Common Stock (3281)	Direct
2012-05-09	Stock Option	$33.55	M	12187	Disposed	2019-02-04	Common Stock (12187)	Direct
2012-05-09	Stock Option	$51.75	M	3375	Disposed	2021-07-12	Common Stock (3375)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1380	Indirect

Footnotes

F1: Open market sales reported on this line occurred at a weighted average price of $60.85 (range $60.85 to $60.95).

F2: Mr. Silva undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F3: Open market sales reported on this line occurred at a weighted average price of $61.08 (range $61.02 to $61.09).