VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2012

May 9, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2012-05-07

Reporting Person: Sachdev Amit (SVP, Corp Affairs & Pub Policy)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-07	Common Stock	M	56250	$29.25	Acquired	89858	Direct
2012-05-07	Common Stock	S	58750	$52.13	Disposed	31108	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-05-07	Stock Option	$29.25	M	56250	Disposed	2017-07-22	Common Stock (56250)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	618	Indirect

Footnotes

F1: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F2: Fully vested.