VERTEX PHARMACEUTICALS INC / MA - Director's Dealing 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2012-05-07

Reporting Person: Wysenski Nancy (EVP, Chief Commercial Officer)

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-05-07	Common Stock	M	6797	$33.82	Acquired	43191	Direct
2012-05-07	Common Stock	M	12500	$39.70	Acquired	55691	Direct
2012-05-07	Common Stock	M	120000	$39.70	Acquired	175691	Direct
2012-05-07	Common Stock	M	3398	$38.80	Acquired	179089	Direct
2012-05-07	Common Stock	S	147695	$54.50	Disposed	31394	Direct
2012-05-08	Common Stock	M	9063	$33.82	Acquired	40457	Direct
2012-05-08	Common Stock	M	10196	$38.80	Acquired	50653	Direct
2012-05-08	Common Stock	M	18750	$39.70	Acquired	69403	Direct
2012-05-08	Common Stock	S	9063	$59.19	Disposed	60340	Direct
2012-05-08	Common Stock	S	10196	$62.08	Disposed	50144	Direct
2012-05-08	Common Stock	S	18750	$63.52	Disposed	31394	Direct

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-05-07	Stock Option	$33.82	M	6797	Disposed	2020-07-13	Common Stock (6897)	Direct
2012-05-07	Stock Option	$39.70	M	12500	Disposed	2019-12-08	Common Stock (12500)	Direct
2012-05-07	Stock Option	$39.70	M	120000	Disposed	2019-12-08	Common Stock (120000)	Direct
2012-05-07	Stock Option	$38.80	M	3398	Disposed	2021-02-02	Common Stock (3398)	Direct
2012-05-08	Stock Option	$33.82	M	9063	Disposed	2020-07-13	Common Stock (9063)	Direct
2012-05-08	Stock Option	$38.80	M	10196	Disposed	2021-02-02	Common Stock (10196)	Direct
2012-05-08	Stock Option	$39.70	M	18750	Disposed	2019-12-08	Common Stock (18750)	Direct

F1: Transaction made pursuant to Ms. Wysenski's company approved trading plan under Rule 10b5-1.