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VERTEX PHARMACEUTICALS INC / MA Director's Dealing 2011

May 18, 2011

29864_dirs_2011-05-18_b0600c75-4a6e-4411-bcd6-d909eac665d5.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2011-05-16

Reporting Person: MUELLER PETER (EVP, Global R&D, CSO)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2011-05-16 Common Stock M 2500 $10.41 Acquired 136235 Direct
2011-05-16 Common Stock S 100 $55.44 Disposed 136135 Direct
2011-05-16 Common Stock S 700 $56.79 Disposed 135435 Direct
2011-05-16 Common Stock S 1700 $57.21 Disposed 133735 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2011-05-16 Stock Options $10.41 M 2500 Disposed 2015-02-02 Common Stock (2500) Direct

Holdings (Non-Derivative)

Security Shares Ownership
Common Stock 4495 Indirect

Footnotes

F1: Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1.

F2: Open market sales reported on this line occurred at a weighted average price of $56.79 (range $56.61 to $56.92).

F3: Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4: Open market sales reported on this line occurred at a weighted average price of $57.21 (range $57.00 to $57.49).

F5: Fully vested.