VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2011

Apr 27, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2011-04-26

Reporting Person: Kelly Lisa (SVP, Human Resources)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-04-26	Common Stock	M	14297	$28.84	Acquired	56539	Direct
2011-04-26	Common Stock	S	14297	$50.50	Disposed	42242	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-04-27	Stock Option	$28.84	M	14297	Disposed	2017-07-11	Common Stock (14297)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1182	Indirect

Footnotes

F1: Transaction made pursuant to Ms. Kelly-Croswell's company approved trading plan under Rule 10b5-1.

F2: Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/12/2007.