VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2011

May 26, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2011-05-25

Reporting Person: SMITH IAN F (EVP & CFO)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-05-25	Common Stock	S	4544	$55.52	Disposed	35333	Direct
2011-05-25	Common Stock	S	7540	$56.21	Disposed	27793	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	5050	Indirect

Footnotes

F1: Transaction made pursuant to Mr. Smith's company approved trading plan under Rule 10b5-1.

F2: Open market sales reported on this line occurred at a weighted average price of $55.52 (range $55.07 to $55.98).

F3: Mr. Smith undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4: Open market sales reported on this line occurred at a weighted average price of $56.21 (range $56.00 to $56.63).