VERTEX PHARMACEUTICALS INC / MA — Director's Dealing 2011

Aug 1, 2011

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: VERTEX PHARMACEUTICALS INC / MA (VRTX)
CIK: 0000875320
Period of Report: 2011-07-29

Reporting Person: Kelly Lisa (SVP, Human Resources)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2011-07-29	Common Stock	M	954	$28.84	Acquired	39036	Direct
2011-07-29	Common Stock	S	954	$52.50	Disposed	38082	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2011-07-29	Stock Option	$28.84	M	954	Disposed	2021-07-12	Common Stock (954)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1520	Indirect

Footnotes

F1: Transaction made pursuant to Ms. Kelly-Croswell's company approved trading plan under Rule 10b5-1.

F2: Fully vested.