Vanda Pharmaceuticals Inc. — Major Shareholding Notification 2012

Feb 14, 2012

SC 13G/A 1 c68528_13ga.htm

CUSIP No. 921659108 13G Page 2 of 10

SECURITIES AND EXCHANGE COMMISSION
Washington,
D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
Information
to be Included in Statements Filed Pursuant to §240.13d-1(b), (c)
and
(d) and Amendments Thereto Filed Pursuant to §240.13d-2
Under
the Securities Exchange Act of 1934
(Amendment No. 4)*
Vanda Pharmaceuticals Inc.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
921659108
(CUSIP Number)
December 31, 2011
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:
(x) Rule 13d-1(b)
( ) Rule 13d-1(c)
( ) Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

(Continued on following page(s))

CUSIP No. 921659108 13G Page 3 of 10

1.	NAME OF REPORTING PERSONS
	TIAA-CREF Investment Management, LLC
2.	CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP		(a) ( )
			(b) ( )
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF
ORGANIZATION
	Delaware
NUMBER OF SHARES
BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:
	5.	SOLE VOTING POWER	1,640,204
	6.	SHARED VOTING POWER	0
	7.	SOLE DISPOSITIVE POWER	1,640,204
	8.	SHARED DISPOSITIVE POWER	0
9.	AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
		1,640,204
10.	CHECK BOX IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ( )
11.	PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW 9
		5.83%
12.	TYPE OF REPORTING PERSON
		IA

CUSIP No. 921659108 13G Page 4 of 10

1.	NAME OF REPORTING PERSONS
	College Retirement Equities Fund- Stock Account
2.	CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP		(a) ( )
			(b) ( )
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF
ORGANIZATION
	New York
NUMBER OF SHARES
BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:
	5.	SOLE VOTING POWER	0
	6.	SHARED VOTING POWER	1,440,089
	7.	SOLE DISPOSITIVE POWER	0
	8.	SHARED DISPOSITIVE POWER	1,440,089
9.	AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
		1,440,089
10.	CHECK BOX IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES CERTAIN
	SHARES		( )
11.	PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW 9
		5.12%
12.	TYPE OF REPORTING PERSON
		IV

CUSIP No. 921659108 13G Page 5 of 10

1.	NAME OF REPORTING PERSONS
	Teachers Advisors, Inc.
2.	CHECK THE APPROPRIATE BOX
IF A MEMBER OF A GROUP		(a) ( )
			(b) ( )
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF
ORGANIZATION
	Delaware
NUMBER OF SHARES
BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:
	5.	SOLE VOTING POWER	565,321
	6.	SHARED VOTING POWER	0
	7.	SOLE DISPOSITIVE POWER	565,321
	8.	SHARED DISPOSITIVE POWER	0
9.	AGGREGATE AMOUNT
BENEFICIALLY OWNED BY EACH REPORTING PERSON
		565,321
10.	CHECK BOX IF THE AGGREGATE
AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ( )
11.	PERCENT OF CLASS
REPRESENTED BY AMOUNT IN ROW 9
		2.01%
12.	TYPE OF REPORTING PERSON
		IA

CUSIP No. 921659108 13G Page 6 of 10

| Item 1(a). | NAME OF ISSUER: | | --- | --- | | | Vanda Pharmaceuticals Inc. | | Item 1(b). | ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES: | | | 9620 Medical Center Drive | | | Suite 300 | | | Rockville, MD 20850 | | Items 2(a)-2(c). | NAME, ADDRESS OF PRINCIPAL BUSINESS OFFICE, AND CITIZENSHIP OF PERSONS FILING: | | | TIAA-CREF Investment Management, LLC (“Investment Management”) | | | 730 Third Avenue | | | New York, NY 10017-3206 | | | Citizenship: Delaware | | | College Retirement Equities Fund-Stock Account (“CREF Stock Account”) | | | 730 Third Avenue | | | New York, NY 10017-3206 | | | Citizenship: New York | | | Teachers Advisors, Inc. (“Advisors”) | | | 730 Third Avenue | | | New York, NY 10017-3206 | | | Citizenship: Delaware | | Item 2(d). | TITLE OF CLASS OF SECURITIES: | | | Common Stock | | Item 2(e). | CUSIP NUMBER: 921659108 | | Item 3. | IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b), OR 13d-2(b) or (c), CHECK WHETHER THE PERSON FILING IS A: |

| Investment Management — (a) | ( ) | Broker or dealer registered under Section 15 of the Exchange Act. | | --- | --- | --- | | (b) | ( ) | Bank as defined in Section 3(a)(6) of the Exchange Act. | | (c) | ( ) | Insurance Company as defined in Section 3(a)(19) of the Exchange Act. |

CUSIP No. 921659108 13G Page 7 of 10

| (d) | ( ) | Investment Company registered under Section 8 of the Investment Company Act of 1940. | | --- | --- | --- | | (e) | (x) | An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E). | | (f) | ( ) | An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F). | | (g) | ( ) | A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G). | | (h) | ( ) | A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act. | | (i) | ( ) | A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940. | | (j) | ( ) | Group, in accordance with Rule 13d-1(b)(1)(ii)(J). | | CREF Stock Account | | | | (a) | ( ) | Broker or dealer registered under Section 15 of the Exchange Act. | | (b) | ( ) | Bank as defined in Section 3(a)(6) of the Exchange Act. | | (c) | ( ) | Insurance Company as defined in Section 3(a)(19) of the Exchange Act. | | (d) | (x) | Investment Company registered under Section 8 of the Investment Company Act of 1940. | | (e) | ( ) | An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E). | | (f) | ( ) | An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F). | | (g) | ( ) | A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G). | | (h) | ( ) | A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act. | | (i) | ( ) | A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940. | | (j) | ( ) | Group, in accordance with Rule 13d-1(b)(1)(ii)(J). | | Advisors | | | | (a) | ( ) | Broker or dealer registered under Section 15 of the Exchange Act. | | (b) | ( ) | Bank as defined in Section 3(a)(6) of the Exchange Act. | | (c) | ( ) | Insurance Company as defined in Section 3(a)(19) of the Exchange Act. | | (d) | ( ) | Investment Company registered under Section 8 of the Investment Company Act of 1940. | | (e) | (x) | An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E). | | (f) | ( ) | An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F). | | (g) | ( ) | A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G). | | (h) | ( ) | A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act. | | (i) | ( ) | A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940. |

CUSIP No. 921659108 13G Page 8 of 10

(j)
If this statement is filed
pursuant to Rule 13d-1(c), check this box. ( )

Item 4.
(a)
Aggregate amount beneficially owned:	2,205,525
(See Exhibit A attached)
(b) Percent
of class:	7.844%
(c) Number
of shares as to which person has:

| Sole Voting

Power:	1,640,204	0	565,321
Shared
Voting Power:	0	1,440,089	0
Sole
Dispositive Power:	1,640,204	0	565,321
Shared
Dispositive Power:	0	1,440,089	0

| Item 5. | OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS. | | --- | --- | | | If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ( ). | | Item 6. | OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON. | | | See Exhibit A attached | | Item 7. | IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY. | | | Not Applicable | | Item 8. | IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. |

CUSIP No. 921659108 13G Page 9 of 10

| | Not Applicable | | --- | --- | | Item 9. | NOTICE OF DISSOLUTION OF GROUP. | | | Not Applicable | | Item 10. | CERTIFICATIONS. | | | By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with nomination under §240.14a-11 | | | SIGNATURE. | | | After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. | | | Date: February 14, 2012 |

| TIAA-CREF

INVESTMENT MANAGEMENT, LLC
By:	/s/ Richard S.
Biegen
Richard
Biegen, Chief Compliance Officer
COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT
By:	/s/ Richard S.
Biegen
Richard Biegen, Chief Compliance Officer
TEACHERS ADVISORS, INC.
By:	/s/ Richard S.
Biegen
Richard
Biegen, Managing Director,
Senior
Compliance Officer

EXHIBIT A

ITEM 6. OWNERSHIP.

TIAA-CREF Investment Management, LLC (“Investment Management”) is the investment adviser to the College Retirement Equities Fund (“CREF”), a registered investment company, and may be deemed to be a beneficial owner of 1,640,204 shares of Issuer’s common stock owned by CREF. Teachers Advisors, Inc. (“Advisors”) is the investment adviser to three registered investment companies, TIAA-CREF Funds (“Funds”), TIAA-CREF Life Funds (“Life Funds”), and TIAA Separate Account VA-1 (“VA-1”), and may be deemed to be a beneficial owner of 565,321 shares of Issuer’s common stock owned separately by Funds, Life Funds and VA-1. Investment Management and Advisors are reporting their combined holdings for the purpose of administrative convenience. These shares were acquired in the ordinary course of business, and not with the purpose or effect of changing or influencing control of the Issuer. Each of Investment Management and Advisors expressly disclaims beneficial ownership of the other’s securities holdings and each disclaims that it is a member of a “group” with the other.