VALIRX PLC — Director's Dealing 2026

Mar 4, 2026

National Storage Mechanism | Additional information

RNS Number : 2124V

ValiRx PLC

04 March 2026

ValiRx PLC

("ValiRx" or the "Company")

Director/PDMR Shareholding

London, UK - ValiRx Plc (AIM: VAL), a life science company focusing on early-stage cancer therapeutics and women's health, announces that it received notification on 3 March 2026 that Mark Eccleston, Chief Executive Officer, made the following purchase of ordinary shares in the Company.  

Director	Purchase price (Aggregated)	Ordinary shares purchased	Resultant interest in ordinary shares	Resultant percentage of issued ordinary shares
Mark Eccleston	0.33 pence	1,000,000	59,746,187	8.04%

Further details are set out in the Notification of Dealing Form below.

This announcement contains inside information for the purposes of the UK Market Abuse Regulation and the Directors of the Company are responsible for the release of this announcement.

*** ENDS ***

Engage with the ValiRx management team directly by asking questions, watching video
summaries and seeing what other shareholders have to say. Navigate to our Interactive Investor
hub here: https://valirx.com/s/cc8ef3

For more information, please contact:

Investor questions on this announcement We encourage all investors to share questions on this announcement via our investor hub	https://valirx.com/link/peg6vy
ValiRx plc Dr Mark Eccleston, CEO	Tel: +44 115 784 0026 www.valirx.com [email protected]
Cairn Financial Advisers LLP (Nominated Adviser) Liam Murray / Ludovico Lazzaretti	Tel: +44 (0) 20 7213 0880
Shard Capital Partners LLP (Sole Broker) Damon Heath	Tel: +44 (0) 20 7186 9000
V Formation (Public Relations) Lucy Wharton - Senior PR Executive Sue Carr - Director	+44 (0) 115 787 0206 www.vformation.biz [email protected] [email protected]

Subscribe to our news alert service: https://valirx.com/s/f298d1

Notes for Editors

About ValiRx

ValiRx is a life science company focused on early-stage cancer therapeutics and women's health, accelerating the translation of innovative science into impactful medicines to improve patient lives.

ValiRx provides the scientific, financial, and commercial framework for enabling rapid translation of innovative science into clinical development.

Using its extensive and proven experience in research and drug development, the team at ValiRx selects and incubates promising novel drug candidates and guides them through an optimised process of development, from pre-clinical studies to clinic and investor-ready assets.

ValiRx connects diverse disciplines across scientific, technical, and commercial domains, with the aim of achieving a more streamlined, less costly, drug development process. The team works closely with carefully selected collaborators and leverages the combined expertise required for science to advance.

Lead candidates from ValiRx's portfolio are outlicensed or partnered with investors through ValiRx subsidiary companies for further clinical development and commercialisation.

ValiRx listed on the AIM Market of the London Stock Exchange in October 2006 and trades under the ticker symbol: VAL.

For further information, visit: www.valirx.com

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them

1

Details of the persons discharging managerial responsibilities / person closely associated

a)

Name

Mark Eccleston

2

Reason for the notification

a)

Position/Status

Chief Executive Officer

b)

Initial notification/ Amendment

Initial

3

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

ValiRx PLC

b)

LEI

213800VQKB9SJCQDET40

4

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial

instrument, type of

instrument

Identification code

Ordinary shares

GB00BLH13C52

b)

Nature of the transaction

Purchase of shares

c)

Price(s) and volume(s)

Price(s)	Volume(s)
0.33 pence	1,000,000

d)

Aggregated information

-      Aggregated volume

-      Price

N/A

e)

Date of transaction

3 March 2026

f)

Place of transaction

AIM

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact [email protected] or visit www.rns.com.

RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy.

END

DSHDBGDXRSGDGLX