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Upstream Bio, Inc. Director's Dealing 2026

Jan 6, 2026

32187_dirs_2026-01-06_241d9e01-d074-4f2b-98fc-b3658d42416c.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Upstream Bio, Inc. (UPB)
CIK: 0002022626
Period of Report: 2026-01-02

Reporting Person: Sutherland Everett Rand (N/A)

Non-Derivative Transactions

Date Security Code Shares Price A/D Holdings After Ownership
2026-01-02 Common Stock A 75000 Acquired 75000 Direct

Derivative Transactions

Date Security Exercise Price Code Shares A/D Expiration Underlying Ownership
2026-01-02 Stock Option (Right to Buy) $27.07 A 225000 Acquired 2036-01-01 Common Stock (225000) Direct

Footnotes

F1: Represents restricted stock units ("RSUs") granted pursuant to the Issuer's 2024 Stock Option and Incentive Plan. Each RSU represents the contingent right to receive one share of the Issuer's Common Stock upon vesting. The RSUs shall vest in sixteen equal quarterly installments following January 1, 2026, subject to the Reporting Person's continued service on each such vesting date.

F2: The shares underlying this option shall vest in forty-eight equal monthly installments following January 1, 2026, subject to the Reporting Person's continued service on each such vesting date.