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Upstream Bio, Inc. Director's Dealing 2025

Feb 7, 2025

32187_dirs_2025-02-07_65571280-e8a7-4b93-b1a4-0176b169649f.zip

Director's Dealing

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SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Upstream Bio, Inc. (UPB)
CIK: 0002022626
Period of Report: 2025-02-06

Reporting Person: Sutherland Everett Rand (N/A)

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2025-02-06	Stock Option (Right to Buy)	$8.53	A	500000	Acquired	2035-02-05	Common Stock (500000)	Direct

Footnotes

F1: The shares underlying this option shall vest in forty-eight equal monthly installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.